This term is obsolete.

GO:0005085 JSON

guanyl-nucleotide exchange factor activity

Molecular Function

Definition (GO:0005085 GONUTS page)

Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. PMID:23303910 PMID:27218782

Secondary IDs

GO:0005086, GO:0005087, GO:0005088, GO:0005089, GO:0005090, GO:0008321, GO:0008433, GO:0016219, GO:0016220, GO:0017034, GO:0017112, GO:0017132, GO:0019839, GO:0030676

464,860 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
Rho guanine nucleotide exchange factor exact
Sar guanyl-nucleotide exchange factor activity narrow
Rap guanyl-nucleotide exchange factor activity narrow
RhoGEF exact
cAMP-dependent guanyl-nucleotide exchange factor activity narrow
Rab guanyl-nucleotide exchange factor activity narrow
Ras guanyl-nucleotide exchange factor activity narrow
Rho guanyl-nucleotide exchange factor activity narrow
Ran guanyl-nucleotide exchange factor activity narrow
Ral guanyl-nucleotide exchange factor activity narrow

Ancestor Chart

Ancestor chart for GO:0005085
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005085

Child Term Relationship to
GO:0005085
regulation of guanyl-nucleotide exchange factor activity
regulates
negative regulation of guanyl-nucleotide exchange factor activity
negatively_regulates
guanyl-nucleotide exchange factor complex
capable_of
positive regulation of guanyl-nucleotide exchange factor activity
positively_regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Binding term considerations Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A2I3SN54 9598 A0A2I3SN54_PANTR GO:0005085 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A5F5PK62 9796 A0A5F5PK62_HORSE GO:0005085 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A5F8G6E0 13616 A0A5F8G6E0_MONDO GO:0005085 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3QDS8 9615 A0A8I3QDS8_CANLF GO:0005085 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I6AEV4 10116 A0A8I6AEV4_RAT GO:0005085 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8V0Z1J8 9031 A0A8V0Z1J8_CHICK GO:0005085 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein D3ZG75 10116 D3ZG75_RAT GO:0005085 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F1M1Y3 10116 F1M1Y3_RAT GO:0005085 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein F1MX99 9913 F1MX99_BOVIN GO:0005085 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein F6TS31 9544 F6TS31_MACMU GO:0005085 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR000904 Sec7 domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
InterPro IPR005414 Guanine nucleotide exchange factor SopE
InterPro IPR005512 PRONE domain
InterPro IPR007515 Mss4
InterPro IPR008937 Ras-like guanine nucleotide exchange factor
InterPro IPR015212 Regulator of G protein signalling-like domain
InterPro IPR016019 Guanine nucleotide exchange factor SopE, GEF domain

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005085 based on ALL annotations
The top 100 of 3,829 co-occurring terms
Co-occurring Term PR S% #Together #Compared
guanyl-nucleotide exchange factor activity
424.26 100.00 459,476 459,476
small GTPase-mediated signal transduction
244.51 19.13 102,253 177,423
Ras protein signal transduction
321.33 9.54 45,235 59,726
regulation of ARF protein signal transduction
343.37 8.97 42,088 52,003
small GTPase binding
74.33 7.28 50,862 290,296
intracellular signal transduction
34.95 4.73 45,993 558,389
eukaryotic translation initiation factor 2B complex
424.10 3.99 18,349 18,356
endocytic vesicle
186.84 3.60 17,331 39,355
GTPase activator activity
26.08 3.25 29,555 480,710
regulation of Rab protein signal transduction
325.84 3.06 14,170 18,450
Totals 1702300 61031875
No co-occurrence statistics for GO:0005085 based on MANUAL annotations
The top 100 of 1,880 co-occurring terms
Co-occurring Term PR S% #Together #Compared
guanyl-nucleotide exchange factor activity
231.84 100.00 5,572 5,572
small GTPase binding
81.72 13.37 988 2,803
Ras protein signal transduction
108.55 11.89 766 1,636
eukaryotic translation initiation factor 2B complex
228.28 8.05 449 456
endocytic vesicle
72.19 6.29 407 1,307
regulation of Rho protein signal transduction
109.45 5.01 296 627
translation initiation factor activity
23.99 4.71 444 4,290
translational elongation
44.10 3.86 257 1,351
small GTPase-mediated signal transduction
57.05 3.72 234 951
translational initiation
20.72 3.10 252 2,820
Totals 21137 644182

