This term is obsolete.
This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator).

GO:0005260 JSON

intracellularly ATP-gated chloride channel activity

Molecular Function

Definition (GO:0005260 GONUTS page)

Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. PMID:24727426 PMID:9922375

Comments

This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator).

Secondary IDs

GO:0005224

1,227 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cystic fibrosis transmembrane conductance regulator narrow
channel-conductance-controlling ATPase activity related
CFTR exact

Ancestor Chart

Ancestor chart for GO:0005260
Chart options
Ancestor chart

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2K0W3 10116 A0A0G2K0W3_RAT GO:0005254 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZKP5 10116 A0A8I5ZKP5_RAT GO:0005254 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZLE9 10116 A0A8I5ZLE9_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZST4 10116 A0A8I5ZST4_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AI08 10116 A0A8I6AI08_RAT GO:0015267 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0PK00 9606 T120B_HUMAN GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6HVQ8 10116 A6HVQ8_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J168 10116 A6J168_RAT GO:0005216 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J4P5 10116 A6J4P5_RAT GO:0015267 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K1R8 10116 A6K1R8_RAT GO:0005254 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
EC 5.6.1.6
MetaCyc 3.6.3.49-RXN
TC 3.A.1.202.1
Wikipedia Cystic_fibrosis_transmembrane_conductance_regulator

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:17996 chloride

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005260 based on ALL annotations
The top 100 of 132 co-occurring terms
Co-occurring Term PR S% #Together #Compared
intracellularly ATP-gated chloride channel activity
164,922.83 100.00 1,182 1,182
bicarbonate transmembrane transporter activity
19,877.54 10.12 458 3,800
intracellular pH elevation
63,027.83 8.72 120 314
transepithelial water transport
50,001.06 8.45 124 409
Sec61 translocon complex binding
164,922.83 7.70 91 91
chloride channel inhibitor activity
31,327.57 7.13 121 637
cellular response to forskolin
19,682.80 5.91 124 1,039
multicellular organismal-level water homeostasis
16,572.47 5.41 124 1,234
chloride transmembrane transporter activity
8,192.36 4.60 457 9,200
membrane hyperpolarization
12,392.45 4.51 120 1,597
Totals 27559 21160111
No co-occurrence statistics for GO:0005260 based on MANUAL annotations
The top 88 of 88 co-occurring terms
Co-occurring Term PR S% #Together #Compared
intracellularly ATP-gated chloride channel activity
30,757.12 100.00 42 42
transepithelial water transport
22,272.40 72.41 42 58
chloride channel inhibitor activity
22,632.60 69.64 39 53
intracellular pH elevation
21,017.36 67.21 41 60
membrane hyperpolarization
15,962.56 51.25 41 79
multicellular organismal-level water homeostasis
11,851.37 38.53 42 109
cellular response to forskolin
9,097.18 29.58 42 142
bicarbonate transmembrane transporter activity
4,393.87 14.29 42 294
bicarbonate transport
4,100.95 13.33 42 315
sperm capacitation
3,880.13 12.58 41 325
Totals 1018 812190

