This term is obsolete.

GO:0005154 JSON

epidermal growth factor receptor binding

Molecular Function

Definition (GO:0005154 GONUTS page)

Binding to an epidermal growth factor receptor.

Secondary IDs

GO:0008185

10,175 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
transforming growth factor alpha narrow
transforming growth factor alpha receptor binding exact
transforming growth factor alpha receptor ligand narrow
epidermal growth factor receptor ligand narrow
epidermal growth factor narrow
TGFalpha receptor binding exact
TGF-alpha receptor binding exact
EGFR binding exact
EGF receptor ligand narrow
EGF narrow

Ancestor Chart

Ancestor chart for GO:0005154
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O95970 9606 LGI1_HUMAN GO:0005102 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20463223
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P63026 9913 VAMP2_BOVIN GO:0005515 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20702699
NOT-qualified manual protein Q86V48 9606 LUZP1_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein Q8K4Y5 10116 LGI1_RAT GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR011170 Growth factor, vaccinia C11R type
InterPro IPR015497 Epidermal growth factor receptor ligand
InterPro IPR043403 Protein Gurken/Spitz

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0005155 obsolete epidermal growth factor receptor activating ligand activity replaced_by GO:0005154
GO:0005156 obsolete epidermal growth factor receptor inhibiting ligand activity replaced_by GO:0005154

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005154 based on ALL annotations
The top 100 of 898 co-occurring terms
Co-occurring Term PR S% #Together #Compared
epidermal growth factor receptor binding
19,766.07 100.00 10,025 10,025
positive regulation of mitotic nuclear division
13,533.02 34.39 4,097 5,984
epidermal growth factor receptor signaling pathway
2,576.28 12.48 7,468 57,297
ERBB signaling pathway
5,799.26 12.14 1,719 5,859
positive regulation of cell population proliferation
2,012.74 9.89 7,788 76,482
basal plasma membrane
3,171.73 9.81 2,022 12,601
transmembrane receptor protein tyrosine kinase activator activity
7,162.49 5.37 595 1,642
ERBB2-EGFR signaling pathway
14,063.26 4.97 508 714
receptor ligand activity
1,146.01 4.18 1,308 22,560
growth factor activity
808.46 3.97 5,662 138,430
Totals 88283 2603919
No co-occurrence statistics for GO:0005154 based on MANUAL annotations
The top 100 of 768 co-occurring terms
Co-occurring Term PR S% #Together #Compared
epidermal growth factor receptor binding
4,238.84 100.00 333 333
epidermal growth factor receptor signaling pathway
1,140.71 21.34 169 628
positive regulation of mitotic nuclear division
1,724.63 18.28 83 204
phosphotyrosine residue binding
958.65 13.45 83 367
growth factor activity
372.58 7.63 122 1,388
regulation of MAPK cascade
372.81 6.70 73 830
transmembrane receptor protein tyrosine kinase activator activity
1,299.91 5.97 23 75
COP9 signalosome
291.37 5.52 73 1,062
ERBB2-EGFR signaling pathway
2,176.70 5.41 19 37
positive regulation of epithelial cell proliferation
322.42 4.56 34 447
Totals 1872 26937

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to an epidermal growth factor receptor.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with the epidermal growth factor receptor.
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
2009-08-09 Deleted RELATION is a GO:0005102 (signaling receptor binding)
2009-08-09 Added RELATION is a GO:0070851 (growth factor receptor binding)
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with the epidermal growth factor receptor.
2009-07-03 Deleted DEFINITION Interacting selectively with the epidermal growth factor receptor.
2008-05-13 Added DEFINITION Interacting selectively with the epidermal growth factor receptor.
Timestamp Action Category Detail
2003-06-10 Updated TERM epidermal growth factor receptor binding
2003-05-30 Updated TERM epidermal growth factor receptor binding activity
2003-03-19 Updated TERM epidermal growth factor receptor ligand activity
2002-02-06 Updated TERM epidermal growth factor receptor ligand
2001-04-03 Updated TERM epidermal growth factor receptor ligand
2001-03-30 Added TERM epidermal growth factor receptor ligand
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to an epidermal growth factor receptor.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with the epidermal growth factor receptor.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with the epidermal growth factor receptor.
2009-07-03 Deleted DEFINITION Interacting selectively with the epidermal growth factor receptor.
2008-05-13 Added DEFINITION Interacting selectively with the epidermal growth factor receptor.
2008-05-12 Deleted DEFINITION Interacting selectively with the epidermal growth factor receptor.
2007-08-09 Added SYNONYM EGF
2007-08-09 Added SYNONYM EGF receptor binding
2007-08-09 Added SYNONYM EGF receptor ligand
2007-08-09 Added SYNONYM EGFR binding
2007-08-09 Added SYNONYM TGF-alpha receptor binding
2007-08-09 Added SYNONYM TGFalpha receptor binding
2007-08-09 Added SYNONYM epidermal growth factor
2007-08-09 Added SYNONYM epidermal growth factor receptor ligand
2007-08-09 Added SYNONYM transforming growth factor alpha
2007-08-09 Added SYNONYM transforming growth factor alpha receptor binding
2007-08-09 Added SYNONYM transforming growth factor alpha receptor ligand
2007-08-09 Deleted SYNONYM TGF-alpha receptor binding
2007-08-09 Deleted SYNONYM TGFalpha receptor binding
2007-08-09 Deleted SYNONYM epidermal growth factor
2007-08-09 Deleted SYNONYM epidermal growth factor receptor ligand
2007-08-09 Deleted SYNONYM transforming growth factor alpha
2007-08-09 Deleted SYNONYM transforming growth factor alpha receptor binding
2007-08-09 Deleted SYNONYM transforming growth factor alpha receptor ligand
2007-08-09 Deleted SYNONYM EGF
2007-08-09 Deleted SYNONYM EGF receptor binding
2007-08-09 Deleted SYNONYM EGF receptor ligand
2007-08-09 Deleted SYNONYM EGFR binding
2004-11-09 Added SYNONYM EGFR binding
2004-04-19 Added SYNONYM epidermal growth factor
2004-04-19 Added SYNONYM EGF receptor binding
2004-04-19 Added SYNONYM EGF
2004-04-16 Deleted SYNONYM EGF receptor binding
2004-04-16 Deleted SYNONYM epidermal growth factor
2004-04-16 Deleted SYNONYM EGF
2004-03-02 Added SYNONYM transforming growth factor alpha
2004-03-02 Added SYNONYM transforming growth factor alpha receptor binding
2004-03-02 Added SYNONYM transforming growth factor alpha receptor ligand
2004-03-02 Added SYNONYM TGF-alpha receptor binding
2004-03-02 Added SYNONYM TGFalpha receptor binding
2004-02-12 Added SYNONYM EGF receptor binding
2004-02-12 Added SYNONYM EGF
2004-02-12 Added SYNONYM EGF receptor ligand
2003-07-25 Added DEFINITION Interacting selectively with the epidermal growth factor receptor.
2003-05-30 Added SYNONYM epidermal growth factor receptor ligand
2001-03-30 Added SYNONYM epidermal growth factor
Timestamp Action Category Detail
2009-08-09 Deleted RELATION is a GO:0005102 (signaling receptor binding)
2009-08-09 Added RELATION is a GO:0070851 (growth factor receptor binding)
2008-04-01 Updated RELATION is a GO:0005102 (signaling receptor binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
2004-03-02 Added SECONDARY GO:0008185 (transforming growth factor alpha receptor binding)
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