GO:0004909
JSON
interleukin-1, type I, activating receptor activity
Molecular Function
Definition (GO:0004909 GONUTS page)
Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins. PMID:15062641 PMID:18613828
Secondary IDs
GO:0019967
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
interleukin-1 activating receptor activity | exact |
IL-1 type I, activating binding | exact |
IL-1 type I, activating receptor | exact |
interleukin-1, type I, activating binding | related |
interleukin-1 type I receptor activity | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0004909 | interleukin-1, type I, activating receptor activity | Never in Taxon | 2 | Bacteria | |
GO:0004909 | interleukin-1, type I, activating receptor activity | Never in Taxon | 2157 | Archaea | |
GO:0004909 | interleukin-1, type I, activating receptor activity | Never in Taxon | 4751 | Fungi |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A6JYJ6 | 10116 | A6JYJ6_RAT | GO:0070498 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZXA5 | 10116 | D3ZXA5_RAT | GO:0070498 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P51617-2 | 9606 | IRAK1_HUMAN | GO:0070498 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:11397809 | |
NOT-qualified manual | protein | Q99JY1 | 10090 | TIRAP_MOUSE | GO:0070498 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000303, ECO:0000314 from these references: PMID:11544529, PMID:12447442 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR004076 | Interleukin-1 receptor type 1 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004909 based on ALL annotations
The top 57 of 57 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
interleukin-1, type I, activating receptor activity
|
160,443.44 | 100.00 | 1,215 | 1,215 |
interleukin-1-mediated signaling pathway
|
60,464.89 | 37.69 | 1,215 | 3,224 |
interleukin-1 binding
|
34,153.17 | 12.15 | 268 | 1,259 |
regulation of inflammatory response
|
12,231.46 | 7.56 | 1,100 | 14,429 |
interleukin-1 receptor activity
|
11,351.94 | 5.71 | 277 | 3,915 |
positive regulation of interleukin-1-mediated signaling pathway
|
160,443.44 | 5.51 | 67 | 67 |
positive regulation of T-helper 1 cell cytokine production
|
20,987.44 | 4.42 | 76 | 581 |
positive regulation of neutrophil extravasation
|
6,782.15 | 2.45 | 67 | 1,585 |
response to interleukin-1
|
4,610.10 | 2.01 | 76 | 2,645 |
positive regulation of T cell differentiation
|
3,453.77 | 1.37 | 44 | 2,044 |
Totals | 9662 | 114884962 |
No co-occurrence statistics for GO:0004909 based on MANUAL annotations
The top 20 of 20 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
interleukin-1, type I, activating receptor activity
|
184,542.70 | 100.00 | 7 | 7 |
interleukin-1-mediated signaling pathway
|
10,334.39 | 5.60 | 7 | 125 |
interleukin-1 receptor activity
|
4,856.39 | 2.27 | 1 | 38 |
microglial cell activation involved in immune response
|
4,291.69 | 2.04 | 1 | 43 |
positive regulation of T-helper 1 cell cytokine production
|
3,025.29 | 1.49 | 1 | 61 |
positive regulation of inflammatory response
|
2,113.08 | 1.14 | 6 | 524 |
response to interleukin-1
|
1,512.65 | 0.78 | 1 | 122 |
platelet-derived growth factor receptor binding
|
1,453.09 | 0.75 | 1 | 127 |
positive regulation of canonical NF-kappaB signal transduction
|
688.16 | 0.37 | 6 | 1,609 |
positive regulation of MAPK cascade
|
515.24 | 0.28 | 6 | 2,149 |
Totals | 48 | 270102 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:2157 (Archaea) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:2 (Bacteria) |
2018-05-31 | Deleted | SYNONYM | interleukin-1, Type I, activating binding |
2018-05-31 | Added | SYNONYM | interleukin-1, type I, activating binding |
2018-05-31 | Deleted | SYNONYM | interleukin-1 Type I receptor activity |
2018-05-31 | Updated | TERM | interleukin-1, type I, activating receptor activity |
2018-05-31 | Added | SYNONYM | interleukin-1 type I receptor activity |
2011-01-30 | Added | RELATION | part of GO:0070498 (interleukin-1-mediated signaling pathway) |
2009-04-29 | Added | DEFINITION | Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-05-31 | Updated | TERM | interleukin-1, type I, activating receptor activity |
2003-03-19 | Updated | TERM | interleukin-1, Type I, activating receptor activity |
2002-02-06 | Updated | TERM | interleukin-1, Type I, activating receptor |
2001-04-03 | Updated | TERM | interleukin-1, Type I, activating receptor |
2001-03-30 | Added | TERM | interleukin-1, Type I, activating receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-05-31 | Deleted | SYNONYM | interleukin-1, Type I, activating binding |
2018-05-31 | Added | SYNONYM | interleukin-1, type I, activating binding |
2018-05-31 | Deleted | SYNONYM | interleukin-1 Type I receptor activity |
2018-05-31 | Added | SYNONYM | interleukin-1 type I receptor activity |
2009-04-29 | Added | DEFINITION | Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins. |
2009-04-29 | Added | SYNONYM | interleukin-1 activating receptor activity |
2009-04-29 | Added | SYNONYM | interleukin-1, Type I, activating binding |
2009-04-29 | Added | SYNONYM | interleukin-1 Type I receptor activity |
2009-04-29 | Added | SYNONYM | IL-1 type I, activating binding |
2007-08-09 | Added | SYNONYM | IL-1 type I, activating receptor |
2007-08-09 | Deleted | SYNONYM | IL-1 type I, activating receptor |
2004-04-19 | Added | SYNONYM | IL-1 type I, activating receptor |
2004-04-16 | Deleted | SYNONYM | IL-1 type I, activating receptor |
2002-08-24 | Added | SYNONYM | IL-1 type I, activating receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-01-30 | Added | RELATION | part of GO:0070498 (interleukin-1-mediated signaling pathway) |
2009-04-29 | Deleted | RELATION | is a GO:0019967 (interleukin-1, Type I, activating binding) |
2008-04-01 | Updated | RELATION | is a GO:0004908 (interleukin-1 receptor activity) |
2008-04-01 | Updated | RELATION | is a GO:0019967 (interleukin-1, Type I, activating binding) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:2157 (Archaea) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:2 (Bacteria) |
2009-04-29 | Added | SECONDARY | GO:0019967 (interleukin-1, Type I, activating binding) |
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