This term is obsolete.

GO:0005091 JSON

guanyl-nucleotide exchange factor adaptor activity

Molecular Function

Definition (GO:0005091 GONUTS page)

The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.

135 annotations

Ancestor Chart

Ancestor chart for GO:0005091
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein Q61387 10090 CO72L_MOUSE GO:0030674 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005091 based on ALL annotations
The top 100 of 101 co-occurring terms
Co-occurring Term PR S% #Together #Compared
guanyl-nucleotide exchange factor adaptor activity
1,548,084.90 100.00 128 128
Grb2-EGFR complex
1,519,416.80 81.54 106 108
neurotrophin TRKA receptor binding
319,254.88 19.78 106 514
negative regulation of natural killer cell mediated cytotoxicity
207,193.17 13.02 106 792
branching involved in labyrinthine layer morphogenesis
192,596.39 11.55 79 635
signal transduction in response to DNA damage
130,339.16 8.27 106 1,259
Schwann cell development
89,262.10 5.68 102 1,769
natural killer cell mediated cytotoxicity
88,366.72 5.64 106 1,857
positive regulation of reactive oxygen species metabolic process
64,758.09 4.15 106 2,534
endodermal cell differentiation
36,341.70 2.33 102 4,345
Totals 5060 171754676
No co-occurrence statistics for GO:0005091 based on MANUAL annotations
The top 89 of 89 co-occurring terms
Co-occurring Term PR S% #Together #Compared
guanyl-nucleotide exchange factor adaptor activity
100,823.79 100.00 14 14
podosome assembly
15,379.90 14.06 9 59
Grb2-EGFR complex
50,411.90 12.50 2 4
positive regulation of Rac protein signal transduction
9,653.34 9.09 9 94
neurotrophin TRKA receptor binding
14,403.40 7.69 2 14
bone resorption
6,980.11 6.67 9 130
podosome
5,041.19 4.86 9 180
lung alveolus development
3,945.28 3.83 9 230
branching involved in labyrinthine layer morphogenesis
4,290.37 3.39 2 47
negative regulation of Rho protein signal transduction
3,411.33 3.32 9 266
Totals 247 960389

Change Log

Timestamp Action Category Detail
2015-02-13 Deleted RELATION is a GO:0005083 (small GTPase regulator activity)
2015-02-13 Added RELATION is a GO:0030695 (GTPase regulator activity)
2012-04-14 Deleted DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
2012-04-14 Added DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.
2010-12-03 Added RELATION is a GO:0030674 (protein-macromolecule adaptor activity)
2010-12-03 Deleted RELATION is a GO:0060090 (molecular adaptor activity)
2008-05-13 Added DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
2008-05-12 Deleted DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
2008-04-01 Updated RELATION is a GO:0060090 (molecular adaptor activity)
2008-04-01 Updated RELATION is a GO:0005083 (small GTPase regulator activity)
Timestamp Action Category Detail
2003-03-19 Updated TERM guanyl-nucleotide exchange factor adaptor activity
2002-02-06 Updated TERM guanyl-nucleotide exchange factor adaptor
2001-04-03 Updated TERM guanyl-nucleotide exchange factor adaptor
2001-03-30 Added TERM guanyl-nucleotide exchange factor adaptor
Timestamp Action Category Detail
2012-04-14 Deleted DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
2012-04-14 Added DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.
2008-05-13 Added DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
2008-05-12 Deleted DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
2007-04-20 Added DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
Timestamp Action Category Detail
2015-02-13 Deleted RELATION is a GO:0005083 (small GTPase regulator activity)
2015-02-13 Added RELATION is a GO:0030695 (GTPase regulator activity)
2010-12-03 Added RELATION is a GO:0030674 (protein-macromolecule adaptor activity)
2010-12-03 Deleted RELATION is a GO:0060090 (molecular adaptor activity)
2008-04-01 Updated RELATION is a GO:0060090 (molecular adaptor activity)
2008-04-01 Updated RELATION is a GO:0005083 (small GTPase regulator activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.