GO:0005254
JSON
chloride channel activity
Molecular Function
Definition (GO:0005254 GONUTS page)
Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel.
Ancestor Chart
Ancestor chart for GO:0005254
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0005254
Child Term | Relationship to GO:0005254 |
---|---|
chloride channel inhibitor activity
|
negatively_regulates |
extracellularly glutamate-gated chloride channel activity
|
is_a |
serotonin-gated chloride channel activity
|
is_a |
chloride channel regulator activity
|
regulates |
volume-sensitive chloride channel activity
|
is_a |
extracellularly glycine-gated chloride channel activity
|
is_a |
intracellularly calcium-gated chloride channel activity
|
is_a |
pH-gated chloride channel activity
|
is_a |
chloride channel complex
|
capable_of |
glycine-gated chloride ion channel activity
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2K0W3 | 10116 | A0A0G2K0W3_RAT | GO:0005254 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZKP5 | 10116 | A0A8I5ZKP5_RAT | GO:0005254 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZLE9 | 10116 | A0A8I5ZLE9_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZST4 | 10116 | A0A8I5ZST4_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AI08 | 10116 | A0A8I6AI08_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0PK00 | 9606 | T120B_HUMAN | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6HVQ8 | 10116 | A6HVQ8_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J168 | 10116 | A6J168_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J4P5 | 10116 | A6J4P5_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K1R8 | 10116 | A6K1R8_RAT | GO:0005254 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR009147 | Cystic fibrosis transmembrane conductance regulator |
InterPro | IPR021134 | Bestrophin-like |
InterPro | IPR030253 | Chloride intracellular channel protein 2, C-terminal domain |
RHEA | 29823 | |
Reactome | R-HSA-2684901 | |
Reactome | R-HSA-2744242 | |
Reactome | R-HSA-2744349 | |
Reactome | R-HSA-2744361 | |
Reactome | R-HSA-427570 | |
Reactome | R-HSA-9659568 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:17996 | chloride |
has_primary_input | CHEBI | CHEBI:17996 | chloride |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0061778 | obsolete intracellular chloride channel activity | replaced_by GO:0005254 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005254 based on ALL annotations
The top 100 of 1,452 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
chloride channel activity
|
1,724.94 | 100.00 | 113,012 | 113,012 |
chloride channel complex
|
1,720.39 | 56.85 | 64,345 | 64,515 |
chloride transmembrane transport
|
926.03 | 53.68 | 113,012 | 210,510 |
chloride transport
|
856.86 | 36.95 | 66,734 | 134,342 |
extracellular ligand-gated monoatomic ion channel activity
|
820.99 | 19.47 | 28,000 | 58,829 |
GABA-A receptor activity
|
1,676.43 | 17.34 | 19,700 | 20,270 |
postsynaptic membrane
|
243.09 | 9.37 | 24,704 | 175,298 |
monoatomic ion transmembrane transport
|
136.03 | 7.48 | 67,193 | 852,025 |
voltage-gated chloride channel activity
|
292.31 | 7.15 | 12,447 | 73,451 |
gamma-aminobutyric acid signaling pathway
|
643.18 | 6.17 | 7,774 | 20,849 |
Totals | 854699 | 46221687 |
No co-occurrence statistics for GO:0005254 based on MANUAL annotations
The top 100 of 667 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
chloride channel activity
|
860.05 | 100.00 | 1,502 | 1,502 |
chloride transmembrane transport
|
527.86 | 51.97 | 1,160 | 1,890 |
transmembrane transporter complex
|
509.97 | 36.82 | 740 | 1,248 |
neurotransmitter receptor activity
|
410.00 | 27.90 | 604 | 1,267 |
GABA-A receptor activity
|
823.45 | 26.64 | 405 | 423 |
GABA-A receptor complex
|
834.34 | 23.60 | 357 | 368 |
GABA-gated chloride ion channel activity
|
788.38 | 13.03 | 198 | 216 |
benzodiazepine receptor activity
|
834.12 | 12.80 | 193 | 199 |
chloride transport
|
433.02 | 12.65 | 217 | 431 |
gamma-aminobutyric acid signaling pathway
|
368.13 | 12.53 | 226 | 528 |
Totals | 11045 | 184934 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-2744361 |
2024-11-06 | Added | XREF | Reactome:R-HSA-2684901 |
2024-11-06 | Added | XREF | Reactome:R-HSA-2744242 |
2024-11-06 | Added | XREF | Reactome:R-HSA-9659568 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-2744242 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-2744361 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9659568 |
2024-11-03 | Added | XREF | Reactome:R-HSA-2744361 |
2024-11-03 | Added | XREF | Reactome:R-HSA-2684901 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-06-09 | Updated | TERM | chloride channel activity |
2010-06-08 | Updated | TERM | chloride channel activity |
2003-03-19 | Updated | TERM | chloride channel activity |
2002-02-06 | Updated | TERM | chloride channel |
