GO:0005154
JSON
epidermal growth factor receptor binding
Molecular Function
Definition (GO:0005154 GONUTS page)
Binding to an epidermal growth factor receptor.
Secondary IDs
GO:0008185
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
transforming growth factor alpha | narrow |
transforming growth factor alpha receptor binding | exact |
transforming growth factor alpha receptor ligand | narrow |
epidermal growth factor receptor ligand | narrow |
epidermal growth factor | narrow |
TGFalpha receptor binding | exact |
TGF-alpha receptor binding | exact |
EGFR binding | exact |
EGF receptor ligand | narrow |
EGF | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A8XY28 | 6238 | A8XY28_CAEBR | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PL19 | 6945 | B7PL19_IXOSC | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PVH4 | 6945 | B7PVH4_IXOSC | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | O16262 | 6239 | NIPI4_CAEEL | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | O95970 | 9606 | LGI1_HUMAN | GO:0005102 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20463223 | |
NOT-qualified manual | protein | P21333-1 | 9606 | FLNA_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | P63026 | 9913 | VAMP2_BOVIN | GO:0005515 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699 | |
NOT-qualified manual | protein | Q86V48 | 9606 | LUZP1_HUMAN | GO:0005515 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684 | |
NOT-qualified manual | protein | Q8K4Y5 | 10116 | LGI1_RAT | GO:0005102 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR011170 | Growth factor, vaccinia C11R type |
InterPro | IPR015497 | Epidermal growth factor receptor ligand |
InterPro | IPR043403 | Protein Gurken/Spitz |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0005155 | obsolete epidermal growth factor receptor activating ligand activity | replaced_by GO:0005154 |
GO:0005156 | obsolete epidermal growth factor receptor inhibiting ligand activity | replaced_by GO:0005154 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005154 based on ALL annotations
The top 100 of 898 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
epidermal growth factor receptor binding
|
19,766.07 | 100.00 | 10,025 | 10,025 |
positive regulation of mitotic nuclear division
|
13,533.02 | 34.39 | 4,097 | 5,984 |
epidermal growth factor receptor signaling pathway
|
2,576.28 | 12.48 | 7,468 | 57,297 |
ERBB signaling pathway
|
5,799.26 | 12.14 | 1,719 | 5,859 |
positive regulation of cell population proliferation
|
2,012.74 | 9.89 | 7,788 | 76,482 |
basal plasma membrane
|
3,171.73 | 9.81 | 2,022 | 12,601 |
transmembrane receptor protein tyrosine kinase activator activity
|
7,162.49 | 5.37 | 595 | 1,642 |
ERBB2-EGFR signaling pathway
|
14,063.26 | 4.97 | 508 | 714 |
receptor ligand activity
|
1,146.01 | 4.18 | 1,308 | 22,560 |
growth factor activity
|
808.46 | 3.97 | 5,662 | 138,430 |
Totals | 88283 | 2603919 |
No co-occurrence statistics for GO:0005154 based on MANUAL annotations
The top 100 of 768 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
epidermal growth factor receptor binding
|
4,238.84 | 100.00 | 333 | 333 |
epidermal growth factor receptor signaling pathway
|
1,140.71 | 21.34 | 169 | 628 |
positive regulation of mitotic nuclear division
|
1,724.63 | 18.28 | 83 | 204 |
phosphotyrosine residue binding
|
958.65 | 13.45 | 83 | 367 |
growth factor activity
|
372.58 | 7.63 | 122 | 1,388 |
regulation of MAPK cascade
|
372.81 | 6.70 | 73 | 830 |
transmembrane receptor protein tyrosine kinase activator activity
|
1,299.91 | 5.97 | 23 | 75 |
COP9 signalosome
|
291.37 | 5.52 | 73 | 1,062 |
ERBB2-EGFR signaling pathway
|
2,176.70 | 5.41 | 19 | 37 |
positive regulation of epithelial cell proliferation
|
322.42 | 4.56 | 34 | 447 |
Totals | 1872 | 26937 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_chembl | 296 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to an epidermal growth factor receptor. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with the epidermal growth factor receptor. |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2009-08-09 | Deleted | RELATION | is a GO:0005102 (signaling receptor binding) |