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_yeast 163
goslim_chembl 296
goslim_drosophila 173

Change Log

Timestamp Action Category Detail
2024-11-05 Deleted XREF Reactome:R-HSA-400092
2024-11-03 Added XREF Reactome:R-HSA-400092
2024-11-02 Deleted XREF Reactome:R-HSA-400092
2024-11-01 Added XREF Reactome:R-HSA-400092
2024-10-26 Deleted XREF Reactome:R-HSA-400092
2024-10-09 Added XREF Reactome:R-HSA-400092
2024-10-08 Deleted XREF Reactome:R-HSA-400092
2024-09-21 Added XREF Reactome:R-HSA-400092
2024-09-20 Deleted XREF Reactome:R-HSA-400092
2024-09-19 Added XREF Reactome:R-HSA-400092
Timestamp Action Category Detail
2003-03-19 Updated TERM guanyl-nucleotide exchange factor activity
2002-02-06 Updated TERM guanyl-nucleotide exchange factor
2001-04-03 Updated TERM guanyl-nucleotide exchange factor
2001-03-30 Added TERM guanyl-nucleotide exchange factor
Timestamp Action Category Detail
2021-02-24 Added DEFINITION Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
2021-02-24 Deleted DEFINITION Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2020-10-25 Added SYNONYM ARF guanyl-nucleotide exchange factor activity
2020-10-25 Added SYNONYM Ral guanyl-nucleotide exchange factor activity
2020-10-25 Added SYNONYM Ras guanyl-nucleotide exchange factor activity
2020-10-25 Added SYNONYM Rho guanine nucleotide exchange factor
2020-10-25 Added SYNONYM Sar guanyl-nucleotide exchange factor activity
2020-10-25 Added SYNONYM Rap guanyl-nucleotide exchange factor activity
2020-10-25 Added SYNONYM RhoGEF
2020-10-25 Added SYNONYM cAMP-dependent guanyl-nucleotide exchange factor activity
2020-10-25 Added SYNONYM Rab guanyl-nucleotide exchange factor activity
2020-10-25 Added SYNONYM Rac guanyl-nucleotide exchange factor activity
2020-10-25 Added SYNONYM Ran guanyl-nucleotide exchange factor activity
2020-10-25 Added SYNONYM Rho guanyl-nucleotide exchange factor activity
2010-10-29 Added SYNONYM GDS
2010-10-29 Added SYNONYM GDP-dissociation stimulator activity
2009-12-15 Added DEFINITION Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2009-12-15 Deleted DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2008-05-13 Added DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2008-05-12 Deleted DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2007-08-09 Deleted SYNONYM GEF
2007-08-09 Deleted SYNONYM guanyl-nucleotide releasing factor
2007-08-09 Deleted SYNONYM GNRP
2007-08-09 Added SYNONYM guanyl-nucleotide release factor activity
2007-08-09 Deleted SYNONYM guanyl-nucleotide release factor activity
2007-08-09 Added SYNONYM GNRP
2007-08-09 Added SYNONYM GEF
2007-08-09 Added SYNONYM guanyl-nucleotide releasing factor
2006-04-14 Updated DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2004-04-19 Added SYNONYM GEF
2004-04-19 Added SYNONYM GNRP
2004-04-19 Added SYNONYM guanyl-nucleotide release factor activity
2004-04-19 Added SYNONYM guanyl-nucleotide releasing factor
2004-04-16 Deleted SYNONYM guanyl-nucleotide releasing factor
2004-04-16 Deleted SYNONYM GNRP
2004-04-16 Deleted SYNONYM GEF
2004-04-16 Deleted SYNONYM guanyl-nucleotide release factor activity
2003-05-28 Added SYNONYM guanyl-nucleotide release factor activity
2003-04-02 Added DEFINITION Stimulates the hydrolysis and exchange of guanyl nucleotides by other proteins.
