This term is obsolete.

GO:0005091 JSON

guanyl-nucleotide exchange factor adaptor activity

Molecular Function

Definition (GO:0005091 GONUTS page)

The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.

136 annotations

Ancestor Chart

Ancestor chart for GO:0005091
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein Q61387 10090 CO72L_MOUSE GO:0030674 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005091 based on ALL annotations
The top 100 of 101 co-occurring terms
Co-occurring Term PR S% #Together #Compared
guanyl-nucleotide exchange factor adaptor activity
1,511,153.40 100.00 129 129
Grb2-EGFR complex
1,483,425.80 81.68 107 109
neurotrophin TRKA receptor binding
313,967.78 19.93 107 515
branching involved in labyrinthine layer morphogenesis
190,082.19 11.68 80 636
signal transduction in response to DNA damage
128,430.02 8.35 107 1,259
natural killer cell mediated cytotoxicity
100,368.34 6.55 107 1,611
Schwann cell development
87,345.01 5.70 103 1,782
positive regulation of reactive oxygen species metabolic process
62,550.64 4.10 107 2,585
endodermal cell differentiation
35,921.72 2.36 103 4,333
insulin receptor substrate binding
25,539.95 1.68 107 6,331
Totals 5016 171504225
No co-occurrence statistics for GO:0005091 based on MANUAL annotations
The top 89 of 89 co-occurring terms
Co-occurring Term PR S% #Together #Compared
guanyl-nucleotide exchange factor adaptor activity
92,271.35 100.00 14 14
podosome assembly
14,829.32 14.75 9 56
Grb2-EGFR complex
46,135.68 12.50 2 4
positive regulation of Rac protein signal transduction
9,026.55 9.28 9 92
neurotrophin TRKA receptor binding
13,181.62 7.69 2 14
bone resorption
6,538.92 6.82 9 127
podosome
5,255.96 5.52 9 158
lung alveolus development
3,610.62 3.83 9 230
negative regulation of Rho protein signal transduction
3,403.45 3.61 9 244
branching involved in labyrinthine layer morphogenesis
3,926.44 3.39 2 47
Totals 246 897291

Change Log

Timestamp Action Category Detail
2015-02-13 Deleted RELATION is a GO:0005083 (small GTPase regulator activity)
2015-02-13 Added RELATION is a GO:0030695 (GTPase regulator activity)
2012-04-14 Deleted DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
2012-04-14 Added DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.
2010-12-03 Added RELATION is a GO:0030674 (protein-macromolecule adaptor activity)
2010-12-03 Deleted RELATION is a GO:0060090 (molecular adaptor activity)
2008-05-13 Added DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
2008-05-12 Deleted DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
2008-04-01 Updated RELATION is a GO:0060090 (molecular adaptor activity)
2008-04-01 Updated RELATION is a GO:0005083 (small GTPase regulator activity)
Timestamp Action Category Detail
2003-03-19 Updated TERM guanyl-nucleotide exchange factor adaptor activity
2002-02-06 Updated TERM guanyl-nucleotide exchange factor adaptor
2001-04-03 Updated TERM guanyl-nucleotide exchange factor adaptor
2001-03-30 Added TERM guanyl-nucleotide exchange factor adaptor
Timestamp Action Category Detail
2012-04-14 Deleted DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
2012-04-14 Added DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.
2008-05-13 Added DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
2008-05-12 Deleted DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
2007-04-20 Added DEFINITION The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way.
Timestamp Action Category Detail
2015-02-13 Deleted RELATION is a GO:0005083 (small GTPase regulator activity)
2015-02-13 Added RELATION is a GO:0030695 (GTPase regulator activity)
2010-12-03 Added RELATION is a GO:0030674 (protein-macromolecule adaptor activity)
2010-12-03 Deleted RELATION is a GO:0060090 (molecular adaptor activity)
2008-04-01 Updated RELATION is a GO:0060090 (molecular adaptor activity)
2008-04-01 Updated RELATION is a GO:0005083 (small GTPase regulator activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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