GO:0005085
JSON
guanyl-nucleotide exchange factor activity
Molecular Function
Definition (GO:0005085 GONUTS page)
Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. PMID:23303910 PMID:27218782
Secondary IDs
GO:0005086, GO:0005087, GO:0005088, GO:0005089, GO:0005090, GO:0008321, GO:0008433, GO:0016219, GO:0016220, GO:0017034, GO:0017112, GO:0017132, GO:0019839, GO:0030676
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
Rho guanine nucleotide exchange factor | exact |
Sar guanyl-nucleotide exchange factor activity | narrow |
Rap guanyl-nucleotide exchange factor activity | narrow |
RhoGEF | exact |
cAMP-dependent guanyl-nucleotide exchange factor activity | narrow |
Rab guanyl-nucleotide exchange factor activity | narrow |
Ras guanyl-nucleotide exchange factor activity | narrow |
Rho guanyl-nucleotide exchange factor activity | narrow |
Ran guanyl-nucleotide exchange factor activity | narrow |
Ral guanyl-nucleotide exchange factor activity | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0005085
Child Term | Relationship to GO:0005085 |
---|---|
regulation of guanyl-nucleotide exchange factor activity
|
regulates |
negative regulation of guanyl-nucleotide exchange factor activity
|
negatively_regulates |
guanyl-nucleotide exchange factor complex
|
capable_of |
positive regulation of guanyl-nucleotide exchange factor activity
|
positively_regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Binding term considerations | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A2I3SN54 | 9598 | A0A2I3SN54_PANTR | GO:0005085 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A5F5PK62 | 9796 | A0A5F5PK62_HORSE | GO:0005085 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A5F8G6E0 | 13616 | A0A5F8G6E0_MONDO | GO:0005085 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I3QDS8 | 9615 | A0A8I3QDS8_CANLF | GO:0005085 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I6AEV4 | 10116 | A0A8I6AEV4_RAT | GO:0005085 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8V0Z1J8 | 9031 | A0A8V0Z1J8_CHICK | GO:0005085 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | D3ZG75 | 10116 | D3ZG75_RAT | GO:0005085 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F1M1Y3 | 10116 | F1M1Y3_RAT | GO:0005085 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | F1MX99 | 9913 | F1MX99_BOVIN | GO:0005085 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | F6TS31 | 9544 | F6TS31_MACMU | GO:0005085 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000219 | Dbl homology (DH) domain |
InterPro | IPR000904 | Sec7 domain |
InterPro | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
InterPro | IPR001895 | Ras guanine-nucleotide exchange factors catalytic domain |
InterPro | IPR005414 | Guanine nucleotide exchange factor SopE |
InterPro | IPR005512 | PRONE domain |
InterPro | IPR007515 | Mss4 |
InterPro | IPR008937 | Ras-like guanine nucleotide exchange factor |
InterPro | IPR015212 | Regulator of G protein signalling-like domain |
InterPro | IPR016019 | Guanine nucleotide exchange factor SopE, GEF domain |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005085 based on ALL annotations
The top 100 of 3,829 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
guanyl-nucleotide exchange factor activity
|
424.26 | 100.00 | 459,476 | 459,476 |
small GTPase-mediated signal transduction
|
244.51 | 19.13 | 102,253 | 177,423 |
Ras protein signal transduction
|
321.33 | 9.54 | 45,235 | 59,726 |
regulation of ARF protein signal transduction
|
343.37 | 8.97 | 42,088 | 52,003 |
small GTPase binding
|
74.33 | 7.28 | 50,862 | 290,296 |
intracellular signal transduction
|
34.95 | 4.73 | 45,993 | 558,389 |
eukaryotic translation initiation factor 2B complex
|
424.10 | 3.99 | 18,349 | 18,356 |
endocytic vesicle
|
186.84 | 3.60 | 17,331 | 39,355 |
GTPase activator activity
|
26.08 | 3.25 | 29,555 | 480,710 |
regulation of Rab protein signal transduction
|
325.84 | 3.06 | 14,170 | 18,450 |
