Note that the name Sar derives from 'secretion-associated, Ras-related'.
GO:0005096
JSON
GTPase activator activity
Molecular Function
Definition (GO:0005096 GONUTS page)
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
Comments
Note that the name Sar derives from 'secretion-associated, Ras-related'.
Secondary IDs
GO:0005097, GO:0005098, GO:0005099, GO:0005100, GO:0005101, GO:0008060, GO:0017123, GO:0030675, GO:0046582
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
Ran GTPase activator activity | narrow |
Rab GAP activity | narrow |
Rab GTPase activator activity | narrow |
RanGAP | narrow |
Rap GAP activity | narrow |
Sar GAP activity | narrow |
Ral GAP activity | narrow |
Rac GAP activity | narrow |
Rac GTPase activator activity | narrow |
Rap GTPase activator activity | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0005096
Child Term | Relationship to GO:0005096 |
---|---|
GTPase activator complex
|
capable_of |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2JUX2 | 10116 | A0A0G2JUX2_RAT | GO:0005096 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2JVX3 | 10116 | A0A0G2JVX3_RAT | GO:0005096 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5XUU6 | 10116 | A0A8I5XUU6_RAT | GO:0005096 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J3E4 | 10116 | A6J3E4_RAT | GO:0005096 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J3E5 | 10116 | A6J3E5_RAT | GO:0005096 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A631 | 10116 | BIG1_RAT | GO:0005096 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | O46094 | 7227 | O46094_DROME | GO:0005096 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:21658948 | |
NOT-qualified manual | protein | Q3KRB8 | 9606 | RHGBB_HUMAN | GO:0005096 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000314 from these references: PMID:25721503, PMID:27957544 | |
NOT-qualified manual | protein | Q54K32 | 44689 | RGAA_DICDI | GO:0005096 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9739079 | |
NOT-qualified manual | protein | Q58DT5 | 9913 | ELMD3_BOVIN | GO:0005096 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000331 | Rap/Ran-GAP domain |
InterPro | IPR001164 | Arf GTPase activating protein |
InterPro | IPR003537 | Type III secretion system effector protein YopE-like |
InterPro | IPR003913 | Tuberin |
InterPro | IPR003914 | Rabaptin |
InterPro | IPR007336 | Der GTPase-activating protein YihI |
InterPro | IPR009109 | Ran-GTPase activating protein 1, C-terminal |
InterPro | IPR015123 | Bcr-Abl oncoprotein oligomerisation |
InterPro | IPR017356 | Chimaerin |
InterPro | IPR018514 | Rabaptin coiled-coil domain |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005096 based on ALL annotations
The top 100 of 3,771 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
GTPase activator activity
|
405.52 | 100.00 | 480,710 | 480,710 |
small GTPase binding
|
104.88 | 10.79 | 75,081 | 290,296 |
regulation of small GTPase mediated signal transduction
|
395.89 | 9.23 | 44,451 | 45,532 |
signal transduction
|
20.14 | 4.31 | 117,671 | 2,368,833 |
nucleocytoplasmic transport
|
124.51 | 4.28 | 22,786 | 74,214 |
small GTPase-mediated signal transduction
|
59.67 | 4.13 | 26,106 | 177,423 |
regulation of G protein-coupled receptor signaling pathway
|
243.69 | 3.84 | 18,954 | 31,541 |
cell cortex
|
70.51 | 3.70 | 21,600 | 124,236 |
perinuclear region of cytoplasm
|
61.67 | 3.65 | 22,025 | 144,837 |
intracellular signal transduction
|
24.00 | 3.28 | 33,042 | 558,389 |
Totals | 1764019 | 45641002 |
No co-occurrence statistics for GO:0005096 based on MANUAL annotations
The top 100 of 2,230 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
GTPase activator activity
|
190.22 | 100.00 | 6,791 | 6,791 |
small GTPase-mediated signal transduction
|
99.61 | 6.87 | 498 | 951 |
small GTPase binding
|
28.71 | 4.61 | 423 | 2,803 |
