GO:0005391
JSON
P-type sodium:potassium-exchanging transporter activity
Molecular Function
Definition (GO:0005391 GONUTS page)
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
sodium:potassium-exchanging ATPase activity | exact |
Na(+)/K(+)-ATPase activity | related |
Na(+)/K(+)-exchanging ATPase activity | related |
Na+/K+-ATPase activity | related |
Na+,K+-ATPase activity | related |
Na+/K+-exchanging ATPase activity | related |
sodium:potassium exchanging ATPase activity | exact |
sodium/potassium-transporting ATPase activity | exact |
Na,K-activated ATPase activity | related |
P-type sodium:potassium-exchanging ATPase activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0005391
Child Term | Relationship to GO:0005391 |
---|---|
P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential
|
is_a |
regulation of P-type sodium:potassium-exchanging transporter activity
|
regulates |
positive regulation of P-type sodium:potassium-exchanging transporter activity
|
positively_regulates |
sodium:potassium-exchanging ATPase complex
|
capable_of |
negative regulation of P-type sodium:potassium-exchanging transporter activity
|
negatively_regulates |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A2WLC1 | 39946 | CDT3_ORYSI | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | A6K7I4 | 10116 | A6K7I4_RAT | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A7MB71 | 9913 | AT1B4_BOVIN | GO:0098662 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | B4YDY0 | 10090 | B4YDY0_MOUSE | GO:0006811 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18624921 | |
NOT-qualified manual | protein | B8B2D0 | 39946 | CDT1_ORYSI | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | D4ABB2 | 10116 | D4ABB2_RAT | GO:0034220 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q5VRD7 | 39947 | CDT3_ORYSJ | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867 | |
NOT-qualified manual | protein | Q5VSB5 | 39947 | CDT1_ORYSJ | GO:0030001 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867 | |
NOT-qualified manual | protein | Q8CHM1 | 10116 | AQP11_RAT | GO:0006811 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000266, ECO:0000314 from these references: GO_REF:0000096, PMID:16650285 | |
NOT-qualified manual | protein | Q8NBQ7 | 9606 | AQP11_HUMAN | GO:0006811 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16650285 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 7.2.2.13 | |
MetaCyc | 3.6.3.9-RXN | |
RHEA | 18353 | |
Reactome | R-HSA-936897 | |
TC | 3.A.3.1.1 | |
Wikipedia | ATPase,_Na%2B/K%2B_transporting,_alpha_1 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:29103 | potassium(1+) |
has_participant | CHEBI | CHEBI:29101 | sodium(1+) |
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:43474 | hydrogenphosphate |
has_participant | CHEBI | CHEBI:15377 | water |
has_primary_input | CHEBI | CHEBI:29103 | potassium(1+) |
has_primary_input | CHEBI | CHEBI:29101 | sodium(1+) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005391 based on ALL annotations
The top 100 of 573 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
P-type sodium:potassium-exchanging transporter activity
|
5,776.99 | 100.00 | 33,744 | 33,744 |
establishment or maintenance of transmembrane electrochemical gradient
|
5,746.34 | 99.47 | 33,744 | 33,924 |
intracellular sodium ion homeostasis
|
4,775.57 | 82.63 | 33,725 | 40,797 |
intracellular potassium ion homeostasis
|
4,151.36 | 71.83 | 33,724 | 46,930 |
sodium ion export across plasma membrane
|
3,398.21 | 58.81 | 33,728 | 57,338 |
potassium ion import across plasma membrane
