GO:0004822
JSON
isoleucine-tRNA ligase activity
Molecular Function
Definition (GO:0004822 GONUTS page)
Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
isoleucine-tRNA synthetase activity | related |
isoleucyl-tRNA synthetase activity | exact |
isoleucyl-transfer ribonucleate synthetase activity | related |
isoleucine-transfer RNA ligase activity | related |
isoleucyl-transfer RNA synthetase activity | related |
L-isoleucine:tRNAIle ligase (AMP-forming) | related |
isoleucine translase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.1.1.5 | |
InterPro | IPR002301 | Isoleucine-tRNA ligase |
InterPro | IPR023585 | Isoleucine-tRNA ligase, type 1 |
InterPro | IPR023586 | Isoleucine-tRNA ligase, type 2 |
KEGG_REACTION | R03656 | |
MetaCyc | ISOLEUCINE--TRNA-LIGASE-RXN | |
RHEA | 11060 | |
Reactome | R-HSA-379893 | |
Reactome | R-HSA-380176 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:33019 | diphosphate(3-) |
has_participant | CHEBI | CHEBI:456215 | adenosine 5'-monophosphate(2-) |
has_participant | CHEBI | CHEBI:78528 | 3'-(L-isoleucyl)adenylyl zwitterionic group |
has_participant | CHEBI | CHEBI:58045 | L-isoleucine zwitterion |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:78442 | AMP 3'-end(1-) residue |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004822 based on ALL annotations
The top 100 of 323 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
isoleucine-tRNA ligase activity
|
2,907.75 | 100.00 | 67,041 | 67,041 |
isoleucyl-tRNA aminoacylation
|
2,907.75 | 98.87 | 66,283 | 66,283 |
aminoacyl-tRNA editing activity
|
504.02 | 16.84 | 57,375 | 331,001 |
aminoacyl-tRNA metabolism involved in translational fidelity
|
449.00 | 15.05 | 57,375 | 371,564 |
tRNA aminoacylation for protein translation
|
172.23 | 5.30 | 22,588 | 381,347 |
aminoacyl-tRNA ligase activity
|
152.28 | 5.23 | 66,153 | 1,263,165 |
tRNA binding
|
123.22 | 4.20 | 54,747 | 1,291,960 |
mitochondrial translation
|
101.81 | 2.44 | 5,004 | 142,916 |
reproductive structure development
|
271.49 | 1.43 | 1,109 | 11,878 |
post-embryonic development
|
126.22 | 1.21 | 1,109 | 25,549 |
Totals | 679537 | 127522390 |
No co-occurrence statistics for GO:0004822 based on MANUAL annotations
The top 32 of 32 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
isoleucine-tRNA ligase activity
|
5,065.88 | 100.00 | 255 | 255 |
isoleucyl-tRNA aminoacylation
|
5,065.88 | 99.61 | 254 | 254 |
mitochondrial translation
|
253.43 | 4.61 | 94 | 1,879 |
GTPase binding
|
176.97 | 1.68 | 8 | 229 |
aminoacyl-tRNA synthetase multienzyme complex
|
78.30 | 1.12 | 10 | 647 |
tRNA aminoacylation for protein translation
|
434.22 | 1.05 | 3 | 35 |
regulation of sprouting angiogenesis
|
72.37 | 0.31 | 1 | 70 |
glutamine-tRNA ligase activity
|
37.53 | 0.26 | 1 | 135 |
arginine-tRNA ligase activity
|
24.12 | 0.22 | 1 | 210 |
mitochondrion
|
10.29 | 0.20 | 93 | 45,791 |
Totals | 798 | 599070 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+. |
2020-10-08 | Added | SYNONYM | isoleucine-transfer RNA ligase activity |
2020-10-08 | Added | SYNONYM | L-isoleucine:tRNAIle ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | isoleucyl-transfer ribonucleate synthetase activity |
2020-10-08 | Deleted | SYNONYM | L-isoleucine:tRNAIle ligase (AMP-forming) |
2020-10-08 | Deleted | SYNONYM | isoleucine-tRNA synthetase activity |
2020-10-08 | Deleted | SYNONYM | isoleucine-transfer RNA ligase activity |
2020-10-08 | Deleted | SYNONYM | isoleucyl-transfer RNA synthetase activity |
