This term is obsolete.
Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.

GO:0005680 JSON

anaphase-promoting complex

Cellular Component

Definition (GO:0005680 GONUTS page)

A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. PMID:10465783 PMID:10611969

Comments

Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.

69,133 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cyclosome exact
anaphase promoting complex exact
APC broad

Ancestor Chart

Ancestor chart for GO:0005680
Chart options
Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005680 anaphase-promoting complex Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2JW23 10116 A0A0G2JW23_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K8T1 10116 A0A0G2K8T1_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1B0GR71 10090 A0A1B0GR71_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1B0GRK6 10090 A0A1B0GRK6_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1D8PHF8 237561 A0A1D8PHF8_CANAL GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y8H4 10116 A0A8I5Y8H4_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A0E5 10116 A0A8I6A0E5_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR007192 Cdc23
InterPro IPR008401 Apc13
InterPro IPR008402 Anaphase-promoting complex subunit 15/mnd2
InterPro IPR016807 Anaphase-promoting complex subunit Mnd2
InterPro IPR016901 Anaphase-promoting complex subunit APC10/Doc1
InterPro IPR017169 Anaphase-promoting complex subunit 4, metazoa
InterPro IPR018860 Anaphase-promoting complex, subunit CDC26
InterPro IPR024274 Anaphase-promoting complex, subunit 9
InterPro IPR024789 Anaphase-promoting complex subunit 4
InterPro IPR024990 Anaphase-promoting complex subunit 1

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0090620 obsolete APC-Cdc20 complex consider GO:0005680
GO:0090621 obsolete APC-fizzy-related complex consider GO:0005680
GO:1990857 obsolete APC-Fzr1/Mfr1 complex consider GO:0005680

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005680 based on ALL annotations
The top 100 of 1,087 co-occurring terms
Co-occurring Term PR S% #Together #Compared
anaphase-promoting complex
2,916.23 100.00 67,949 67,949
anaphase-promoting complex-dependent catabolic process
2,795.11 78.86 55,479 57,883
protein K11-linked ubiquitination
2,738.41 36.81 25,625 27,289
positive regulation of mitotic metaphase/anaphase transition
2,675.42 24.86 17,276 18,831
metaphase/anaphase transition of mitotic cell cycle
2,874.28 22.21 15,141 15,362
positive regulation of anaphase-promoting complex-dependent catabolic process
2,907.11 21.10 14,348 14,393
ubiquitin ligase activator activity
2,810.27 20.95 14,348 14,889
ubiquitin-protein transferase activator activity
2,728.89 20.81 14,348 15,333
anaphase-promoting complex binding
2,279.02 20.04 14,428 18,462
nuclear periphery
670.01 5.23 4,312 18,768
Totals 372547 19084467
No co-occurrence statistics for GO:0005680 based on MANUAL annotations
The top 100 of 283 co-occurring terms
Co-occurring Term PR S% #Together #Compared
anaphase-promoting complex
770.49 100.00 1,832 1,832
anaphase-promoting complex-dependent catabolic process
674.37 64.98 1,312 1,499
protein K11-linked ubiquitination
621.86 34.19 682 845
positive regulation of mitotic metaphase/anaphase transition
727.91 28.45 530 561
positive regulation of anaphase-promoting complex-dependent catabolic process
766.05 28.23 518 521
ubiquitin ligase activator activity
719.12 27.72 518 555
anaphase-promoting complex binding
699.22 27.59 520 573
metaphase/anaphase transition of mitotic cell cycle
709.31 19.90 371 403
cell division
302.65 18.65 480 1,222
protein branched polyubiquitination
616.39 4.96 92 115
Totals 9208 371063

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2011-03-23 Added RELATION is a GO:0031461 (cullin-RING ubiquitin ligase complex)
2009-02-05 Added XREF Wikipedia:Anaphase-promoting_complex
2008-08-31 Added SYNONYM APC
2008-08-31 Deleted SYNONYM APC
2008-05-13 Added DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
2008-05-12 Deleted DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
2008-04-01 Updated RELATION is a GO:0000152 (nuclear ubiquitin ligase complex)
2007-08-09 Added SYNONYM APC
2007-08-09 Deleted SYNONYM anaphase promoting complex
Timestamp Action Category Detail
2002-02-06 Updated TERM anaphase-promoting complex
2001-04-03 Updated TERM anaphase-promoting complex
2001-03-30 Added TERM anaphase-promoting complex
Timestamp Action Category Detail
2008-08-31 Added SYNONYM APC
2008-08-31 Deleted SYNONYM APC
2008-05-13 Added DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
2008-05-12 Deleted DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
2007-08-09 Added SYNONYM APC
2007-08-09 Deleted SYNONYM anaphase promoting complex
2007-08-09 Deleted SYNONYM cyclosome
2007-08-09 Deleted SYNONYM APC
2007-08-09 Added SYNONYM cyclosome
2007-08-09 Added SYNONYM anaphase promoting complex
2006-08-28 Added SYNONYM anaphase promoting complex
2005-04-20 Updated DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
2004-04-19 Added SYNONYM APC
2004-04-19 Added SYNONYM cyclosome
2004-04-16 Deleted SYNONYM cyclosome
2004-04-16 Deleted SYNONYM APC
2001-08-06 Added DEFINITION A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.
2001-03-30 Added SYNONYM cyclosome
2001-03-30 Added SYNONYM APC
Timestamp Action Category Detail
2011-03-23 Added RELATION is a GO:0031461 (cullin-RING ubiquitin ligase complex)
2008-04-01 Updated RELATION is a GO:0000152 (nuclear ubiquitin ligase complex)
Timestamp Action Category Detail
2009-02-05 Added XREF Wikipedia:Anaphase-promoting_complex
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.