Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'.
GO:0005234
JSON
extracellularly glutamate-gated ion channel activity
Molecular Function
Definition (GO:0005234 GONUTS page)
Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
Comments
Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
extracellular-glutamate-gated ion channel activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0005234
Child Term | Relationship to GO:0005234 |
---|---|
extracellularly glutamate-gated chloride channel activity
|
is_a |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0005234 | extracellularly glutamate-gated ion channel activity | Only in Taxon | 33208 | Metazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5ZLE9 | 10116 | A0A8I5ZLE9_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZST4 | 10116 | A0A8I5ZST4_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AI08 | 10116 | A0A8I6AI08_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0PK00 | 9606 | T120B_HUMAN | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6HVQ8 | 10116 | A6HVQ8_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J168 | 10116 | A6J168_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J4P5 | 10116 | A6J4P5_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K7I4 | 10116 | A6K7I4_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K7I4 | 10116 | A6K7I4_RAT | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6QPF8 | 9913 | T120B_BOVIN | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005234 based on ALL annotations
The top 100 of 254 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
extracellularly glutamate-gated ion channel activity
|
1,725,121.90 | 100.00 | 113 | 113 |
mossy fiber rosette
|
1,613,101.10 | 61.02 | 72 | 77 |
detection of cold stimulus involved in thermoception
|
1,110,078.50 | 48.05 | 74 | 115 |
kainate selective glutamate receptor activity
|
398,431.12 | 22.07 | 94 | 407 |
kainate selective glutamate receptor complex
|
411,548.70 | 21.10 | 73 | 306 |
proton binding
|
784,146.40 | 11.45 | 15 | 33 |
glutamate-gated calcium ion channel activity
|
201,903.16 | 11.14 | 79 | 675 |
regulation of long-term neuronal synaptic plasticity
|
109,672.70 | 6.15 | 74 | 1,164 |
regulation of monoatomic cation transmembrane transport
|
155,169.70 | 5.96 | 17 | 189 |
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
|
97,172.20 | 5.49 | 77 | 1,367 |
Totals | 2470 | 360909 |
No co-occurrence statistics for GO:0005234 based on MANUAL annotations
The top 100 of 241 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
extracellularly glutamate-gated ion channel activity
|
47,844.41 | 100.00 | 27 | 27 |
regulation of monoatomic cation transmembrane transport
|
21,404.08 | 35.42 | 17 | 38 |
proton binding
|
23,150.52 | 34.88 | 15 | 31 |
voltage-gated monoatomic cation channel activity
|
11,777.09 | 21.05 | 16 | 65 |
glutamate binding
|
9,786.36 | 18.56 | 18 | 88 |
detection of cold stimulus involved in thermoception
|
19,935.17 | 14.71 | 5 | 12 |
glutamate-gated receptor activity
|
7,475.69 | 12.35 | 10 | 64 |
glutamate-gated calcium ion channel activity
|
8,320.77 | 12.31 | 8 | 46 |
positive regulation of excitatory postsynaptic potential
|
6,069.81 | 11.81 | 17 | 134 |
ionotropic glutamate receptor signaling pathway
|
5,681.52 | 11.31 | 19 | 160 |
Totals | 432 | 7888 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
2022-11-08 | Added | DEFINITION | Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. |
2022-11-08 | Deleted | DEFINITION | Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. |
2017-11-01 | Deleted | DEFINITION | Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. |
2017-11-01 | Updated | TERM | extracellularly glutamate-gated ion channel activity |
2017-11-01 | Added | SYNONYM | extracellular-glutamate-gated ion channel activity |
2017-11-01 | Added | DEFINITION | Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. |
2015-05-11 | Deleted | DEFINITION | Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. |
2015-05-11 | Added | DEFINITION | Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. |
2008-05-13 | Added | DEFINITION | Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-11-01 | Updated | TERM | extracellularly glutamate-gated ion channel activity |
2007-07-11 | Updated | TERM | extracellular-glutamate-gated ion channel activity |
2003-03-19 | Updated | TERM | glutamate-gated ion channel activity |
2002-02-06 | Updated | TERM | glutamate-gated ion channel |
2001-04-03 | Updated | TERM | glutamate-gated ion channel |
2001-03-30 | Added | TERM | glutamate-gated ion channel |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-11-08 | Added | DEFINITION | Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. |
2022-11-08 | Deleted | DEFINITION | Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. |
2017-11-01 | Deleted | DEFINITION | Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. |
2017-11-01 | Added | SYNONYM | extracellular-glutamate-gated ion channel activity |
2017-11-01 | Added | DEFINITION | Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. |
2015-05-11 | Deleted | DEFINITION | Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. |
2015-05-11 | Added | DEFINITION | Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. |
2008-05-13 | Added | DEFINITION | Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. |
2008-03-11 | Updated | DEFINITION | Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. |
2007-07-27 | Updated | DEFINITION | Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. |
2003-05-13 | Added | DEFINITION | See comment. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0005231 (excitatory extracellular ligand-gated monoatomic ion channel activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-07-11 | Deleted | XREF | TC:1.A.10.-.- |
2001-03-30 | Added | XREF | TC:1.A.10.-.- |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
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