This term is obsolete.

GO:0005856 JSON

cytoskeleton

Cellular Component

Definition (GO:0005856 GONUTS page)

A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. PMID:16959967 PMID:27419875

4,512,072 annotations

Ancestor Chart

Ancestor chart for GO:0005856
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005856

Child Term Relationship to
GO:0005856
axoneme
part_of
septin cap
part_of
tubulin complex
part_of
cortical cytoskeleton
is_a
intermediate filament cytoskeleton
is_a
contractile vacuole pore
part_of
ciliary microtubule quartet
part_of
septin filament array
part_of
postsynaptic cytoskeleton
is_a
microtubule cytoskeleton
is_a

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005856 cytoskeleton Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5ZRZ8 10116 A0A8I5ZRZ8_RAT GO:0005856 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZT22 10116 A0A8I5ZT22_RAT GO:0005856 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6IVM5 10116 A6IVM5_RAT GO:0005856 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6IVM6 10116 A6IVM6_RAT GO:0005856 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZJL1 10116 D3ZJL1_RAT GO:0005856 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q9Y4C4 9606 MFHA1_HUMAN GO:0005856 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:24286120

Cross-references

Database ID Description
InterPro IPR000299 FERM domain
InterPro IPR000857 MyTH4 domain
InterPro IPR001101 Plectin repeat
InterPro IPR007204 Actin-related protein 2/3 complex subunit 3
InterPro IPR007477 SAB domain
InterPro IPR008379 Band 4.1, C-terminal
InterPro IPR017354 Vasodilator-stimulated phosphoprotein/ENA/VASP-like
InterPro IPR028288 SCAR/WAVE family
InterPro IPR029774 Centriole, cilia and spindle-associated protein
InterPro IPR029775 Nephrocystin-4

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0044430 obsolete cytoskeletal part consider GO:0005856

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0005856 based on ALL annotations
The top 100 of 9,867 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cytoskeleton
160.01 100.00 1,218,329 1,218,329
microtubule
111.47 26.58 366,209 525,653
microtubule binding
74.31 13.78 199,552 429,694
actin binding
57.17 12.64 199,244 557,639
microtubule-based movement
86.03 9.96 132,712 246,841
cell projection
61.03 9.72 140,530 368,432
centrosome
81.44 9.22 123,285 242,205
actin filament binding
47.66 7.61 112,902 379,052
spindle
121.57 7.52 93,807 123,469
microtubule motor activity
93.57 6.76 86,541 147,982
Totals 6525499 59221140
No co-occurrence statistics for GO:0005856 based on MANUAL annotations
The top 100 of 2,926 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cytoskeleton
379.72 100.00 3,402 3,402
cortical cytoskeleton organization
316.23 14.91 523 628
regulation of cell shape
129.92 13.93 647 1,891
establishment or maintenance of cell polarity
194.83 13.55 529 1,031
regulation of actin cytoskeleton organization
130.43 13.16 598 1,741
cell projection
151.39 11.87 492 1,234
actomyosin structure organization
262.49 11.49 412 596
actin filament organization
68.45 10.82 725 4,022
intermediate filament organization
160.81 8.93 346 817
cytoplasmic vesicle
63.84 8.86 537 3,194
Totals 19096 367756

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_candida 86
goslim_generic 141
goslim_pir 439
goslim_plant 97
goslim_yeast 163
goslim_prokaryote 97
goslim_chembl 296
goslim_mouse 45
goslim_agr 53
goslim_flybase_ribbon 44
goslim_drosophila 173
goslim_plant_ribbon 62
goslim_euk_cellular_processes_ribbon 61

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2024-03-22 Added SUBSET goslim_euk_cellular_processes_ribbon
2024-03-21 Added SUBSET goslim_plant_ribbon
2023-12-15 Added SUBSET goslim_prokaryote
2022-04-08 Deleted SUBSET goslim_aspergillus
2022-04-05 Deleted DEFINITION Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2022-04-05 Added DEFINITION A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2020-02-28 Deleted XREF MIPS_funcat:70.04
2019-11-09 Added SUBSET goslim_drosophila
2019-05-04 Added XREF MIPS_funcat:70.04
Timestamp Action Category Detail
2002-02-06 Updated TERM cytoskeleton
2001-04-03 Updated TERM cytoskeleton
2001-03-30 Added TERM cytoskeleton
Timestamp Action Category Detail
2022-04-05 Deleted DEFINITION Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2022-04-05 Added DEFINITION A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2008-05-13 Added DEFINITION Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2008-05-12 Deleted DEFINITION Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2007-05-27 Updated DEFINITION Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2007-02-20 Updated DEFINITION Any of the various filamentous elements that form the internal framework of eukaryotic cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2002-11-27 Updated DEFINITION Any of the various filamentous elements within the cytoplasm of eukaryotic cells that remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
2001-08-06 Added DEFINITION Any of the various filamentous elements within the cytoplasm of eukaryotic cells that remain after treatment of the cells with mild detergent to remove membrane constituents and soluble componens of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
Timestamp Action Category Detail
2016-12-15 Deleted RELATION is a GO:0005575 (cellular_component)
2016-12-15 Added RELATION is a GO:0043232 (intracellular membraneless organelle)
2016-12-09 Deleted RELATION is a GO:0043232 (intracellular membraneless organelle)
2016-12-09 Added RELATION is a GO:0005575 (cellular_component)
2008-04-01 Updated RELATION is a GO:0043232 (intracellular membraneless organelle)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:70.04
2019-05-04 Added XREF MIPS_funcat:70.04
2009-02-08 Added XREF Wikipedia:Cytoskeleton
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2024-03-22 Added SUBSET goslim_euk_cellular_processes_ribbon
2024-03-21 Added SUBSET goslim_plant_ribbon
2023-12-15 Added SUBSET goslim_prokaryote
2022-04-08 Deleted SUBSET goslim_aspergillus
2019-11-09 Added SUBSET goslim_drosophila
2018-09-22 Added SUBSET goslim_flybase_ribbon
2017-03-04 Added SUBSET goslim_agr
2016-12-17 Added SUBSET goslim_mouse
2016-07-23 Deleted SUBSET goslim_metagenomics
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-11 Added SUBSET goslim_ChEMBL
2013-04-18 Updated SUBSET goslim_aspergillus
2013-04-18 Updated SUBSET goslim_metagenomics
2013-04-18 Updated SUBSET goslim_candida
2013-04-18 Updated SUBSET goslim_generic
2013-04-18 Updated SUBSET goslim_pir
2013-04-18 Updated SUBSET goslim_plant
2013-04-18 Updated SUBSET goslim_yeast
2012-02-17 Added SUBSET goslim_metagenomics
2011-11-05 Added SUBSET goslim_aspergillus
2008-06-09 Added SUBSET goslim_pir
2008-06-09 Added SUBSET goslim_generic
2008-06-09 Added SUBSET goslim_candida
2008-06-09 Added SUBSET goslim_plant
2008-06-09 Added SUBSET goslim_yeast
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