Change Log

Timestamp Action Category Detail
2022-02-17 Deleted SYNONYM ATP-binding and phosphorylation-dependent chloride channel activity
2022-02-17 Added XREF TC:3.A.1.202.1
2022-02-17 Added SYNONYM channel-conductance-controlling ATPase activity
2022-02-17 Deleted SYNONYM cystic-fibrosis membrane-conductance-regulating protein activity
2022-02-17 Added XREF Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator
2022-02-17 Deleted SYNONYM channel-conductance-controlling ATPase activity
2022-02-17 Deleted SYNONYM ATP phosphohydrolase (channel-conductance-controlling)
2022-02-17 Added SYNONYM CFTR
2020-10-08 Deleted SYNONYM ATP phosphohydrolase (channel-conductance-controlling)
2020-10-08 Added SYNONYM ATP phosphohydrolase (channel-conductance-controlling)
Timestamp Action Category Detail
2017-11-01 Updated TERM intracellularly ATP-gated chloride channel activity
2017-01-02 Updated TERM intracellular ATPase-gated chloride channel activity
2003-03-19 Updated TERM channel-conductance-controlling ATPase activity
2002-02-06 Updated TERM channel-conductance-controlling ATPase
2001-04-03 Updated TERM channel-conductance-controlling ATPase
2001-03-30 Added TERM channel-conductance-controlling ATPase
Timestamp Action Category Detail
2022-02-17 Deleted SYNONYM ATP-binding and phosphorylation-dependent chloride channel activity
2022-02-17 Added SYNONYM channel-conductance-controlling ATPase activity
2022-02-17 Deleted SYNONYM cystic-fibrosis membrane-conductance-regulating protein activity
2022-02-17 Deleted SYNONYM channel-conductance-controlling ATPase activity
2022-02-17 Deleted SYNONYM ATP phosphohydrolase (channel-conductance-controlling)
2022-02-17 Added SYNONYM CFTR
2020-10-08 Deleted SYNONYM ATP phosphohydrolase (channel-conductance-controlling)
2020-10-08 Added SYNONYM ATP phosphohydrolase (channel-conductance-controlling)
2017-11-01 Added DEFINITION Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane.
2017-11-01 Deleted DEFINITION Enables passage of a chloride ion through a transmembrane channel that opens when intracellular ATP is bound and hydrolysed. Passage is via passive diffusion once the channel is open.
2017-01-02 Added SYNONYM channel-conductance-controlling ATPase activity
2017-01-02 Added SYNONYM ATP-binding and phosphorylation-dependent chloride channel activity
2017-01-02 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.
2017-01-02 Added DEFINITION Enables passage of a chloride ion through a transmembrane channel that opens when intracellular ATP is bound and hydrolysed. Passage is via passive diffusion once the channel is open.
2008-05-13 Added DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.
2008-05-12 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.
2007-11-08 Added SYNONYM ATP phosphohydrolase (channel-conductance-controlling)
2007-09-06 Added SYNONYM cystic-fibrosis membrane-conductance-regulating protein activity
2007-08-09 Added SYNONYM cystic fibrosis transmembrane conductance regulator
2007-08-09 Deleted SYNONYM cystic fibrosis transmembrane conductance regulator
2007-07-27 Updated DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.
2004-04-19 Added SYNONYM cystic fibrosis transmembrane conductance regulator
2004-04-16 Deleted SYNONYM cystic fibrosis transmembrane conductance regulator
2003-10-27 Added SYNONYM cystic fibrosis transmembrane conductance regulator
2003-08-21 Deleted SYNONYM cystic fibrosis transmembrane conductance regulator
2003-03-26 Updated DEFINITION Catalysis of the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.
2003-03-19 Deleted SYNONYM channel-conductance-controlling ATPase
2003-03-19 Deleted SYNONYM cystic fibrosis transmembrane conductance exporter
2002-11-27 Updated DEFINITION ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.
2001-08-06 Added DEFINITION .
2001-03-30 Added SYNONYM cystic fibrosis transmembrane conductance regulator
2001-03-30 Added SYNONYM channel-conductance-controlling ATPase
2001-03-30 Added SYNONYM cystic fibrosis transmembrane conductance exporter
Timestamp Action Category Detail
2019-05-04 Deleted RELATION is a GO:0042623 (ATPase activity, coupled)
2017-10-25 Added RELATION is a GO:0042623 (ATPase activity, coupled)
2017-10-25 Deleted RELATION is a GO:0016887 (ATP hydrolysis activity)
2017-01-02 Deleted RELATION is a GO:0043225 (ATPase-coupled inorganic anion transmembrane transporter activity)
2017-01-02 Added RELATION is a GO:0016887 (ATP hydrolysis activity)
2017-01-02 Added RELATION is a GO:0099095 (ligand-gated monoatomic anion channel activity)
2017-01-02 Added RELATION is a GO:0099142 (intracellularly ATP-gated ion channel activity)
2016-12-15 Added RELATION is a GO:0043225 (ATPase-coupled inorganic anion transmembrane transporter activity)
2016-12-15 Deleted RELATION is a GO:0042626 (ATPase-coupled transmembrane transporter activity)
2008-04-01 Updated RELATION is a GO:0005254 (chloride channel activity)
2008-04-01 Updated RELATION is a GO:0042626 (ATPase-coupled transmembrane transporter activity)
Timestamp Action Category Detail
2022-02-17 Added XREF TC:3.A.1.202.1
2022-02-17 Added XREF Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator
2019-09-30 Added XREF EC:5.6.1.6
2019-09-30 Deleted XREF EC:3.6.3.49
2007-07-11 Deleted XREF TC:3.A.1.202.1
2003-10-27 Added XREF MetaCyc:3.6.3.49-RXN
2003-10-27 Added XREF TC:3.A.1.202.1
2003-08-21 Deleted XREF TC:3.A.1.202.1
2001-03-30 Added XREF TC:3.A.1.202.1
2001-03-30 Added XREF EC:3.6.3.49
Timestamp Action Category Detail
2017-01-02 Added SECONDARY GO:0005224 (ATP-binding and phosphorylation-dependent chloride channel activity)
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