|
2,316.46 | 40.09 | 33,726 | 84,109 |
P-type potassium transmembrane transporter activity
|
748.61 | 9.35 | 8,478 | 65,424 |
sodium:potassium-exchanging ATPase complex
|
1,209.59 | 4.92 | 2,040 | 9,743 |
P-type ion transporter activity
|
281.06 | 3.44 | 3,531 | 72,576 |
P-type potassium:proton transporter activity
|
5,374.08 | 2.80 | 947 | 1,018 |
Totals | 378017 | 58295226 |
No co-occurrence statistics for GO:0005391 based on MANUAL annotations
The top 100 of 368 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
P-type sodium:potassium-exchanging transporter activity
|
6,151.42 | 100.00 | 210 | 210 |
sodium ion export across plasma membrane
|
3,554.16 | 53.06 | 182 | 315 |
intracellular sodium ion homeostasis
|
3,226.40 | 48.53 | 182 | 347 |
intracellular potassium ion homeostasis
|
2,961.19 | 44.69 | 181 | 376 |
potassium ion import across plasma membrane
|
1,093.72 | 17.29 | 181 | 1,018 |
sodium:potassium-exchanging ATPase complex
|
1,762.69 | 14.76 | 49 | 171 |
proton transmembrane transport
|
835.61 | 13.25 | 177 | 1,303 |
P-type potassium:proton transporter activity
|
3,645.29 | 7.24 | 16 | 27 |
establishment or maintenance of transmembrane electrochemical gradient
|
2,288.90 | 6.75 | 16 | 43 |
potassium ion binding
|
1,230.28 | 6.38 | 18 | 90 |
Totals | 1643 | 19997 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-11 | Updated | TERM | P-type sodium:potassium-exchanging transporter activity |
2021-02-11 | Added | SYNONYM | P-type sodium:potassium-exchanging ATPase activity |
2021-02-11 | Added | XREF | TC:3.A.3.1.1 |
2021-02-11 | Deleted | RELATION | is a GO:0022853 (active monoatomic ion transmembrane transporter activity) |
2021-02-11 | Deleted | RELATION | is a GO:0015079 (potassium ion transmembrane transporter activity) |
2021-02-11 | Added | RELATION | is a GO:0008554 (P-type sodium transporter activity) |
2021-02-11 | Deleted | RELATION | is a GO:0140358 (P-type transmembrane transporter activity) |
2021-02-11 | Deleted | RELATION | is a GO:0015081 (sodium ion transmembrane transporter activity) |
2021-02-11 | Deleted | SYNONYM | P-type sodium:potassium-exchanging ATPase activity |
2021-02-11 | Added | RELATION | is a GO:0008556 (P-type potassium transmembrane transporter activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-11 | Updated | TERM | P-type sodium:potassium-exchanging transporter activity |
2020-12-17 | Updated | TERM | P-type sodium:potassium-exchanging ATPase activity |
2010-06-09 | Updated | TERM | sodium:potassium-exchanging ATPase activity |
2010-06-08 | Updated | TERM | sodium:potassium-exchanging ATPase activity |
2004-07-26 | Updated | TERM | sodium:potassium-exchanging ATPase activity |
2003-03-19 | Updated | TERM | sodium/potassium-exchanging ATPase activity |
2002-02-06 | Updated | TERM | sodium/potassium-exchanging ATPase |
2001-04-03 | Updated | TERM | sodium/potassium-exchanging ATPase |
2001-03-30 | Added | TERM | sodium/potassium-exchanging ATPase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-11 | Added | SYNONYM | P-type sodium:potassium-exchanging ATPase activity |
2021-02-11 | Deleted | SYNONYM | P-type sodium:potassium-exchanging ATPase activity |
2020-12-17 | Added | SYNONYM | sodium:potassium-exchanging ATPase activity |
2020-10-08 | Deleted | SYNONYM | Na,K-activated ATPase activity |
2020-10-08 | Deleted | SYNONYM | Na+,K+-ATPase activity |
2020-10-08 | Deleted | SYNONYM | Na+/K+-exchanging ATPase activity |
2020-10-08 | Deleted | SYNONYM | Na(+)/K(+)-exchanging ATPase activity |
2020-10-08 | Deleted | SYNONYM | Na(+)/K(+)-ATPase activity |