Totals | 1702300 | 61031875 |
No co-occurrence statistics for GO:0005085 based on MANUAL annotations
The top 100 of 1,880 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
guanyl-nucleotide exchange factor activity
|
231.84 | 100.00 | 5,572 | 5,572 |
small GTPase binding
|
81.72 | 13.37 | 988 | 2,803 |
Ras protein signal transduction
|
108.55 | 11.89 | 766 | 1,636 |
eukaryotic translation initiation factor 2B complex
|
228.28 | 8.05 | 449 | 456 |
endocytic vesicle
|
72.19 | 6.29 | 407 | 1,307 |
regulation of Rho protein signal transduction
|
109.45 | 5.01 | 296 | 627 |
translation initiation factor activity
|
23.99 | 4.71 | 444 | 4,290 |
translational elongation
|
44.10 | 3.86 | 257 | 1,351 |
small GTPase-mediated signal transduction
|
57.05 | 3.72 | 234 | 951 |
translational initiation
|
20.72 | 3.10 | 252 | 2,820 |
Totals | 21137 | 644182 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_yeast | 163 |
goslim_chembl | 296 |
goslim_drosophila | 173 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-05 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-11-03 | Added | XREF | Reactome:R-HSA-400092 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-11-01 | Added | XREF | Reactome:R-HSA-400092 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-10-09 | Added | XREF | Reactome:R-HSA-400092 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-09-21 | Added | XREF | Reactome:R-HSA-400092 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-09-19 | Added | XREF | Reactome:R-HSA-400092 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | guanyl-nucleotide exchange factor activity |
2002-02-06 | Updated | TERM | guanyl-nucleotide exchange factor |
2001-04-03 | Updated | TERM | guanyl-nucleotide exchange factor |
2001-03-30 | Added | TERM | guanyl-nucleotide exchange factor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-24 | Added | DEFINITION | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
2021-02-24 | Deleted | DEFINITION | Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
2020-10-25 | Added | SYNONYM | ARF guanyl-nucleotide exchange factor activity |
2020-10-25 | Added | SYNONYM | Ral guanyl-nucleotide exchange factor activity |
2020-10-25 | Added | SYNONYM | Ras guanyl-nucleotide exchange factor activity |
2020-10-25 | Added | SYNONYM | Rho guanine nucleotide exchange factor |
2020-10-25 | Added | SYNONYM | Sar guanyl-nucleotide exchange factor activity |
2020-10-25 | Added | SYNONYM | Rap guanyl-nucleotide exchange factor activity |
2020-10-25 | Added | SYNONYM | RhoGEF |
2020-10-25 | Added | SYNONYM | cAMP-dependent guanyl-nucleotide exchange factor activity |
2020-10-25 | Added | SYNONYM | Rab guanyl-nucleotide exchange factor activity |
2020-10-25 | Added | SYNONYM | Rac guanyl-nucleotide exchange factor activity |
2020-10-25 | Added | SYNONYM | Ran guanyl-nucleotide exchange factor activity |
2020-10-25 | Added | SYNONYM | Rho guanyl-nucleotide exchange factor activity |
2010-10-29 | Added | SYNONYM | GDS |
2010-10-29 | Added | SYNONYM | GDP-dissociation stimulator activity |
2009-12-15 | Added | DEFINITION | Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
2009-12-15 | Deleted | DEFINITION | Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
2008-05-13 | Added | DEFINITION | Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
2008-05-12 | Deleted | DEFINITION | Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
2007-08-09 | Deleted | SYNONYM | GEF |
2007-08-09 | Deleted | SYNONYM | guanyl-nucleotide releasing factor |
2007-08-09 | Deleted | SYNONYM | GNRP |
2007-08-09 | Added | SYNONYM | guanyl-nucleotide release factor activity |
2007-08-09 | Deleted | SYNONYM | guanyl-nucleotide release factor activity |
2007-08-09 | Added | SYNONYM | GNRP |
2007-08-09 | Added | SYNONYM | GEF |
2007-08-09 | Added | SYNONYM | guanyl-nucleotide releasing factor |
2006-04-14 | Updated | DEFINITION | Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
