This term is obsolete.

GO:0005681 JSON

spliceosomal complex

Cellular Component

Definition (GO:0005681 GONUTS page)

Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. PMID:19239890

670,565 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
spliceosome complex exact
spliceosome broad

Ancestor Chart

Ancestor chart for GO:0005681
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005681

Child Term Relationship to
GO:0005681
U2-type spliceosomal complex
is_a
prespliceosome
is_a
post-spliceosomal complex
is_a
U12-type spliceosomal complex
is_a
catalytic step 2 spliceosome
is_a
post-mRNA release spliceosomal complex
is_a
supraspliceosomal complex
is_a
precatalytic spliceosome
is_a
trans spliceosomal complex
is_a
catalytic step 1 spliceosome
is_a

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005681 spliceosomal complex Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2JW23 10116 A0A0G2JW23_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K8T1 10116 A0A0G2K8T1_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1B0GR71 10090 A0A1B0GR71_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1B0GRK6 10090 A0A1B0GRK6_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1D8PHF8 237561 A0A1D8PHF8_CANAL GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y8H4 10116 A0A8I5Y8H4_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A0E5 10116 A0A8I6A0E5_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR004015 SKI-interacting protein SKIP, SNW domain
InterPro IPR004098 Prp18
InterPro IPR006973 Pre-mRNA-splicing factor Cwf15/Cwc15
InterPro IPR017364 Gem-associated protein 2
InterPro IPR017862 SKI-interacting protein, SKIP
InterPro IPR024598 Splicing factor SF3a60 /Prp9 subunit, C-terminal
InterPro IPR026300 CWF11 family
InterPro IPR027078 Small nuclear ribonucleoprotein E
InterPro IPR027652 Pre-mRNA-processing-splicing factor 8
InterPro IPR034098 Small nuclear ribonucleoprotein G

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0030530 obsolete heterogeneous nuclear ribonucleoprotein complex consider GO:0005681

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005681 based on ALL annotations
The top 100 of 2,690 co-occurring terms
Co-occurring Term PR S% #Together #Compared
spliceosomal complex
754.88 100.00 258,238 258,238
RNA splicing
353.54 40.61 194,595 415,501
mRNA splicing, via spliceosome
342.38 33.76 146,920 323,929
mRNA processing
193.94 23.70 194,640 757,621
catalytic step 2 spliceosome
253.58 13.85 49,248 146,604
Prp19 complex
589.14 11.76 31,413 40,250
U4/U6 x U5 tri-snRNP complex
160.91 10.72 45,832 215,007
U5 snRNP
442.87 9.49 26,275 44,786
spliceosomal snRNP assembly
409.30 8.80 24,548 45,274
precatalytic spliceosome
259.84 8.34 25,607 74,394
Totals 1917832 37866253
No co-occurrence statistics for GO:0005681 based on MANUAL annotations
The top 100 of 727 co-occurring terms
Co-occurring Term PR S% #Together #Compared
spliceosomal complex
466.52 100.00 2,769 2,769
mRNA splicing, via spliceosome
72.68 13.50 1,393 8,942
positive regulation of mRNA splicing, via spliceosome
335.98 11.46 332 461
U2AF complex
262.20 9.96 299 532
pre-mRNA 3'-splice site binding
256.94 9.74 293 532
mRNA cis splicing, via spliceosome
155.69 8.36 278 833
U5 snRNP
84.36 6.39 249 1,377
helicase activity
78.08 5.99 236 1,410
U4/U6 x U5 tri-snRNP complex
59.27 5.97 280 2,204
Prp19 complex
78.29 5.20 194 1,156
Totals 11631 488199

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_pir 439

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2020-11-03 Added RELATION is a GO:0140513 (nuclear protein-containing complex)
2020-11-03 Deleted RELATION part of GO:0005634 (nucleus)
2019-09-12 Deleted RELATION is a GO:0044428 (obsolete nuclear part)
2019-09-12 Added RELATION part of GO:0005634 (nucleus)
2018-03-11 Deleted RELATION is a GO:0030529 (intracellular ribonucleoprotein complex)
2018-03-11 Added RELATION is a GO:1990904 (ribonucleoprotein complex)
2015-03-16 Deleted DEFINITION Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron.
2015-03-16 Added DEFINITION Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
2013-04-18 Updated SUBSET goslim_pir
Timestamp Action Category Detail
2009-08-03 Updated TERM spliceosomal complex
2007-01-15 Updated TERM spliceosome
2002-05-24 Updated TERM spliceosome complex
2002-02-06 Updated TERM spliceosome
2001-04-03 Updated TERM spliceosome
2001-03-30 Added TERM spliceosome
Timestamp Action Category Detail
2015-03-16 Deleted DEFINITION Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron.
2015-03-16 Added DEFINITION Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
2012-03-17 Added SYNONYM spliceosome
2009-08-03 Added DEFINITION Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron.
2009-08-03 Deleted DEFINITION A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron.
2008-05-13 Added DEFINITION A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron.
2008-05-12 Deleted DEFINITION A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron.
2007-08-09 Added SYNONYM spliceosome complex
2007-08-09 Deleted SYNONYM spliceosome complex
2007-01-15 Added SYNONYM spliceosome complex
2001-08-06 Added DEFINITION A ribonucleoprotein complex, containing RNA and small nuclear ribonucleoproteins (snRNPs) that is assembled during the splicing of messenger RNA primary transcript to excise an intron.
Timestamp Action Category Detail
2020-11-03 Added RELATION is a GO:0140513 (nuclear protein-containing complex)
2020-11-03 Deleted RELATION part of GO:0005634 (nucleus)
2019-09-12 Deleted RELATION is a GO:0044428 (obsolete nuclear part)
2019-09-12 Added RELATION part of GO:0005634 (nucleus)
2018-03-11 Deleted RELATION is a GO:0030529 (intracellular ribonucleoprotein complex)
2018-03-11 Added RELATION is a GO:1990904 (ribonucleoprotein complex)
2008-04-01 Updated RELATION is a GO:0030529 (intracellular ribonucleoprotein complex)
2008-04-01 Updated RELATION is a GO:0044428 (obsolete nuclear part)
Timestamp Action Category Detail
2009-02-05 Added XREF Wikipedia:Spliceosome
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2013-04-18 Updated SUBSET goslim_pir
2008-06-09 Added SUBSET goslim_pir
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