nuclear pore
|
37.31 | 4.41 | 366 | 1,866 |
COPII-coated vesicle cargo loading
|
64.64 | 4.03 | 297 | 874 |
endoplasmic reticulum exit site
|
39.06 | 3.77 | 300 | 1,461 |
COPII vesicle coat
|
43.09 | 3.77 | 294 | 1,298 |
myosin II binding
|
168.67 | 3.33 | 227 | 256 |
Golgi to plasma membrane transport
|
31.84 | 2.88 | 228 | 1,362 |
negative regulation of small GTPase mediated signal transduction
|
169.87 | 2.82 | 192 | 215 |
Totals | 22135 | 629550 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9018806 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013144 |
2023-04-02 | Added | XREF | Reactome:R-HSA-8981637 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9693282 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013111 |
2023-04-02 | Deleted | XREF | Reactome:R-HSA-194922 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9018745 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013161 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013022 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9017488 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | GTPase activator activity |
2002-02-06 | Updated | TERM | GTPase activator |
2001-04-03 | Updated | TERM | GTPase activator |
2001-03-30 | Added | TERM | GTPase activator |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-07-11 | Deleted | DEFINITION | Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
2015-07-11 | Added | DEFINITION | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
2015-02-13 | Added | SYNONYM | Rap GTPase activator activity |
2015-02-13 | Added | SYNONYM | Rho GTPase activator activity |
2015-02-13 | Added | SYNONYM | Sar GTPase activator activity |
2015-02-13 | Added | SYNONYM | ARF GAP activity |
2015-02-13 | Added | SYNONYM | Ras GAP activity |
2015-02-13 | Added | SYNONYM | Ras GTPase activator activity |
2015-02-13 | Added | SYNONYM | Rho GAP activity |
2015-02-13 | Added | SYNONYM | Ral GTPase activator activity |
2015-02-13 | Added | SYNONYM | Ran GAP activity |
2015-02-13 | Added | SYNONYM | Ran GTPase activator activity |
2015-02-13 | Added | SYNONYM | Rab GAP activity |
2015-02-13 | Added | SYNONYM | Rab GTPase activator activity |
2015-02-13 | Added | SYNONYM | RanGAP |
2015-02-13 | Added | SYNONYM | Rap GAP activity |
2015-02-13 | Added | SYNONYM | Sar GAP activity |
2015-02-13 | Added | SYNONYM | Ral GAP activity |
2015-02-13 | Added | SYNONYM | ARF GTPase activator activity |
2015-02-13 | Added | SYNONYM | Rac GAP activity |
2015-02-13 | Added | SYNONYM | Rac GTPase activator activity |
2008-10-02 | Added | SYNONYM | GAP activity |
2008-10-02 | Deleted | SYNONYM | GAP |
2008-05-13 | Added | DEFINITION | Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
2008-05-12 | Deleted | DEFINITION | Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
2007-08-09 | Deleted | SYNONYM | GAP |
2007-08-09 | Added | SYNONYM | GAP |
2004-04-19 | Added | SYNONYM | GAP |
2004-04-16 | Deleted | SYNONYM | GAP |
2004-01-08 | Updated | DEFINITION | Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
2003-04-25 | Added | DEFINITION | Increases the rate of GTP hydrolysis by a GTPase. |
2001-03-30 | Added | SYNONYM | GAP |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-10-04 | Added | RELATION | is a GO:0008047 (enzyme activator activity) |
2021-07-10 | Deleted | RELATION | is a GO:0008047 (enzyme activator activity) |
2021-04-20 | Added | RELATION | is a GO:0008047 (enzyme activator activity) |
2021-02-24 | Deleted | RELATION | is a GO:0008047 (enzyme activator activity) |
2021-02-24 | Deleted | RELATION | part of GO:0043547 (positive regulation of GTPase activity) |
2011-03-10 | Added | RELATION | part of GO:0043547 (positive regulation of GTPase activity) |
2010-06-15 | Added | RELATION | positively regulates GO:0003924 (GTPase activity) |
2010-06-14 | Deleted | RELATION | positively regulates GO:0003924 (GTPase activity) |
