GO:0005091
JSON
guanyl-nucleotide exchange factor adaptor activity
Molecular Function
Definition (GO:0005091 GONUTS page)
The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.
Ancestor Chart
Ancestor chart for GO:0005091
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | Q61387 | 10090 | CO72L_MOUSE | GO:0030674 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005091 based on ALL annotations
The top 100 of 101 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
guanyl-nucleotide exchange factor adaptor activity
|
1,511,153.40 | 100.00 | 129 | 129 |
Grb2-EGFR complex
|
1,483,425.80 | 81.68 | 107 | 109 |
neurotrophin TRKA receptor binding
|
313,967.78 | 19.93 | 107 | 515 |
branching involved in labyrinthine layer morphogenesis
|
190,082.19 | 11.68 | 80 | 636 |
signal transduction in response to DNA damage
|
128,430.02 | 8.35 | 107 | 1,259 |
natural killer cell mediated cytotoxicity
|
100,368.34 | 6.55 | 107 | 1,611 |
Schwann cell development
|
87,345.01 | 5.70 | 103 | 1,782 |
positive regulation of reactive oxygen species metabolic process
|
62,550.64 | 4.10 | 107 | 2,585 |
endodermal cell differentiation
|
35,921.72 | 2.36 | 103 | 4,333 |
insulin receptor substrate binding
|
25,539.95 | 1.68 | 107 | 6,331 |
Totals | 5016 | 171504225 |
No co-occurrence statistics for GO:0005091 based on MANUAL annotations
The top 89 of 89 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
guanyl-nucleotide exchange factor adaptor activity
|
92,271.35 | 100.00 | 14 | 14 |
podosome assembly
|
14,829.32 | 14.75 | 9 | 56 |
Grb2-EGFR complex
|
46,135.68 | 12.50 | 2 | 4 |
positive regulation of Rac protein signal transduction
|
9,026.55 | 9.28 | 9 | 92 |
neurotrophin TRKA receptor binding
|
13,181.62 | 7.69 | 2 | 14 |
bone resorption
|
6,538.92 | 6.82 | 9 | 127 |
podosome
|
5,255.96 | 5.52 | 9 | 158 |
lung alveolus development
|
3,610.62 | 3.83 | 9 | 230 |
negative regulation of Rho protein signal transduction
|
3,403.45 | 3.61 | 9 | 244 |
branching involved in labyrinthine layer morphogenesis
|
3,926.44 | 3.39 | 2 | 47 |
Totals | 246 | 897291 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2015-02-13 | Deleted | RELATION | is a GO:0005083 (small GTPase regulator activity) |
2015-02-13 | Added | RELATION | is a GO:0030695 (GTPase regulator activity) |
2012-04-14 | Deleted | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
2012-04-14 | Added | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way. |
2010-12-03 | Added | RELATION | is a GO:0030674 (protein-macromolecule adaptor activity) |
2010-12-03 | Deleted | RELATION | is a GO:0060090 (molecular adaptor activity) |
2008-05-13 | Added | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
2008-05-12 | Deleted | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
2008-04-01 | Updated | RELATION | is a GO:0060090 (molecular adaptor activity) |
2008-04-01 | Updated | RELATION | is a GO:0005083 (small GTPase regulator activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | guanyl-nucleotide exchange factor adaptor activity |
2002-02-06 | Updated | TERM | guanyl-nucleotide exchange factor adaptor |
2001-04-03 | Updated | TERM | guanyl-nucleotide exchange factor adaptor |
2001-03-30 | Added | TERM | guanyl-nucleotide exchange factor adaptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-04-14 | Deleted | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
2012-04-14 | Added | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way. |
2008-05-13 | Added | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
2008-05-12 | Deleted | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
2007-04-20 | Added | DEFINITION | The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-02-13 | Deleted | RELATION | is a GO:0005083 (small GTPase regulator activity) |
2015-02-13 | Added | RELATION | is a GO:0030695 (GTPase regulator activity) |
2010-12-03 | Added | RELATION | is a GO:0030674 (protein-macromolecule adaptor activity) |
2010-12-03 | Deleted | RELATION | is a GO:0060090 (molecular adaptor activity) |
2008-04-01 | Updated | RELATION | is a GO:0060090 (molecular adaptor activity) |
2008-04-01 | Updated | RELATION | is a GO:0005083 (small GTPase regulator activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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