This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.
GO:0004888
JSON
transmembrane signaling receptor activity
Molecular Function
Definition (GO:0004888 GONUTS page)
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
Comments
This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.
Secondary IDs
GO:0004926, GO:0099600
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
transmembrane signalling receptor activity | exact |
transmembrane receptor activity | broad |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004888
Child Term | Relationship to GO:0004888 |
---|---|
neurotensin receptor activity, non-G protein-coupled
|
is_a |
GABA receptor activity
|
is_a |
cytokinin receptor activity
|
is_a |
G protein-coupled receptor activity
|
is_a |
non-tyrosine kinase fibroblast growth factor receptor activity
|
is_a |
glutamate receptor activity
|
is_a |
semaphorin receptor activity
|
is_a |
axon guidance receptor activity
|
is_a |
netrin receptor activity
|
is_a |
immunoglobulin receptor activity
|
is_a |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000609 | 7TM GPCR, serpentine receptor class g (Srg) |
InterPro | IPR002184 | 7TM GPCR, serpentine receptor class b (Srb) |
InterPro | IPR003110 | Phosphorylated immunoreceptor signalling ITAM |
InterPro | IPR004075 | Interleukin-1 receptor type I/Toll precursor |
InterPro | IPR004090 | Chemotaxis methyl-accepting receptor |
InterPro | IPR006028 | Gamma-aminobutyric acid A receptor/Glycine receptor alpha |
InterPro | IPR006201 | Neurotransmitter-gated ion-channel |
InterPro | IPR008063 | Fas receptor |
InterPro | IPR009167 | Erythropoietin receptor |
InterPro | IPR015149 | Thrombomodulin-like, EGF-like |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0004927 | obsolete sevenless receptor activity | consider GO:0004888 |
GO:0045233 | obsolete natural killer cell receptor activity | consider GO:0004888 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004888 based on ALL annotations
The top 100 of 3,589 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
transmembrane signaling receptor activity
|
652.53 | 100.00 | 298,744 | 298,744 |
chemotaxis
|
186.71 | 23.16 | 163,936 | 572,937 |
extracellular ligand-gated monoatomic ion channel activity
|
373.28 | 10.39 | 33,653 | 58,829 |
excitatory postsynaptic potential
|
479.80 | 9.33 | 28,831 | 39,210 |
regulation of postsynaptic membrane potential
|
587.33 | 8.61 | 25,980 | 28,864 |
acetylcholine-gated monoatomic cation-selective channel activity
|
649.13 | 8.57 | 25,611 | 25,745 |
postsynaptic membrane
|
134.89 | 8.28 | 36,238 | 175,298 |
signal transduction
|
48.11 | 7.01 | 174,658 | 2,368,833 |
cell surface receptor signaling pathway
|
113.32 | 6.95 | 31,052 | 178,804 |
monoatomic ion transmembrane transport
|
51.37 | 6.19 | 67,079 | 852,025 |
Totals | 1695402 | 86409906 |
No co-occurrence statistics for GO:0004888 based on MANUAL annotations
The top 100 of 1,875 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
transmembrane signaling receptor activity
|
1,045.14 | 100.00 | 1,236 | 1,236 |
stimulatory C-type lectin receptor signaling pathway
|
764.04 | 8.31 | 106 | 145 |
positive regulation of natural killer cell mediated cytotoxicity
|
482.37 | 7.93 | 108 | 234 |
external side of plasma membrane
|
67.93 | 5.67 | 381 | 5,862 |
cell surface receptor signaling pathway
|
70.87 | 5.44 | 266 | 3,923 |
chemotaxis
|
116.97 | 4.17 | 77 | 688 |
alpha-beta T cell receptor complex
|
533.02 | 3.97 | 51 | 100 |
positive thymic T cell selection
|
575.42 | 3.84 | 49 | 89 |
glial cell differentiation
|
150.20 | 3.15 | 48 | 334 |
positive regulation of neuroblast proliferation
|
143.21 | 3.07 | 47 | 343 |
Totals | 4953 | 97529 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-193672 |
2019-04-01 | Added | XREF | Reactome:R-HSA-193672 |
2018-12-11 | Added | XREF | reactome:R-HSA-193672 |
2018-03-05 | Deleted | SYNONYM | non-G-protein coupled 7TM receptor activity |
2018-03-05 | Deleted | SYNONYM | non-G-protein-coupled 7TM receptor activity |
2018-03-05 | Deleted | SYNONYM | non G protein coupled 7TM receptor activity |
2018-03-05 | Deleted | RELATION | is a GO:0099600 (transmembrane receptor activity) |
2018-03-05 | Deleted | RELATION | part of GO:0007165 (signal transduction) |
2018-03-05 | Added | SECONDARY | GO:0099600 (transmembrane receptor activity) |
2016-03-02 | Added | DEFINITION | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-08-04 | Updated | TERM | transmembrane signaling receptor activity |
2003-03-19 | Updated | TERM | transmembrane receptor activity |
2002-02-06 | Updated | TERM | transmembrane receptor |
2001-04-03 | Updated | TERM | transmembrane receptor |
2001-03-30 | Added | TERM | transmembrane receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-03-05 | Deleted | SYNONYM | non-G-protein coupled 7TM receptor activity |
2018-03-05 | Deleted | SYNONYM | non-G-protein-coupled 7TM receptor activity |
2018-03-05 | Deleted | SYNONYM | non G protein coupled 7TM receptor activity |
2016-03-02 | Added | DEFINITION | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. |
2016-03-02 | Deleted | DEFINITION | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
2012-04-14 | Added | SYNONYM | transmembrane signalling receptor activity |
2011-08-04 | Added | SYNONYM | transmembrane receptor activity |
2011-01-30 | Deleted | DEFINITION | Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. |
2011-01-30 | Added | DEFINITION | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
2010-10-07 | Added | SYNONYM | non-G-protein-coupled 7TM receptor activity |
2010-10-07 | Added | SYNONYM | non-G-protein coupled 7TM receptor activity |
2010-10-07 | Added | SYNONYM | non G protein coupled 7TM receptor activity |
2008-05-13 | Added | DEFINITION | Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. |
2008-05-12 | Deleted | DEFINITION | Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. |
2005-06-30 | Added | DEFINITION | Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-03-05 | Deleted | RELATION | is a GO:0099600 (transmembrane receptor activity) |
2018-03-05 | Deleted | RELATION | part of GO:0007165 (signal transduction) |
2016-03-02 | Added | RELATION | is a GO:0099600 (transmembrane receptor activity) |
2016-03-02 | Added | RELATION | part of GO:0007165 (signal transduction) |
2011-08-04 | Deleted | RELATION | is a GO:0004872 (receptor activity) |
2011-08-04 | Added | RELATION | is a GO:0038023 (signaling receptor activity) |
2008-04-01 | Updated | RELATION | is a GO:0004872 (receptor activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-193672 |
2019-04-01 | Added | XREF | Reactome:R-HSA-193672 |
2018-12-11 | Added | XREF | reactome:R-HSA-193672 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-03-05 | Added | SECONDARY | GO:0099600 (transmembrane receptor activity) |
2010-10-07 | Added | SECONDARY | GO:0004926 (non-G-protein coupled 7TM receptor activity) |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link