This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator).
GO:0005260
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intracellularly ATP-gated chloride channel activity
Molecular Function
Definition (GO:0005260 GONUTS page)
Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. PMID:24727426 PMID:9922375
Comments
This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator).
Secondary IDs
GO:0005224
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
cystic fibrosis transmembrane conductance regulator | narrow |
channel-conductance-controlling ATPase activity | related |
CFTR | exact |
Ancestor Chart
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2K0W3 | 10116 | A0A0G2K0W3_RAT | GO:0005254 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZKP5 | 10116 | A0A8I5ZKP5_RAT | GO:0005254 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZLE9 | 10116 | A0A8I5ZLE9_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZST4 | 10116 | A0A8I5ZST4_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AI08 | 10116 | A0A8I6AI08_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0PK00 | 9606 | T120B_HUMAN | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6HVQ8 | 10116 | A6HVQ8_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J168 | 10116 | A6J168_RAT | GO:0005216 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J4P5 | 10116 | A6J4P5_RAT | GO:0015267 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K1R8 | 10116 | A6K1R8_RAT | GO:0005254 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 5.6.1.6 | |
MetaCyc | 3.6.3.49-RXN | |
TC | 3.A.1.202.1 | |
Wikipedia | Cystic_fibrosis_transmembrane_conductance_regulator |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_input | CHEBI | CHEBI:17996 | chloride |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005260 based on ALL annotations
The top 100 of 132 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
intracellularly ATP-gated chloride channel activity
|
164,922.83 | 100.00 | 1,182 | 1,182 |
bicarbonate transmembrane transporter activity
|
19,877.54 | 10.12 | 458 | 3,800 |
intracellular pH elevation
|
63,027.83 | 8.72 | 120 | 314 |
transepithelial water transport
|
50,001.06 | 8.45 | 124 | 409 |
Sec61 translocon complex binding
|
164,922.83 | 7.70 | 91 | 91 |
chloride channel inhibitor activity
|
31,327.57 | 7.13 | 121 | 637 |
cellular response to forskolin
|
19,682.80 | 5.91 | 124 | 1,039 |
multicellular organismal-level water homeostasis
|
16,572.47 | 5.41 | 124 | 1,234 |
chloride transmembrane transporter activity
|
8,192.36 | 4.60 | 457 | 9,200 |
membrane hyperpolarization
|
12,392.45 | 4.51 | 120 | 1,597 |
Totals | 27559 | 21160111 |
No co-occurrence statistics for GO:0005260 based on MANUAL annotations
The top 88 of 88 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
intracellularly ATP-gated chloride channel activity
|
30,757.12 | 100.00 | 42 | 42 |
transepithelial water transport
|
22,272.40 | 72.41 | 42 | 58 |
chloride channel inhibitor activity
|
22,632.60 | 69.64 | 39 | 53 |
intracellular pH elevation
|
21,017.36 | 67.21 | 41 | 60 |
membrane hyperpolarization
|
15,962.56 | 51.25 | 41 | 79 |
multicellular organismal-level water homeostasis
|
11,851.37 | 38.53 | 42 | 109 |
cellular response to forskolin
|
9,097.18 | 29.58 | 42 | 142 |
bicarbonate transmembrane transporter activity
|
4,393.87 | 14.29 | 42 | 294 |
bicarbonate transport
|
4,100.95 | 13.33 | 42 | 315 |
sperm capacitation
|
3,880.13 | 12.58 | 41 | 325 |
Totals | 1018 | 812190 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-17 | Deleted | SYNONYM | ATP-binding and phosphorylation-dependent chloride channel activity |
2022-02-17 | Added | XREF | TC:3.A.1.202.1 |
2022-02-17 | Added | SYNONYM | channel-conductance-controlling ATPase activity |
2022-02-17 | Deleted | SYNONYM | cystic-fibrosis membrane-conductance-regulating protein activity |
2022-02-17 | Added | XREF | Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator |
2022-02-17 | Deleted | SYNONYM | channel-conductance-controlling ATPase activity |
2022-02-17 | Deleted | SYNONYM | ATP phosphohydrolase (channel-conductance-controlling) |
2022-02-17 | Added | SYNONYM | CFTR |
2020-10-08 | Deleted | SYNONYM | ATP phosphohydrolase (channel-conductance-controlling) |
2020-10-08 | Added | SYNONYM | ATP phosphohydrolase (channel-conductance-controlling) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-11-01 | Updated | TERM | intracellularly ATP-gated chloride channel activity |
2017-01-02 | Updated | TERM | intracellular ATPase-gated chloride channel activity |
2003-03-19 | Updated | TERM | channel-conductance-controlling ATPase activity |
2002-02-06 | Updated | TERM | channel-conductance-controlling ATPase |
2001-04-03 | Updated | TERM | channel-conductance-controlling ATPase |
