GO:0004935
JSON
adrenergic receptor activity
Molecular Function
Definition (GO:0004935 GONUTS page)
Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
adrenoceptor activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004935
Child Term | Relationship to GO:0004935 |
---|---|
alpha-adrenergic receptor activity
|
is_a |
beta-adrenergic receptor activity
|
is_a |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0004935 | adrenergic receptor activity | Only in Taxon | 6072 | Eumetazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A2ARI4 | 10090 | LGR4_MOUSE | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21693646 | |
NOT-qualified manual | protein | B0BLW3 | 8364 | LGR4_XENTR | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | D4AC13 | 10116 | LGR5_RAT | GO:0004930 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | E5DHB5 | 8355 | LGR5A_XENLA | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | E7FE13 | 7955 | LGR4_DANRE | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F1MLX5 | 9913 | LGR4_BOVIN | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F1MT22 | 9913 | LGR5_BOVIN | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F7D3V9 | 8364 | LGR5_XENTR | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | G3QNC0 | 9595 | G3QNC0_GORGO | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:8910290 | |
NOT-qualified manual | protein | O15529 | 9606 | GPR42_HUMAN | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12496283 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR002233 | Adrenoceptor family |
Wikipedia | Adrenergic_receptor |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0071876 | obsolete initiation of adrenergic receptor signal transduction | consider GO:0004935 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004935 based on ALL annotations
The top 100 of 157 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
adrenergic receptor activity
|
71,642.33 | 100.00 | 2,721 | 2,721 |
alpha2-adrenergic receptor activity
|
23,639.22 | 27.03 | 1,631 | 4,943 |
epinephrine binding
|
21,720.84 | 23.35 | 1,371 | 4,522 |
adrenergic receptor signaling pathway
|
12,120.03 | 15.99 | 2,024 | 11,964 |
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
|
20,866.70 | 12.34 | 480 | 1,648 |
alpha1-adrenergic receptor activity
|
13,968.67 | 12.12 | 660 | 3,385 |
norepinephrine binding
|
19,588.16 | 10.51 | 397 | 1,452 |
beta2-adrenergic receptor activity
|
17,567.47 | 8.63 | 320 | 1,305 |
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
|
11,217.43 | 8.27 | 406 | 2,593 |
adenylate cyclase-activating adrenergic receptor signaling pathway
|
3,472.68 | 4.60 | 1,282 | 26,448 |
Totals | 23250 | 3930068 |
No co-occurrence statistics for GO:0004935 based on MANUAL annotations
The top 56 of 56 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
adrenergic receptor activity
|
322,949.75 | 100.00 | 4 | 4 |
negative regulation of uterine smooth muscle contraction
|
161,474.88 | 20.00 | 1 | 2 |
phospholipase C-activating adrenergic receptor signaling pathway
|
80,737.44 | 14.29 | 1 | 4 |
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
|
46,135.68 | 10.00 | 1 | 7 |
fear response
|
23,922.20 | 6.90 | 2 | 27 |
alpha2-adrenergic receptor activity
|
21,529.98 | 6.67 | 4 | 60 |
thermoception
|
26,912.48 | 6.67 | 1 | 12 |
positive regulation of uterine smooth muscle contraction
|
26,912.48 | 6.67 | 1 | 12 |
regulation of vascular associated smooth muscle contraction
|
21,529.98 | 5.56 | 1 | 15 |
alpha-2C adrenergic receptor binding
|
16,147.49 | 4.35 | 1 | 20 |
Totals | 80 | 406535 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-22 | Added | CONSTRAINT | in_taxon NCBITaxon:6072 (Eumetazoa) |
2017-05-01 | Added | RELATION | has part GO:0071875 (adrenergic receptor signaling pathway) |
2011-10-24 | Deleted | DEFINITION | Combining with epinephrine or norepinephrine to initiate a change in cell activity. |
2011-10-24 | Added | DEFINITION | Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. |
2010-09-15 | Added | SYNONYM | adrenoceptor activity |
2010-09-15 | Added | RELATION | part of GO:0071875 (adrenergic receptor signaling pathway) |
2010-09-15 | Deleted | SYNONYM | adrenergic receptor |
2010-09-15 | Updated | TERM | adrenergic receptor activity |
2010-06-09 | Updated | TERM | adrenoceptor activity |
2010-06-08 | Updated | TERM | adrenoceptor activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-09-15 | Updated | TERM | adrenergic receptor activity |
2010-06-09 | Updated | TERM | adrenoceptor activity |
2010-06-08 | Updated | TERM | adrenoceptor activity |
2003-03-19 | Updated | TERM | adrenoceptor activity |
2002-02-06 | Updated | TERM | adrenoceptor |
2002-01-09 | Updated | TERM | adrenoceptor |
2001-04-03 | Updated | TERM | adrenergic receptor |
2001-03-30 | Added | TERM | adrenergic receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-10-24 | Deleted | DEFINITION | Combining with epinephrine or norepinephrine to initiate a change in cell activity. |
2011-10-24 | Added | DEFINITION | Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. |
2010-09-15 | Added | SYNONYM | adrenoceptor activity |
2010-09-15 | Deleted | SYNONYM | adrenergic receptor |
2009-02-25 | Added | DEFINITION | Combining with epinephrine or norepinephrine to initiate a change in cell activity. |
2007-08-09 | Deleted | SYNONYM | adrenergic receptor |
2007-08-09 | Added | SYNONYM | adrenergic receptor |
2004-04-19 | Added | SYNONYM | adrenergic receptor |
2004-04-16 | Deleted | SYNONYM | adrenergic receptor |
2002-01-09 | Added | SYNONYM | adrenergic receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-05-01 | Added | RELATION | has part GO:0071875 (adrenergic receptor signaling pathway) |
2010-09-15 | Added | RELATION | part of GO:0071875 (adrenergic receptor signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0008227 (G protein-coupled amine receptor activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-02-25 | Added | XREF | Wikipedia:Adrenergic_receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-22 | Added | CONSTRAINT | in_taxon NCBITaxon:6072 (Eumetazoa) |
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