GO:0006086
JSON
acetyl-CoA biosynthetic process from pyruvate
Biological Process
Definition (GO:0006086 GONUTS page)
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
pyruvate dehydrogenase pathway | exact |
acetyl-CoA synthesis from pyruvate | exact |
acetyl-CoA formation from pyruvate | exact |
acetyl-CoA anabolism from pyruvate | exact |
Ancestor Chart
Ancestor chart for GO:0006086
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0006086
Child Term | Relationship to GO:0006086 |
---|---|
pyruvate synthase activity
|
part_of |
regulation of acetyl-CoA biosynthetic process from pyruvate
|
regulates |
negative regulation of acetyl-CoA biosynthetic process from pyruvate
|
negatively_regulates |
pyruvate dehydrogenase (NAD+) activity
|
part_of |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR017597 | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y |
InterPro | IPR027110 | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial-type |
InterPro | IPR045257 | Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component |
MetaCyc | PYRUVDEHYD-PWY |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_input | CHEBI | CHEBI:15361 | pyruvate |
has_primary_output | CHEBI | CHEBI:57288 | acetyl-CoA(4-) |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0061732 | obsolete mitochondrial acetyl-CoA biosynthetic process from pyruvate | replaced_by GO:0006086 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0006086 based on ALL annotations
The top 100 of 530 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
acetyl-CoA biosynthetic process from pyruvate
|
2,101.83 | 100.00 | 92,747 | 92,747 |
pyruvate dehydrogenase complex
|
2,078.56 | 38.45 | 35,819 | 36,220 |
pyruvate dehydrogenase (acetyl-transferring) activity
|
1,217.47 | 35.43 | 44,246 | 76,386 |
dihydrolipoyllysine-residue acetyltransferase activity
|
1,912.06 | 30.35 | 29,027 | 31,908 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
|
367.78 | 10.06 | 17,746 | 101,417 |
lipoic acid binding
|
435.65 | 8.91 | 12,527 | 60,437 |
pyruvate synthase activity
|
2,101.83 | 8.52 | 7,899 | 7,899 |
acetyltransferase activity
|
229.55 | 6.45 | 12,613 | 115,491 |
pyruvate metabolic process
|
157.22 | 5.87 | 19,852 | 265,404 |
2-oxobutyrate synthase activity
|
2,101.83 | 3.36 | 3,112 | 3,112 |
Totals | 451275 | 103574481 |
No co-occurrence statistics for GO:0006086 based on MANUAL annotations
The top 100 of 122 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
acetyl-CoA biosynthetic process from pyruvate
|
2,131.68 | 100.00 | 606 | 606 |
pyruvate dehydrogenase (acetyl-transferring) activity
|
2,101.90 | 80.59 | 494 | 501 |
pyruvate dehydrogenase complex
|
1,563.66 | 35.25 | 245 | 334 |
dihydrolipoyllysine-residue acetyltransferase activity
|
764.19 | 10.24 | 76 | 212 |
pyruvate dehydrogenase (NAD+) activity
|
2,046.41 | 3.95 | 24 | 25 |
lipoic acid binding
|
166.72 | 1.82 | 14 | 179 |
pyruvate dehydrogenase activity
|
1,918.51 | 1.48 | 9 | 10 |
acetyltransferase activity
|
64.23 | 1.43 | 16 | 531 |
dihydrolipoyl dehydrogenase activity
|
72.02 | 1.12 | 10 | 296 |
acetyltransferase complex
|
2,131.68 | 0.99 | 6 | 6 |
Totals | 1731 | 99237 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-05-30 | Deleted | XREF | Reactome:R-HSA-372342.1 |
2024-05-30 | Deleted | XREF | Reactome:R-HSA-71397.1 |
2022-11-08 | Added | XREF | Reactome:R-HSA-71397.1 |
2022-11-08 | Added | XREF | Reactome:R-HSA-372342.1 |
