This term is obsolete.

GO:0005254 JSON

chloride channel activity

Molecular Function

Definition (GO:0005254 GONUTS page)

Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel.

210,490 annotations

Ancestor Chart

Ancestor chart for GO:0005254
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005254

Child Term Relationship to
GO:0005254
chloride channel inhibitor activity
negatively_regulates
extracellularly glutamate-gated chloride channel activity
is_a
serotonin-gated chloride channel activity
is_a
chloride channel regulator activity
regulates
volume-sensitive chloride channel activity
is_a
extracellularly glycine-gated chloride channel activity
is_a
intracellularly calcium-gated chloride channel activity
is_a
pH-gated chloride channel activity
is_a
chloride channel complex
capable_of
glycine-gated chloride ion channel activity
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2K0W3 10116 A0A0G2K0W3_RAT GO:0005254 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZKP5 10116 A0A8I5ZKP5_RAT GO:0005254 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZLE9 10116 A0A8I5ZLE9_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZST4 10116 A0A8I5ZST4_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AI08 10116 A0A8I6AI08_RAT GO:0015267 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0PK00 9606 T120B_HUMAN GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6HVQ8 10116 A6HVQ8_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J168 10116 A6J168_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J4P5 10116 A6J4P5_RAT GO:0015267 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K1R8 10116 A6K1R8_RAT GO:0005254 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR009147 Cystic fibrosis transmembrane conductance regulator
InterPro IPR021134 Bestrophin-like
InterPro IPR030253 Chloride intracellular channel protein 2, C-terminal domain
RHEA 29823
Reactome R-HSA-2684901
Reactome R-HSA-2744242
Reactome R-HSA-2744349
Reactome R-HSA-2744361
Reactome R-HSA-427570
Reactome R-HSA-9659568

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:17996 chloride
has_primary_input CHEBI CHEBI:17996 chloride

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0061778 obsolete intracellular chloride channel activity replaced_by GO:0005254

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005254 based on ALL annotations
The top 100 of 1,452 co-occurring terms
Co-occurring Term PR S% #Together #Compared
chloride channel activity
1,724.94 100.00 113,012 113,012
chloride channel complex
1,720.39 56.85 64,345 64,515
chloride transmembrane transport
926.03 53.68 113,012 210,510
chloride transport
856.86 36.95 66,734 134,342
extracellular ligand-gated monoatomic ion channel activity
820.99 19.47 28,000 58,829
GABA-A receptor activity
1,676.43 17.34 19,700 20,270
postsynaptic membrane
243.09 9.37 24,704 175,298
monoatomic ion transmembrane transport
136.03 7.48 67,193 852,025
voltage-gated chloride channel activity
292.31 7.15 12,447 73,451
gamma-aminobutyric acid signaling pathway
643.18 6.17 7,774 20,849
Totals 854699 46221687
No co-occurrence statistics for GO:0005254 based on MANUAL annotations
The top 100 of 667 co-occurring terms
Co-occurring Term PR S% #Together #Compared
chloride channel activity
860.05 100.00 1,502 1,502
chloride transmembrane transport
527.86 51.97 1,160 1,890
transmembrane transporter complex
509.97 36.82 740 1,248
neurotransmitter receptor activity
410.00 27.90 604 1,267
GABA-A receptor activity
823.45 26.64 405 423
GABA-A receptor complex
834.34 23.60 357 368
GABA-gated chloride ion channel activity
788.38 13.03 198 216
benzodiazepine receptor activity
834.12 12.80 193 199
chloride transport
433.02 12.65 217 431
gamma-aminobutyric acid signaling pathway
368.13 12.53 226 528
Totals 11045 184934

Change Log

Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-2744361
2024-11-06 Added XREF Reactome:R-HSA-2684901
2024-11-06 Added XREF Reactome:R-HSA-2744242
2024-11-06 Added XREF Reactome:R-HSA-9659568
2024-11-05 Deleted XREF Reactome:R-HSA-2684901
2024-11-05 Deleted XREF Reactome:R-HSA-2744242
2024-11-05 Deleted XREF Reactome:R-HSA-2744361
2024-11-05 Deleted XREF Reactome:R-HSA-9659568
2024-11-03 Added XREF Reactome:R-HSA-2744361
2024-11-03 Added XREF Reactome:R-HSA-2684901
Timestamp Action Category Detail
2010-06-09 Updated TERM chloride channel activity
2010-06-08 Updated TERM chloride channel activity
2003-03-19 Updated TERM chloride channel activity
2002-02-06 Updated TERM chloride channel
2001-04-03 Updated TERM chloride channel
2001-03-30 Added TERM chloride channel
Timestamp Action Category Detail
2024-05-01 Deleted DEFINITION Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2024-05-01 Added DEFINITION Enables the energy-independent facilitated diffusion of a chloride ion through a transmembrane aqueous pore or channel.
2016-01-10 Deleted SYNONYM chloride-specific channel activity
2016-01-10 Deleted DEFINITION Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2016-01-10 Added DEFINITION Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2015-05-19 Added DEFINITION Enables the selective, facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2015-05-19 Deleted DEFINITION Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2015-05-19 Added SYNONYM chloride-specific channel activity
2015-05-11 Added DEFINITION Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2015-05-11 Deleted DEFINITION Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2008-08-17 Added DEFINITION Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2008-08-17 Deleted DEFINITION Catalysis of facilitated diffusion of an chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2008-05-13 Added DEFINITION Catalysis of facilitated diffusion of an chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2008-05-12 Deleted DEFINITION Catalysis of facilitated diffusion of an chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
2007-07-27 Added DEFINITION Catalysis of facilitated diffusion of an chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
Timestamp Action Category Detail
2022-02-17 Added RELATION is a GO:0015108 (chloride transmembrane transporter activity)
2021-02-17 Deleted RELATION is a GO:0015108 (chloride transmembrane transporter activity)
2013-10-30 Deleted RELATION part of GO:0006821 (chloride transport)
2012-06-01 Added RELATION is a GO:0015108 (chloride transmembrane transporter activity)
2010-06-15 Added RELATION part of GO:0006821 (chloride transport)
2010-06-14 Deleted RELATION part of GO:0006821 (chloride transport)
2010-06-08 Added RELATION part of GO:0006821 (chloride transport)
2008-04-01 Updated RELATION is a GO:0005253 (monoatomic anion channel activity)
Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-2744361
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