This term is obsolete.

GO:0005391 JSON

P-type sodium:potassium-exchanging transporter activity

Molecular Function

Definition (GO:0005391 GONUTS page)

Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).

33,904 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
sodium:potassium-exchanging ATPase activity exact
Na(+)/K(+)-ATPase activity related
Na(+)/K(+)-exchanging ATPase activity related
Na+/K+-ATPase activity related
Na+,K+-ATPase activity related
Na+/K+-exchanging ATPase activity related
sodium:potassium exchanging ATPase activity exact
sodium/potassium-transporting ATPase activity exact
Na,K-activated ATPase activity related
P-type sodium:potassium-exchanging ATPase activity exact

Ancestor Chart

Ancestor chart for GO:0005391
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005391

Child Term Relationship to
GO:0005391
P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential
is_a
regulation of P-type sodium:potassium-exchanging transporter activity
regulates
positive regulation of P-type sodium:potassium-exchanging transporter activity
positively_regulates
sodium:potassium-exchanging ATPase complex
capable_of
negative regulation of P-type sodium:potassium-exchanging transporter activity
negatively_regulates

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A2WLC1 39946 CDT3_ORYSI GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein A6K7I4 10116 A6K7I4_RAT GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A7MB71 9913 AT1B4_BOVIN GO:0098662 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein B4YDY0 10090 B4YDY0_MOUSE GO:0006811 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18624921
NOT-qualified manual protein B8B2D0 39946 CDT1_ORYSI GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein D4ABB2 10116 D4ABB2_RAT GO:0034220 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q5VRD7 39947 CDT3_ORYSJ GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867
NOT-qualified manual protein Q5VSB5 39947 CDT1_ORYSJ GO:0030001 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23888867
NOT-qualified manual protein Q8CHM1 10116 AQP11_RAT GO:0006811 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000266, ECO:0000314 from these references: GO_REF:0000096, PMID:16650285
NOT-qualified manual protein Q8NBQ7 9606 AQP11_HUMAN GO:0006811 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16650285

Cross-references

Database ID Description
EC 7.2.2.13
MetaCyc 3.6.3.9-RXN
RHEA 18353
Reactome R-HSA-936897
TC 3.A.3.1.1
Wikipedia ATPase,_Na%2B/K%2B_transporting,_alpha_1

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:29103 potassium(1+)
has_participant CHEBI CHEBI:29101 sodium(1+)
has_participant CHEBI CHEBI:456216 ADP(3-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:43474 hydrogenphosphate
has_participant CHEBI CHEBI:15377 water
has_primary_input CHEBI CHEBI:29103 potassium(1+)
has_primary_input CHEBI CHEBI:29101 sodium(1+)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005391 based on ALL annotations
The top 100 of 573 co-occurring terms
Co-occurring Term PR S% #Together #Compared
P-type sodium:potassium-exchanging transporter activity
5,776.99 100.00 33,744 33,744
establishment or maintenance of transmembrane electrochemical gradient
5,746.34 99.47 33,744 33,924
intracellular sodium ion homeostasis
4,775.57 82.63 33,725 40,797
intracellular potassium ion homeostasis
4,151.36 71.83 33,724 46,930
sodium ion export across plasma membrane
3,398.21 58.81 33,728 57,338
potassium ion import across plasma membrane
2,316.46 40.09 33,726 84,109
P-type potassium transmembrane transporter activity
748.61 9.35 8,478 65,424
sodium:potassium-exchanging ATPase complex
1,209.59 4.92 2,040 9,743
P-type ion transporter activity
281.06 3.44 3,531 72,576
P-type potassium:proton transporter activity
5,374.08 2.80 947 1,018
Totals 378017 58295226
No co-occurrence statistics for GO:0005391 based on MANUAL annotations
The top 100 of 368 co-occurring terms
Co-occurring Term PR S% #Together #Compared
P-type sodium:potassium-exchanging transporter activity
6,151.42 100.00 210 210
sodium ion export across plasma membrane
3,554.16 53.06 182 315
intracellular sodium ion homeostasis
3,226.40 48.53 182 347
intracellular potassium ion homeostasis
2,961.19 44.69 181 376
potassium ion import across plasma membrane
1,093.72 17.29 181 1,018
sodium:potassium-exchanging ATPase complex
1,762.69 14.76 49 171
proton transmembrane transport
835.61 13.25 177 1,303
P-type potassium:proton transporter activity
3,645.29 7.24 16 27
establishment or maintenance of transmembrane electrochemical gradient
2,288.90 6.75 16 43
potassium ion binding
1,230.28 6.38 18 90
Totals 1643 19997