2019-03-05 | Added | RELATION | is a GO:0006090 (pyruvate metabolic process) |
2019-02-28 | Deleted | RELATION | is a GO:0006090 (pyruvate metabolic process) |
2017-08-13 | Deleted | RELATION | is a GO:0044711 (obsolete single-organism biosynthetic process) |
2013-11-28 | Added | RELATION | is a GO:0044711 (obsolete single-organism biosynthetic process) |
2008-05-13 | Added | DEFINITION | The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. |
2008-05-12 | Deleted | DEFINITION | The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-01-15 | Updated | TERM | acetyl-CoA biosynthetic process from pyruvate |
2002-10-12 | Updated | TERM | acetyl-CoA biosynthesis from pyruvate |
2002-02-06 | Updated | TERM | acetyl-CoA biosynthesis, from pyruvate |
2001-10-15 | Updated | TERM | acetyl-CoA biosynthesis, from pyruvate |
2001-04-03 | Updated | TERM | pyruvate dehydrogenase pathway |
2001-03-30 | Added | TERM | pyruvate dehydrogenase pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. |
2008-05-12 | Deleted | DEFINITION | The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. |
2008-01-27 | Updated | DEFINITION | The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. |
2007-08-09 | Added | SYNONYM | pyruvate dehydrogenase pathway |
2007-08-09 | Deleted | SYNONYM | pyruvate dehydrogenase pathway |
2007-08-09 | Deleted | SYNONYM | acetyl-CoA synthesis from pyruvate |
2007-08-09 | Deleted | SYNONYM | acetyl-CoA formation from pyruvate |
2007-08-09 | Deleted | SYNONYM | acetyl-CoA anabolism from pyruvate |
2007-08-09 | Added | SYNONYM | acetyl-CoA synthesis from pyruvate |
2007-08-09 | Added | SYNONYM | acetyl-CoA formation from pyruvate |
2007-08-09 | Added | SYNONYM | acetyl-CoA anabolism from pyruvate |
2006-05-04 | Updated | DEFINITION | The chemical reactions and pathways resulting in the formation of acetyl-CoA from other compounds, including pyruvate. |
2005-08-10 | Added | SYNONYM | acetyl-CoA formation from pyruvate |
2005-08-10 | Added | SYNONYM | acetyl-CoA anabolism from pyruvate |
2005-08-10 | Added | SYNONYM | acetyl-CoA synthesis from pyruvate |
2004-04-19 | Added | SYNONYM | pyruvate dehydrogenase pathway |
2004-04-16 | Deleted | SYNONYM | pyruvate dehydrogenase pathway |
2003-10-27 | Added | SYNONYM | pyruvate dehydrogenase pathway |
2003-03-19 | Deleted | SYNONYM | pyruvate dehydrogenase pathway |
2002-11-27 | Added | DEFINITION | The formation of acetyl-CoA from simpler components, including pyruvate. |
2001-10-15 | Added | SYNONYM | pyruvate dehydrogenase pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-03-05 | Added | RELATION | is a GO:0006090 (pyruvate metabolic process) |
2019-02-28 | Deleted | RELATION | is a GO:0006090 (pyruvate metabolic process) |
2017-08-13 | Deleted | RELATION | is a GO:0044711 (obsolete single-organism biosynthetic process) |
2013-11-28 | Added | RELATION | is a GO:0044711 (obsolete single-organism biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0006085 (acetyl-CoA biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0006090 (pyruvate metabolic process) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-05-30 | Deleted | XREF | Reactome:R-HSA-372342.1 |
2024-05-30 | Deleted | XREF | Reactome:R-HSA-71397.1 |
2022-11-08 | Added | XREF | Reactome:R-HSA-71397.1 |
2022-11-08 | Added | XREF | Reactome:R-HSA-372342.1 |
2003-10-27 | Added | XREF | MetaCyc:PYRUVDEHYD-PWY |
Timestamp | Action | Category | Detail |
---|
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