2001-04-03 | Updated | TERM | chloride channel |
2001-03-30 | Added | TERM | chloride channel |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-05-01 | Deleted | DEFINITION | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
2024-05-01 | Added | DEFINITION | Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel. |
2016-01-10 | Deleted | SYNONYM | chloride-specific channel activity |
2016-01-10 | Deleted | DEFINITION | Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
2016-01-10 | Added | DEFINITION | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
2015-05-19 | Added | DEFINITION | Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
2015-05-19 | Deleted | DEFINITION | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
2015-05-19 | Added | SYNONYM | chloride-specific channel activity |
2015-05-11 | Added | DEFINITION | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
2015-05-11 | Deleted | DEFINITION | Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
2008-08-17 | Added | DEFINITION | Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
2008-08-17 | Deleted | DEFINITION | Catalysis of facilitated diffusion of an chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
2008-05-13 | Added | DEFINITION | Catalysis of facilitated diffusion of an chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
2008-05-12 | Deleted | DEFINITION | Catalysis of facilitated diffusion of an chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
2007-07-27 | Added | DEFINITION | Catalysis of facilitated diffusion of an chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-17 | Added | RELATION | is a GO:0015108 (chloride transmembrane transporter activity) |
2021-02-17 | Deleted | RELATION | is a GO:0015108 (chloride transmembrane transporter activity) |
2013-10-30 | Deleted | RELATION | part of GO:0006821 (chloride transport) |
2012-06-01 | Added | RELATION | is a GO:0015108 (chloride transmembrane transporter activity) |
2010-06-15 | Added | RELATION | part of GO:0006821 (chloride transport) |
2010-06-14 | Deleted | RELATION | part of GO:0006821 (chloride transport) |
2010-06-08 | Added | RELATION | part of GO:0006821 (chloride transport) |
2008-04-01 | Updated | RELATION | is a GO:0005253 (monoatomic anion channel activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-06 | Added | XREF | Reactome:R-HSA-2744361 |
2024-11-06 | Added | XREF | Reactome:R-HSA-2684901 |
2024-11-06 | Added | XREF | Reactome:R-HSA-2744242 |
2024-11-06 | Added | XREF | Reactome:R-HSA-9659568 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-2744242 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-2744361 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9659568 |
2024-11-03 | Added | XREF | Reactome:R-HSA-2744361 |
2024-11-03 | Added | XREF | Reactome:R-HSA-2684901 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9659568 |
2024-11-03 | Added | XREF | Reactome:R-HSA-2744242 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-2744242 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-2744361 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-9659568 |
2024-11-02 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-11-01 | Added | XREF | Reactome:R-HSA-2684901 |
2024-11-01 | Added | XREF | Reactome:R-HSA-2744361 |
2024-11-01 | Added | XREF | Reactome:R-HSA-2744242 |
2024-11-01 | Added | XREF | Reactome:R-HSA-9659568 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-2744361 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-2744242 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-9659568 |
2024-10-26 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-10-09 | Added | XREF | Reactome:R-HSA-2684901 |
2024-10-09 | Added | XREF | Reactome:R-HSA-2744361 |
2024-10-09 | Added | XREF | Reactome:R-HSA-2744242 |
2024-10-09 | Added | XREF | Reactome:R-HSA-9659568 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-2744361 |
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2024-10-08 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-10-08 | Deleted | XREF | Reactome:R-HSA-9659568 |
2024-09-21 | Added | XREF | Reactome:R-HSA-9659568 |
2024-09-21 | Added | XREF | Reactome:R-HSA-2744361 |
2024-09-21 | Added | XREF | Reactome:R-HSA-2684901 |
2024-09-21 | Added | XREF | Reactome:R-HSA-2744242 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-2744242 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-9659568 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-2744361 |
2024-09-20 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-09-19 | Added | XREF | Reactome:R-HSA-2684901 |
2024-09-19 | Added | XREF | Reactome:R-HSA-2744242 |
2024-09-19 | Added | XREF | Reactome:R-HSA-2744361 |
2024-09-19 | Added | XREF | Reactome:R-HSA-9659568 |
2024-09-14 | Added | XREF | RHEA:29823 |
2024-09-13 | Deleted | XREF | Reactome:R-HSA-2744361 |