2001-12-10 Added SYNONYM guanyl-nucleotide releasing factor
2001-12-10 Added SYNONYM GNRP
2001-03-30 Added SYNONYM GEF
Timestamp Action Category Detail
2023-04-02 Deleted RELATION is a GO:0140677 (molecular function activator activity)
2023-04-02 Deleted RELATION is a GO:0140678 (molecular function inhibitor activity)
2022-09-16 Added RELATION is a GO:0140678 (molecular function inhibitor activity)
2022-09-16 Added RELATION is a GO:0140677 (molecular function activator activity)
2021-10-30 Added RELATION is a GO:0030695 (GTPase regulator activity)
2021-10-30 Deleted RELATION is a GO:0005096 (GTPase activator activity)
2021-02-24 Added RELATION is a GO:0005096 (GTPase activator activity)
2021-02-24 Deleted RELATION is a GO:0030695 (GTPase regulator activity)
2020-10-25 Deleted RELATION is a GO:0051020 (GTPase binding)
2020-10-25 Deleted RELATION is a GO:0098772 (molecular function regulator activity)
2020-10-25 Added RELATION is a GO:0030695 (GTPase regulator activity)
2017-09-30 Added RELATION positively regulates GO:0005525 (GTP binding)
2017-09-30 Added RELATION is a GO:0051020 (GTPase binding)
2017-09-30 Deleted RELATION part of GO:0043547 (positive regulation of GTPase activity)
2015-06-25 Deleted RELATION is a GO:0003674 (molecular_function)
2015-01-29 Added RELATION is a GO:0098772 (molecular function regulator activity)
2014-06-11 Deleted RELATION part of GO:0043087 (regulation of GTPase activity)
2014-06-11 Added RELATION part of GO:0043547 (positive regulation of GTPase activity)
2013-11-15 Deleted RELATION is a GO:0030695 (GTPase regulator activity)
2013-11-15 Added RELATION part of GO:0043087 (regulation of GTPase activity)
2013-11-15 Added RELATION is a GO:0003674 (molecular_function)
2010-10-29 Added RELATION negatively regulates GO:0019003 (GDP binding)
2008-04-01 Updated RELATION is a GO:0030695 (GTPase regulator activity)
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Timestamp Action Category Detail
2020-10-25 Added SECONDARY GO:0017034 (Rap guanyl-nucleotide exchange factor activity)
2020-10-25 Added SECONDARY GO:0017112 (Rab guanyl-nucleotide exchange factor activity)
2020-10-25 Added SECONDARY GO:0017132 (cAMP-dependent guanyl-nucleotide exchange factor activity)
2020-10-25 Added SECONDARY GO:0016220 (RAL GDP-dissociation stimulator activity)
2020-10-25 Added SECONDARY GO:0008321 (Ral guanyl-nucleotide exchange factor activity)
2020-10-25 Added SECONDARY GO:0005086 (ARF guanyl-nucleotide exchange factor activity)
2020-10-25 Added SECONDARY GO:0005087 (Ran guanyl-nucleotide exchange factor activity)
2020-10-25 Added SECONDARY GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
2020-10-25 Added SECONDARY GO:0005089 (Rho guanyl-nucleotide exchange factor activity)
2020-10-25 Added SECONDARY GO:0005090 (Sar guanyl-nucleotide exchange factor activity)
2020-10-25 Added SECONDARY GO:0030676 (Rac guanyl-nucleotide exchange factor activity)
2019-11-09 Added SUBSET goslim_drosophila
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
2014-08-02 Added SUBSET goslim_yeast
2010-10-29 Added SECONDARY GO:0016219 (GDP-dissociation stimulator activity)
2003-05-28 Added SECONDARY GO:0019839 (guanyl-nucleotide release factor activity)
2001-12-10 Added SECONDARY GO:0008433 (guanyl-nucleotide releasing factor)
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