This term is obsolete.

GO:0005242 JSON

inward rectifier potassium channel activity

Molecular Function

Definition (GO:0005242 GONUTS page)

Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. PMID:14977398

33,927 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
Kir channel activity exact

Ancestor Chart

Ancestor chart for GO:0005242
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005242

Child Term Relationship to
GO:0005242
G-protein activated inward rectifier potassium channel activity
is_a
regulation of inward rectifier potassium channel activity
regulates
ATP-activated inward rectifier potassium channel activity
is_a
negative regulation of inward rectifier potassium channel activity
negatively_regulates
inward rectifier potassium channel inhibitor activity
negatively_regulates
positive regulation of inward rectifier potassium channel activity
positively_regulates
inward rectifier potassium channel complex
capable_of

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5ZLE9 10116 A0A8I5ZLE9_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZST4 10116 A0A8I5ZST4_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AI08 10116 A0A8I6AI08_RAT GO:0022832 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AI08 10116 A0A8I6AI08_RAT GO:0015267 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0PK00 9606 T120B_HUMAN GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A2AHD2 10090 A2AHD2_MOUSE GO:0005267 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000008
NOT-qualified manual protein A2WLC1 39946 CDT3_ORYSI GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6HVQ8 10116 A6HVQ8_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J168 10116 A6J168_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J4P5 10116 A6J4P5_RAT GO:0015267 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR003268 FPotassium channel, inwardly rectifying, Kir1.1
InterPro IPR003269 Potassium channel, inwardly rectifying, Kir1.2
InterPro IPR003270 Potassium channel, inwardly rectifying, Kir1.3
InterPro IPR003271 Potassium channel, inwardly rectifying, Kir2.1
InterPro IPR003272 Potassium channel, inwardly rectifying, Kir2.2
InterPro IPR003273 Potassium channel, inwardly rectifying, Kir2.3
InterPro IPR008061 Potassium channel, inwardly rectifying, Kir5
InterPro IPR008062 Inward rectifier potassium channel 13
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
Reactome R-HSA-1296045

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0005241 obsolete inward rectifier channel consider GO:0005242

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005242 based on ALL annotations
The top 100 of 532 co-occurring terms
Co-occurring Term PR S% #Together #Compared
inward rectifier potassium channel activity
7,388.88 100.00 26,818 26,818
regulation of monoatomic ion transmembrane transport
6,083.91 64.09 19,926 24,200
potassium ion import across plasma membrane
1,731.31 21.74 20,138 85,945
monoatomic ion channel complex
1,029.05 13.79 25,012 179,593
G-protein activated inward rectifier potassium channel activity
7,104.98 13.74 3,704 3,852
membrane repolarization during cardiac muscle cell action potential
6,921.55 9.87 2,666 2,846
regulation of heart rate by cardiac conduction
2,134.50 8.47 2,868 9,928
regulation of ventricular cardiac muscle cell membrane repolarization
2,160.93 7.98 2,652 9,068
regulation of membrane potential
573.05 5.23 3,714 47,888
potassium ion transport
369.73 5.00 26,005 519,696
Totals 213118 26823059
No co-occurrence statistics for GO:0005242 based on MANUAL annotations
The top 100 of 282 co-occurring terms
Co-occurring Term PR S% #Together #Compared
inward rectifier potassium channel activity
2,767.71 100.00 510 510
regulation of monoatomic ion transmembrane transport
2,112.93 61.05 384 503
potassium ion import across plasma membrane
952.38 31.25 394 1,145
membrane repolarization during cardiac muscle cell action potential
1,976.94 8.52 45 63
regulation of heart rate by cardiac conduction
563.99 7.49 54 265
regulation of ventricular cardiac muscle cell membrane repolarization
656.26 6.99 46 194
potassium ion transport
130.17 3.56 65 1,382
regulation of membrane potential
123.85 3.48 69 1,542
potassium ion transmembrane transport
87.40 2.87 123 3,895
potassium channel activity
197.69 2.60 20 280
Totals 2600 180196

Change Log

Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9731072
2023-04-02 Added XREF Reactome:R-HSA-9729870
2023-04-02 Added XREF Reactome:R-HSA-9730521
2019-05-04 Added XREF Reactome:R-HSA-5678418
2019-04-30 Deleted XREF Reactome:R-HSA-5678418
2019-04-29 Added XREF Reactome:R-HSA-5678418
2019-04-28 Deleted XREF Reactome:R-HSA-5678418
2019-04-27 Added XREF Reactome:R-HSA-5678418
2019-04-23 Deleted XREF Reactome:R-HSA-5678418
2019-04-01 Deleted XREF reactome:R-HSA-1369017
Timestamp Action Category Detail
2003-03-19 Updated TERM inward rectifier potassium channel activity
2002-02-06 Updated TERM inward rectifier potassium channel
2001-04-03 Updated TERM inward rectifier potassium channel
2001-03-30 Added TERM inward rectifier potassium channel
Timestamp Action Category Detail
2015-05-11 Added DEFINITION Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
2015-05-11 Deleted DEFINITION Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
2009-02-13 Added DEFINITION Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
2009-02-13 Added SYNONYM Kir channel activity
2007-10-06 Deleted SYNONYM inward rectifier channel
2007-08-09 Deleted SYNONYM inward rectifier channel
2007-08-09 Added SYNONYM inward rectifier channel
2005-08-10 Added SYNONYM inward rectifier channel
Timestamp Action Category Detail
2016-11-28 Deleted RELATION is a GO:0015276 (ligand-gated monoatomic ion channel activity)
2016-11-28 Added RELATION is a GO:0099094 (ligand-gated monoatomic cation channel activity)
2009-02-13 Added RELATION is a GO:0015276 (ligand-gated monoatomic ion channel activity)
2008-04-01 Updated RELATION is a GO:0005249 (voltage-gated potassium channel activity)
Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9731072
2023-04-02 Added XREF Reactome:R-HSA-9729870
2023-04-02 Added XREF Reactome:R-HSA-9730521
2019-05-04 Added XREF Reactome:R-HSA-5678418
2019-04-30 Deleted XREF Reactome:R-HSA-5678418
2019-04-29 Added XREF Reactome:R-HSA-5678418
2019-04-28 Deleted XREF Reactome:R-HSA-5678418
2019-04-27 Added XREF Reactome:R-HSA-5678418
2019-04-23 Deleted XREF Reactome:R-HSA-5678418
2019-04-01 Deleted XREF reactome:R-HSA-1369017
2019-04-01 Added XREF Reactome:R-HSA-5678261
2019-04-01 Added XREF Reactome:R-HSA-1296045
2019-04-01 Added XREF Reactome:R-HSA-1369017
2019-04-01 Added XREF Reactome:R-HSA-1296046
2019-04-01 Deleted XREF reactome:R-HSA-5678261
2019-04-01 Deleted XREF reactome:R-HSA-1296045
2019-04-01 Deleted XREF reactome:R-HSA-1296046
2019-04-01 Added XREF Reactome:R-HSA-5678418
2018-12-11 Added XREF reactome:R-HSA-1296045
2018-12-11 Added XREF reactome:R-HSA-1369017
2018-12-11 Added XREF reactome:R-HSA-5678261
2018-12-11 Added XREF reactome:R-HSA-1296046
2007-07-11 Deleted XREF TC:1.A.1.8.1
2001-03-30 Added XREF TC:1.A.1.8.1
Timestamp Action Category Detail
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