This term is obsolete.

GO:0005770 JSON

late endosome

Cellular Component

Definition (GO:0005770 GONUTS page)

A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. PMID:11964142 PMID:2557062

257,586 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
prevacuolar compartment exact
PVC broad

Ancestor Chart

Ancestor chart for GO:0005770
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005770

Child Term Relationship to
GO:0005770
multivesicular body
is_a
late endosome lumen
part_of
Mon1-Ccz1 complex
part_of
late endosome membrane
part_of

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005770 late endosome Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0D1E8X3 237631 A0A0D1E8X3_USTMA GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A0G2JZ79 10116 SIR1_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1D8PHF8 237561 A0A1D8PHF8_CANAL GO:0031410 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936
NOT-qualified manual protein A0A1L8G9S0 8355 A0A1L8G9S0_XENLA GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4L3K3 6945 A0A1S4L3K3_IXOSC GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A2K5ATM2 6239 A0A2K5ATM2_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2K5ATM9 6239 A0A2K5ATM9_CAEEL GO:0005737 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR029867 StAR-related lipid transfer protein 3, C-terminal
InterPro IPR033759 Systemic RNA interference defective protein 5
NIF_Subcellular nlx_subcell_20090702
UniProtKB-SubCell SL-0152 Late endosome

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005770 based on ALL annotations
The top 100 of 3,704 co-occurring terms
Co-occurring Term PR S% #Together #Compared
late endosome
1,819.72 100.00 107,126 107,126
early endosome
355.46 12.73 28,684 146,843
protein targeting to vacuole
487.02 10.97 16,786 62,720
endosome to lysosome transport
750.07 9.82 12,231 29,673
endosomal vesicle fusion
982.67 9.77 11,418 21,144
HOPS complex
805.91 9.59 11,676 26,364
phagocytic vesicle
803.01 9.11 11,033 25,002
macroautophagy
615.65 8.71 11,253 33,261
lysosome
194.23 8.24 28,471 266,736
early endosome to late endosome transport
1,067.13 7.85 8,902 15,180
Totals 649189 12419023
No co-occurrence statistics for GO:0005770 based on MANUAL annotations
The top 100 of 3,000 co-occurring terms
Co-occurring Term PR S% #Together #Compared
late endosome
603.36 100.00 2,141 2,141
lysosome
118.33 12.99 595 3,034
protein targeting to vacuole
159.74 12.20 395 1,492
endosomal vesicle fusion
327.23 11.36 269 496
HOPS complex
258.72 10.93 274 639
early endosome
100.76 10.88 509 3,048
endosomal transport
83.19 6.54 237 1,719
phagocytic vesicle
127.84 6.46 182 859
retromer complex
171.92 6.19 157 551
regulation of autophagosome maturation
457.85 5.91 129 170
Totals 10705 145415

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2014-10-05 Added XREF NIF_Subcellular:nlx_subcell_20090702
2008-05-13 Added DEFINITION A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2008-05-12 Deleted DEFINITION A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2008-04-01 Updated RELATION is a GO:0005768 (endosome)
2007-08-09 Deleted SYNONYM prevacuolar compartment
2007-08-09 Deleted SYNONYM PVC
2007-08-09 Added SYNONYM prevacuolar compartment
2007-08-09 Added SYNONYM PVC
2006-08-15 Updated DEFINITION A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
Timestamp Action Category Detail
2002-02-06 Updated TERM late endosome
2001-04-03 Updated TERM late endosome
2001-03-30 Added TERM late endosome
Timestamp Action Category Detail
2008-05-13 Added DEFINITION A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2008-05-12 Deleted DEFINITION A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2007-08-09 Deleted SYNONYM prevacuolar compartment
2007-08-09 Deleted SYNONYM PVC
2007-08-09 Added SYNONYM prevacuolar compartment
2007-08-09 Added SYNONYM PVC
2006-08-15 Updated DEFINITION A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2004-04-26 Added SYNONYM PVC
2004-04-19 Added SYNONYM prevacuolar compartment
2004-04-16 Deleted SYNONYM prevacuolar compartment
2004-03-19 Updated DEFINITION A prelysosomal endocytic organelle defined by the time it takes for endocytosed macromolecules to be delivered. The time of delivery may vary ; for example, late endosomes are usually loaded 4-30 min after endocytic uptake in mammalian cells. late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. They are differentiated from early endosomes by their lower lumenal pH and different protein composition.
2004-03-12 Updated DEFINITION A prelysosomal endocytic organelle defined by the time it takes for endocytosed macromolecules to be delivered. The time of delivery may vary ; for example, late endosomes are usually loaded 4-30?min after endocytic uptake in mammalian cells. late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. They are differentiated from early endosomes by their lower lumenal pH and different protein composition.
2004-03-11 Added DEFINITION A prelysosomal endocytic organelle defined by the time it takes for endocytosed macromolecules to be delivered. The time of delivery may vary ; for example, late endosomes are usually loaded 4-30�min after endocytic uptake in mammalian cells. late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. They are differentiated from early endosomes by their lower lumenal pH and different protein composition.
2002-08-20 Added SYNONYM prevacuolar compartment
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0005768 (endosome)
Timestamp Action Category Detail
2014-10-05 Added XREF NIF_Subcellular:nlx_subcell_20090702
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
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