2001-03-30 | Added | TERM | channel-conductance-controlling ATPase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-17 | Deleted | SYNONYM | ATP-binding and phosphorylation-dependent chloride channel activity |
2022-02-17 | Added | SYNONYM | channel-conductance-controlling ATPase activity |
2022-02-17 | Deleted | SYNONYM | cystic-fibrosis membrane-conductance-regulating protein activity |
2022-02-17 | Deleted | SYNONYM | channel-conductance-controlling ATPase activity |
2022-02-17 | Deleted | SYNONYM | ATP phosphohydrolase (channel-conductance-controlling) |
2022-02-17 | Added | SYNONYM | CFTR |
2020-10-08 | Deleted | SYNONYM | ATP phosphohydrolase (channel-conductance-controlling) |
2020-10-08 | Added | SYNONYM | ATP phosphohydrolase (channel-conductance-controlling) |
2017-11-01 | Added | DEFINITION | Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. |
2017-11-01 | Deleted | DEFINITION | Enables passage of a chloride ion through a transmembrane channel that opens when intracellular ATP is bound and hydrolysed. Passage is via passive diffusion once the channel is open. |
2017-01-02 | Added | SYNONYM | channel-conductance-controlling ATPase activity |
2017-01-02 | Added | SYNONYM | ATP-binding and phosphorylation-dependent chloride channel activity |
2017-01-02 | Deleted | DEFINITION | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels. |
2017-01-02 | Added | DEFINITION | Enables passage of a chloride ion through a transmembrane channel that opens when intracellular ATP is bound and hydrolysed. Passage is via passive diffusion once the channel is open. |
2008-05-13 | Added | DEFINITION | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels. |
2007-11-08 | Added | SYNONYM | ATP phosphohydrolase (channel-conductance-controlling) |
2007-09-06 | Added | SYNONYM | cystic-fibrosis membrane-conductance-regulating protein activity |
2007-08-09 | Added | SYNONYM | cystic fibrosis transmembrane conductance regulator |
2007-08-09 | Deleted | SYNONYM | cystic fibrosis transmembrane conductance regulator |
2007-07-27 | Updated | DEFINITION | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels. |
2004-04-19 | Added | SYNONYM | cystic fibrosis transmembrane conductance regulator |
2004-04-16 | Deleted | SYNONYM | cystic fibrosis transmembrane conductance regulator |
2003-10-27 | Added | SYNONYM | cystic fibrosis transmembrane conductance regulator |
2003-08-21 | Deleted | SYNONYM | cystic fibrosis transmembrane conductance regulator |
2003-03-26 | Updated | DEFINITION | Catalysis of the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels. |
2003-03-19 | Deleted | SYNONYM | channel-conductance-controlling ATPase |
2003-03-19 | Deleted | SYNONYM | cystic fibrosis transmembrane conductance exporter |
2002-11-27 | Updated | DEFINITION | ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels. |
2001-08-06 | Added | DEFINITION | . |
2001-03-30 | Added | SYNONYM | cystic fibrosis transmembrane conductance regulator |
2001-03-30 | Added | SYNONYM | channel-conductance-controlling ATPase |
2001-03-30 | Added | SYNONYM | cystic fibrosis transmembrane conductance exporter |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-05-04 | Deleted | RELATION | is a GO:0042623 (ATPase activity, coupled) |
2017-10-25 | Added | RELATION | is a GO:0042623 (ATPase activity, coupled) |
2017-10-25 | Deleted | RELATION | is a GO:0016887 (ATP hydrolysis activity) |
2017-01-02 | Deleted | RELATION | is a GO:0043225 (ATPase-coupled inorganic anion transmembrane transporter activity) |
2017-01-02 | Added | RELATION | is a GO:0016887 (ATP hydrolysis activity) |
2017-01-02 | Added | RELATION | is a GO:0099095 (ligand-gated monoatomic anion channel activity) |
2017-01-02 | Added | RELATION | is a GO:0099142 (intracellularly ATP-gated ion channel activity) |
2016-12-15 | Added | RELATION | is a GO:0043225 (ATPase-coupled inorganic anion transmembrane transporter activity) |
2016-12-15 | Deleted | RELATION | is a GO:0042626 (ATPase-coupled transmembrane transporter activity) |
2008-04-01 | Updated | RELATION | is a GO:0005254 (chloride channel activity) |
2008-04-01 | Updated | RELATION | is a GO:0042626 (ATPase-coupled transmembrane transporter activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-17 | Added | XREF | TC:3.A.1.202.1 |
2022-02-17 | Added | XREF | Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator |
2019-09-30 | Added | XREF | EC:5.6.1.6 |
2019-09-30 | Deleted | XREF | EC:3.6.3.49 |
2007-07-11 | Deleted | XREF | TC:3.A.1.202.1 |
2003-10-27 | Added | XREF | MetaCyc:3.6.3.49-RXN |
2003-10-27 | Added | XREF | TC:3.A.1.202.1 |
2003-08-21 | Deleted | XREF | TC:3.A.1.202.1 |
2001-03-30 | Added | XREF | TC:3.A.1.202.1 |
2001-03-30 | Added | XREF | EC:3.6.3.49 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-01-02 | Added | SECONDARY | GO:0005224 (ATP-binding and phosphorylation-dependent chloride channel activity) |
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