2024-09-13 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-09-13 | Deleted | XREF | Reactome:R-HSA-9659568 |
2024-09-13 | Deleted | XREF | Reactome:R-HSA-2744242 |
2024-09-10 | Added | XREF | Reactome:R-HSA-2684901 |
2024-09-10 | Added | XREF | Reactome:R-HSA-2744361 |
2024-09-10 | Added | XREF | Reactome:R-HSA-2744242 |
2024-09-10 | Added | XREF | Reactome:R-HSA-9659568 |
2024-09-08 | Deleted | XREF | Reactome:R-HSA-2744242 |
2024-09-08 | Deleted | XREF | Reactome:R-HSA-2744361 |
2024-09-08 | Deleted | XREF | Reactome:R-HSA-9659568 |
2024-09-08 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-09-07 | Added | XREF | Reactome:R-HSA-2744361 |
2024-09-07 | Added | XREF | Reactome:R-HSA-2744242 |
2024-09-07 | Added | XREF | Reactome:R-HSA-2684901 |
2024-09-07 | Added | XREF | Reactome:R-HSA-9659568 |
2024-09-06 | Deleted | XREF | Reactome:R-HSA-2744242 |
2024-09-06 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-09-06 | Deleted | XREF | Reactome:R-HSA-2744361 |
2024-09-06 | Deleted | XREF | Reactome:R-HSA-9659568 |
2024-09-05 | Added | XREF | Reactome:R-HSA-9659568 |
2024-09-05 | Added | XREF | Reactome:R-HSA-2684901 |
2024-09-05 | Added | XREF | Reactome:R-HSA-2744361 |
2024-09-05 | Added | XREF | Reactome:R-HSA-2744242 |
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2024-08-20 | Added | XREF | Reactome:R-HSA-2744242 |
2024-08-20 | Added | XREF | Reactome:R-HSA-2744361 |
2024-08-20 | Added | XREF | Reactome:R-HSA-2684901 |
2024-08-20 | Added | XREF | Reactome:R-HSA-9659568 |
2024-08-16 | Deleted | XREF | Reactome:R-HSA-2744242 |
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2024-08-15 | Added | XREF | Reactome:R-HSA-2684901 |
2024-08-15 | Added | XREF | Reactome:R-HSA-2744242 |
2024-08-15 | Added | XREF | Reactome:R-HSA-9659568 |
2024-08-08 | Added | XREF | Reactome:R-HSA-9659568 |
2024-08-08 | Added | XREF | Reactome:R-HSA-2744361 |
2024-08-08 | Deleted | XREF | Reactome:R-HSA-2684901 |
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2024-08-08 | Deleted | XREF | Reactome:R-HSA-2744361 |
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2024-08-08 | Added | XREF | Reactome:R-HSA-2744242 |
2024-08-06 | Deleted | XREF | Reactome:R-HSA-2744361 |
2024-08-06 | Deleted | XREF | Reactome:R-HSA-9659568 |
2024-08-06 | Deleted | XREF | Reactome:R-HSA-2744242 |
2024-08-06 | Deleted | XREF | Reactome:R-HSA-2684901 |
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2024-08-05 | Added | XREF | Reactome:R-HSA-2684901 |
2024-08-05 | Added | XREF | Reactome:R-HSA-2744242 |
2024-08-05 | Added | XREF | Reactome:R-HSA-2744361 |
2024-07-28 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-07-28 | Deleted | XREF | Reactome:R-HSA-2744242 |
2024-07-28 | Deleted | XREF | Reactome:R-HSA-9659568 |
2024-07-28 | Deleted | XREF | Reactome:R-HSA-2744361 |
2024-07-27 | Added | XREF | Reactome:R-HSA-2744361 |
2024-07-27 | Added | XREF | Reactome:R-HSA-2684901 |
2024-07-27 | Added | XREF | Reactome:R-HSA-9659568 |
2024-07-27 | Added | XREF | Reactome:R-HSA-2744242 |
2024-07-26 | Deleted | XREF | Reactome:R-HSA-9659568 |
2024-07-26 | Deleted | XREF | Reactome:R-HSA-2744361 |
2024-07-26 | Deleted | XREF | Reactome:R-HSA-2744242 |
2024-07-26 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-07-25 | Added | XREF | Reactome:R-HSA-2684901 |
2024-07-25 | Added | XREF | Reactome:R-HSA-2744361 |
2024-07-25 | Added | XREF | Reactome:R-HSA-2744242 |
2024-07-25 | Added | XREF | Reactome:R-HSA-9659568 |
2024-07-20 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-07-20 | Deleted | XREF | Reactome:R-HSA-2744242 |
2024-07-20 | Deleted | XREF | Reactome:R-HSA-9659568 |
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2024-07-10 | Added | XREF | Reactome:R-HSA-2684901 |
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2024-07-09 | Deleted | XREF | Reactome:R-HSA-2744361 |
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2024-07-06 | Added | XREF | Reactome:R-HSA-9659568 |
2024-07-06 | Added | XREF | Reactome:R-HSA-2744361 |
2024-07-06 | Added | XREF | Reactome:R-HSA-2684901 |
2024-07-06 | Added | XREF | Reactome:R-HSA-2744242 |
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2024-07-03 | Added | XREF | Reactome:R-HSA-2684901 |
2024-07-03 | Added | XREF | Reactome:R-HSA-2744361 |
2024-07-03 | Added | XREF | Reactome:R-HSA-9659568 |
2024-06-30 | Deleted | XREF | Reactome:R-HSA-2684901 |
2024-06-30 | Deleted | XREF | Reactome:R-HSA-2744242 |
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2024-06-29 | Added | XREF | Reactome:R-HSA-2744361 |
2024-06-29 | Added | XREF | Reactome:R-HSA-2684901 |
2024-06-29 | Added | XREF | Reactome:R-HSA-2744242 |
2024-06-29 | Added | XREF | Reactome:R-HSA-9659568 |
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2024-06-27 | Added | XREF | Reactome:R-HSA-2744242 |
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