This term is obsolete.

GO:0004909 JSON

interleukin-1, type I, activating receptor activity

Molecular Function

Definition (GO:0004909 GONUTS page)

Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins. PMID:15062641 PMID:18613828

Secondary IDs

GO:0019967

1,216 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
interleukin-1 activating receptor activity exact
IL-1 type I, activating binding exact
IL-1 type I, activating receptor exact
interleukin-1, type I, activating binding related
interleukin-1 type I receptor activity exact

Ancestor Chart

Ancestor chart for GO:0004909
Chart options
Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0004909 interleukin-1, type I, activating receptor activity Never in Taxon 2 Bacteria
GO:0004909 interleukin-1, type I, activating receptor activity Never in Taxon 2157 Archaea
GO:0004909 interleukin-1, type I, activating receptor activity Never in Taxon 4751 Fungi

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A6JYJ6 10116 A6JYJ6_RAT GO:0070498 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZXA5 10116 D3ZXA5_RAT GO:0070498 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P51617-2 9606 IRAK1_HUMAN GO:0070498 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:11397809
NOT-qualified manual protein Q99JY1 10090 TIRAP_MOUSE GO:0070498 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000303, ECO:0000314 from these references: PMID:11544529, PMID:12447442

Cross-references

Database ID Description
InterPro IPR004076 Interleukin-1 receptor type 1

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004909 based on ALL annotations
The top 57 of 57 co-occurring terms
Co-occurring Term PR S% #Together #Compared
interleukin-1, type I, activating receptor activity
160,443.44 100.00 1,215 1,215
interleukin-1-mediated signaling pathway
60,464.89 37.69 1,215 3,224
interleukin-1 binding
34,153.17 12.15 268 1,259
regulation of inflammatory response
12,231.46 7.56 1,100 14,429
interleukin-1 receptor activity
11,351.94 5.71 277 3,915
positive regulation of interleukin-1-mediated signaling pathway
160,443.44 5.51 67 67
positive regulation of T-helper 1 cell cytokine production
20,987.44 4.42 76 581
positive regulation of neutrophil extravasation
6,782.15 2.45 67 1,585
response to interleukin-1
4,610.10 2.01 76 2,645
positive regulation of T cell differentiation
3,453.77 1.37 44 2,044
Totals 9662 114884962
No co-occurrence statistics for GO:0004909 based on MANUAL annotations
The top 20 of 20 co-occurring terms
Co-occurring Term PR S% #Together #Compared
interleukin-1, type I, activating receptor activity
184,542.70 100.00 7 7
interleukin-1-mediated signaling pathway
10,334.39 5.60 7 125
interleukin-1 receptor activity
4,856.39 2.27 1 38
microglial cell activation involved in immune response
4,291.69 2.04 1 43
positive regulation of T-helper 1 cell cytokine production
3,025.29 1.49 1 61
positive regulation of inflammatory response
2,113.08 1.14 6 524
response to interleukin-1
1,512.65 0.78 1 122
platelet-derived growth factor receptor binding
1,453.09 0.75 1 127
positive regulation of canonical NF-kappaB signal transduction
688.16 0.37 6 1,609
positive regulation of MAPK cascade
515.24 0.28 6 2,149
Totals 48 270102

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:2157 (Archaea)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:2 (Bacteria)
2018-05-31 Deleted SYNONYM interleukin-1, Type I, activating binding
2018-05-31 Added SYNONYM interleukin-1, type I, activating binding
2018-05-31 Deleted SYNONYM interleukin-1 Type I receptor activity
2018-05-31 Updated TERM interleukin-1, type I, activating receptor activity
2018-05-31 Added SYNONYM interleukin-1 type I receptor activity
2011-01-30 Added RELATION part of GO:0070498 (interleukin-1-mediated signaling pathway)
2009-04-29 Added DEFINITION Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins.
Timestamp Action Category Detail
2018-05-31 Updated TERM interleukin-1, type I, activating receptor activity
2003-03-19 Updated TERM interleukin-1, Type I, activating receptor activity
2002-02-06 Updated TERM interleukin-1, Type I, activating receptor
2001-04-03 Updated TERM interleukin-1, Type I, activating receptor
2001-03-30 Added TERM interleukin-1, Type I, activating receptor
Timestamp Action Category Detail
2018-05-31 Deleted SYNONYM interleukin-1, Type I, activating binding
2018-05-31 Added SYNONYM interleukin-1, type I, activating binding
2018-05-31 Deleted SYNONYM interleukin-1 Type I receptor activity
2018-05-31 Added SYNONYM interleukin-1 type I receptor activity
2009-04-29 Added DEFINITION Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins.
2009-04-29 Added SYNONYM interleukin-1 activating receptor activity
2009-04-29 Added SYNONYM interleukin-1, Type I, activating binding
2009-04-29 Added SYNONYM interleukin-1 Type I receptor activity
2009-04-29 Added SYNONYM IL-1 type I, activating binding
2007-08-09 Added SYNONYM IL-1 type I, activating receptor
2007-08-09 Deleted SYNONYM IL-1 type I, activating receptor
2004-04-19 Added SYNONYM IL-1 type I, activating receptor
2004-04-16 Deleted SYNONYM IL-1 type I, activating receptor
2002-08-24 Added SYNONYM IL-1 type I, activating receptor
Timestamp Action Category Detail
2011-01-30 Added RELATION part of GO:0070498 (interleukin-1-mediated signaling pathway)
2009-04-29 Deleted RELATION is a GO:0019967 (interleukin-1, Type I, activating binding)
2008-04-01 Updated RELATION is a GO:0004908 (interleukin-1 receptor activity)
2008-04-01 Updated RELATION is a GO:0019967 (interleukin-1, Type I, activating binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:2157 (Archaea)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:2 (Bacteria)
2009-04-29 Added SECONDARY GO:0019967 (interleukin-1, Type I, activating binding)
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