2020-10-08 | Added | SYNONYM | isoleucyl-transfer RNA synthetase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | isoleucine-tRNA ligase activity |
2002-02-06 | Updated | TERM | isoleucine-tRNA ligase |
2001-11-07 | Updated | TERM | isoleucine-tRNA ligase |
2001-04-03 | Updated | TERM | isoleucine--tRNA ligase |
2001-03-30 | Added | TERM | isoleucine--tRNA ligase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | DEFINITION | Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+). |
2022-09-01 | Added | DEFINITION | Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+. |
2020-10-08 | Added | SYNONYM | isoleucine-transfer RNA ligase activity |
2020-10-08 | Added | SYNONYM | L-isoleucine:tRNAIle ligase (AMP-forming) |
2020-10-08 | Added | SYNONYM | isoleucyl-transfer ribonucleate synthetase activity |
2020-10-08 | Deleted | SYNONYM | L-isoleucine:tRNAIle ligase (AMP-forming) |
2020-10-08 | Deleted | SYNONYM | isoleucine-tRNA synthetase activity |
2020-10-08 | Deleted | SYNONYM | isoleucine-transfer RNA ligase activity |
2020-10-08 | Deleted | SYNONYM | isoleucyl-transfer RNA synthetase activity |
2020-10-08 | Added | SYNONYM | isoleucyl-transfer RNA synthetase activity |
2020-10-08 | Added | SYNONYM | isoleucine translase activity |
2020-10-08 | Deleted | SYNONYM | isoleucyl-transfer ribonucleate synthetase activity |
2020-10-08 | Added | SYNONYM | isoleucine-tRNA synthetase activity |
2020-10-08 | Deleted | SYNONYM | isoleucine translase activity |
2010-10-11 | Deleted | DEFINITION | Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). |
2010-10-11 | Added | DEFINITION | Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+). |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). |
2007-11-08 | Added | SYNONYM | isoleucyl-transfer ribonucleate synthetase activity |
2007-11-08 | Added | SYNONYM | isoleucyl-transfer RNA synthetase activity |
2007-11-08 | Added | SYNONYM | isoleucine-transfer RNA ligase activity |
2007-11-08 | Added | SYNONYM | isoleucine-tRNA synthetase activity |
2007-11-08 | Added | SYNONYM | L-isoleucine:tRNAIle ligase (AMP-forming) |
2007-09-06 | Added | SYNONYM | isoleucine translase activity |
2007-08-09 | Added | SYNONYM | isoleucyl-tRNA synthetase activity |
2007-08-09 | Deleted | SYNONYM | isoleucyl-tRNA synthetase activity |
2004-04-19 | Added | SYNONYM | isoleucyl-tRNA synthetase activity |
2004-04-16 | Deleted | SYNONYM | isoleucyl-tRNA synthetase activity |
2003-12-16 | Added | SYNONYM | isoleucyl-tRNA synthetase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0004812 (aminoacyl-tRNA ligase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-20 | Deleted | XREF | KEGG:R03656 |
2019-06-20 | Added | XREF | KEGG_REACTION:R03656 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-380176 |
2019-04-01 | Added | XREF | Reactome:R-HSA-379893 |
2019-04-01 | Added | XREF | Reactome:R-HSA-380176 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-379893 |
2018-12-11 | Added | XREF | reactome:R-HSA-379893 |
2018-12-11 | Added | XREF | reactome:R-HSA-380176 |
2018-07-13 | Deleted | XREF | RHEA:11063 |
2018-07-13 | Added | XREF | RHEA:11060 |
2010-10-11 | Added | XREF | RHEA:11063 |
2010-10-11 | Added | XREF | KEGG:R03656 |
2003-10-27 | Added | XREF | MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN |
2001-03-30 | Added | XREF | EC:6.1.1.5 |
Timestamp | Action | Category | Detail |
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