GO:0005681
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spliceosomal complex
Cellular Component
Definition (GO:0005681 GONUTS page)
Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. PMID:19239890
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
spliceosome complex | exact |
spliceosome | broad |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0005681
Child Term | Relationship to GO:0005681 |
---|---|
U2-type spliceosomal complex
|
is_a |
prespliceosome
|
is_a |
post-spliceosomal complex
|
is_a |
U12-type spliceosomal complex
|
is_a |
catalytic step 2 spliceosome
|
is_a |
post-mRNA release spliceosomal complex
|
is_a |
supraspliceosomal complex
|
is_a |
precatalytic spliceosome
|
is_a |
trans spliceosomal complex
|
is_a |
catalytic step 1 spliceosome
|
is_a |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0005681 | spliceosomal complex | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2JW23 | 10116 | A0A0G2JW23_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K8T1 | 10116 | A0A0G2K8T1_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1B0GR71 | 10090 | A0A1B0GR71_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1B0GRK6 | 10090 | A0A1B0GRK6_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1D8PHF8 | 237561 | A0A1D8PHF8_CANAL | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y8H4 | 10116 | A0A8I5Y8H4_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A0E5 | 10116 | A0A8I6A0E5_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR004015 | SKI-interacting protein SKIP, SNW domain |
InterPro | IPR004098 | Prp18 |
InterPro | IPR006973 | Pre-mRNA-splicing factor Cwf15/Cwc15 |
InterPro | IPR017364 | Gem-associated protein 2 |
InterPro | IPR017862 | SKI-interacting protein, SKIP |
InterPro | IPR024598 | Splicing factor SF3a60 /Prp9 subunit, C-terminal |
InterPro | IPR026300 | CWF11 family |
InterPro | IPR027078 | Small nuclear ribonucleoprotein E |
InterPro | IPR027652 | Pre-mRNA-processing-splicing factor 8 |
InterPro | IPR034098 | Small nuclear ribonucleoprotein G |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex | consider GO:0005681 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005681 based on ALL annotations
The top 100 of 2,690 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
spliceosomal complex
|
754.88 | 100.00 | 258,238 | 258,238 |
RNA splicing
|
353.54 | 40.61 | 194,595 | 415,501 |
mRNA splicing, via spliceosome
|
342.38 | 33.76 | 146,920 | 323,929 |
mRNA processing
|
193.94 | 23.70 | 194,640 | 757,621 |
catalytic step 2 spliceosome
|
253.58 | 13.85 | 49,248 | 146,604 |
Prp19 complex
|
589.14 | 11.76 | 31,413 | 40,250 |
U4/U6 x U5 tri-snRNP complex
|
160.91 | 10.72 | 45,832 | 215,007 |
U5 snRNP
|
442.87 | 9.49 | 26,275 | 44,786 |
spliceosomal snRNP assembly
|
409.30 | 8.80 | 24,548 | 45,274 |
precatalytic spliceosome
|
259.84 | 8.34 | 25,607 | 74,394 |
Totals | 1917832 | 37866253 |
No co-occurrence statistics for GO:0005681 based on MANUAL annotations
The top 100 of 727 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
spliceosomal complex
|
466.52 | 100.00 | 2,769 | 2,769 |
mRNA splicing, via spliceosome
|
72.68 | 13.50 | 1,393 | 8,942 |
positive regulation of mRNA splicing, via spliceosome
|
335.98 | 11.46 | 332 | 461 |
U2AF complex
|
262.20 | 9.96 | 299 | 532 |
pre-mRNA 3'-splice site binding
|
256.94 | 9.74 | 293 | 532 |
mRNA cis splicing, via spliceosome
|
155.69 | 8.36 | 278 | 833 |
U5 snRNP
|
84.36 | 6.39 | 249 | 1,377 |
helicase activity
|
78.08 | 5.99 | 236 | 1,410 |
U4/U6 x U5 tri-snRNP complex
|
59.27 | 5.97 | 280 | 2,204 |
Prp19 complex
|
78.29 | 5.20 | 194 | 1,156 |
Totals | 11631 | 488199 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_pir | 439 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2020-11-03 | Added | RELATION | is a GO:0140513 (nuclear protein-containing complex) |
2020-11-03 | Deleted | RELATION | part of GO:0005634 (nucleus) |
2019-09-12 | Deleted | RELATION | is a GO:0044428 (obsolete nuclear part) |
2019-09-12 | Added | RELATION | part of GO:0005634 (nucleus) |
2018-03-11 | Deleted | RELATION | is a GO:0030529 (intracellular ribonucleoprotein complex) |
2018-03-11 | Added | RELATION | is a GO:1990904 (ribonucleoprotein complex) |
2015-03-16 | Deleted | DEFINITION | Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron. |
2015-03-16 | Added | DEFINITION | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
2013-04-18 | Updated | SUBSET | goslim_pir |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-08-03 | Updated | TERM | spliceosomal complex |
2007-01-15 | Updated | TERM | spliceosome |
2002-05-24 | Updated | TERM | spliceosome complex |
2002-02-06 | Updated | TERM | spliceosome |
2001-04-03 | Updated | TERM | spliceosome |
2001-03-30 | Added | TERM | spliceosome |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-03-16 | Deleted | DEFINITION | Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron. |
2015-03-16 | Added | DEFINITION | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
2012-03-17 | Added | SYNONYM | spliceosome |
2009-08-03 | Added | DEFINITION | Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron. |
2009-08-03 | Deleted | DEFINITION | A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron. |
2008-05-13 | Added | DEFINITION | A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron. |
2008-05-12 | Deleted | DEFINITION | A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron. |
2007-08-09 | Added | SYNONYM | spliceosome complex |
2007-08-09 | Deleted | SYNONYM | spliceosome complex |
2007-01-15 | Added | SYNONYM | spliceosome complex |
2001-08-06 | Added | DEFINITION | A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-03 | Added | RELATION | is a GO:0140513 (nuclear protein-containing complex) |
2020-11-03 | Deleted | RELATION | part of GO:0005634 (nucleus) |
2019-09-12 | Deleted | RELATION | is a GO:0044428 (obsolete nuclear part) |
2019-09-12 | Added | RELATION | part of GO:0005634 (nucleus) |
2018-03-11 | Deleted | RELATION | is a GO:0030529 (intracellular ribonucleoprotein complex) |
2018-03-11 | Added | RELATION | is a GO:1990904 (ribonucleoprotein complex) |
2008-04-01 | Updated | RELATION | is a GO:0030529 (intracellular ribonucleoprotein complex) |
2008-04-01 | Updated | RELATION | is a GO:0044428 (obsolete nuclear part) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-02-05 | Added | XREF | Wikipedia:Spliceosome |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2013-04-18 | Updated | SUBSET | goslim_pir |
2008-06-09 | Added | SUBSET | goslim_pir |
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