2009-08-09 | Added | RELATION | is a GO:0070851 (growth factor receptor binding) |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with the epidermal growth factor receptor. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with the epidermal growth factor receptor. |
2008-05-13 | Added | DEFINITION | Interacting selectively with the epidermal growth factor receptor. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-06-10 | Updated | TERM | epidermal growth factor receptor binding |
2003-05-30 | Updated | TERM | epidermal growth factor receptor binding activity |
2003-03-19 | Updated | TERM | epidermal growth factor receptor ligand activity |
2002-02-06 | Updated | TERM | epidermal growth factor receptor ligand |
2001-04-03 | Updated | TERM | epidermal growth factor receptor ligand |
2001-03-30 | Added | TERM | epidermal growth factor receptor ligand |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Added | DEFINITION | Binding to an epidermal growth factor receptor. |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with the epidermal growth factor receptor. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with the epidermal growth factor receptor. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with the epidermal growth factor receptor. |
2008-05-13 | Added | DEFINITION | Interacting selectively with the epidermal growth factor receptor. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with the epidermal growth factor receptor. |
2007-08-09 | Added | SYNONYM | EGF |
2007-08-09 | Added | SYNONYM | EGF receptor binding |
2007-08-09 | Added | SYNONYM | EGF receptor ligand |
2007-08-09 | Added | SYNONYM | EGFR binding |
2007-08-09 | Added | SYNONYM | TGF-alpha receptor binding |
2007-08-09 | Added | SYNONYM | TGFalpha receptor binding |
2007-08-09 | Added | SYNONYM | epidermal growth factor |
2007-08-09 | Added | SYNONYM | epidermal growth factor receptor ligand |
2007-08-09 | Added | SYNONYM | transforming growth factor alpha |
2007-08-09 | Added | SYNONYM | transforming growth factor alpha receptor binding |
2007-08-09 | Added | SYNONYM | transforming growth factor alpha receptor ligand |
2007-08-09 | Deleted | SYNONYM | TGF-alpha receptor binding |
2007-08-09 | Deleted | SYNONYM | TGFalpha receptor binding |
2007-08-09 | Deleted | SYNONYM | epidermal growth factor |
2007-08-09 | Deleted | SYNONYM | epidermal growth factor receptor ligand |
2007-08-09 | Deleted | SYNONYM | transforming growth factor alpha |
2007-08-09 | Deleted | SYNONYM | transforming growth factor alpha receptor binding |
2007-08-09 | Deleted | SYNONYM | transforming growth factor alpha receptor ligand |
2007-08-09 | Deleted | SYNONYM | EGF |
2007-08-09 | Deleted | SYNONYM | EGF receptor binding |
2007-08-09 | Deleted | SYNONYM | EGF receptor ligand |
2007-08-09 | Deleted | SYNONYM | EGFR binding |
2004-11-09 | Added | SYNONYM | EGFR binding |
2004-04-19 | Added | SYNONYM | epidermal growth factor |
2004-04-19 | Added | SYNONYM | EGF receptor binding |
2004-04-19 | Added | SYNONYM | EGF |
2004-04-16 | Deleted | SYNONYM | EGF receptor binding |
2004-04-16 | Deleted | SYNONYM | epidermal growth factor |
2004-04-16 | Deleted | SYNONYM | EGF |
2004-03-02 | Added | SYNONYM | transforming growth factor alpha |
2004-03-02 | Added | SYNONYM | transforming growth factor alpha receptor binding |
2004-03-02 | Added | SYNONYM | transforming growth factor alpha receptor ligand |
2004-03-02 | Added | SYNONYM | TGF-alpha receptor binding |
2004-03-02 | Added | SYNONYM | TGFalpha receptor binding |
2004-02-12 | Added | SYNONYM | EGF receptor binding |
2004-02-12 | Added | SYNONYM | EGF |
2004-02-12 | Added | SYNONYM | EGF receptor ligand |
2003-07-25 | Added | DEFINITION | Interacting selectively with the epidermal growth factor receptor. |
2003-05-30 | Added | SYNONYM | epidermal growth factor receptor ligand |
2001-03-30 | Added | SYNONYM | epidermal growth factor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-08-09 | Deleted | RELATION | is a GO:0005102 (signaling receptor binding) |
2009-08-09 | Added | RELATION | is a GO:0070851 (growth factor receptor binding) |
2008-04-01 | Updated | RELATION | is a GO:0005102 (signaling receptor binding) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2004-03-02 | Added | SECONDARY | GO:0008185 (transforming growth factor alpha receptor binding) |
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