2004-04-19 | Added | SYNONYM | GEF |
2004-04-19 | Added | SYNONYM | GNRP |
2004-04-19 | Added | SYNONYM | guanyl-nucleotide release factor activity |
2004-04-19 | Added | SYNONYM | guanyl-nucleotide releasing factor |
2004-04-16 | Deleted | SYNONYM | guanyl-nucleotide releasing factor |
2004-04-16 | Deleted | SYNONYM | GNRP |
2004-04-16 | Deleted | SYNONYM | GEF |
2004-04-16 | Deleted | SYNONYM | guanyl-nucleotide release factor activity |
2003-05-28 | Added | SYNONYM | guanyl-nucleotide release factor activity |
2003-04-02 | Added | DEFINITION | Stimulates the hydrolysis and exchange of guanyl nucleotides by other proteins. |
2001-12-10 | Added | SYNONYM | guanyl-nucleotide releasing factor |
2001-12-10 | Added | SYNONYM | GNRP |
2001-03-30 | Added | SYNONYM | GEF |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Deleted | RELATION | is a GO:0140677 (molecular function activator activity) |
2023-04-02 | Deleted | RELATION | is a GO:0140678 (molecular function inhibitor activity) |
2022-09-16 | Added | RELATION | is a GO:0140678 (molecular function inhibitor activity) |
2022-09-16 | Added | RELATION | is a GO:0140677 (molecular function activator activity) |
2021-10-30 | Added | RELATION | is a GO:0030695 (GTPase regulator activity) |
2021-10-30 | Deleted | RELATION | is a GO:0005096 (GTPase activator activity) |
2021-02-24 | Added | RELATION | is a GO:0005096 (GTPase activator activity) |
2021-02-24 | Deleted | RELATION | is a GO:0030695 (GTPase regulator activity) |
2020-10-25 | Deleted | RELATION | is a GO:0051020 (GTPase binding) |
2020-10-25 | Deleted | RELATION | is a GO:0098772 (molecular function regulator activity) |
2020-10-25 | Added | RELATION | is a GO:0030695 (GTPase regulator activity) |
2017-09-30 | Added | RELATION | positively regulates GO:0005525 (GTP binding) |
2017-09-30 | Added | RELATION | is a GO:0051020 (GTPase binding) |
2017-09-30 | Deleted | RELATION | part of GO:0043547 (positive regulation of GTPase activity) |
2015-06-25 | Deleted | RELATION | is a GO:0003674 (molecular_function) |
2015-01-29 | Added | RELATION | is a GO:0098772 (molecular function regulator activity) |
2014-06-11 | Deleted | RELATION | part of GO:0043087 (regulation of GTPase activity) |
2014-06-11 | Added | RELATION | part of GO:0043547 (positive regulation of GTPase activity) |
2013-11-15 | Deleted | RELATION | is a GO:0030695 (GTPase regulator activity) |
2013-11-15 | Added | RELATION | part of GO:0043087 (regulation of GTPase activity) |
2013-11-15 | Added | RELATION | is a GO:0003674 (molecular_function) |
2010-10-29 | Added | RELATION | negatively regulates GO:0019003 (GDP binding) |
2008-04-01 | Updated | RELATION | is a GO:0030695 (GTPase regulator activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-05 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-11-03 | Added | XREF | Reactome:R-HSA-400092 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-11-01 | Added | XREF | Reactome:R-HSA-400092 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-10-09 | Added | XREF | Reactome:R-HSA-400092 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-09-21 | Added | XREF | Reactome:R-HSA-400092 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-09-19 | Added | XREF | Reactome:R-HSA-400092 |
2024-09-13 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-09-10 | Added | XREF | Reactome:R-HSA-400092 |
2024-09-08 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-09-07 | Added | XREF | Reactome:R-HSA-400092 |
2024-09-06 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-09-05 | Added | XREF | Reactome:R-HSA-400092 |
2024-09-02 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-08-20 | Added | XREF | Reactome:R-HSA-400092 |
2024-08-16 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-08-15 | Added | XREF | Reactome:R-HSA-400092 |
2024-08-08 | Added | XREF | Reactome:R-HSA-400092 |
