GO:0005856
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cytoskeleton
Cellular Component
Definition (GO:0005856 GONUTS page)
A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. PMID:16959967 PMID:27419875
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0005856
Child Term | Relationship to GO:0005856 |
---|---|
axoneme
|
part_of |
septin cap
|
part_of |
tubulin complex
|
part_of |
cortical cytoskeleton
|
is_a |
intermediate filament cytoskeleton
|
is_a |
contractile vacuole pore
|
part_of |
ciliary microtubule quartet
|
part_of |
septin filament array
|
part_of |
postsynaptic cytoskeleton
|
is_a |
microtubule cytoskeleton
|
is_a |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0005856 | cytoskeleton | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5ZRZ8 | 10116 | A0A8I5ZRZ8_RAT | GO:0005856 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZT22 | 10116 | A0A8I5ZT22_RAT | GO:0005856 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6IVM5 | 10116 | A6IVM5_RAT | GO:0005856 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6IVM6 | 10116 | A6IVM6_RAT | GO:0005856 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZJL1 | 10116 | D3ZJL1_RAT | GO:0005856 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q9Y4C4 | 9606 | MFHA1_HUMAN | GO:0005856 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:24286120 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000299 | FERM domain |
InterPro | IPR000857 | MyTH4 domain |
InterPro | IPR001101 | Plectin repeat |
InterPro | IPR007204 | Actin-related protein 2/3 complex subunit 3 |
InterPro | IPR007477 | SAB domain |
InterPro | IPR008379 | Band 4.1, C-terminal |
InterPro | IPR017354 | Vasodilator-stimulated phosphoprotein/ENA/VASP-like |
InterPro | IPR028288 | SCAR/WAVE family |
InterPro | IPR029774 | Centriole, cilia and spindle-associated protein |
InterPro | IPR029775 | Nephrocystin-4 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0044430 | obsolete cytoskeletal part | consider GO:0005856 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0005856 based on ALL annotations
The top 100 of 9,867 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cytoskeleton
|
160.01 | 100.00 | 1,218,329 | 1,218,329 |
microtubule
|
111.47 | 26.58 | 366,209 | 525,653 |
microtubule binding
|
74.31 | 13.78 | 199,552 | 429,694 |
actin binding
|
57.17 | 12.64 | 199,244 | 557,639 |
microtubule-based movement
|
86.03 | 9.96 | 132,712 | 246,841 |
cell projection
|
61.03 | 9.72 | 140,530 | 368,432 |
centrosome
|
81.44 | 9.22 | 123,285 | 242,205 |
actin filament binding
|
47.66 | 7.61 | 112,902 | 379,052 |
spindle
|
121.57 | 7.52 | 93,807 | 123,469 |
microtubule motor activity
|
93.57 | 6.76 | 86,541 | 147,982 |
Totals | 6525499 | 59221140 |
No co-occurrence statistics for GO:0005856 based on MANUAL annotations
The top 100 of 2,926 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cytoskeleton
|
379.72 | 100.00 | 3,402 | 3,402 |
cortical cytoskeleton organization
|
316.23 | 14.91 | 523 | 628 |
regulation of cell shape
|
129.92 | 13.93 | 647 | 1,891 |
establishment or maintenance of cell polarity
|
194.83 | 13.55 | 529 | 1,031 |
regulation of actin cytoskeleton organization
|
130.43 | 13.16 | 598 | 1,741 |
cell projection
|
151.39 | 11.87 | 492 | 1,234 |
actomyosin structure organization
|
262.49 | 11.49 | 412 | 596 |
actin filament organization
|
68.45 | 10.82 | 725 | 4,022 |
intermediate filament organization
|
160.81 | 8.93 | 346 | 817 |
cytoplasmic vesicle
|
63.84 | 8.86 | 537 | 3,194 |
Totals | 19096 | 367756 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_candida | 86 |
goslim_generic | 141 |
goslim_pir | 439 |
goslim_plant | 97 |
goslim_yeast | 163 |
goslim_prokaryote | 97 |
goslim_chembl | 296 |
goslim_mouse | 45 |
goslim_agr | 53 |
goslim_flybase_ribbon | 44 |
goslim_drosophila | 173 |
goslim_plant_ribbon | 62 |
goslim_euk_cellular_processes_ribbon | 61 |
