This term is obsolete.

GO:0005178 JSON

integrin binding

Molecular Function

Definition (GO:0005178 GONUTS page)

Binding to an integrin.

87,290 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
integrin ligand narrow

Ancestor Chart

Ancestor chart for GO:0005178
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005178

Child Term Relationship to
GO:0005178
integrin binding involved in cell-matrix adhesion
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y865 10116 A0A8I5Y865_RAT GO:0044877 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J8YB21 10116 A0A8J8YB21_RAT GO:0044877 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B2GUV6 10116 B2GUV6_RAT GO:0044877 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0005102 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein O95970 9606 LGI1_HUMAN GO:0005102 2 NOT-qualified manual annotations exist with evidence code ECO:0000353 from this reference: PMID:20463223
NOT-qualified manual protein P21333-1 9606 FLNA_HUMAN GO:0005515 1 NOT-qualified manual annotation exists with evidence code ECO:0000353 from this reference: PMID:30990684
NOT-qualified manual protein P52164 10116 MAX_RAT GO:0044877 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:7791753

Cross-references

Database ID Description
InterPro IPR033292 Thy-1 membrane glycoprotein
InterPro IPR037904 Nischarin, PX domain
InterPro IPR047012 Intercellular adhesion molecule/vascular cell adhesion molecule

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005178 based on ALL annotations
The top 100 of 3,241 co-occurring terms
Co-occurring Term PR S% #Together #Compared
integrin binding
2,273.87 100.00 85,730 85,730
cell adhesion mediated by integrin
2,248.00 48.48 41,799 42,280
integrin-mediated signaling pathway
1,564.90 46.17 50,053 72,729
cell-matrix adhesion
1,463.34 43.47 49,086 76,274
integrin complex
1,925.07 42.12 39,097 46,181
cell-cell adhesion
535.50 19.94 48,501 205,947
focal adhesion
539.73 15.38 26,066 109,815
cell adhesion
258.13 10.98 65,948 580,935
external side of plasma membrane
302.82 10.50 28,442 213,567
positive regulation of cell differentiation
1,430.43 8.86 8,010 12,733
Totals 696230 7553533
No co-occurrence statistics for GO:0005178 based on MANUAL annotations
The top 100 of 2,894 co-occurring terms
Co-occurring Term PR S% #Together #Compared
integrin binding
770.76 100.00 1,676 1,676
integrin-mediated signaling pathway
528.05 34.79 694 1,013
integrin complex
761.15 32.92 554 561
cell-matrix adhesion
410.04 26.60 582 1,094
cell adhesion mediated by integrin
673.86 25.96 452 517
cell-cell adhesion
170.31 16.74 685 3,100
focal adhesion
129.57 11.05 409 2,433
cell adhesion
87.66 8.01 357 3,139
external side of plasma membrane
61.01 6.56 464 5,862
positive regulation of cell differentiation
255.56 6.48 125 377
Totals 11200 101709

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to an integrin.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with an integrin.
2018-02-18 Added RELATION is a GO:0044877 (protein-containing complex binding)
2018-02-18 Deleted RELATION is a GO:0032403 (protein complex binding)
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-11 Added SUBSET goslim_ChEMBL
2014-05-11 Added RELATION is a GO:0050839 (cell adhesion molecule binding)
2009-07-03 Deleted DEFINITION Interacting selectively with an integrin.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with an integrin.
Timestamp Action Category Detail
2003-06-10 Updated TERM integrin binding
2003-03-19 Updated TERM integrin binding activity
2002-07-23 Updated TERM integrin binding
2002-02-06 Updated TERM integrin ligand
2001-04-03 Updated TERM integrin ligand
2001-03-30 Added TERM integrin ligand
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to an integrin.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with an integrin.
2009-07-03 Deleted DEFINITION Interacting selectively with an integrin.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with an integrin.
2008-05-13 Added DEFINITION Interacting selectively with an integrin.
2008-05-12 Deleted DEFINITION Interacting selectively with an integrin.
2007-08-09 Added SYNONYM integrin ligand
2007-08-09 Deleted SYNONYM integrin ligand
2003-03-26 Updated DEFINITION Interacting selectively with an integrin.
2002-11-27 Added DEFINITION Interacting selectively and stoichiometrically with an integrin.
2002-07-23 Added SYNONYM integrin ligand
Timestamp Action Category Detail
2018-02-18 Added RELATION is a GO:0044877 (protein-containing complex binding)
2018-02-18 Deleted RELATION is a GO:0032403 (protein complex binding)
2014-05-11 Added RELATION is a GO:0050839 (cell adhesion molecule binding)
2008-04-01 Updated RELATION is a GO:0005102 (signaling receptor binding)
2008-04-01 Updated RELATION is a GO:0032403 (protein complex binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-11 Added SUBSET goslim_ChEMBL
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