Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
GO:0005680
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anaphase-promoting complex
Cellular Component
Definition (GO:0005680 GONUTS page)
A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. PMID:10465783 PMID:10611969
Comments
Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
cyclosome | exact |
APC | broad |
anaphase promoting complex | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0005680 | anaphase-promoting complex | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2JW23 | 10116 | A0A0G2JW23_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K8T1 | 10116 | A0A0G2K8T1_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1B0GR71 | 10090 | A0A1B0GR71_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1B0GRK6 | 10090 | A0A1B0GRK6_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1D8PHF8 | 237561 | A0A1D8PHF8_CANAL | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y8H4 | 10116 | A0A8I5Y8H4_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A0E5 | 10116 | A0A8I6A0E5_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR007192 | Cdc23 |
InterPro | IPR008401 | Apc13 |
InterPro | IPR008402 | Anaphase-promoting complex subunit 15/mnd2 |
InterPro | IPR016807 | Anaphase-promoting complex subunit Mnd2 |
InterPro | IPR016901 | Anaphase-promoting complex subunit APC10/Doc1 |
InterPro | IPR017169 | Anaphase-promoting complex subunit 4, metazoa |
InterPro | IPR018860 | Anaphase-promoting complex, subunit CDC26 |
InterPro | IPR024274 | Anaphase-promoting complex, subunit 9 |
InterPro | IPR024789 | Anaphase-promoting complex subunit 4 |
InterPro | IPR024990 | Anaphase-promoting complex subunit 1 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0090620 | obsolete APC-Cdc20 complex | consider GO:0005680 |
GO:0090621 | obsolete APC-fizzy-related complex | consider GO:0005680 |
GO:1990857 | obsolete APC-Fzr1/Mfr1 complex | consider GO:0005680 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005680 based on ALL annotations
The top 100 of 1,092 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
anaphase-promoting complex
|
2,954.02 | 100.00 | 65,991 | 65,991 |
anaphase-promoting complex-dependent catabolic process
|
2,828.52 | 78.26 | 53,504 | 55,878 |
protein K11-linked ubiquitination
|
2,769.00 | 36.57 | 24,738 | 26,391 |
positive regulation of mitotic metaphase/anaphase transition
|
2,702.19 | 24.66 | 16,653 | 18,205 |
metaphase/anaphase transition of mitotic cell cycle
|
2,909.99 | 22.06 | 14,606 | 14,827 |
positive regulation of anaphase-promoting complex-dependent catabolic process
|
2,944.33 | 20.71 | 13,679 | 13,724 |
ubiquitin ligase activator activity
|
2,841.83 | 20.56 | 13,679 | 14,219 |
ubiquitin-protein transferase activator activity
|
2,748.86 | 20.41 | 13,680 | 14,701 |
anaphase-promoting complex binding
|
2,290.89 | 19.66 | 13,760 | 17,743 |
nuclear periphery
|
671.06 | 5.20 | 4,169 | 18,352 |
Totals | 354279 | 13513062 |
No co-occurrence statistics for GO:0005680 based on MANUAL annotations
The top 100 of 292 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
anaphase-promoting complex
|
769.84 | 100.00 | 1,678 | 1,678 |
anaphase-promoting complex-dependent catabolic process
|
670.01 | 65.02 | 1,208 | 1,388 |
protein K11-linked ubiquitination
|
622.74 | 34.74 | 635 | 785 |
positive regulation of mitotic metaphase/anaphase transition
|
723.59 | 28.38 | 485 | 516 |
positive regulation of anaphase-promoting complex-dependent catabolic process
|
764.89 | 27.54 | 463 | 466 |
ubiquitin ligase activator activity
|
714.30 | 27.01 | 463 | 499 |
anaphase-promoting complex binding
|
691.08 | 26.86 | 465 | 518 |
metaphase/anaphase transition of mitotic cell cycle
|
704.67 | 20.23 | 346 | 378 |
cell division
|
304.53 | 18.93 | 447 | 1,130 |
protein branched polyubiquitination
|
615.88 | 5.41 | 92 | 115 |
Totals | 8489 | 331921 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2011-03-23 | Added | RELATION | is a GO:0031461 (cullin-RING ubiquitin ligase complex) |
2009-02-05 | Added | XREF | Wikipedia:Anaphase-promoting_complex |
2008-08-31 | Added | SYNONYM | APC |
2008-08-31 | Deleted | SYNONYM | APC |
2008-05-13 | Added | DEFINITION | A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. |
2008-05-12 | Deleted | DEFINITION | A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. |
2008-04-01 | Updated | RELATION | is a GO:0000152 (nuclear ubiquitin ligase complex) |
2007-08-09 | Added | SYNONYM | APC |
2007-08-09 | Deleted | SYNONYM | APC |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-02-06 | Updated | TERM | anaphase-promoting complex |
2001-04-03 | Updated | TERM | anaphase-promoting complex |
2001-03-30 | Added | TERM | anaphase-promoting complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-08-31 | Added | SYNONYM | APC |
2008-08-31 | Deleted | SYNONYM | APC |
2008-05-13 | Added | DEFINITION | A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. |
2008-05-12 | Deleted | DEFINITION | A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. |
2007-08-09 | Added | SYNONYM | APC |
2007-08-09 | Deleted | SYNONYM | APC |
2007-08-09 | Deleted | SYNONYM | anaphase promoting complex |
2007-08-09 | Added | SYNONYM | cyclosome |
2007-08-09 | Added | SYNONYM | anaphase promoting complex |
2007-08-09 | Deleted | SYNONYM | cyclosome |
2006-08-28 | Added | SYNONYM | anaphase promoting complex |
2005-04-20 | Updated | DEFINITION | A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. |
2004-04-19 | Added | SYNONYM | APC |
2004-04-19 | Added | SYNONYM | cyclosome |
2004-04-16 | Deleted | SYNONYM | APC |
2004-04-16 | Deleted | SYNONYM | cyclosome |
2001-08-06 | Added | DEFINITION | A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. |
2001-03-30 | Added | SYNONYM | cyclosome |
2001-03-30 | Added | SYNONYM | APC |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-03-23 | Added | RELATION | is a GO:0031461 (cullin-RING ubiquitin ligase complex) |
2008-04-01 | Updated | RELATION | is a GO:0000152 (nuclear ubiquitin ligase complex) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-02-05 | Added | XREF | Wikipedia:Anaphase-promoting_complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
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