Change Log
- All changes
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- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2024-03-22 | Added | SUBSET | goslim_euk_cellular_processes_ribbon |
2024-03-21 | Added | SUBSET | goslim_plant_ribbon |
2023-12-15 | Added | SUBSET | goslim_prokaryote |
2022-04-08 | Deleted | SUBSET | goslim_aspergillus |
2022-04-05 | Deleted | DEFINITION | Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
2022-04-05 | Added | DEFINITION | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
2020-02-28 | Deleted | XREF | MIPS_funcat:70.04 |
2019-11-09 | Added | SUBSET | goslim_drosophila |
2019-05-04 | Added | XREF | MIPS_funcat:70.04 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-02-06 | Updated | TERM | cytoskeleton |
2001-04-03 | Updated | TERM | cytoskeleton |
2001-03-30 | Added | TERM | cytoskeleton |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-04-05 | Deleted | DEFINITION | Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
2022-04-05 | Added | DEFINITION | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
2008-05-13 | Added | DEFINITION | Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
2008-05-12 | Deleted | DEFINITION | Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
2007-05-27 | Updated | DEFINITION | Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
2007-02-20 | Updated | DEFINITION | Any of the various filamentous elements that form the internal framework of eukaryotic cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
2002-11-27 | Updated | DEFINITION | Any of the various filamentous elements within the cytoplasm of eukaryotic cells that remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
2001-08-06 | Added | DEFINITION | Any of the various filamentous elements within the cytoplasm of eukaryotic cells that remain after treatment of the cells with mild detergent to remove membrane constituents and soluble componens of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-12-15 | Deleted | RELATION | is a GO:0005575 (cellular_component) |
2016-12-15 | Added | RELATION | is a GO:0043232 (intracellular membraneless organelle) |
2016-12-09 | Deleted | RELATION | is a GO:0043232 (intracellular membraneless organelle) |
2016-12-09 | Added | RELATION | is a GO:0005575 (cellular_component) |
2008-04-01 | Updated | RELATION | is a GO:0043232 (intracellular membraneless organelle) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-02-28 | Deleted | XREF | MIPS_funcat:70.04 |
2019-05-04 | Added | XREF | MIPS_funcat:70.04 |
2009-02-08 | Added | XREF | Wikipedia:Cytoskeleton |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2024-03-22 | Added | SUBSET | goslim_euk_cellular_processes_ribbon |
2024-03-21 | Added | SUBSET | goslim_plant_ribbon |
2023-12-15 | Added | SUBSET | goslim_prokaryote |
2022-04-08 | Deleted | SUBSET | goslim_aspergillus |
2019-11-09 | Added | SUBSET | goslim_drosophila |
2018-09-22 | Added | SUBSET | goslim_flybase_ribbon |
2017-03-04 | Added | SUBSET | goslim_agr |
2016-12-17 | Added | SUBSET | goslim_mouse |
2016-07-23 | Deleted | SUBSET | goslim_metagenomics |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2013-04-18 | Updated | SUBSET | goslim_aspergillus |
2013-04-18 | Updated | SUBSET | goslim_metagenomics |
2013-04-18 | Updated | SUBSET | goslim_candida |
2013-04-18 | Updated | SUBSET | goslim_generic |
2013-04-18 | Updated | SUBSET | goslim_pir |
2013-04-18 | Updated | SUBSET | goslim_plant |
2013-04-18 | Updated | SUBSET | goslim_yeast |
2012-02-17 | Added | SUBSET | goslim_metagenomics |
2011-11-05 | Added | SUBSET | goslim_aspergillus |
2008-06-09 | Added | SUBSET | goslim_pir |
2008-06-09 | Added | SUBSET | goslim_generic |
2008-06-09 | Added | SUBSET | goslim_candida |
2008-06-09 | Added | SUBSET | goslim_plant |
2008-06-09 | Added | SUBSET | goslim_yeast |
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