This term is obsolete.

GO:0006084 JSON

acetyl-CoA metabolic process

Biological Process

Definition (GO:0006084 GONUTS page)

The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.

345,641 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
acetyl coenzyme A metabolism exact
acetyl coenzyme A metabolic process exact
acetyl-CoA metabolism exact

Ancestor Chart

Ancestor chart for GO:0006084
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006084

Child Term Relationship to
GO:0006084
butyryl-CoA biosynthetic process from acetyl-CoA
is_a
acetyl-CoA catabolic process
is_a
L-lysine catabolic process to acetyl-CoA
is_a
acetyl-CoA biosynthetic process
is_a
isopentenyl diphosphate biosynthetic process, mevalonate pathway
is_a
tryptophan catabolic process to acetyl-CoA
is_a
L-threonine catabolic process to acetyl-CoA
is_a

Cross-references

Database ID Description
InterPro IPR004460 Acetyl-CoA decarbonylase/synthase complex subunit alpha
InterPro IPR004461 CO dehydrogenase/acetyl-CoA synthase complex beta subunit
InterPro IPR006472 Citrate lyase, alpha subunit
InterPro IPR006475 Citrate lyase, beta subunit, bacteria
InterPro IPR013746 Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain
InterPro IPR017821 Succinate CoA transferase
InterPro IPR023427 Acetyl-CoA decarbonylase/synthase complex, gamma subunit, archaea
InterPro IPR023432 Acetyl-CoA decarbonylase/synthase complex subunit beta, archaeal

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input_or_output CHEBI CHEBI:57288 acetyl-CoA(4-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0006084 based on ALL annotations
The top 100 of 388 co-occurring terms
Co-occurring Term PR S% #Together #Compared
acetyl-CoA metabolic process
5,829.16 100.00 33,442 33,442
hydroxymethylglutaryl-CoA synthase activity
5,698.52 40.45 13,653 13,966
farnesyl diphosphate biosynthetic process, mevalonate pathway
4,431.03 25.20 9,156 12,045
acetyl-CoA hydrolase activity
4,147.82 20.11 7,322 10,290
ATP-independent citrate lyase complex
5,829.16 20.05 6,705 6,705
citrate (pro-3S)-lyase activity
4,892.82 16.51 5,701 6,792
citrate CoA-transferase activity
5,827.95 14.41 4,818 4,819
acetate CoA-transferase activity
1,548.08 14.27 7,882 29,679
anaerobic carbon-monoxide dehydrogenase activity
1,988.01 9.79 4,039 11,843
acetate metabolic process
685.96 8.52 7,883 66,988
Totals 181209 98695893
No co-occurrence statistics for GO:0006084 based on MANUAL annotations
The top 100 of 169 co-occurring terms
Co-occurring Term PR S% #Together #Compared
acetyl-CoA metabolic process
5,792.82 100.00 223 223
hydroxymethylglutaryl-CoA synthase activity
5,664.80 77.97 177 181
farnesyl diphosphate biosynthetic process, mevalonate pathway
3,953.83 56.77 172 252
acetyl-CoA hydrolase activity
1,823.67 6.54 17 54
biotin binding
1,737.85 3.69 9 30
intracellular aspartate homeostasis
5,792.82 3.59 8 8
lactic acid secretion
5,149.17 3.57 8 9
regulation of cardiac muscle hypertrophy in response to stress
4,634.26 3.56 8 10
intracellular glutamate homeostasis
2,317.13 3.40 8 20
negative regulation of fatty acid beta-oxidation
1,930.94 3.35 8 24
Totals 952 16864

Change Log

Timestamp Action Category Detail
2020-05-09 Deleted RELATION is a GO:0006732 (obsolete coenzyme metabolic process)
2020-05-08 Added RELATION is a GO:0006732 (obsolete coenzyme metabolic process)
2012-11-02 Deleted RELATION is a GO:0006732 (obsolete coenzyme metabolic process)
2012-11-02 Added RELATION is a GO:0006637 (acyl-CoA metabolic process)
2008-05-13 Added DEFINITION The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
2008-04-01 Updated RELATION is a GO:0006732 (obsolete coenzyme metabolic process)
2007-08-09 Added SYNONYM acetyl coenzyme A metabolic process
2007-08-09 Added SYNONYM acetyl coenzyme A metabolism
2007-08-09 Added SYNONYM acetyl-CoA metabolism
Timestamp Action Category Detail
2007-01-15 Updated TERM acetyl-CoA metabolic process
2002-02-06 Updated TERM acetyl-CoA metabolism
2001-04-03 Updated TERM acetyl-CoA metabolism
2001-03-30 Added TERM acetyl-CoA metabolism
Timestamp Action Category Detail
2008-05-13 Added DEFINITION The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
2007-08-09 Added SYNONYM acetyl coenzyme A metabolic process
2007-08-09 Added SYNONYM acetyl coenzyme A metabolism
2007-08-09 Added SYNONYM acetyl-CoA metabolism
2007-08-09 Deleted SYNONYM acetyl-CoA metabolism
2007-08-09 Deleted SYNONYM acetyl coenzyme A metabolic process
2007-08-09 Deleted SYNONYM acetyl coenzyme A metabolism
2007-01-29 Added SYNONYM acetyl-CoA metabolism
2007-01-15 Added SYNONYM acetyl coenzyme A metabolic process
2006-05-04 Updated DEFINITION The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
2005-07-09 Added SYNONYM acetyl coenzyme A metabolism
2005-01-21 Updated DEFINITION The chemical reactions involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
2004-03-13 Updated DEFINITION The chemical reactions and physical changes involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
2003-10-18 Updated DEFINITION The chemical reactions and physical changes involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (eg. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
2003-04-24 Updated DEFINITION The chemical reactions and physical changes involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e. g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
2003-03-26 Updated DEFINITION The chemical reactions and physical changes involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.
2002-11-27 Updated DEFINITION The chemical reactions and physical changes involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism); further metabolized by the tricarboxylic acid cycle; a key intermediate in lipid and terpenoid biosynthesis.
2001-08-06 Added DEFINITION Metabolism of acetyl-coenzyme A: a derivative of coenzyme A in which the sulfhydryl group is acetylated; a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism); further metabolised by the tricarboxylic acid cycle; a key intermediate in lipid and terpenoid biosynthesis.
Timestamp Action Category Detail
2020-05-09 Deleted RELATION is a GO:0006732 (obsolete coenzyme metabolic process)
2020-05-08 Added RELATION is a GO:0006732 (obsolete coenzyme metabolic process)
2012-11-02 Deleted RELATION is a GO:0006732 (obsolete coenzyme metabolic process)
2012-11-02 Added RELATION is a GO:0006637 (acyl-CoA metabolic process)
2008-04-01 Updated RELATION is a GO:0006732 (obsolete coenzyme metabolic process)
Timestamp Action Category Detail
Timestamp Action Category Detail
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