This term is obsolete.

GO:0004908 JSON

interleukin-1 receptor activity

Molecular Function

Definition (GO:0004908 GONUTS page)

Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.

5,962 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
IL-1R exact
IL-1 receptor activity exact

Ancestor Chart

Ancestor chart for GO:0004908
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004908

Child Term Relationship to
GO:0004908
interleukin-1, type II, blocking receptor activity
is_a
interleukin-1 receptor complex
capable_of
interleukin-1, type I, activating receptor activity
is_a

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0004908 interleukin-1 receptor activity Never in Taxon 2 Bacteria
GO:0004908 interleukin-1 receptor activity Never in Taxon 2157 Archaea
GO:0004908 interleukin-1 receptor activity Never in Taxon 4751 Fungi

More information on taxon constraints in GO is available here

Cross-references

Database ID Description
InterPro IPR004074 Interleukin-1 receptor type I/II
Wikipedia Interleukin-1_receptor

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004908 based on ALL annotations
The top 100 of 199 co-occurring terms
Co-occurring Term PR S% #Together #Compared
interleukin-1 receptor activity
49,792.79 100.00 3,915 3,915
interleukin-1 binding
40,182.27 24.43 1,016 1,259
interleukin-1, type II, blocking receptor activity
39,172.00 15.35 627 797
interleukin-18 receptor activity
16,547.11 9.12 437 1,315
interleukin-33 binding
28,065.03 8.85 372 660
interleukin-18-mediated signaling pathway
12,762.14 8.43 437 1,705
interleukin-1, type I, activating receptor activity
11,351.94 5.71 277 1,215
interleukin-1-mediated signaling pathway
5,729.88 5.48 371 3,224
cytokine-mediated signaling pathway
2,299.78 4.57 3,179 68,829
negative regulation of exocytosis
6,787.08 4.10 217 1,592
Totals 20411 5102840
No co-occurrence statistics for GO:0004908 based on MANUAL annotations
The top 60 of 60 co-occurring terms
Co-occurring Term PR S% #Together #Compared
interleukin-1 receptor activity
33,994.71 100.00 38 38
interleukin-1 binding
8,945.98 9.62 5 19
interleukin-1-mediated signaling pathway
3,263.49 7.95 12 125
positive regulation of interleukin-1-mediated signaling pathway
33,994.71 5.26 2 2
interleukin-33 receptor activity
13,597.89 4.88 2 5
interleukin-33-mediated signaling pathway
3,187.00 4.48 3 32
negative regulation of interleukin-1 alpha production
5,665.79 4.17 2 12
trans-synaptic signaling by trans-synaptic complex
3,999.38 3.77 2 17
positive regulation of T-helper 1 cell cytokine production
1,671.87 3.13 3 61
negative regulation of interleukin-1-mediated signaling pathway
1,446.58 2.41 2 47
Totals 264 522562

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-09-02 Added CONSTRAINT never_in_taxon NCBITaxon:2 (Bacteria)
2024-09-02 Added CONSTRAINT never_in_taxon NCBITaxon:2157 (Archaea)
2024-09-02 Deleted CONSTRAINT never_in_taxon NCBITaxon_Union:23 (Fungi or Bacteria or Archaea)
2023-11-01 Added CONSTRAINT never_in_taxon NCBITaxon_Union:23 (Fungi or Bacteria or Archaea)
2011-10-28 Deleted RELATION is a GO:0019966 (interleukin-1 binding)
2009-06-11 Deleted XREF Wikipedia::Interleukin-1_receptor
2009-06-11 Added XREF Wikipedia:Interleukin-1_receptor
2009-02-25 Added XREF Wikipedia::Interleukin-1_receptor
2008-12-08 Added SYNONYM IL-1 receptor activity
Timestamp Action Category Detail
2003-03-19 Updated TERM interleukin-1 receptor activity
2002-02-06 Updated TERM interleukin-1 receptor
2001-04-03 Updated TERM interleukin-1 receptor
2001-03-30 Added TERM interleukin-1 receptor
Timestamp Action Category Detail
2008-12-08 Added SYNONYM IL-1 receptor activity
2008-05-13 Added DEFINITION Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
2008-05-12 Deleted DEFINITION Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
2007-08-09 Added SYNONYM IL-1R
2007-08-09 Deleted SYNONYM IL-1R
2004-04-19 Added SYNONYM IL-1R
2004-04-16 Deleted SYNONYM IL-1R
2004-01-03 Updated DEFINITION Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
2003-05-08 Updated DEFINITION The function of combining with interleukin-1 to initiate a change in cell function. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
2002-11-27 Added DEFINITION Combines with a high structural selectivity to interleukin-1, specifically altering cell function. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
2002-08-24 Added SYNONYM IL-1R
Timestamp Action Category Detail
2011-10-28 Deleted RELATION is a GO:0019966 (interleukin-1 binding)
2008-11-13 Added RELATION is a GO:0004896 (cytokine receptor activity)
2008-11-13 Deleted RELATION is a GO:0004907 (interleukin receptor activity)
2008-04-01 Updated RELATION is a GO:0004907 (interleukin receptor activity)
2008-04-01 Updated RELATION is a GO:0019966 (interleukin-1 binding)
Timestamp Action Category Detail
2009-06-11 Deleted XREF Wikipedia::Interleukin-1_receptor
2009-06-11 Added XREF Wikipedia:Interleukin-1_receptor
2009-02-25 Added XREF Wikipedia::Interleukin-1_receptor
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-09-02 Added CONSTRAINT never_in_taxon NCBITaxon:2 (Bacteria)
2024-09-02 Added CONSTRAINT never_in_taxon NCBITaxon:2157 (Archaea)
2024-09-02 Deleted CONSTRAINT never_in_taxon NCBITaxon_Union:23 (Fungi or Bacteria or Archaea)
2023-11-01 Added CONSTRAINT never_in_taxon NCBITaxon_Union:23 (Fungi or Bacteria or Archaea)
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