This term is obsolete.
Note that the name Sar derives from 'secretion-associated, Ras-related'.

GO:0005096 JSON

GTPase activator activity

Molecular Function

Definition (GO:0005096 GONUTS page)

Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

Comments

Note that the name Sar derives from 'secretion-associated, Ras-related'.

Secondary IDs

GO:0005097, GO:0005098, GO:0005099, GO:0005100, GO:0005101, GO:0008060, GO:0017123, GO:0030675, GO:0046582

498,177 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
Ran GAP activity narrow
Ran GTPase activator activity narrow
Rab GAP activity narrow
Rab GTPase activator activity narrow
Rho GAP activity narrow
Ras GTPase activator activity narrow
Ras GAP activity narrow
ARF GAP activity narrow
Sar GTPase activator activity narrow
Rho GTPase activator activity narrow

Ancestor Chart

Ancestor chart for GO:0005096
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005096

Child Term Relationship to
GO:0005096
GTPase activator complex
capable_of

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2JUX2 10116 A0A0G2JUX2_RAT GO:0005096 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2JVX3 10116 A0A0G2JVX3_RAT GO:0005096 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5XUU6 10116 A0A8I5XUU6_RAT GO:0005096 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J3E4 10116 A6J3E4_RAT GO:0005096 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J3E5 10116 A6J3E5_RAT GO:0005096 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A631 10116 BIG1_RAT GO:0005096 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O46094 7227 O46094_DROME GO:0005096 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:21658948
NOT-qualified manual protein Q3KRB8 9606 RHGBB_HUMAN GO:0005096 2 NOT-qualified manual annotations exist with evidence code ECO:0000314 from these references: PMID:25721503, PMID:27957544
NOT-qualified manual protein Q54K32 44689 RGAA_DICDI GO:0005096 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9739079
NOT-qualified manual protein Q58DT5 9913 ELMD3_BOVIN GO:0005096 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Cross-references

Database ID Description
InterPro IPR000331 Rap/Ran-GAP domain
InterPro IPR001164 Arf GTPase activating protein
InterPro IPR003537 Type III secretion system effector protein YopE-like
InterPro IPR003913 Tuberin
InterPro IPR003914 Rabaptin
InterPro IPR007336 Der GTPase-activating protein YihI
InterPro IPR009109 Ran-GTPase activating protein 1, C-terminal
InterPro IPR015123 Bcr-Abl oncoprotein oligomerisation
InterPro IPR017356 Chimaerin
InterPro IPR018514 Rabaptin coiled-coil domain

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005096 based on ALL annotations
The top 100 of 3,708 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GTPase activator activity
401.73 100.00 493,255 493,255
small GTPase binding
103.63 10.78 77,123 298,974
regulation of small GTPase mediated signal transduction
392.59 9.27 45,828 46,895
nucleocytoplasmic transport
123.39 4.29 23,450 76,345
signal transduction
19.75 4.26 119,365 2,428,262
small GTPase-mediated signal transduction
58.70 4.12 26,738 182,984
regulation of G protein-coupled receptor signaling pathway
242.42 3.85 19,472 32,268
cell cortex
70.01 3.67 21,947 125,943
perinuclear region of cytoplasm
63.26 3.66 22,480 142,747
intracellular signal transduction
23.82 3.29 33,926 572,152
Totals 1890778 53510393
No co-occurrence statistics for GO:0005096 based on MANUAL annotations
The top 100 of 2,198 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GTPase activator activity
196.32 100.00 7,190 7,190
small GTPase-mediated signal transduction
105.07 6.95 532 994
small GTPase binding
33.31 5.26 509 3,000
COPII-coated vesicle cargo loading
66.87 4.18 327 960
COPII vesicle coat
44.39 3.90 324 1,433
endoplasmic reticulum exit site
40.41 3.90 330 1,603
myosin II binding
175.69 3.42 247 276
Golgi to plasma membrane transport
33.23 2.95 248 1,465
negative regulation of small GTPase mediated signal transduction
175.07 2.86 206 231
cell cortex
21.03 2.79 261 2,436
Totals 23715 688281

