This term is obsolete.
This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.

GO:0004888 JSON

transmembrane signaling receptor activity

Molecular Function

Definition (GO:0004888 GONUTS page)

Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.

Comments

This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.

Secondary IDs

GO:0004926, GO:0099600

2,760,706 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
transmembrane signalling receptor activity exact
transmembrane receptor activity broad

Ancestor Chart

Ancestor chart for GO:0004888
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004888

Child Term Relationship to
GO:0004888
neurotensin receptor activity, non-G protein-coupled
is_a
GABA receptor activity
is_a
cytokinin receptor activity
is_a
G protein-coupled receptor activity
is_a
non-tyrosine kinase fibroblast growth factor receptor activity
is_a
glutamate receptor activity
is_a
semaphorin receptor activity
is_a
axon guidance receptor activity
is_a
netrin receptor activity
is_a
immunoglobulin receptor activity
is_a

Cross-references

Database ID Description
InterPro IPR000609 7TM GPCR, serpentine receptor class g (Srg)
InterPro IPR002184 7TM GPCR, serpentine receptor class b (Srb)
InterPro IPR003110 Phosphorylated immunoreceptor signalling ITAM
InterPro IPR004075 Interleukin-1 receptor type I/Toll precursor
InterPro IPR004090 Chemotaxis methyl-accepting receptor
InterPro IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR008063 Fas receptor
InterPro IPR009167 Erythropoietin receptor
InterPro IPR015149 Thrombomodulin-like, EGF-like

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0004927 obsolete sevenless receptor activity consider GO:0004888
GO:0045233 obsolete natural killer cell receptor activity consider GO:0004888

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004888 based on ALL annotations
The top 100 of 3,589 co-occurring terms
Co-occurring Term PR S% #Together #Compared
transmembrane signaling receptor activity
652.53 100.00 298,744 298,744
chemotaxis
186.71 23.16 163,936 572,937
extracellular ligand-gated monoatomic ion channel activity
373.28 10.39 33,653 58,829
excitatory postsynaptic potential
479.80 9.33 28,831 39,210
regulation of postsynaptic membrane potential
587.33 8.61 25,980 28,864
acetylcholine-gated monoatomic cation-selective channel activity
649.13 8.57 25,611 25,745
postsynaptic membrane
134.89 8.28 36,238 175,298
signal transduction
48.11 7.01 174,658 2,368,833
cell surface receptor signaling pathway
113.32 6.95 31,052 178,804
monoatomic ion transmembrane transport
51.37 6.19 67,079 852,025
Totals 1695402 86409906
No co-occurrence statistics for GO:0004888 based on MANUAL annotations
The top 100 of 1,875 co-occurring terms
Co-occurring Term PR S% #Together #Compared
transmembrane signaling receptor activity
1,045.14 100.00 1,236 1,236
stimulatory C-type lectin receptor signaling pathway
764.04 8.31 106 145
positive regulation of natural killer cell mediated cytotoxicity
482.37 7.93 108 234
external side of plasma membrane
67.93 5.67 381 5,862
cell surface receptor signaling pathway
70.87 5.44 266 3,923
chemotaxis
116.97 4.17 77 688
alpha-beta T cell receptor complex
533.02 3.97 51 100
positive thymic T cell selection
575.42 3.84 49 89
glial cell differentiation
150.20 3.15 48 334
positive regulation of neuroblast proliferation
143.21 3.07 47 343
Totals 4953 97529

Change Log

Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-193672
2019-04-01 Added XREF Reactome:R-HSA-193672
2018-12-11 Added XREF reactome:R-HSA-193672
2018-03-05 Deleted SYNONYM non-G-protein coupled 7TM receptor activity
2018-03-05 Deleted SYNONYM non-G-protein-coupled 7TM receptor activity
2018-03-05 Deleted SYNONYM non G protein coupled 7TM receptor activity
2018-03-05 Deleted RELATION is a GO:0099600 (transmembrane receptor activity)
2018-03-05 Deleted RELATION part of GO:0007165 (signal transduction)
2018-03-05 Added SECONDARY GO:0099600 (transmembrane receptor activity)
2016-03-02 Added DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
Timestamp Action Category Detail
2011-08-04 Updated TERM transmembrane signaling receptor activity
2003-03-19 Updated TERM transmembrane receptor activity
2002-02-06 Updated TERM transmembrane receptor
2001-04-03 Updated TERM transmembrane receptor
2001-03-30 Added TERM transmembrane receptor
Timestamp Action Category Detail
2018-03-05 Deleted SYNONYM non-G-protein coupled 7TM receptor activity
2018-03-05 Deleted SYNONYM non-G-protein-coupled 7TM receptor activity
2018-03-05 Deleted SYNONYM non G protein coupled 7TM receptor activity
2016-03-02 Added DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
2016-03-02 Deleted DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2012-04-14 Added SYNONYM transmembrane signalling receptor activity
2011-08-04 Added SYNONYM transmembrane receptor activity
2011-01-30 Deleted DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2011-01-30 Added DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2010-10-07 Added SYNONYM non-G-protein-coupled 7TM receptor activity
2010-10-07 Added SYNONYM non-G-protein coupled 7TM receptor activity
2010-10-07 Added SYNONYM non G protein coupled 7TM receptor activity
2008-05-13 Added DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2008-05-12 Deleted DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2005-06-30 Added DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
Timestamp Action Category Detail
2018-03-05 Deleted RELATION is a GO:0099600 (transmembrane receptor activity)
2018-03-05 Deleted RELATION part of GO:0007165 (signal transduction)
2016-03-02 Added RELATION is a GO:0099600 (transmembrane receptor activity)
2016-03-02 Added RELATION part of GO:0007165 (signal transduction)
2011-08-04 Deleted RELATION is a GO:0004872 (receptor activity)
2011-08-04 Added RELATION is a GO:0038023 (signaling receptor activity)
2008-04-01 Updated RELATION is a GO:0004872 (receptor activity)
Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-193672
2019-04-01 Added XREF Reactome:R-HSA-193672
2018-12-11 Added XREF reactome:R-HSA-193672
Timestamp Action Category Detail
2018-03-05 Added SECONDARY GO:0099600 (transmembrane receptor activity)
2010-10-07 Added SECONDARY GO:0004926 (non-G-protein coupled 7TM receptor activity)
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