GO:0005770
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late endosome
Cellular Component
Definition (GO:0005770 GONUTS page)
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. PMID:11964142 PMID:2557062
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
prevacuolar compartment | exact |
PVC | broad |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0005770
Child Term | Relationship to GO:0005770 |
---|---|
multivesicular body
|
is_a |
late endosome lumen
|
part_of |
Mon1-Ccz1 complex
|
part_of |
late endosome membrane
|
part_of |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0005770 | late endosome | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0D1E8X3 | 237631 | A0A0D1E8X3_USTMA | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A0G2JZ79 | 10116 | SIR1_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1D8PHF8 | 237561 | A0A1D8PHF8_CANAL | GO:0031410 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936 | |
NOT-qualified manual | protein | A0A1L8G9S0 | 8355 | A0A1L8G9S0_XENLA | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4L3K3 | 6945 | A0A1S4L3K3_IXOSC | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A2K5ATM2 | 6239 | A0A2K5ATM2_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2K5ATM9 | 6239 | A0A2K5ATM9_CAEEL | GO:0005737 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR029867 | StAR-related lipid transfer protein 3, C-terminal |
InterPro | IPR033759 | Systemic RNA interference defective protein 5 |
NIF_Subcellular | nlx_subcell_20090702 | |
UniProtKB-SubCell | SL-0152 | Late endosome |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005770 based on ALL annotations
The top 100 of 3,704 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
late endosome
|
1,819.72 | 100.00 | 107,126 | 107,126 |
early endosome
|
355.46 | 12.73 | 28,684 | 146,843 |
protein targeting to vacuole
|
487.02 | 10.97 | 16,786 | 62,720 |
endosome to lysosome transport
|
750.07 | 9.82 | 12,231 | 29,673 |
endosomal vesicle fusion
|
982.67 | 9.77 | 11,418 | 21,144 |
HOPS complex
|
805.91 | 9.59 | 11,676 | 26,364 |
phagocytic vesicle
|
803.01 | 9.11 | 11,033 | 25,002 |
macroautophagy
|
615.65 | 8.71 | 11,253 | 33,261 |
lysosome
|
194.23 | 8.24 | 28,471 | 266,736 |
early endosome to late endosome transport
|
1,067.13 | 7.85 | 8,902 | 15,180 |
Totals | 649189 | 12419023 |
No co-occurrence statistics for GO:0005770 based on MANUAL annotations
The top 100 of 3,000 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
late endosome
|
603.36 | 100.00 | 2,141 | 2,141 |
lysosome
|
118.33 | 12.99 | 595 | 3,034 |
protein targeting to vacuole
|
159.74 | 12.20 | 395 | 1,492 |
endosomal vesicle fusion
|
327.23 | 11.36 | 269 | 496 |
HOPS complex
|
258.72 | 10.93 | 274 | 639 |
early endosome
|
100.76 | 10.88 | 509 | 3,048 |
endosomal transport
|
83.19 | 6.54 | 237 | 1,719 |
phagocytic vesicle
|
127.84 | 6.46 | 182 | 859 |
retromer complex
|
171.92 | 6.19 | 157 | 551 |
regulation of autophagosome maturation
|
457.85 | 5.91 | 129 | 170 |
Totals | 10705 | 145415 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2014-10-05 | Added | XREF | NIF_Subcellular:nlx_subcell_20090702 |
2008-05-13 | Added | DEFINITION | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
2008-05-12 | Deleted | DEFINITION | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
2008-04-01 | Updated | RELATION | is a GO:0005768 (endosome) |
2007-08-09 | Deleted | SYNONYM | prevacuolar compartment |
2007-08-09 | Deleted | SYNONYM | PVC |
2007-08-09 | Added | SYNONYM | prevacuolar compartment |
2007-08-09 | Added | SYNONYM | PVC |
2006-08-15 | Updated | DEFINITION | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-02-06 | Updated | TERM | late endosome |
2001-04-03 | Updated | TERM | late endosome |
2001-03-30 | Added | TERM | late endosome |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
2008-05-12 | Deleted | DEFINITION | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
2007-08-09 | Deleted | SYNONYM | prevacuolar compartment |
2007-08-09 | Deleted | SYNONYM | PVC |
2007-08-09 | Added | SYNONYM | prevacuolar compartment |
2007-08-09 | Added | SYNONYM | PVC |
2006-08-15 | Updated | DEFINITION | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
2004-04-26 | Added | SYNONYM | PVC |
2004-04-19 | Added | SYNONYM | prevacuolar compartment |
2004-04-16 | Deleted | SYNONYM | prevacuolar compartment |
2004-03-19 | Updated | DEFINITION | A prelysosomal endocytic organelle defined by the time it takes for endocytosed macromolecules to be delivered. The time of delivery may vary ; for example, late endosomes are usually loaded 4-30 min after endocytic uptake in mammalian cells. late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. They are differentiated from early endosomes by their lower lumenal pH and different protein composition. |
2004-03-12 | Updated | DEFINITION | A prelysosomal endocytic organelle defined by the time it takes for endocytosed macromolecules to be delivered. The time of delivery may vary ; for example, late endosomes are usually loaded 4-30?min after endocytic uptake in mammalian cells. late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. They are differentiated from early endosomes by their lower lumenal pH and different protein composition. |
2004-03-11 | Added | DEFINITION | A prelysosomal endocytic organelle defined by the time it takes for endocytosed macromolecules to be delivered. The time of delivery may vary ; for example, late endosomes are usually loaded 4-30�min after endocytic uptake in mammalian cells. late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. They are differentiated from early endosomes by their lower lumenal pH and different protein composition. |
2002-08-20 | Added | SYNONYM | prevacuolar compartment |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0005768 (endosome) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2014-10-05 | Added | XREF | NIF_Subcellular:nlx_subcell_20090702 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
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