GO:0005091
JSON
guanyl-nucleotide exchange factor adaptor activity
Molecular Function
Definition (GO:0005091 GONUTS page)
The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.
Ancestor Chart
Ancestor chart for GO:0005091
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | Q61387 | 10090 | CO72L_MOUSE | GO:0030674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005091 based on ALL annotations
The top 100 of 101 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
guanyl-nucleotide exchange factor adaptor activity
|
1,548,084.90 | 100.00 | 128 | 128 |
Grb2-EGFR complex
|
1,519,416.80 | 81.54 | 106 | 108 |
neurotrophin TRKA receptor binding
|
319,254.88 | 19.78 | 106 | 514 |
negative regulation of natural killer cell mediated cytotoxicity
|
207,193.17 | 13.02 | 106 | 792 |
branching involved in labyrinthine layer morphogenesis
|
192,596.39 | 11.55 | 79 | 635 |
signal transduction in response to DNA damage
|
130,339.16 | 8.27 | 106 | 1,259 |
Schwann cell development
|
89,262.10 | 5.68 | 102 | 1,769 |
natural killer cell mediated cytotoxicity
|
88,366.72 | 5.64 | 106 | 1,857 |
positive regulation of reactive oxygen species metabolic process
|
64,758.09 | 4.15 | 106 | 2,534 |
endodermal cell differentiation
|
36,341.70 | 2.33 | 102 | 4,345 |
Totals | 5060 | 171754676 |
No co-occurrence statistics for GO:0005091 based on MANUAL annotations
The top 89 of 89 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
guanyl-nucleotide exchange factor adaptor activity
|
100,823.79 | 100.00 | 14 | 14 |
podosome assembly
|
15,379.90 | 14.06 | 9 | 59 |
Grb2-EGFR complex
|
50,411.90 | 12.50 | 2 | 4 |
positive regulation of Rac protein signal transduction
|
9,653.34 | 9.09 | 9 | 94 |
neurotrophin TRKA receptor binding
|
14,403.40 | 7.69 | 2 | 14 |
bone resorption
|
6,980.11 | 6.67 | 9 | 130 |
podosome
|
5,041.19 | 4.86 | 9 | 180 |
lung alveolus development
|
3,945.28 | 3.83 | 9 | 230 |
branching involved in labyrinthine layer morphogenesis
|
4,290.37 | 3.39 | 2 | 47 |
negative regulation of Rho protein signal transduction
|
3,411.33 | 3.32 | 9 | 266 |
Totals | 247 | 960389 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2015-02-13 | Deleted | RELATION | is a GO:0005083 (small GTPase regulator activity) |
2015-02-13 | Added | RELATION | is a GO:0030695 (GTPase regulator activity) |
2012-04-14 | Deleted | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
2012-04-14 | Added | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way. |
2010-12-03 | Added | RELATION | is a GO:0030674 (protein-macromolecule adaptor activity) |
2010-12-03 | Deleted | RELATION | is a GO:0060090 (molecular adaptor activity) |
2008-05-13 | Added | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
2008-05-12 | Deleted | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
2008-04-01 | Updated | RELATION | is a GO:0060090 (molecular adaptor activity) |
2008-04-01 | Updated | RELATION | is a GO:0005083 (small GTPase regulator activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | guanyl-nucleotide exchange factor adaptor activity |
2002-02-06 | Updated | TERM | guanyl-nucleotide exchange factor adaptor |
2001-04-03 | Updated | TERM | guanyl-nucleotide exchange factor adaptor |
2001-03-30 | Added | TERM | guanyl-nucleotide exchange factor adaptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-04-14 | Deleted | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
2012-04-14 | Added | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way. |
2008-05-13 | Added | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
2008-05-12 | Deleted | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
2007-04-20 | Added | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-02-13 | Deleted | RELATION | is a GO:0005083 (small GTPase regulator activity) |
2015-02-13 | Added | RELATION | is a GO:0030695 (GTPase regulator activity) |
2010-12-03 | Added | RELATION | is a GO:0030674 (protein-macromolecule adaptor activity) |
2010-12-03 | Deleted | RELATION | is a GO:0060090 (molecular adaptor activity) |
2008-04-01 | Updated | RELATION | is a GO:0060090 (molecular adaptor activity) |
2008-04-01 | Updated | RELATION | is a GO:0005083 (small GTPase regulator activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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