GO:0004939
JSON
beta-adrenergic receptor activity
Molecular Function
Definition (GO:0004939 GONUTS page)
Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
beta adrenoceptor | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004939
Child Term | Relationship to GO:0004939 |
---|---|
beta2-adrenergic receptor activity
|
is_a |
beta3-adrenergic receptor activity
|
is_a |
beta1-adrenergic receptor activity
|
is_a |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0004939 | beta-adrenergic receptor activity | Only in Taxon | 6072 | Eumetazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A2ARI4 | 10090 | LGR4_MOUSE | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21693646 | |
NOT-qualified manual | protein | B0BLW3 | 8364 | LGR4_XENTR | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | D4AC13 | 10116 | LGR5_RAT | GO:0004930 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | E5DHB5 | 8355 | LGR5A_XENLA | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | E7FE13 | 7955 | LGR4_DANRE | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F1MLX5 | 9913 | LGR4_BOVIN | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F1MT22 | 9913 | LGR5_BOVIN | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F7D3V9 | 8364 | LGR5_XENTR | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | G3QNC0 | 9595 | G3QNC0_GORGO | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:8910290 | |
NOT-qualified manual | protein | O15529 | 9606 | GPR42_HUMAN | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12496283 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000681 | Beta 3 adrenoceptor |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004939 based on ALL annotations
The top 60 of 60 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
beta-adrenergic receptor activity
|
789,225.80 | 100.00 | 247 | 247 |
beta3-adrenergic receptor activity
|
230,664.97 | 28.34 | 223 | 763 |
beta-3 adrenergic receptor binding
|
328,488.60 | 21.69 | 77 | 185 |
heat generation
|
176,388.58 | 15.06 | 78 | 349 |
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
|
67,874.03 | 8.52 | 223 | 2,593 |
diet induced thermogenesis
|
80,786.89 | 8.38 | 78 | 762 |
norepinephrine binding
|
52,723.77 | 6.05 | 97 | 1,452 |
negative regulation of multicellular organism growth
|
53,952.34 | 5.95 | 78 | 1,141 |
epinephrine binding
|
38,222.13 | 4.81 | 219 | 4,522 |
brown fat cell differentiation
|
22,586.72 | 2.67 | 69 | 2,411 |
Totals | 3536 | 99546896 |
No co-occurrence statistics for GO:0004939 based on MANUAL annotations
The top 40 of 40 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
beta-adrenergic receptor activity
|
86,119.94 | 100.00 | 15 | 15 |
beta3-adrenergic receptor activity
|
41,575.14 | 46.67 | 14 | 29 |
norepinephrine binding
|
24,605.70 | 28.00 | 14 | 49 |
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
|
10,764.99 | 11.27 | 8 | 64 |
beta-3 adrenergic receptor binding
|
34,447.98 | 11.11 | 2 | 5 |
epinephrine binding
|
6,079.05 | 6.38 | 6 | 85 |
heat generation
|
6,379.25 | 5.00 | 2 | 27 |
diet induced thermogenesis
|
3,444.80 | 3.17 | 2 | 50 |
beta1-adrenergic receptor activity
|
3,588.33 | 2.63 | 1 | 24 |
adenylate cyclase-activating adrenergic receptor signaling pathway
|
2,215.78 | 2.57 | 15 | 583 |
Totals | 168 | 269094 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:6072 (Eumetazoa) |
2010-06-09 | Updated | TERM | beta-adrenergic receptor activity |
2010-06-08 | Updated | TERM | beta-adrenergic receptor activity |
2009-03-02 | Added | DEFINITION | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. |
2009-03-02 | Deleted | DEFINITION | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors. |
2009-02-25 | Added | DEFINITION | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors. |
2008-04-01 | Updated | RELATION | is a GO:0004935 (adrenergic receptor activity) |
2007-08-09 | Deleted | SYNONYM | beta adrenoceptor |
2007-08-09 | Added | SYNONYM | beta adrenoceptor |
2004-04-19 | Added | SYNONYM | beta adrenoceptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-06-09 | Updated | TERM | beta-adrenergic receptor activity |
2010-06-08 | Updated | TERM | beta-adrenergic receptor activity |
2003-03-19 | Updated | TERM | beta-adrenergic receptor activity |
2002-02-06 | Updated | TERM | beta-adrenergic receptor |
2002-01-09 | Updated | TERM | beta-adrenergic receptor |
2001-04-03 | Updated | TERM | beta adrenergic receptor |
2001-03-30 | Added | TERM | beta adrenergic receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-03-02 | Added | DEFINITION | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. |
2009-03-02 | Deleted | DEFINITION | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors. |
2009-02-25 | Added | DEFINITION | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors. |
2007-08-09 | Deleted | SYNONYM | beta adrenoceptor |
2007-08-09 | Added | SYNONYM | beta adrenoceptor |
2004-04-19 | Added | SYNONYM | beta adrenoceptor |
2004-04-16 | Deleted | SYNONYM | beta adrenoceptor |
2002-01-09 | Added | SYNONYM | beta adrenoceptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0004935 (adrenergic receptor activity) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:6072 (Eumetazoa) |
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