Change Log

Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9693282
2023-04-02 Added XREF Reactome:R-HSA-9013437
2023-04-02 Added XREF Reactome:R-HSA-9014295
2023-04-02 Added XREF Reactome:R-HSA-9013161
2023-04-02 Added XREF Reactome:R-HSA-9013144
2023-04-02 Added XREF Reactome:R-HSA-8981637
2023-04-02 Added XREF Reactome:R-HSA-9017488
2023-04-02 Added XREF Reactome:R-HSA-9013111
2023-04-02 Added XREF Reactome:R-HSA-9014434
2023-04-02 Added XREF Reactome:R-HSA-9013022
Timestamp Action Category Detail
2003-03-19 Updated TERM GTPase activator activity
2002-02-06 Updated TERM GTPase activator
2001-04-03 Updated TERM GTPase activator
2001-03-30 Added TERM GTPase activator
Timestamp Action Category Detail
2015-07-11 Added DEFINITION Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
2015-07-11 Deleted DEFINITION Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
2015-02-13 Added SYNONYM RanGAP
2015-02-13 Added SYNONYM Rap GAP activity
2015-02-13 Added SYNONYM Sar GAP activity
2015-02-13 Added SYNONYM Ral GAP activity
2015-02-13 Added SYNONYM ARF GTPase activator activity
2015-02-13 Added SYNONYM Rac GAP activity
2015-02-13 Added SYNONYM Rac GTPase activator activity
2015-02-13 Added SYNONYM Rap GTPase activator activity
2015-02-13 Added SYNONYM Rho GTPase activator activity
2015-02-13 Added SYNONYM Sar GTPase activator activity
2015-02-13 Added SYNONYM ARF GAP activity
2015-02-13 Added SYNONYM Ras GAP activity
2015-02-13 Added SYNONYM Ras GTPase activator activity
2015-02-13 Added SYNONYM Rho GAP activity
2015-02-13 Added SYNONYM Ral GTPase activator activity
2015-02-13 Added SYNONYM Ran GAP activity
2015-02-13 Added SYNONYM Ran GTPase activator activity
2015-02-13 Added SYNONYM Rab GAP activity
2015-02-13 Added SYNONYM Rab GTPase activator activity
2008-10-02 Deleted SYNONYM GAP
2008-10-02 Added SYNONYM GAP activity
2008-05-13 Added DEFINITION Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
2008-05-12 Deleted DEFINITION Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
2007-08-09 Deleted SYNONYM GAP
2007-08-09 Added SYNONYM GAP
2004-04-19 Added SYNONYM GAP
2004-04-16 Deleted SYNONYM GAP
2004-01-08 Updated DEFINITION Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
2003-04-25 Added DEFINITION Increases the rate of GTP hydrolysis by a GTPase.
2001-03-30 Added SYNONYM GAP
Timestamp Action Category Detail
2021-10-04 Added RELATION is a GO:0008047 (enzyme activator activity)
2021-07-10 Deleted RELATION is a GO:0008047 (enzyme activator activity)
2021-04-20 Added RELATION is a GO:0008047 (enzyme activator activity)
2021-02-24 Deleted RELATION part of GO:0043547 (positive regulation of GTPase activity)
2021-02-24 Deleted RELATION is a GO:0008047 (enzyme activator activity)
2011-03-10 Added RELATION part of GO:0043547 (positive regulation of GTPase activity)
2010-06-15 Added RELATION positively regulates GO:0003924 (GTPase activity)
2010-06-14 Deleted RELATION positively regulates GO:0003924 (GTPase activity)
2010-06-08 Added RELATION positively regulates GO:0003924 (GTPase activity)