2010-06-08 | Added | RELATION | positively regulates GO:0003924 (GTPase activity) |
2009-02-25 | Deleted | RELATION | positively regulates GO:0003924 (GTPase activity) |
2009-02-22 | Added | RELATION | positively regulates GO:0003924 (GTPase activity) |
2008-04-01 | Updated | RELATION | is a GO:0030695 (GTPase regulator activity) |
2008-04-01 | Updated | RELATION | is a GO:0008047 (enzyme activator activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9018806 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013144 |
2023-04-02 | Added | XREF | Reactome:R-HSA-8981637 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9693282 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013111 |
2023-04-02 | Deleted | XREF | Reactome:R-HSA-194922 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9018745 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013161 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013022 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9017488 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9014295 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9013437 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9014434 |
2020-07-19 | Added | XREF | Reactome:R-HSA-9624893 |
2020-02-28 | Deleted | XREF | MIPS_funcat:18.02.01.01.01 |
2019-05-04 | Added | XREF | MIPS_funcat:18.02.01.01.01 |
2019-04-01 | Added | XREF | Reactome:R-HSA-416559 |
2019-04-01 | Added | XREF | Reactome:R-HSA-392513 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5638007 |
2019-04-01 | Added | XREF | Reactome:R-HSA-428533 |
2019-04-01 | Added | XREF | Reactome:R-HSA-428522 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-416546 |
2019-04-01 | Added | XREF | Reactome:R-HSA-399935 |
2019-04-01 | Added | XREF | Reactome:R-HSA-416546 |
2019-04-01 | Added | XREF | Reactome:R-HSA-194922 |
2019-04-01 | Added | XREF | Reactome:R-HSA-8985594 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-8985594 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-399935 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-416559 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-4093339 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-194922 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-392513 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-428522 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5638007 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-428533 |
2019-04-01 | Added | XREF | Reactome:R-HSA-4093339 |
2018-12-11 | Added | XREF | reactome:R-HSA-4093339 |
2018-12-11 | Added | XREF | reactome:R-HSA-194922 |
2018-12-11 | Added | XREF | reactome:R-HSA-428522 |
2018-12-11 | Added | XREF | reactome:R-HSA-8985594 |
2018-12-11 | Added | XREF | reactome:R-HSA-399935 |
2018-12-11 | Added | XREF | reactome:R-HSA-416559 |
2018-12-11 | Added | XREF | reactome:R-HSA-392513 |
2018-12-11 | Added | XREF | reactome:R-HSA-428533 |
2018-12-11 | Added | XREF | reactome:R-HSA-416546 |
2018-12-11 | Added | XREF | reactome:R-HSA-5638007 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-02-13 | Added | SECONDARY | GO:0017123 (Ral GTPase activator activity) |
2015-02-13 | Added | SECONDARY | GO:0008060 (ARF GTPase activator activity) |
2015-02-13 | Added | SECONDARY | GO:0005097 (Rab GTPase activator activity) |
2015-02-13 | Added | SECONDARY | GO:0005098 (Ran GTPase activator activity) |
2015-02-13 | Added | SECONDARY | GO:0005099 (Ras GTPase activator activity) |
2015-02-13 | Added | SECONDARY | GO:0005100 (Rho GTPase activator activity) |
2015-02-13 | Added | SECONDARY | GO:0005101 (Sar GTPase activator activity) |
2015-02-13 | Added | SECONDARY | GO:0046582 (Rap GTPase activator activity) |
2015-02-13 | Added | SECONDARY | GO:0030675 (Rac GTPase activator activity) |
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