This term is obsolete.
This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.

GO:0004888 JSON

transmembrane signaling receptor activity

Molecular Function

Definition (GO:0004888 GONUTS page)

Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.

Comments

This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores.

Secondary IDs

GO:0004926, GO:0099600

2,818,736 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
transmembrane receptor activity broad
transmembrane signalling receptor activity exact

Ancestor Chart

Ancestor chart for GO:0004888
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004888

Child Term Relationship to
GO:0004888
semaphorin receptor activity
is_a
axon guidance receptor activity
is_a
G protein-coupled receptor activity
is_a
netrin receptor activity
is_a
taste receptor activity
is_a
glutamate receptor activity
is_a
cytokinin receptor activity
is_a
GABA receptor activity
is_a
nucleotide receptor activity
is_a
latrotoxin receptor activity
is_a

Cross-references

Database ID Description
InterPro IPR000609 7TM GPCR, serpentine receptor class g (Srg)
InterPro IPR002184 7TM GPCR, serpentine receptor class b (Srb)
InterPro IPR003110 Phosphorylated immunoreceptor signalling ITAM
InterPro IPR004075 Interleukin-1 receptor type I/Toll precursor
InterPro IPR004090 Chemotaxis methyl-accepting receptor
InterPro IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR008063 Fas receptor
InterPro IPR009167 Erythropoietin receptor
InterPro IPR015149 Thrombomodulin-like, EGF-like

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0004927 obsolete sevenless receptor activity consider GO:0004888
GO:0045233 obsolete natural killer cell receptor activity consider GO:0004888

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004888 based on ALL annotations
The top 100 of 3,608 co-occurring terms
Co-occurring Term PR S% #Together #Compared
647.69 100.00 305,943 305,943
185.69 23.13 166,652 581,292
374.01 10.63 35,276 61,088
477.72 9.37 29,651 40,200
582.57 8.66 26,760 29,751
644.74 8.59 26,284 26,404
134.86 8.28 36,943 177,424
112.31 6.99 32,093 185,076
47.43 6.96 177,804 2,428,262
49.76 6.09 69,549 905,266
Totals 1727709 89603905
No co-occurrence statistics for GO:0004888 based on MANUAL annotations
The top 100 of 1,950 co-occurring terms
Co-occurring Term PR S% #Together #Compared
952.45 100.00 1,482 1,482
76.23 6.35 348 4,348
62.91 5.68 428 6,480
467.57 5.17 81 165
300.58 4.99 83 263
838.16 4.43 66 75
421.70 3.73 58 131
555.60 3.68 56 96
79.89 3.31 77 918
32.87 2.94 247 7,158
Totals 5704 110382

Change Log

Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-193672
2019-04-01 Added XREF Reactome:R-HSA-193672
2018-12-11 Added XREF reactome:R-HSA-193672
2018-03-05 Deleted SYNONYM non-G-protein coupled 7TM receptor activity
2018-03-05 Deleted SYNONYM non-G-protein-coupled 7TM receptor activity
2018-03-05 Deleted SYNONYM non G protein coupled 7TM receptor activity
2018-03-05 Deleted RELATION part of GO:0007165 (signal transduction)
2018-03-05 Deleted RELATION is a GO:0099600 (transmembrane receptor activity)
2018-03-05 Added SECONDARY GO:0099600 (transmembrane receptor activity)
2016-03-02 Added DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
Timestamp Action Category Detail
2011-08-04 Updated TERM transmembrane signaling receptor activity
2003-03-19 Updated TERM transmembrane receptor activity
2002-02-06 Updated TERM transmembrane receptor
2001-04-03 Updated TERM transmembrane receptor
2001-03-30 Added TERM transmembrane receptor
Timestamp Action Category Detail
2018-03-05 Deleted SYNONYM non-G-protein coupled 7TM receptor activity
2018-03-05 Deleted SYNONYM non-G-protein-coupled 7TM receptor activity
2018-03-05 Deleted SYNONYM non G protein coupled 7TM receptor activity
2016-03-02 Added DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
2016-03-02 Deleted DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2012-04-14 Added SYNONYM transmembrane signalling receptor activity
2011-08-04 Added SYNONYM transmembrane receptor activity
2011-01-30 Deleted DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2011-01-30 Added DEFINITION Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2010-10-07 Added SYNONYM non G protein coupled 7TM receptor activity
2010-10-07 Added SYNONYM non-G-protein-coupled 7TM receptor activity
2010-10-07 Added SYNONYM non-G-protein coupled 7TM receptor activity
2008-05-13 Added DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2008-05-12 Deleted DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
2005-06-30 Added DEFINITION Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
Timestamp Action Category Detail
2018-03-05 Deleted RELATION part of GO:0007165 (signal transduction)
2018-03-05 Deleted RELATION is a GO:0099600 (transmembrane receptor activity)
2016-03-02 Added RELATION is a GO:0099600 (transmembrane receptor activity)
2016-03-02 Added RELATION part of GO:0007165 (signal transduction)
2011-08-04 Added RELATION is a GO:0038023 (signaling receptor activity)
2011-08-04 Deleted RELATION is a GO:0004872 (receptor activity)
2008-04-01 Updated RELATION is a GO:0004872 (receptor activity)
Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-193672
2019-04-01 Added XREF Reactome:R-HSA-193672
2018-12-11 Added XREF reactome:R-HSA-193672
Timestamp Action Category Detail
2018-03-05 Added SECONDARY GO:0099600 (transmembrane receptor activity)
2010-10-07 Added SECONDARY GO:0004926 (non-G-protein coupled 7TM receptor activity)
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.