This term is obsolete.

GO:0004854 JSON

xanthine dehydrogenase activity

Molecular Function

Definition (GO:0004854 GONUTS page)

Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.

18,075 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
xanthine oxidoreductase activity broad
xanthine-NAD oxidoreductase activity related
xanthine/NAD(+) oxidoreductase activity related
xanthine:NAD+ oxidoreductase activity related
xanthine/NAD+ oxidoreductase activity related
NAD-xanthine dehydrogenase activity related

Ancestor Chart

Ancestor chart for GO:0004854
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004854

Child Term Relationship to
GO:0004854
xanthine dehydrogenase complex
capable_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.17.1.4
InterPro IPR014307 Xanthine dehydrogenase, small subunit
InterPro IPR050028 Xanthine dehydrogenase subunit XdhA
InterPro IPR050031 Xanthine dehydrogenase subunit XdhB
InterPro IPR050033 Xanthine dehydrogenase subunit XdhC
MetaCyc RXN0-901
RHEA 16669
Reactome R-HSA-9727349

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57945 NADH(2-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:17712 9H-xanthine
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:17775 7,9-dihydro-1H-purine-2,6,8(3H)-trione

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004854 based on ALL annotations
The top 100 of 200 co-occurring terms
Co-occurring Term PR S% #Together #Compared
xanthine dehydrogenase activity
10,828.13 100.00 18,003 18,003
xanthine dehydrogenase complex
10,821.71 9.36 1,686 1,687
xanthine oxidase activity
10,407.49 4.25 767 798
molybdenum ion binding
190.54 1.60 2,692 152,986
FAD binding
144.15 1.32 10,472 786,652
2 iron, 2 sulfur cluster binding
128.90 1.18 10,027 842,312
nicotinate dehydrogenase activity
1,998.37 0.98 184 997
iron ion binding
91.21 0.84 14,569 1,729,644
molybdopterin cofactor binding
91.67 0.77 1,478 174,586
purine nucleobase metabolic process
103.06 0.76 667 70,076
Totals 87964 71098438
No co-occurrence statistics for GO:0004854 based on MANUAL annotations
The top 77 of 77 co-occurring terms
Co-occurring Term PR S% #Together #Compared
xanthine dehydrogenase activity
34,913.48 100.00 37 37
xanthine catabolic process
28,482.05 70.45 31 38
xanthine oxidase activity
34,913.48 16.22 6 6
hypoxanthine catabolic process
16,113.92 13.64 6 13
hypoxanthine dehydrogenase activity
34,913.49 10.81 4 4
guanine catabolic process
9,521.86 6.67 3 11
deoxyinosine catabolic process
8,728.37 6.52 3 12
inosine catabolic process
5,818.91 5.77 3 18
molybdopterin cofactor binding
2,235.84 5.73 13 203
hypoxanthine oxidase activity
34,913.49 5.41 2 2
Totals 265 579470

Change Log

Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9727349
2020-10-08 Deleted SYNONYM xanthine-NAD oxidoreductase activity
2020-10-08 Deleted SYNONYM NAD-xanthine dehydrogenase activity
2020-10-08 Deleted SYNONYM xanthine:NAD+ oxidoreductase activity
2020-10-08 Added SYNONYM xanthine-NAD oxidoreductase activity
2020-10-08 Added SYNONYM xanthine/NAD(+) oxidoreductase activity
2020-10-08 Added SYNONYM xanthine/NAD+ oxidoreductase activity
2020-10-08 Added SYNONYM xanthine:NAD+ oxidoreductase activity
2020-10-08 Added SYNONYM NAD-xanthine dehydrogenase activity
2020-10-08 Deleted SYNONYM xanthine/NAD(+) oxidoreductase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM xanthine dehydrogenase activity
2002-02-06 Updated TERM xanthine dehydrogenase
2001-04-03 Updated TERM xanthine dehydrogenase
2001-03-30 Added TERM xanthine dehydrogenase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM xanthine-NAD oxidoreductase activity
2020-10-08 Deleted SYNONYM NAD-xanthine dehydrogenase activity
2020-10-08 Deleted SYNONYM xanthine:NAD+ oxidoreductase activity
2020-10-08 Added SYNONYM xanthine-NAD oxidoreductase activity
2020-10-08 Added SYNONYM xanthine/NAD(+) oxidoreductase activity
2020-10-08 Added SYNONYM xanthine/NAD+ oxidoreductase activity
2020-10-08 Added SYNONYM xanthine:NAD+ oxidoreductase activity
2020-10-08 Added SYNONYM NAD-xanthine dehydrogenase activity
2020-10-08 Deleted SYNONYM xanthine/NAD(+) oxidoreductase activity
2020-10-08 Deleted SYNONYM xanthine/NAD+ oxidoreductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
2007-11-08 Added SYNONYM xanthine:NAD+ oxidoreductase activity
2007-11-08 Added SYNONYM xanthine/NAD+ oxidoreductase activity
2007-09-06 Added SYNONYM NAD-xanthine dehydrogenase activity
2007-09-06 Added SYNONYM xanthine-NAD oxidoreductase activity
2007-09-06 Added SYNONYM xanthine/NAD(+) oxidoreductase activity
2007-09-06 Added SYNONYM xanthine oxidoreductase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016726 (oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor)
Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9727349
2020-06-22 Added XREF RHEA:16669
2009-05-21 Added XREF MetaCyc:RXN0-901
2009-05-21 Deleted XREF MetaCyc:XANTHINE-DEHYDROGENASE-RXN
2005-08-29 Deleted XREF EC:1.1.1.204
2005-08-29 Added XREF EC:1.17.1.4
2003-10-27 Added XREF MetaCyc:XANTHINE-DEHYDROGENASE-RXN
2001-03-30 Added XREF EC:1.1.1.204
Timestamp Action Category Detail
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