This term is obsolete.

GO:0005307 JSON

choline:sodium symporter activity

Molecular Function

Definition (GO:0005307 GONUTS page)

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).

3,874 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
sodium/choline symporter activity exact

Ancestor Chart

Ancestor chart for GO:0005307
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Ancestor chart

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A2WLC1 39946 CDT3_ORYSI GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6K7I4 10116 A6K7I4_RAT GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A7MB71 9913 AT1B4_BOVIN GO:0098662 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein B4YDY0 10090 B4YDY0_MOUSE GO:0006811 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18624921
NOT-qualified manual protein B8B2D0 39946 CDT1_ORYSI GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein D4ABB2 10116 D4ABB2_RAT GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q5VRD7 39947 CDT3_ORYSJ GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867
NOT-qualified manual protein Q5VSB5 39947 CDT1_ORYSJ GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867
NOT-qualified manual protein Q8CHM1 10116 AQP11_RAT GO:0006811 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000266, ECO:0000314 from these references: GO_REF:0000096, PMID:16650285
NOT-qualified manual protein Q8IWA5-3 9606 CTL2_HUMAN GO:0015871 2 NOT-qualified manual annotations exist with evidence code ECO:0000314 from these references: PMID:10677542, PMID:20665236

Cross-references

Database ID Description
RHEA 76443

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:29101 sodium(1+)
has_participant CHEBI CHEBI:15354 choline
has_primary_input CHEBI CHEBI:29101 sodium(1+)
has_primary_input CHEBI CHEBI:15354 choline

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005307 based on ALL annotations
The top 67 of 67 co-occurring terms
Co-occurring Term PR S% #Together #Compared
choline:sodium symporter activity
50,541.56 100.00 3,857 3,857
acetylcholine biosynthetic process
32,783.25 64.66 3,838 5,917
choline transmembrane transporter activity
9,283.56 18.18 3,647 19,855
synaptic transmission, cholinergic
7,307.21 10.07 960 6,640
choline transport
3,588.91 7.10 3,857 54,317
neuromuscular synaptic transmission
2,836.43 4.80 960 17,106
perikaryon
1,404.79 2.56 953 34,287
sodium ion transport
429.18 0.85 3,857 454,207
symporter activity
384.48 0.76 3,857 507,017
dendrite
258.56 0.50 953 186,285
Totals 44731 214654414
No co-occurrence statistics for GO:0005307 based on MANUAL annotations
The top 31 of 31 co-occurring terms
Co-occurring Term PR S% #Together #Compared
choline:sodium symporter activity
19,280.58 100.00 67 67
acetylcholine biosynthetic process
12,235.75 62.86 66 104
choline transport
7,574.51 39.05 66 168
synaptic transmission, cholinergic
1,149.17 5.13 18 302
neuromuscular synaptic transmission
871.99 4.03 18 398
choline transmembrane transporter activity
1,161.48 3.45 5 83
perikaryon
610.37 2.90 17 537
choline binding
2,570.74 2.50 2 15
neurotransmitter transport
198.77 0.61 1 97
clathrin-coated endocytic vesicle
122.81 0.45 1 157
Totals 413 359212

Change Log

Timestamp Action Category Detail
2024-04-05 Added XREF RHEA:76443
2020-06-02 Added RELATION is a GO:0015370 (solute:sodium symporter activity)
2020-06-02 Deleted RELATION is a GO:0005328 (neurotransmitter:sodium symporter activity)
2017-11-29 Deleted RELATION is a GO:0015370 (solute:sodium symporter activity)
2017-11-29 Added RELATION is a GO:0005328 (neurotransmitter:sodium symporter activity)
2017-10-13 Added DEFINITION Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).
2017-10-13 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).
2010-06-09 Updated TERM choline:sodium symporter activity
2010-06-08 Updated TERM choline:sodium symporter activity
2009-07-30 Added SYNONYM sodium/choline symporter activity
Timestamp Action Category Detail
2010-06-09 Updated TERM choline:sodium symporter activity
2010-06-08 Updated TERM choline:sodium symporter activity
2003-03-19 Updated TERM choline:sodium symporter activity
2002-02-06 Updated TERM choline:sodium symporter
2001-04-03 Updated TERM choline:sodium symporter
2001-03-30 Added TERM choline:sodium symporter
Timestamp Action Category Detail
2017-10-13 Added DEFINITION Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).
2017-10-13 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).
2009-07-30 Added SYNONYM sodium/choline symporter activity
2009-07-30 Deleted SYNONYM sodium/choline symporter
2008-05-13 Added DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).
2008-05-12 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).
2007-08-09 Deleted SYNONYM sodium/choline symporter
2007-08-09 Added SYNONYM sodium/choline symporter
2007-07-27 Updated DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).
2004-04-19 Added SYNONYM sodium/choline symporter
2004-04-16 Deleted SYNONYM sodium/choline symporter
2003-03-26 Added DEFINITION Catalysis of the reaction: choline(out) + Na+(out) = choline(in) + Na+(in).
2001-03-30 Added SYNONYM sodium/choline symporter
Timestamp Action Category Detail
2020-06-02 Added RELATION is a GO:0015370 (solute:sodium symporter activity)
2020-06-02 Deleted RELATION is a GO:0005328 (neurotransmitter:sodium symporter activity)
2017-11-29 Deleted RELATION is a GO:0015370 (solute:sodium symporter activity)
2017-11-29 Added RELATION is a GO:0005328 (neurotransmitter:sodium symporter activity)
2008-04-01 Updated RELATION is a GO:0015220 (choline transmembrane transporter activity)
2008-04-01 Updated RELATION is a GO:0015370 (solute:sodium symporter activity)
Timestamp Action Category Detail
2024-04-05 Added XREF RHEA:76443
2007-07-11 Deleted XREF TC:2.A.22.3.5
2001-03-30 Added XREF TC:2.A.22.3.5
Timestamp Action Category Detail
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