GO:0004854
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xanthine dehydrogenase activity
Molecular Function
Definition (GO:0004854 GONUTS page)
Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
xanthine oxidoreductase activity | broad |
xanthine-NAD oxidoreductase activity | related |
xanthine/NAD(+) oxidoreductase activity | related |
xanthine:NAD+ oxidoreductase activity | related |
xanthine/NAD+ oxidoreductase activity | related |
NAD-xanthine dehydrogenase activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004854
Child Term | Relationship to GO:0004854 |
---|---|
xanthine dehydrogenase complex
|
capable_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.17.1.4 | |
InterPro | IPR014307 | Xanthine dehydrogenase, small subunit |
InterPro | IPR050028 | Xanthine dehydrogenase subunit XdhA |
InterPro | IPR050031 | Xanthine dehydrogenase subunit XdhB |
InterPro | IPR050033 | Xanthine dehydrogenase subunit XdhC |
MetaCyc | RXN0-901 | |
RHEA | 16669 | |
Reactome | R-HSA-9727349 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:57945 | NADH(2-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:17712 | 9H-xanthine |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:17775 | 7,9-dihydro-1H-purine-2,6,8(3H)-trione |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004854 based on ALL annotations
The top 100 of 200 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
xanthine dehydrogenase activity
|
10,828.13 | 100.00 | 18,003 | 18,003 |
xanthine dehydrogenase complex
|
10,821.71 | 9.36 | 1,686 | 1,687 |
xanthine oxidase activity
|
10,407.49 | 4.25 | 767 | 798 |
molybdenum ion binding
|
190.54 | 1.60 | 2,692 | 152,986 |
FAD binding
|
144.15 | 1.32 | 10,472 | 786,652 |
2 iron, 2 sulfur cluster binding
|
128.90 | 1.18 | 10,027 | 842,312 |
nicotinate dehydrogenase activity
|
1,998.37 | 0.98 | 184 | 997 |
iron ion binding
|
91.21 | 0.84 | 14,569 | 1,729,644 |
molybdopterin cofactor binding
|
91.67 | 0.77 | 1,478 | 174,586 |
purine nucleobase metabolic process
|
103.06 | 0.76 | 667 | 70,076 |
Totals | 87964 | 71098438 |
No co-occurrence statistics for GO:0004854 based on MANUAL annotations
The top 77 of 77 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
xanthine dehydrogenase activity
|
34,913.48 | 100.00 | 37 | 37 |
xanthine catabolic process
|
28,482.05 | 70.45 | 31 | 38 |
xanthine oxidase activity
|
34,913.48 | 16.22 | 6 | 6 |
hypoxanthine catabolic process
|
16,113.92 | 13.64 | 6 | 13 |
hypoxanthine dehydrogenase activity
|
34,913.49 | 10.81 | 4 | 4 |
guanine catabolic process
|
9,521.86 | 6.67 | 3 | 11 |
deoxyinosine catabolic process
|
8,728.37 | 6.52 | 3 | 12 |
inosine catabolic process
|
5,818.91 | 5.77 | 3 | 18 |
molybdopterin cofactor binding
|
2,235.84 | 5.73 | 13 | 203 |
hypoxanthine oxidase activity
|
34,913.49 | 5.41 | 2 | 2 |
Totals | 265 | 579470 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9727349 |
2020-10-08 | Deleted | SYNONYM | xanthine-NAD oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | NAD-xanthine dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | xanthine:NAD+ oxidoreductase activity |
2020-10-08 | Added | SYNONYM | xanthine-NAD oxidoreductase activity |
2020-10-08 | Added | SYNONYM | xanthine/NAD(+) oxidoreductase activity |
2020-10-08 | Added | SYNONYM | xanthine/NAD+ oxidoreductase activity |
2020-10-08 | Added | SYNONYM | xanthine:NAD+ oxidoreductase activity |
2020-10-08 | Added | SYNONYM | NAD-xanthine dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | xanthine/NAD(+) oxidoreductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | xanthine dehydrogenase activity |
2002-02-06 | Updated | TERM | xanthine dehydrogenase |
2001-04-03 | Updated | TERM | xanthine dehydrogenase |
2001-03-30 | Added | TERM | xanthine dehydrogenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | xanthine-NAD oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | NAD-xanthine dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | xanthine:NAD+ oxidoreductase activity |
2020-10-08 | Added | SYNONYM | xanthine-NAD oxidoreductase activity |
2020-10-08 | Added | SYNONYM | xanthine/NAD(+) oxidoreductase activity |
2020-10-08 | Added | SYNONYM | xanthine/NAD+ oxidoreductase activity |
2020-10-08 | Added | SYNONYM | xanthine:NAD+ oxidoreductase activity |
2020-10-08 | Added | SYNONYM | NAD-xanthine dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | xanthine/NAD(+) oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | xanthine/NAD+ oxidoreductase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+. |
2007-11-08 | Added | SYNONYM | xanthine:NAD+ oxidoreductase activity |
2007-11-08 | Added | SYNONYM | xanthine/NAD+ oxidoreductase activity |
2007-09-06 | Added | SYNONYM | NAD-xanthine dehydrogenase activity |
2007-09-06 | Added | SYNONYM | xanthine-NAD oxidoreductase activity |
2007-09-06 | Added | SYNONYM | xanthine/NAD(+) oxidoreductase activity |
2007-09-06 | Added | SYNONYM | xanthine oxidoreductase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016726 (oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9727349 |
2020-06-22 | Added | XREF | RHEA:16669 |
2009-05-21 | Added | XREF | MetaCyc:RXN0-901 |
2009-05-21 | Deleted | XREF | MetaCyc:XANTHINE-DEHYDROGENASE-RXN |
2005-08-29 | Deleted | XREF | EC:1.1.1.204 |
2005-08-29 | Added | XREF | EC:1.17.1.4 |
2003-10-27 | Added | XREF | MetaCyc:XANTHINE-DEHYDROGENASE-RXN |
2001-03-30 | Added | XREF | EC:1.1.1.204 |
Timestamp | Action | Category | Detail |
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