This term is obsolete.

GO:0005540 JSON

hyaluronic acid binding

Molecular Function

Definition (GO:0005540 GONUTS page)

Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.

19,910 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
hyaluronan binding exact

Ancestor Chart

Ancestor chart for GO:0005540
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Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2K2H3 10116 A0A0G2K2H3_RAT GO:0005540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JL46 10116 A6JL46_RAT GO:0005540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6KG22 10116 A6KG22_RAT GO:0005540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6X935 10090 ITIH4_MOUSE GO:0005540 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:11803570
NOT-qualified manual protein D3ZFC6 10116 D3ZFC6_RAT GO:0005540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZI86 10116 D3ZI86_RAT GO:0005540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EYF5 10116 F7EYF5_RAT GO:0005540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O35802 10116 O35802_RAT GO:0005540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q5EBC0 10116 Q5EBC0_RAT GO:0005540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q6QN14 9606 U17L6_HUMAN GO:0005540 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:17109758

Cross-references

Database ID Description
InterPro IPR000538 Link domain
InterPro IPR026203 Intracellular hyaluronic acid binding protein
InterPro IPR043210 CD44 antigen-like
UniProtKB-KW KW-0373 Hyaluronic acid

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:16336 hyaluronic acid

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005540 based on ALL annotations
The top 100 of 503 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0005540
hyaluronic acid binding
10,013.38 100.00 19,789 19,789
GO:0072534
perineuronal net
8,996.36 37.74 7,802 8,684
GO:0010001
glial cell differentiation
7,094.59 33.32 7,642 10,786
GO:0002052
positive regulation of neuroblast proliferation
6,650.64 32.31 7,642 11,506
GO:0001501
skeletal system development
3,770.01 23.79 7,766 20,627
GO:0033165
interphotoreceptor matrix
9,264.19 15.37 3,079 3,328
GO:0007417
central nervous system development
1,584.21 12.71 7,766 49,087
GO:0035692
macrophage migration inhibitory factor receptor complex
9,546.62 9.77 1,943 2,038
GO:0001750
photoreceptor outer segment
1,698.35 8.83 3,075 18,130
GO:0001917
photoreceptor inner segment
1,068.20 5.71 2,168 20,323
Totals 152574 7867602
No co-occurrence statistics for GO:0005540 based on MANUAL annotations
The top 100 of 261 co-occurring terms
Co-occurring Term PR S% #Together #Compared
GO:0005540
hyaluronic acid binding
9,048.29 100.00 156 156
GO:0035692
macrophage migration inhibitory factor receptor complex
8,042.92 15.09 24 27
GO:0030294
receptor signaling protein tyrosine kinase inhibitor activity
8,545.61 10.83 17 18
GO:0061099
negative regulation of protein tyrosine kinase activity
6,409.20 10.43 17 24
GO:0033906
hyaluronoglucuronidase activity
4,157.32 9.66 17 37
GO:0042117
monocyte activation
3,944.13 9.55 17 39
GO:0019064
fusion of virus membrane with host plasma membrane
3,845.52 9.50 17 40
GO:0006027
glycosaminoglycan catabolic process
2,604.81 9.36 19 66
GO:0004415
hyalurononglucosaminidase activity
1,925.17 8.70 20 94
GO:0070295
renal water absorption
2,698.61 8.67 17 57
Totals 1131 27774

Change Log

Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2020-11-03 Deleted RELATION is a GO:0031406 (carboxylic acid binding)
2017-04-06 Added RELATION is a GO:0031406 (carboxylic acid binding)
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2009-07-03 Deleted DEFINITION Interacting selectively with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2008-05-13 Added DEFINITION Interacting selectively with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2008-05-12 Deleted DEFINITION Interacting selectively with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2008-04-01 Updated RELATION is a GO:0005539 (glycosaminoglycan binding)
2007-08-09 Deleted SYNONYM hyaluronan binding
Timestamp Action Category Detail
2003-06-10 Updated TERM hyaluronic acid binding
2003-03-19 Updated TERM hyaluronic acid binding activity
2002-02-06 Updated TERM hyaluronic acid binding
2001-04-03 Updated TERM hyaluronic acid binding
2001-03-30 Added TERM hyaluronic acid binding
Timestamp Action Category Detail
2021-05-24 Added DEFINITION Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2009-07-03 Deleted DEFINITION Interacting selectively with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2008-05-13 Added DEFINITION Interacting selectively with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2008-05-12 Deleted DEFINITION Interacting selectively with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
2007-08-09 Deleted SYNONYM hyaluronan binding
2007-08-09 Added SYNONYM hyaluronan binding
2005-12-21 Added SYNONYM hyaluronan binding
2003-03-26 Added DEFINITION Interacting selectively with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
Timestamp Action Category Detail
2020-11-03 Deleted RELATION is a GO:0031406 (carboxylic acid binding)
2017-04-06 Added RELATION is a GO:0031406 (carboxylic acid binding)
2008-04-01 Updated RELATION is a GO:0005539 (glycosaminoglycan binding)
Timestamp Action Category Detail
Timestamp Action Category Detail
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