This term is obsolete.

GO:0005020 JSON

stem cell factor receptor activity

Molecular Function

Definition (GO:0005020 GONUTS page)

Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. PMID:10698217

42,491 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
SCF receptor activity exact
KIT related
KL receptor activity exact
KIT ligand receptor activity exact

Ancestor Chart

Ancestor chart for GO:0005020
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0B4K7S5 7227 A0A0B4K7S5_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514
NOT-qualified manual protein A0A0G2QC55 10116 A0A0G2QC55_RAT GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A126GUQ5 7227 A0A126GUQ5_DROME GO:0004672 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514
NOT-qualified manual protein A0A1D5RK28 9544 A0A1D5RK28_MACMU GO:0004714 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8GFH0 8355 A0A1L8GFH0_XENLA GO:0004714 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8GFH0 8355 A0A1L8GFH0_XENLA GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8GM33 8355 A0A1L8GM33_XENLA GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 2.7.10.1

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005020 based on ALL annotations
The top 100 of 2,033 co-occurring terms
Co-occurring Term PR S% #Together #Compared
stem cell factor receptor activity
4,588.31 100.00 42,486 42,486
boss receptor activity
4,587.44 99.89 42,447 42,455
GPI-linked ephrin receptor activity
4,573.44 99.58 42,447 42,585
insulin-like growth factor receptor activity
4,583.21 99.36 42,259 42,306
hepatocyte growth factor receptor activity
4,566.59 99.00 42,259 42,460
platelet-derived growth factor alpha-receptor activity
4,539.11 98.40 42,259 42,717
platelet-derived growth factor receptor-alpha signaling pathway
4,538.69 98.40 42,259 42,721
macrophage colony-stimulating factor receptor activity
4,518.68 98.39 42,447 43,101
platelet-derived growth factor beta-receptor activity
4,531.58 98.24 42,259 42,788
brain-derived neurotrophic factor receptor activity
4,530.31 98.22 42,259 42,800
Totals 1569318 4294312
No co-occurrence statistics for GO:0005020 based on MANUAL annotations
The top 87 of 87 co-occurring terms
Co-occurring Term PR S% #Together #Compared
stem cell factor receptor activity
161,474.88 100.00 8 8
positive regulation of pyloric antrum smooth muscle contraction
161,474.88 87.50 7 7
positive regulation of colon smooth muscle contraction
141,290.52 77.78 7 8
positive regulation of small intestine smooth muscle contraction
113,032.41 63.64 7 10
melanocyte adhesion
86,119.94 53.33 8 15
Fc receptor signaling pathway
75,988.18 47.06 8 17
regulation of bile acid metabolic process
70,645.26 41.18 7 16
mast cell chemotaxis
62,795.79 36.84 7 18
positive regulation of mast cell proliferation
58,718.13 36.36 8 22
mast cell differentiation
58,718.13 36.36 8 22
Totals 638 284377

Change Log

Timestamp Action Category Detail
2024-08-16 Added XREF EC:2.7.10.1
2022-04-05 Deleted DEFINITION Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.
2022-04-05 Added DEFINITION Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.
2012-04-29 Deleted DEFINITION Combining with stem cell factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.
2012-04-29 Added DEFINITION Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.
2012-04-29 Added SYNONYM KL receptor activity
2012-04-29 Added SYNONYM SCF receptor activity
2012-04-29 Added SYNONYM KIT ligand receptor activity
2012-04-29 Added SYNONYM KIT
2012-03-24 Deleted DEFINITION Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity.
Timestamp Action Category Detail
2003-03-19 Updated TERM stem cell factor receptor activity
2002-02-06 Updated TERM stem cell factor receptor
2001-04-03 Updated TERM stem cell factor receptor
2001-03-30 Added TERM stem cell factor receptor
Timestamp Action Category Detail
2022-04-05 Deleted DEFINITION Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.
2022-04-05 Added DEFINITION Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.
2012-04-29 Deleted DEFINITION Combining with stem cell factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.
2012-04-29 Added DEFINITION Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.
2012-04-29 Added SYNONYM KL receptor activity
2012-04-29 Added SYNONYM SCF receptor activity
2012-04-29 Added SYNONYM KIT ligand receptor activity
2012-04-29 Added SYNONYM KIT
2012-03-24 Deleted DEFINITION Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity.
2012-03-24 Added DEFINITION Combining with stem cell factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation.
2008-05-13 Added DEFINITION Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity.
2008-05-12 Deleted DEFINITION Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity.
2004-01-03 Updated DEFINITION Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity.
2003-05-14 Updated DEFINITION The function of combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell function.
2002-11-27 Added DEFINITION A type III transmembrane receptor kinase whose ligand is usually stem cell factor (SCF), a cytokine that stimulates mast cell growth and differentiation.
Timestamp Action Category Detail
2012-03-24 Added RELATION part of GO:0038109 (Kit signaling pathway)
2008-04-01 Updated RELATION is a GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
Timestamp Action Category Detail
2024-08-16 Added XREF EC:2.7.10.1
Timestamp Action Category Detail
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