2020-10-08 | Added | SYNONYM | Na+,K+-ATPase activity |
2020-10-08 | Added | SYNONYM | Na+/K+-ATPase activity |
2020-10-08 | Added | SYNONYM | Na(+)/K(+)-ATPase activity |
2020-10-08 | Added | SYNONYM | Na,K-activated ATPase activity |
2020-10-08 | Deleted | SYNONYM | Na+/K+-ATPase activity |
2020-10-08 | Added | SYNONYM | Na+/K+-exchanging ATPase activity |
2020-10-08 | Added | SYNONYM | Na(+)/K(+)-exchanging ATPase activity |
2019-05-29 | Added | SYNONYM | P-type sodium:potassium-exchanging ATPase activity |
2019-05-23 | Deleted | SYNONYM | Na+,K+ pump |
2019-05-23 | Deleted | SYNONYM | Na,K-pump |
2019-05-23 | Deleted | SYNONYM | (Na+ + K+)-activated ATPase activity |
2019-05-23 | Deleted | SYNONYM | ATP phosphohydrolase (Na+/K+-exchanging) |
2019-05-23 | Deleted | SYNONYM | (Na+ + K+)-ATPase activity |
2017-10-13 | Added | DEFINITION | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
2017-10-13 | Deleted | DEFINITION | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
2011-10-28 | Deleted | SYNONYM | na+/K+-exchanging ATPase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
2007-11-08 | Added | SYNONYM | Na+/K+-ATPase activity |
2007-11-08 | Added | SYNONYM | Na+/K+-exchanging ATPase activity |
2007-11-08 | Added | SYNONYM | Na,K-pump |
2007-11-08 | Added | SYNONYM | na+/K+-exchanging ATPase activity |
2007-11-08 | Added | SYNONYM | (Na+ + K+)-activated ATPase activity |
2007-11-08 | Added | SYNONYM | (Na+ + K+)-ATPase activity |
2007-11-08 | Added | SYNONYM | Na+,K+ pump |
2007-11-08 | Added | SYNONYM | ATP phosphohydrolase (Na+/K+-exchanging) |
2007-11-08 | Added | SYNONYM | Na+,K+-ATPase activity |
2007-09-06 | Added | SYNONYM | Na(+)/K(+)-ATPase activity |
2007-09-06 | Added | SYNONYM | sodium/potassium-transporting ATPase activity |
2007-09-06 | Added | SYNONYM | Na,K-activated ATPase activity |
2007-09-06 | Added | SYNONYM | Na(+)/K(+)-exchanging ATPase activity |
2007-08-09 | Deleted | SYNONYM | sodium:potassium exchanging ATPase activity |
2007-08-09 | Added | SYNONYM | sodium:potassium exchanging ATPase activity |
2007-08-09 | Deleted | SYNONYM | sodium/potassium-exchanging ATPase activity |
2007-08-09 | Deleted | SYNONYM | sodium pump |
2007-08-09 | Added | SYNONYM | sodium pump |
2007-08-09 | Added | SYNONYM | sodium/potassium-exchanging ATPase activity |
2007-07-27 | Updated | DEFINITION | Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
2005-07-29 | Added | SYNONYM | sodium:potassium exchanging ATPase activity |
2004-07-26 | Added | SYNONYM | sodium/potassium-exchanging ATPase activity |
2004-04-19 | Added | SYNONYM | sodium pump |
2004-04-16 | Deleted | SYNONYM | sodium pump |
2003-10-27 | Added | SYNONYM | sodium pump |
2003-08-21 | Deleted | SYNONYM | sodium pump |
2003-03-26 | Updated | DEFINITION | Catalysis of the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
2002-11-27 | Updated | DEFINITION | Catalysis of the efflux of three sodium ions and influx of two potassium ions per ATP hydrolyzed. It is apparently involved in generating the plasma membrane electrical potential. |
2001-08-06 | Added | DEFINITION | A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three sodium ions and influx of two potassium ions per ATP hydrolysed. It is apparently involved in generating the plasma membrane electrical potential. |
2001-03-30 | Added | SYNONYM | sodium pump |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-11 | Deleted | RELATION | is a GO:0022853 (active monoatomic ion transmembrane transporter activity) |
2021-02-11 | Deleted | RELATION | is a GO:0015079 (potassium ion transmembrane transporter activity) |