Change Log

Timestamp Action Category Detail
2021-02-11 Updated TERM P-type sodium:potassium-exchanging transporter activity
2021-02-11 Added SYNONYM P-type sodium:potassium-exchanging ATPase activity
2021-02-11 Added XREF TC:3.A.3.1.1
2021-02-11 Deleted RELATION is a GO:0022853 (active monoatomic ion transmembrane transporter activity)
2021-02-11 Deleted RELATION is a GO:0015079 (potassium ion transmembrane transporter activity)
2021-02-11 Added RELATION is a GO:0008554 (P-type sodium transporter activity)
2021-02-11 Deleted RELATION is a GO:0140358 (P-type transmembrane transporter activity)
2021-02-11 Deleted RELATION is a GO:0015081 (sodium ion transmembrane transporter activity)
2021-02-11 Deleted SYNONYM P-type sodium:potassium-exchanging ATPase activity
2021-02-11 Added RELATION is a GO:0008556 (P-type potassium transmembrane transporter activity)
Timestamp Action Category Detail
2021-02-11 Updated TERM P-type sodium:potassium-exchanging transporter activity
2020-12-17 Updated TERM P-type sodium:potassium-exchanging ATPase activity
2010-06-09 Updated TERM sodium:potassium-exchanging ATPase activity
2010-06-08 Updated TERM sodium:potassium-exchanging ATPase activity
2004-07-26 Updated TERM sodium:potassium-exchanging ATPase activity
2003-03-19 Updated TERM sodium/potassium-exchanging ATPase activity
2002-02-06 Updated TERM sodium/potassium-exchanging ATPase
2001-04-03 Updated TERM sodium/potassium-exchanging ATPase
2001-03-30 Added TERM sodium/potassium-exchanging ATPase
Timestamp Action Category Detail
2021-02-11 Added SYNONYM P-type sodium:potassium-exchanging ATPase activity
2021-02-11 Deleted SYNONYM P-type sodium:potassium-exchanging ATPase activity
2020-12-17 Added SYNONYM sodium:potassium-exchanging ATPase activity
2020-10-08 Deleted SYNONYM Na,K-activated ATPase activity
2020-10-08 Deleted SYNONYM Na+,K+-ATPase activity
2020-10-08 Deleted SYNONYM Na+/K+-exchanging ATPase activity
2020-10-08 Deleted SYNONYM Na(+)/K(+)-exchanging ATPase activity
2020-10-08 Deleted SYNONYM Na(+)/K(+)-ATPase activity
2020-10-08 Added SYNONYM Na+,K+-ATPase activity
2020-10-08 Added SYNONYM Na+/K+-ATPase activity
2020-10-08 Added SYNONYM Na(+)/K(+)-ATPase activity
2020-10-08 Added SYNONYM Na,K-activated ATPase activity
2020-10-08 Deleted SYNONYM Na+/K+-ATPase activity
2020-10-08 Added SYNONYM Na+/K+-exchanging ATPase activity
2020-10-08 Added SYNONYM Na(+)/K(+)-exchanging ATPase activity
2019-05-29 Added SYNONYM P-type sodium:potassium-exchanging ATPase activity
2019-05-23 Deleted SYNONYM Na+,K+ pump
2019-05-23 Deleted SYNONYM Na,K-pump
2019-05-23 Deleted SYNONYM (Na+ + K+)-activated ATPase activity
2019-05-23 Deleted SYNONYM ATP phosphohydrolase (Na+/K+-exchanging)
2019-05-23 Deleted SYNONYM (Na+ + K+)-ATPase activity
2017-10-13 Added DEFINITION Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2017-10-13 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2011-10-28 Deleted SYNONYM na+/K+-exchanging ATPase activity
2008-05-13 Added DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2008-05-12 Deleted DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2007-11-08 Added SYNONYM Na+/K+-ATPase activity
2007-11-08 Added SYNONYM Na+/K+-exchanging ATPase activity
2007-11-08 Added SYNONYM Na,K-pump
2007-11-08 Added SYNONYM na+/K+-exchanging ATPase activity
2007-11-08 Added SYNONYM (Na+ + K+)-activated ATPase activity
2007-11-08 Added SYNONYM (Na+ + K+)-ATPase activity
2007-11-08 Added SYNONYM Na+,K+ pump
2007-11-08 Added SYNONYM ATP phosphohydrolase (Na+/K+-exchanging)
2007-11-08 Added SYNONYM Na+,K+-ATPase activity
2007-09-06 Added SYNONYM Na(+)/K(+)-ATPase activity
2007-09-06 Added SYNONYM sodium/potassium-transporting ATPase activity
2007-09-06 Added SYNONYM Na,K-activated ATPase activity
2007-09-06 Added SYNONYM Na(+)/K(+)-exchanging ATPase activity
2007-08-09 Deleted SYNONYM sodium:potassium exchanging ATPase activity
2007-08-09 Added SYNONYM sodium:potassium exchanging ATPase activity
2007-08-09 Deleted SYNONYM sodium/potassium-exchanging ATPase activity
2007-08-09 Deleted SYNONYM sodium pump
2007-08-09 Added SYNONYM sodium pump
2007-08-09 Added SYNONYM sodium/potassium-exchanging ATPase activity
2007-07-27 Updated DEFINITION Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2005-07-29 Added SYNONYM sodium:potassium exchanging ATPase activity