2024-08-08 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-08-06 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-08-05 | Added | XREF | Reactome:R-HSA-400092 |
2024-07-28 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-07-27 | Added | XREF | Reactome:R-HSA-400092 |
2024-07-26 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-07-25 | Added | XREF | Reactome:R-HSA-400092 |
2024-07-20 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-07-19 | Added | XREF | Reactome:R-HSA-400092 |
2024-07-18 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-07-14 | Added | XREF | Reactome:R-HSA-400092 |
2024-07-11 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-07-10 | Added | XREF | Reactome:R-HSA-400092 |
2024-07-09 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-07-06 | Added | XREF | Reactome:R-HSA-400092 |
2024-07-04 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-07-03 | Added | XREF | Reactome:R-HSA-400092 |
2024-06-30 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-06-29 | Added | XREF | Reactome:R-HSA-400092 |
2024-06-28 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-06-27 | Added | XREF | Reactome:R-HSA-400092 |
2024-06-26 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-06-23 | Added | XREF | Reactome:R-HSA-400092 |
2024-06-20 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-06-19 | Added | XREF | Reactome:R-HSA-400092 |
2024-06-14 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-06-13 | Added | XREF | Reactome:R-HSA-400092 |
2024-06-12 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-06-11 | Added | XREF | Reactome:R-HSA-400092 |
2024-06-07 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-06-01 | Added | XREF | Reactome:R-HSA-400092 |
2024-05-31 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-05-30 | Added | XREF | Reactome:R-HSA-400092 |
2024-05-29 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-05-25 | Added | XREF | Reactome:R-HSA-400092 |
2024-05-24 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-05-23 | Added | XREF | Reactome:R-HSA-400092 |
2024-05-22 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-05-16 | Added | XREF | Reactome:R-HSA-400092 |
2024-05-15 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-05-14 | Added | XREF | Reactome:R-HSA-400092 |
2024-05-11 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-05-09 | Added | XREF | Reactome:R-HSA-400092 |
2024-05-09 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-05-08 | Added | XREF | Reactome:R-HSA-400092 |
2024-05-05 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-05-03 | Added | XREF | Reactome:R-HSA-400092 |
2024-05-02 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-05-01 | Added | XREF | Reactome:R-HSA-400092 |
2024-04-25 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-04-24 | Added | XREF | Reactome:R-HSA-400092 |
2024-04-21 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-04-19 | Added | XREF | Reactome:R-HSA-400092 |
2024-04-18 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-04-14 | Added | XREF | Reactome:R-HSA-400092 |
2024-04-13 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-04-12 | Added | XREF | Reactome:R-HSA-400092 |
2024-04-11 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-04-09 | Added | XREF | Reactome:R-HSA-400092 |
2024-04-07 | Deleted | XREF | Reactome:R-HSA-400092 |
2024-04-06 | Added | XREF | Reactome:R-HSA-400092 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9751201 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9018804 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9017491 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9036301 |
2023-04-02 | Deleted | XREF | Reactome:R-HSA-194913 |
2023-04-02 | Deleted | XREF | Reactome:R-HSA-8853307 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9018747 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9018825 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9693111 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013435 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9014433 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013159 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9018768 |
