GO:0005242
JSON
inward rectifier potassium channel activity
Molecular Function
Definition (GO:0005242 GONUTS page)
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. PMID:14977398
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
Kir channel activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0005242
Child Term | Relationship to GO:0005242 |
---|---|
G-protein activated inward rectifier potassium channel activity
|
is_a |
regulation of inward rectifier potassium channel activity
|
regulates |
ATP-activated inward rectifier potassium channel activity
|
is_a |
negative regulation of inward rectifier potassium channel activity
|
negatively_regulates |
inward rectifier potassium channel inhibitor activity
|
negatively_regulates |
positive regulation of inward rectifier potassium channel activity
|
positively_regulates |
inward rectifier potassium channel complex
|
capable_of |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5ZLE9 | 10116 | A0A8I5ZLE9_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZST4 | 10116 | A0A8I5ZST4_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AI08 | 10116 | A0A8I6AI08_RAT | GO:0022832 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AI08 | 10116 | A0A8I6AI08_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0PK00 | 9606 | T120B_HUMAN | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A2AHD2 | 10090 | A2AHD2_MOUSE | GO:0005267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000008 | |
NOT-qualified manual | protein | A2WLC1 | 39946 | CDT3_ORYSI | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6HVQ8 | 10116 | A6HVQ8_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J168 | 10116 | A6J168_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J4P5 | 10116 | A6J4P5_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR003268 | FPotassium channel, inwardly rectifying, Kir1.1 |
InterPro | IPR003269 | Potassium channel, inwardly rectifying, Kir1.2 |
InterPro | IPR003270 | Potassium channel, inwardly rectifying, Kir1.3 |
InterPro | IPR003271 | Potassium channel, inwardly rectifying, Kir2.1 |
InterPro | IPR003272 | Potassium channel, inwardly rectifying, Kir2.2 |
InterPro | IPR003273 | Potassium channel, inwardly rectifying, Kir2.3 |
InterPro | IPR008061 | Potassium channel, inwardly rectifying, Kir5 |
InterPro | IPR008062 | Inward rectifier potassium channel 13 |
InterPro | IPR016449 | Potassium channel, inwardly rectifying, Kir |
Reactome | R-HSA-1296045 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0005241 | obsolete inward rectifier channel | consider GO:0005242 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005242 based on ALL annotations
The top 100 of 532 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
inward rectifier potassium channel activity
|
7,388.88 | 100.00 | 26,818 | 26,818 |
regulation of monoatomic ion transmembrane transport
|
6,083.91 | 64.09 | 19,926 | 24,200 |
potassium ion import across plasma membrane
|
1,731.31 | 21.74 | 20,138 | 85,945 |
monoatomic ion channel complex
|
1,029.05 | 13.79 | 25,012 | 179,593 |
G-protein activated inward rectifier potassium channel activity
|
7,104.98 | 13.74 | 3,704 | 3,852 |
membrane repolarization during cardiac muscle cell action potential
|
6,921.55 | 9.87 | 2,666 | 2,846 |
regulation of heart rate by cardiac conduction
|
2,134.50 | 8.47 | 2,868 | 9,928 |
regulation of ventricular cardiac muscle cell membrane repolarization
|
2,160.93 | 7.98 | 2,652 | 9,068 |
regulation of membrane potential
|
573.05 | 5.23 | 3,714 | 47,888 |
potassium ion transport
|
369.73 | 5.00 | 26,005 | 519,696 |
Totals | 213118 | 26823059 |
No co-occurrence statistics for GO:0005242 based on MANUAL annotations
The top 100 of 282 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
inward rectifier potassium channel activity
|
2,767.71 | 100.00 | 510 | 510 |
regulation of monoatomic ion transmembrane transport
|
2,112.93 | 61.05 | 384 | 503 |
potassium ion import across plasma membrane
|
952.38 | 31.25 | 394 | 1,145 |
membrane repolarization during cardiac muscle cell action potential
|
1,976.94 | 8.52 | 45 | 63 |
regulation of heart rate by cardiac conduction
|
563.99 | 7.49 | 54 | 265 |
regulation of ventricular cardiac muscle cell membrane repolarization
|
656.26 | 6.99 | 46 | 194 |
potassium ion transport
|
130.17 | 3.56 | 65 | 1,382 |
regulation of membrane potential
|
123.85 | 3.48 | 69 | 1,542 |
potassium ion transmembrane transport
|
87.40 | 2.87 | 123 | 3,895 |
potassium channel activity
|
197.69 | 2.60 | 20 | 280 |
Totals | 2600 | 180196 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9731072 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9729870 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9730521 |
2019-05-04 | Added | XREF | Reactome:R-HSA-5678418 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-5678418 |
2019-04-29 | Added | XREF | Reactome:R-HSA-5678418 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-5678418 |
2019-04-27 | Added | XREF | Reactome:R-HSA-5678418 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-5678418 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1369017 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | inward rectifier potassium channel activity |
2002-02-06 | Updated | TERM | inward rectifier potassium channel |
2001-04-03 | Updated | TERM | inward rectifier potassium channel |
2001-03-30 | Added | TERM | inward rectifier potassium channel |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-11 | Added | DEFINITION | Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. |
2015-05-11 | Deleted | DEFINITION | Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. |
2009-02-13 | Added | DEFINITION | Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. |
2009-02-13 | Added | SYNONYM | Kir channel activity |
2007-10-06 | Deleted | SYNONYM | inward rectifier channel |
2007-08-09 | Deleted | SYNONYM | inward rectifier channel |
2007-08-09 | Added | SYNONYM | inward rectifier channel |
2005-08-10 | Added | SYNONYM | inward rectifier channel |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-11-28 | Deleted | RELATION | is a GO:0015276 (ligand-gated monoatomic ion channel activity) |
2016-11-28 | Added | RELATION | is a GO:0099094 (ligand-gated monoatomic cation channel activity) |
2009-02-13 | Added | RELATION | is a GO:0015276 (ligand-gated monoatomic ion channel activity) |
2008-04-01 | Updated | RELATION | is a GO:0005249 (voltage-gated potassium channel activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-04-02 | Added | XREF | Reactome:R-HSA-9731072 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9729870 |
2023-04-02 | Added | XREF | Reactome:R-HSA-9730521 |
2019-05-04 | Added | XREF | Reactome:R-HSA-5678418 |
2019-04-30 | Deleted | XREF | Reactome:R-HSA-5678418 |
2019-04-29 | Added | XREF | Reactome:R-HSA-5678418 |
2019-04-28 | Deleted | XREF | Reactome:R-HSA-5678418 |
2019-04-27 | Added | XREF | Reactome:R-HSA-5678418 |
2019-04-23 | Deleted | XREF | Reactome:R-HSA-5678418 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1369017 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5678261 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1296045 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1369017 |
2019-04-01 | Added | XREF | Reactome:R-HSA-1296046 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5678261 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1296045 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-1296046 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5678418 |
2018-12-11 | Added | XREF | reactome:R-HSA-1296045 |
2018-12-11 | Added | XREF | reactome:R-HSA-1369017 |
2018-12-11 | Added | XREF | reactome:R-HSA-5678261 |
2018-12-11 | Added | XREF | reactome:R-HSA-1296046 |
2007-07-11 | Deleted | XREF | TC:1.A.1.8.1 |
2001-03-30 | Added | XREF | TC:1.A.1.8.1 |
Timestamp | Action | Category | Detail |
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