2004-07-26 Added SYNONYM sodium/potassium-exchanging ATPase activity
2004-04-19 Added SYNONYM sodium pump
2004-04-16 Deleted SYNONYM sodium pump
2003-10-27 Added SYNONYM sodium pump
2003-08-21 Deleted SYNONYM sodium pump
2003-03-26 Updated DEFINITION Catalysis of the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2002-11-27 Updated DEFINITION Catalysis of the efflux of three sodium ions and influx of two potassium ions per ATP hydrolyzed. It is apparently involved in generating the plasma membrane electrical potential.
2001-08-06 Added DEFINITION A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three sodium ions and influx of two potassium ions per ATP hydrolysed. It is apparently involved in generating the plasma membrane electrical potential.
2001-03-30 Added SYNONYM sodium pump
Timestamp Action Category Detail
2021-02-11 Deleted RELATION is a GO:0022853 (active monoatomic ion transmembrane transporter activity)
2021-02-11 Deleted RELATION is a GO:0015079 (potassium ion transmembrane transporter activity)
2021-02-11 Added RELATION is a GO:0008554 (P-type sodium transporter activity)
2021-02-11 Deleted RELATION is a GO:0140358 (P-type transmembrane transporter activity)
2021-02-11 Deleted RELATION is a GO:0015081 (sodium ion transmembrane transporter activity)
2021-02-11 Added RELATION is a GO:0008556 (P-type potassium transmembrane transporter activity)
2021-01-30 Deleted RELATION is a GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity)
2021-01-30 Added RELATION is a GO:0022853 (active monoatomic ion transmembrane transporter activity)
2020-12-17 Added RELATION is a GO:0140358 (P-type transmembrane transporter activity)
2020-12-17 Added RELATION is a GO:0019829 (ATPase-coupled monoatomic cation transmembrane transporter activity)
2020-12-17 Added RELATION is a GO:0015081 (sodium ion transmembrane transporter activity)
2020-12-17 Added RELATION is a GO:0015079 (potassium ion transmembrane transporter activity)
2020-12-17 Deleted RELATION is a GO:0008556 (P-type potassium transmembrane transporter activity)
2020-12-17 Deleted RELATION is a GO:0008554 (P-type sodium transporter activity)
2019-05-31 Added RELATION is a GO:0008554 (P-type sodium transporter activity)
2019-05-31 Deleted RELATION is a GO:0015081 (sodium ion transmembrane transporter activity)
2018-02-09 Deleted RELATION part of GO:0090662 (ATP hydrolysis coupled transmembrane transport)
2017-11-22 Added RELATION part of GO:0090662 (ATP hydrolysis coupled transmembrane transport)
2017-11-08 Deleted RELATION part of GO:0090662 (ATP hydrolysis coupled transmembrane transport)
2017-05-22 Added RELATION part of GO:0090662 (ATP hydrolysis coupled transmembrane transport)
2017-04-06 Deleted RELATION part of GO:0090662 (ATP hydrolysis coupled transmembrane transport)
2015-10-23 Added RELATION part of GO:0090662 (ATP hydrolysis coupled transmembrane transport)
2015-10-23 Added RELATION part of GO:0010248 (establishment or maintenance of transmembrane electrochemical gradient)
2010-09-03 Deleted RELATION is a GO:0015662 (P-type ion transporter activity)
2010-06-08 Added RELATION is a GO:0015081 (sodium ion transmembrane transporter activity)
2010-06-04 Added RELATION is a GO:0008556 (P-type potassium transmembrane transporter activity)
2008-04-01 Updated RELATION is a GO:0015662 (P-type ion transporter activity)
Timestamp Action Category Detail
2021-02-11 Added XREF TC:3.A.3.1.1
2020-12-17 Added XREF Wikipedia:ATPase,_Na%2B/K%2B_transporting,_alpha_1
2019-05-23 Added XREF EC:7.2.2.13
2019-05-23 Deleted XREF EC:3.6.3.9
2019-04-01 Added XREF Reactome:R-HSA-936897
2019-04-01 Deleted XREF reactome:R-HSA-936897
2018-12-11 Added XREF reactome:R-HSA-936897
2018-07-13 Added XREF RHEA:18353
2018-07-13 Deleted XREF RHEA:18356
2011-09-16 Added XREF RHEA:18356
2007-07-11 Deleted XREF TC:3.A.3.1.2
2007-07-11 Deleted XREF TC:3.A.3.1.1
2003-10-27 Added XREF TC:3.A.3.1.2
2003-10-27 Added XREF TC:3.A.3.1.1
2003-10-27 Added XREF MetaCyc:3.6.3.9-RXN
2003-08-21 Deleted XREF TC:3.A.3.1.1
2003-08-21 Deleted XREF TC:3.A.3.1.2
2001-03-30 Added XREF EC:3.6.3.9
2001-03-30 Added XREF TC:3.A.3.1.1
2001-03-30 Added XREF TC:3.A.3.1.2
Timestamp Action Category Detail
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