GO:0006084
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acetyl-CoA metabolic process
Biological Process
Definition (GO:0006084 GONUTS page)
The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
acetyl coenzyme A metabolism | exact |
acetyl coenzyme A metabolic process | exact |
acetyl-CoA metabolism | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0006084
Child Term | Relationship to GO:0006084 |
---|---|
butyryl-CoA biosynthetic process from acetyl-CoA
|
is_a |
acetyl-CoA catabolic process
|
is_a |
L-lysine catabolic process to acetyl-CoA
|
is_a |
acetyl-CoA biosynthetic process
|
is_a |
isopentenyl diphosphate biosynthetic process, mevalonate pathway
|
is_a |
tryptophan catabolic process to acetyl-CoA
|
is_a |
L-threonine catabolic process to acetyl-CoA
|
is_a |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR004460 | Acetyl-CoA decarbonylase/synthase complex subunit alpha |
InterPro | IPR004461 | CO dehydrogenase/acetyl-CoA synthase complex beta subunit |
InterPro | IPR006472 | Citrate lyase, alpha subunit |
InterPro | IPR006475 | Citrate lyase, beta subunit, bacteria |
InterPro | IPR013746 | Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain |
InterPro | IPR017821 | Succinate CoA transferase |
InterPro | IPR023427 | Acetyl-CoA decarbonylase/synthase complex, gamma subunit, archaea |
InterPro | IPR023432 | Acetyl-CoA decarbonylase/synthase complex subunit beta, archaeal |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_input_or_output | CHEBI | CHEBI:57288 | acetyl-CoA(4-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0006084 based on ALL annotations
The top 100 of 388 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
acetyl-CoA metabolic process
|
5,829.16 | 100.00 | 33,442 | 33,442 |
hydroxymethylglutaryl-CoA synthase activity
|
5,698.52 | 40.45 | 13,653 | 13,966 |
farnesyl diphosphate biosynthetic process, mevalonate pathway
|
4,431.03 | 25.20 | 9,156 | 12,045 |
acetyl-CoA hydrolase activity
|
4,147.82 | 20.11 | 7,322 | 10,290 |
ATP-independent citrate lyase complex
|
5,829.16 | 20.05 | 6,705 | 6,705 |
citrate (pro-3S)-lyase activity
|
4,892.82 | 16.51 | 5,701 | 6,792 |
citrate CoA-transferase activity
|
5,827.95 | 14.41 | 4,818 | 4,819 |
acetate CoA-transferase activity
|
1,548.08 | 14.27 | 7,882 | 29,679 |
anaerobic carbon-monoxide dehydrogenase activity
|
1,988.01 | 9.79 | 4,039 | 11,843 |
acetate metabolic process
|
685.96 | 8.52 | 7,883 | 66,988 |
Totals | 181209 | 98695893 |
No co-occurrence statistics for GO:0006084 based on MANUAL annotations
The top 100 of 169 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
acetyl-CoA metabolic process
|
5,792.82 | 100.00 | 223 | 223 |
hydroxymethylglutaryl-CoA synthase activity
|
5,664.80 | 77.97 | 177 | 181 |
farnesyl diphosphate biosynthetic process, mevalonate pathway
|
3,953.83 | 56.77 | 172 | 252 |
acetyl-CoA hydrolase activity
|
1,823.67 | 6.54 | 17 | 54 |
biotin binding
|
1,737.85 | 3.69 | 9 | 30 |
intracellular aspartate homeostasis
|
5,792.82 | 3.59 | 8 | 8 |
lactic acid secretion
|
5,149.17 | 3.57 | 8 | 9 |
regulation of cardiac muscle hypertrophy in response to stress
|
4,634.26 | 3.56 | 8 | 10 |
intracellular glutamate homeostasis
|
2,317.13 | 3.40 | 8 | 20 |
negative regulation of fatty acid beta-oxidation
|
1,930.94 | 3.35 | 8 | 24 |
Totals | 952 | 16864 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-05-09 | Deleted | RELATION | is a GO:0006732 (obsolete coenzyme metabolic process) |
2020-05-08 | Added | RELATION | is a GO:0006732 (obsolete coenzyme metabolic process) |
2012-11-02 | Deleted | RELATION | is a GO:0006732 (obsolete coenzyme metabolic process) |
2012-11-02 | Added | RELATION | is a GO:0006637 (acyl-CoA metabolic process) |
2008-05-13 | Added | DEFINITION | The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
2008-05-12 | Deleted | DEFINITION | The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
2008-04-01 | Updated | RELATION | is a GO:0006732 (obsolete coenzyme metabolic process) |
2007-08-09 | Added | SYNONYM | acetyl coenzyme A metabolic process |
2007-08-09 | Added | SYNONYM | acetyl coenzyme A metabolism |
2007-08-09 | Added | SYNONYM | acetyl-CoA metabolism |
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-01-15 | Updated | TERM | acetyl-CoA metabolic process |
2002-02-06 | Updated | TERM | acetyl-CoA metabolism |
2001-04-03 | Updated | TERM | acetyl-CoA metabolism |
2001-03-30 | Added | TERM | acetyl-CoA metabolism |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
2008-05-12 | Deleted | DEFINITION | The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
2007-08-09 | Added | SYNONYM | acetyl coenzyme A metabolic process |
2007-08-09 | Added | SYNONYM | acetyl coenzyme A metabolism |
2007-08-09 | Added | SYNONYM | acetyl-CoA metabolism |
2007-08-09 | Deleted | SYNONYM | acetyl-CoA metabolism |
2007-08-09 | Deleted | SYNONYM | acetyl coenzyme A metabolic process |
2007-08-09 | Deleted | SYNONYM | acetyl coenzyme A metabolism |
2007-01-29 | Added | SYNONYM | acetyl-CoA metabolism |
2007-01-15 | Added | SYNONYM | acetyl coenzyme A metabolic process |
2006-05-04 | Updated | DEFINITION | The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
2005-07-09 | Added | SYNONYM | acetyl coenzyme A metabolism |
2005-01-21 | Updated | DEFINITION | The chemical reactions involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
2004-03-13 | Updated | DEFINITION | The chemical reactions and physical changes involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
2003-10-18 | Updated | DEFINITION | The chemical reactions and physical changes involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (eg. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
2003-04-24 | Updated | DEFINITION | The chemical reactions and physical changes involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e. g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
2003-03-26 | Updated | DEFINITION | The chemical reactions and physical changes involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. |
2002-11-27 | Updated | DEFINITION | The chemical reactions and physical changes involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism); further metabolized by the tricarboxylic acid cycle; a key intermediate in lipid and terpenoid biosynthesis. |
2001-08-06 | Added | DEFINITION | Metabolism of acetyl-coenzyme A: a derivative of coenzyme A in which the sulfhydryl group is acetylated; a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism); further metabolised by the tricarboxylic acid cycle; a key intermediate in lipid and terpenoid biosynthesis. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-05-09 | Deleted | RELATION | is a GO:0006732 (obsolete coenzyme metabolic process) |
2020-05-08 | Added | RELATION | is a GO:0006732 (obsolete coenzyme metabolic process) |
2012-11-02 | Deleted | RELATION | is a GO:0006732 (obsolete coenzyme metabolic process) |
2012-11-02 | Added | RELATION | is a GO:0006637 (acyl-CoA metabolic process) |
2008-04-01 | Updated | RELATION | is a GO:0006732 (obsolete coenzyme metabolic process) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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