2021-02-11 | Added | RELATION | is a GO:0008554 (P-type sodium transporter activity) |
2021-02-11 | Deleted | RELATION | is a GO:0140358 (P-type transmembrane transporter activity) |
2021-02-11 | Deleted | RELATION | is a GO:0015081 (sodium ion transmembrane transporter activity) |
2021-02-11 | Added | RELATION | is a GO:0008556 (P-type potassium transmembrane transporter activity) |
2021-01-30 | Deleted | RELATION | is a GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity) |
2021-01-30 | Added | RELATION | is a GO:0022853 (active monoatomic ion transmembrane transporter activity) |
2020-12-17 | Added | RELATION | is a GO:0140358 (P-type transmembrane transporter activity) |
2020-12-17 | Added | RELATION | is a GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity) |
2020-12-17 | Added | RELATION | is a GO:0015081 (sodium ion transmembrane transporter activity) |
2020-12-17 | Added | RELATION | is a GO:0015079 (potassium ion transmembrane transporter activity) |
2020-12-17 | Deleted | RELATION | is a GO:0008556 (P-type potassium transmembrane transporter activity) |
2020-12-17 | Deleted | RELATION | is a GO:0008554 (P-type sodium transporter activity) |
2019-05-31 | Added | RELATION | is a GO:0008554 (P-type sodium transporter activity) |
2019-05-31 | Deleted | RELATION | is a GO:0015081 (sodium ion transmembrane transporter activity) |
2018-02-09 | Deleted | RELATION | part of GO:0090662 (ATP hydrolysis coupled transmembrane transport) |
2017-11-22 | Added | RELATION | part of GO:0090662 (ATP hydrolysis coupled transmembrane transport) |
2017-11-08 | Deleted | RELATION | part of GO:0090662 (ATP hydrolysis coupled transmembrane transport) |
2017-05-22 | Added | RELATION | part of GO:0090662 (ATP hydrolysis coupled transmembrane transport) |
2017-04-06 | Deleted | RELATION | part of GO:0090662 (ATP hydrolysis coupled transmembrane transport) |
2015-10-23 | Added | RELATION | part of GO:0090662 (ATP hydrolysis coupled transmembrane transport) |
2015-10-23 | Added | RELATION | part of GO:0010248 (establishment or maintenance of transmembrane electrochemical gradient) |
2010-09-03 | Deleted | RELATION | is a GO:0015662 (P-type ion transporter activity) |
2010-06-08 | Added | RELATION | is a GO:0015081 (sodium ion transmembrane transporter activity) |
2010-06-04 | Added | RELATION | is a GO:0008556 (P-type potassium transmembrane transporter activity) |
2008-04-01 | Updated | RELATION | is a GO:0015662 (P-type ion transporter activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-11 | Added | XREF | TC:3.A.3.1.1 |
2020-12-17 | Added | XREF | Wikipedia:ATPase,_Na%2B/K%2B_transporting,_alpha_1 |
2019-05-23 | Added | XREF | EC:7.2.2.13 |
2019-05-23 | Deleted | XREF | EC:3.6.3.9 |
2019-04-01 | Added | XREF | Reactome:R-HSA-936897 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-936897 |
2018-12-11 | Added | XREF | reactome:R-HSA-936897 |
2018-07-13 | Added | XREF | RHEA:18353 |
2018-07-13 | Deleted | XREF | RHEA:18356 |
2011-09-16 | Added | XREF | RHEA:18356 |
2007-07-11 | Deleted | XREF | TC:3.A.3.1.2 |
2007-07-11 | Deleted | XREF | TC:3.A.3.1.1 |
2003-10-27 | Added | XREF | TC:3.A.3.1.2 |
2003-10-27 | Added | XREF | TC:3.A.3.1.1 |
2003-10-27 | Added | XREF | MetaCyc:3.6.3.9-RXN |
2003-08-21 | Deleted | XREF | TC:3.A.3.1.1 |
2003-08-21 | Deleted | XREF | TC:3.A.3.1.2 |
2001-03-30 | Added | XREF | EC:3.6.3.9 |
2001-03-30 | Added | XREF | TC:3.A.3.1.1 |
2001-03-30 | Added | XREF | TC:3.A.3.1.2 |
Timestamp | Action | Category | Detail |
---|
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link