GO:0005020
JSON
stem cell factor receptor activity
Molecular Function
Definition (GO:0005020 GONUTS page)
Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. PMID:10698217
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
SCF receptor activity | exact |
KIT | related |
KL receptor activity | exact |
KIT ligand receptor activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A0B4K7S5 | 7227 | A0A0B4K7S5_DROME | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514 | |
NOT-qualified manual | protein | A0A0G2QC55 | 10116 | A0A0G2QC55_RAT | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A126GUQ5 | 7227 | A0A126GUQ5_DROME | GO:0004672 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19809514 | |
NOT-qualified manual | protein | A0A1D5RK28 | 9544 | A0A1D5RK28_MACMU | GO:0004714 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8END5 | 8355 | A0A1L8END5_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8EV37 | 8355 | A0A1L8EV37_XENLA | GO:0016773 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8GFH0 | 8355 | A0A1L8GFH0_XENLA | GO:0004714 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8GFH0 | 8355 | A0A1L8GFH0_XENLA | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8GM33 | 8355 | A0A1L8GM33_XENLA | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.7.10.1 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005020 based on ALL annotations
The top 100 of 2,033 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
stem cell factor receptor activity
|
4,588.31 | 100.00 | 42,486 | 42,486 |
boss receptor activity
|
4,587.44 | 99.89 | 42,447 | 42,455 |
GPI-linked ephrin receptor activity
|
4,573.44 | 99.58 | 42,447 | 42,585 |
insulin-like growth factor receptor activity
|
4,583.21 | 99.36 | 42,259 | 42,306 |
hepatocyte growth factor receptor activity
|
4,566.59 | 99.00 | 42,259 | 42,460 |
platelet-derived growth factor alpha-receptor activity
|
4,539.11 | 98.40 | 42,259 | 42,717 |
platelet-derived growth factor receptor-alpha signaling pathway
|
4,538.69 | 98.40 | 42,259 | 42,721 |
macrophage colony-stimulating factor receptor activity
|
4,518.68 | 98.39 | 42,447 | 43,101 |
platelet-derived growth factor beta-receptor activity
|
4,531.58 | 98.24 | 42,259 | 42,788 |
brain-derived neurotrophic factor receptor activity
|
4,530.31 | 98.22 | 42,259 | 42,800 |
Totals | 1569318 | 4294312 |
No co-occurrence statistics for GO:0005020 based on MANUAL annotations
The top 87 of 87 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
stem cell factor receptor activity
|
161,474.88 | 100.00 | 8 | 8 |
positive regulation of pyloric antrum smooth muscle contraction
|
161,474.88 | 87.50 | 7 | 7 |
positive regulation of colon smooth muscle contraction
|
141,290.52 | 77.78 | 7 | 8 |
positive regulation of small intestine smooth muscle contraction
|
113,032.41 | 63.64 | 7 | 10 |
melanocyte adhesion
|
86,119.94 | 53.33 | 8 | 15 |
Fc receptor signaling pathway
|
75,988.18 | 47.06 | 8 | 17 |
regulation of bile acid metabolic process
|
70,645.26 | 41.18 | 7 | 16 |
mast cell chemotaxis
|
62,795.79 | 36.84 | 7 | 18 |
positive regulation of mast cell proliferation
|
58,718.13 | 36.36 | 8 | 22 |
mast cell differentiation
|
58,718.13 | 36.36 | 8 | 22 |
Totals | 638 | 284377 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-16 | Added | XREF | EC:2.7.10.1 |
2022-04-05 | Deleted | DEFINITION | Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. |
2022-04-05 | Added | DEFINITION | Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. |
2012-04-29 | Deleted | DEFINITION | Combining with stem cell factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. |
2012-04-29 | Added | DEFINITION | Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. |
2012-04-29 | Added | SYNONYM | KL receptor activity |
2012-04-29 | Added | SYNONYM | SCF receptor activity |
2012-04-29 | Added | SYNONYM | KIT ligand receptor activity |
2012-04-29 | Added | SYNONYM | KIT |
2012-03-24 | Deleted | DEFINITION | Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | stem cell factor receptor activity |
2002-02-06 | Updated | TERM | stem cell factor receptor |
2001-04-03 | Updated | TERM | stem cell factor receptor |
2001-03-30 | Added | TERM | stem cell factor receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-04-05 | Deleted | DEFINITION | Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. |
2022-04-05 | Added | DEFINITION | Combining with stem cell factor (SCF) receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. |
2012-04-29 | Deleted | DEFINITION | Combining with stem cell factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. |
2012-04-29 | Added | DEFINITION | Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. |
2012-04-29 | Added | SYNONYM | KL receptor activity |
2012-04-29 | Added | SYNONYM | SCF receptor activity |
2012-04-29 | Added | SYNONYM | KIT ligand receptor activity |
2012-04-29 | Added | SYNONYM | KIT |
2012-03-24 | Deleted | DEFINITION | Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity. |
2012-03-24 | Added | DEFINITION | Combining with stem cell factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. |
2008-05-13 | Added | DEFINITION | Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity. |
2008-05-12 | Deleted | DEFINITION | Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity. |
2004-01-03 | Updated | DEFINITION | Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity. |
2003-05-14 | Updated | DEFINITION | The function of combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell function. |
2002-11-27 | Added | DEFINITION | A type III transmembrane receptor kinase whose ligand is usually stem cell factor (SCF), a cytokine that stimulates mast cell growth and differentiation. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-03-24 | Added | RELATION | part of GO:0038109 (Kit signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0004714 (transmembrane receptor protein tyrosine kinase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-16 | Added | XREF | EC:2.7.10.1 |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link