This term is obsolete.

GO:0004935 JSON

adrenergic receptor activity

Molecular Function

Definition (GO:0004935 GONUTS page)

Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex.

14,599 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
adrenoceptor activity exact

Ancestor Chart

Ancestor chart for GO:0004935
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004935

Child Term Relationship to
GO:0004935
alpha-adrenergic receptor activity
is_a
beta-adrenergic receptor activity
is_a

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0004935 adrenergic receptor activity Only in Taxon 6072 Eumetazoa

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A2ARI4 10090 LGR4_MOUSE GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21693646
NOT-qualified manual protein B0BLW3 8364 LGR4_XENTR GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein D4AC13 10116 LGR5_RAT GO:0004930 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein E5DHB5 8355 LGR5A_XENLA GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein E7FE13 7955 LGR4_DANRE GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F1MLX5 9913 LGR4_BOVIN GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F1MT22 9913 LGR5_BOVIN GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F7D3V9 8364 LGR5_XENTR GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein G3QNC0 9595 G3QNC0_GORGO GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:8910290
NOT-qualified manual protein O15529 9606 GPR42_HUMAN GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12496283

Cross-references

Database ID Description
InterPro IPR002233 Adrenoceptor family
Wikipedia Adrenergic_receptor

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0071876 obsolete initiation of adrenergic receptor signal transduction consider GO:0004935

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004935 based on ALL annotations
The top 100 of 157 co-occurring terms
Co-occurring Term PR S% #Together #Compared
adrenergic receptor activity
71,642.33 100.00 2,721 2,721
alpha2-adrenergic receptor activity
23,639.22 27.03 1,631 4,943
epinephrine binding
21,720.84 23.35 1,371 4,522
adrenergic receptor signaling pathway
12,120.03 15.99 2,024 11,964
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
20,866.70 12.34 480 1,648
alpha1-adrenergic receptor activity
13,968.67 12.12 660 3,385
norepinephrine binding
19,588.16 10.51 397 1,452
beta2-adrenergic receptor activity
17,567.47 8.63 320 1,305
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
11,217.43 8.27 406 2,593
adenylate cyclase-activating adrenergic receptor signaling pathway
3,472.68 4.60 1,282 26,448
Totals 23250 3930068
No co-occurrence statistics for GO:0004935 based on MANUAL annotations
The top 56 of 56 co-occurring terms
Co-occurring Term PR S% #Together #Compared
adrenergic receptor activity
322,949.75 100.00 4 4
negative regulation of uterine smooth muscle contraction
161,474.88 20.00 1 2
phospholipase C-activating adrenergic receptor signaling pathway
80,737.44 14.29 1 4
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
46,135.68 10.00 1 7
fear response
23,922.20 6.90 2 27
alpha2-adrenergic receptor activity
21,529.98 6.67 4 60
thermoception
26,912.48 6.67 1 12
positive regulation of uterine smooth muscle contraction
26,912.48 6.67 1 12
regulation of vascular associated smooth muscle contraction
21,529.98 5.56 1 15
alpha-2C adrenergic receptor binding
16,147.49 4.35 1 20
Totals 80 406535

Change Log

Timestamp Action Category Detail
2024-03-22 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
2017-05-01 Added RELATION has part GO:0071875 (adrenergic receptor signaling pathway)
2011-10-24 Deleted DEFINITION Combining with epinephrine or norepinephrine to initiate a change in cell activity.
2011-10-24 Added DEFINITION Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex.
2010-09-15 Added SYNONYM adrenoceptor activity
2010-09-15 Added RELATION part of GO:0071875 (adrenergic receptor signaling pathway)
2010-09-15 Deleted SYNONYM adrenergic receptor
2010-09-15 Updated TERM adrenergic receptor activity
2010-06-09 Updated TERM adrenoceptor activity
2010-06-08 Updated TERM adrenoceptor activity
Timestamp Action Category Detail
2010-09-15 Updated TERM adrenergic receptor activity
2010-06-09 Updated TERM adrenoceptor activity
2010-06-08 Updated TERM adrenoceptor activity
2003-03-19 Updated TERM adrenoceptor activity
2002-02-06 Updated TERM adrenoceptor
2002-01-09 Updated TERM adrenoceptor
2001-04-03 Updated TERM adrenergic receptor
2001-03-30 Added TERM adrenergic receptor
Timestamp Action Category Detail
2011-10-24 Deleted DEFINITION Combining with epinephrine or norepinephrine to initiate a change in cell activity.
2011-10-24 Added DEFINITION Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex.
2010-09-15 Added SYNONYM adrenoceptor activity
2010-09-15 Deleted SYNONYM adrenergic receptor
2009-02-25 Added DEFINITION Combining with epinephrine or norepinephrine to initiate a change in cell activity.
2007-08-09 Deleted SYNONYM adrenergic receptor
2007-08-09 Added SYNONYM adrenergic receptor
2004-04-19 Added SYNONYM adrenergic receptor
2004-04-16 Deleted SYNONYM adrenergic receptor
2002-01-09 Added SYNONYM adrenergic receptor
Timestamp Action Category Detail
2017-05-01 Added RELATION has part GO:0071875 (adrenergic receptor signaling pathway)
2010-09-15 Added RELATION part of GO:0071875 (adrenergic receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0008227 (G protein-coupled amine receptor activity)
Timestamp Action Category Detail
2009-02-25 Added XREF Wikipedia:Adrenergic_receptor
Timestamp Action Category Detail
2024-03-22 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
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