2009-02-25 Deleted RELATION positively regulates GO:0003924 (GTPase activity)
2009-02-22 Added RELATION positively regulates GO:0003924 (GTPase activity)
2008-04-01 Updated RELATION is a GO:0030695 (GTPase regulator activity)
2008-04-01 Updated RELATION is a GO:0008047 (enzyme activator activity)
Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9693282
2023-04-02 Added XREF Reactome:R-HSA-9013437
2023-04-02 Added XREF Reactome:R-HSA-9014295
2023-04-02 Added XREF Reactome:R-HSA-9013161
2023-04-02 Added XREF Reactome:R-HSA-9013144
2023-04-02 Added XREF Reactome:R-HSA-8981637
2023-04-02 Added XREF Reactome:R-HSA-9017488
2023-04-02 Added XREF Reactome:R-HSA-9013111
2023-04-02 Added XREF Reactome:R-HSA-9014434
2023-04-02 Added XREF Reactome:R-HSA-9013022
2023-04-02 Added XREF Reactome:R-HSA-9018806
2023-04-02 Added XREF Reactome:R-HSA-9018745
2023-04-02 Deleted XREF Reactome:R-HSA-194922
2020-07-19 Added XREF Reactome:R-HSA-9624893
2020-02-28 Deleted XREF MIPS_funcat:18.02.01.01.01
2019-05-04 Added XREF MIPS_funcat:18.02.01.01.01
2019-04-01 Deleted XREF reactome:R-HSA-392513
2019-04-01 Deleted XREF reactome:R-HSA-428522
2019-04-01 Deleted XREF reactome:R-HSA-5638007
2019-04-01 Deleted XREF reactome:R-HSA-4093339
2019-04-01 Added XREF Reactome:R-HSA-416559
2019-04-01 Added XREF Reactome:R-HSA-392513
2019-04-01 Added XREF Reactome:R-HSA-5638007
2019-04-01 Deleted XREF reactome:R-HSA-428533
2019-04-01 Added XREF Reactome:R-HSA-428533
2019-04-01 Added XREF Reactome:R-HSA-428522
2019-04-01 Deleted XREF reactome:R-HSA-416546
2019-04-01 Added XREF Reactome:R-HSA-4093339
2019-04-01 Added XREF Reactome:R-HSA-399935
2019-04-01 Added XREF Reactome:R-HSA-416546
2019-04-01 Added XREF Reactome:R-HSA-194922
2019-04-01 Deleted XREF reactome:R-HSA-194922
2019-04-01 Deleted XREF reactome:R-HSA-416559
2019-04-01 Deleted XREF reactome:R-HSA-399935
2019-04-01 Deleted XREF reactome:R-HSA-8985594
2019-04-01 Added XREF Reactome:R-HSA-8985594
2018-12-11 Added XREF reactome:R-HSA-194922
2018-12-11 Added XREF reactome:R-HSA-428522
2018-12-11 Added XREF reactome:R-HSA-392513
2018-12-11 Added XREF reactome:R-HSA-5638007
2018-12-11 Added XREF reactome:R-HSA-428533
2018-12-11 Added XREF reactome:R-HSA-416559
2018-12-11 Added XREF reactome:R-HSA-416546
2018-12-11 Added XREF reactome:R-HSA-399935
2018-12-11 Added XREF reactome:R-HSA-8985594
2018-12-11 Added XREF reactome:R-HSA-4093339
Timestamp Action Category Detail
2015-02-13 Added SECONDARY GO:0046582 (Rap GTPase activator activity)
2015-02-13 Added SECONDARY GO:0005097 (Rab GTPase activator activity)
2015-02-13 Added SECONDARY GO:0005098 (Ran GTPase activator activity)
2015-02-13 Added SECONDARY GO:0005099 (Ras GTPase activator activity)
2015-02-13 Added SECONDARY GO:0005100 (Rho GTPase activator activity)
2015-02-13 Added SECONDARY GO:0005101 (Sar GTPase activator activity)
2015-02-13 Added SECONDARY GO:0030675 (Rac GTPase activator activity)
2015-02-13 Added SECONDARY GO:0017123 (Ral GTPase activator activity)
2015-02-13 Added SECONDARY GO:0008060 (ARF GTPase activator activity)
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