2023-04-02 | Added | XREF | Reactome:R-HSA-8980691 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9014296 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9018817 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9680385 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013143 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013109 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013023 |
2020-12-17 | Added | XREF | Reactome:R-HSA-9703441 |
2020-12-17 | Added | XREF | Reactome:R-HSA-9695853 |
2020-10-25 | Added | XREF | Reactome:R-HSA-1250383 |
2020-10-25 | Added | XREF | Reactome:R-HSA-1250498 |
2020-10-25 | Added | XREF | Reactome:R-HSA-392054 |
2020-10-25 | Added | XREF | Reactome:R-HSA-399938 |
2020-10-25 | Added | XREF | Reactome:R-HSA-418856 |
2020-10-25 | Added | XREF | Reactome:R-HSA-428535 |
2020-10-25 | Added | XREF | Reactome:R-HSA-5623521 |
2020-10-25 | Added | XREF | Reactome:R-HSA-5654413 |
2020-10-25 | Added | XREF | Reactome:R-HSA-5686318 |
2020-10-25 | Added | XREF | Reactome:R-HSA-8875318 |
2020-10-25 | Added | XREF | Reactome:R-HSA-8877998 |
2020-10-25 | Added | XREF | Reactome:R-HSA-9033292 |
2020-10-25 | Added | XREF | Reactome:R-HSA-9607304 |
2020-10-25 | Added | XREF | Reactome:R-HSA-9634418 |
2020-10-25 | Added | XREF | Reactome:R-HSA-9665009 |
2020-10-25 | Added | XREF | Reactome:R-HSA-9665404 |
2020-10-25 | Added | XREF | Reactome:R-HSA-9665700 |
2020-10-25 | Added | XREF | Reactome:R-HSA-5623508 |
2020-10-25 | Added | XREF | Reactome:R-HSA-5654663 |
2020-10-25 | Added | XREF | Reactome:R-HSA-5672965 |
2020-10-25 | Added | XREF | Reactome:R-HSA-8876190 |
2020-10-25 | Added | XREF | Reactome:R-HSA-8876616 |
2020-10-25 | Added | XREF | Reactome:R-HSA-8877451 |
2020-10-25 | Added | XREF | Reactome:R-HSA-9026891 |
2020-10-25 | Added | XREF | Reactome:R-HSA-9029158 |
2020-10-25 | Added | XREF | Reactome:R-HSA-9665707 |
2020-10-25 | Added | XREF | Reactome:R-HSA-109807 |
2020-10-25 | Added | XREF | Reactome:R-HSA-1225951 |
2020-10-25 | Added | XREF | Reactome:R-HSA-1433471 |
2020-10-25 | Added | XREF | Reactome:R-HSA-186834 |
2020-10-25 | Added | XREF | Reactome:R-HSA-194518 |
2020-10-25 | Added | XREF | Reactome:R-HSA-5637808 |
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-25 | Added | SECONDARY | GO:0017034 (Rap guanyl-nucleotide exchange factor activity) |
2020-10-25 | Added | SECONDARY | GO:0017112 (Rab guanyl-nucleotide exchange factor activity) |
2020-10-25 | Added | SECONDARY | GO:0017132 (cAMP-dependent guanyl-nucleotide exchange factor activity) |
2020-10-25 | Added | SECONDARY | GO:0016220 (RAL GDP-dissociation stimulator activity) |
2020-10-25 | Added | SECONDARY | GO:0008321 (Ral guanyl-nucleotide exchange factor activity) |
2020-10-25 | Added | SECONDARY | GO:0005086 (ARF guanyl-nucleotide exchange factor activity) |
2020-10-25 | Added | SECONDARY | GO:0005087 (Ran guanyl-nucleotide exchange factor activity) |
2020-10-25 | Added | SECONDARY | GO:0005088 (Ras guanyl-nucleotide exchange factor activity) |
2020-10-25 | Added | SECONDARY | GO:0005089 (Rho guanyl-nucleotide exchange factor activity) |
2020-10-25 | Added | SECONDARY | GO:0005090 (Sar guanyl-nucleotide exchange factor activity) |
2020-10-25 | Added | SECONDARY | GO:0030676 (Rac guanyl-nucleotide exchange factor activity) |
2019-11-09 | Added | SUBSET | goslim_drosophila |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2014-08-02 | Added | SUBSET | goslim_yeast |
2010-10-29 | Added | SECONDARY | GO:0016219 (GDP-dissociation stimulator activity) |
2003-05-28 | Added | SECONDARY | GO:0019839 (guanyl-nucleotide release factor activity) |
2001-12-10 | Added | SECONDARY | GO:0008433 (guanyl-nucleotide releasing factor) |
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