GO:0006086
JSON
pyruvate decarboxylation to acetyl-CoA
Biological Process
Definition (GO:0006086 GONUTS page)
The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
acetyl-CoA biosynthetic process from pyruvate | exact |
pyruvate decarboxylation | narrow |
oxidative decarboxylation of pyruvate | exact |
pyruvate dehydrogenase pathway | exact |
acetyl-CoA synthesis from pyruvate | exact |
acetyl-CoA formation from pyruvate | exact |
acetyl-CoA anabolism from pyruvate | exact |
Ancestor Chart
Ancestor chart for GO:0006086
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0006086
Child Term | Relationship to GO:0006086 |
---|---|
negative regulation of acetyl-CoA biosynthetic process from pyruvate
|
negatively_regulates |
regulation of acetyl-CoA biosynthetic process from pyruvate
|
regulates |
pyruvate synthase activity
|
part_of |
pyruvate dehydrogenase (NAD+) activity
|
part_of |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR017597 | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y |
InterPro | IPR027110 | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial-type |
InterPro | IPR045257 | Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component |
MetaCyc | PYRUVDEHYD-PWY | |
Reactome | R-HSA-9861559 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_input | CHEBI | CHEBI:15361 | pyruvate |
has_primary_output | CHEBI | CHEBI:57288 | acetyl-CoA(4-) |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0061732 | obsolete mitochondrial acetyl-CoA biosynthetic process from pyruvate | replaced_by GO:0006086 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0006086 based on ALL annotations
The top 100 of 540 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
pyruvate decarboxylation to acetyl-CoA
|
2,099.63 | 100.00 | 94,376 | 94,376 |
pyruvate dehydrogenase complex
|
2,077.27 | 38.62 | 36,601 | 36,995 |
pyruvate dehydrogenase (acetyl-transferring) activity
|
1,278.34 | 36.56 | 45,101 | 74,077 |
dihydrolipoyllysine-residue acetyltransferase activity
|
1,984.87 | 27.29 | 26,167 | 27,680 |
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
|
365.05 | 10.01 | 18,006 | 103,565 |
lipoic acid binding
|
432.72 | 8.88 | 12,747 | 61,851 |
pyruvate synthase activity
|
2,099.63 | 8.32 | 7,850 | 7,850 |
acetyltransferase activity
|
228.19 | 6.43 | 12,833 | 118,082 |
2-oxobutyrate synthase activity
|
2,099.63 | 3.34 | 3,150 | 3,150 |
pyruvate metabolic process
|
85.80 | 3.09 | 10,648 | 260,574 |
Totals | 446375 | 102464195 |
No co-occurrence statistics for GO:0006086 based on MANUAL annotations
The top 100 of 121 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
pyruvate decarboxylation to acetyl-CoA
|
2,109.91 | 100.00 | 669 | 669 |
pyruvate dehydrogenase (acetyl-transferring) activity
|
2,079.67 | 81.24 | 550 | 558 |
pyruvate dehydrogenase complex
|
1,541.86 | 34.68 | 266 | 364 |
dihydrolipoyllysine-residue acetyltransferase activity
|
768.95 | 10.10 | 82 | 225 |
pyruvate dehydrogenase (NAD+) activity
|
2,025.52 | 3.58 | 24 | 25 |
lipoic acid binding
|
152.26 | 1.65 | 14 | 194 |
acetyltransferase activity
|
59.96 | 1.32 | 16 | 563 |
pyruvate dehydrogenase activity
|
1,875.48 | 1.19 | 8 | 9 |
dihydrolipoyl dehydrogenase (NADH) activity
|
67.19 | 1.03 | 10 | 314 |
acetyltransferase complex
|
2,109.91 | 0.90 | 6 | 6 |
Totals | 1881 | 106584 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2025-01-21 | Updated | TERM | pyruvate decarboxylation to acetyl-CoA |
2025-01-21 | Added | SYNONYM | oxidative decarboxylation of pyruvate |
2025-01-21 | Added | SYNONYM | pyruvate decarboxylation |
2025-01-21 | Added | SYNONYM | acetyl-CoA biosynthetic process from pyruvate |
2024-12-05 | Added | XREF | Reactome:R-HSA-9861559 |
2024-05-30 | Deleted | XREF | Reactome:R-HSA-372342.1 |
2024-05-30 | Deleted | XREF | Reactome:R-HSA-71397.1 |
2022-11-08 | Added | XREF | Reactome:R-HSA-372342.1 |
2022-11-08 | Added | XREF | Reactome:R-HSA-71397.1 |
2019-03-05 | Added | RELATION | is a GO:0006090 (pyruvate metabolic process) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2025-01-21 | Updated | TERM | pyruvate decarboxylation to acetyl-CoA |
2007-01-15 | Updated | TERM | acetyl-CoA biosynthetic process from pyruvate |
2002-10-12 | Updated | TERM | acetyl-CoA biosynthesis from pyruvate |
2002-02-06 | Updated | TERM | acetyl-CoA biosynthesis, from pyruvate |
2001-10-15 | Updated | TERM | acetyl-CoA biosynthesis, from pyruvate |
2001-04-03 | Updated | TERM | pyruvate dehydrogenase pathway |
2001-03-30 | Added | TERM | pyruvate dehydrogenase pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2025-01-21 | Added | SYNONYM | oxidative decarboxylation of pyruvate |
2025-01-21 | Added | SYNONYM | pyruvate decarboxylation |
2025-01-21 | Added | SYNONYM | acetyl-CoA biosynthetic process from pyruvate |
2008-05-13 | Added | DEFINITION | The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. |
2008-05-12 | Deleted | DEFINITION | The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. |
2008-01-27 | Updated | DEFINITION | The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. |
2007-08-09 | Added | SYNONYM | pyruvate dehydrogenase pathway |
2007-08-09 | Added | SYNONYM | acetyl-CoA anabolism from pyruvate |
2007-08-09 | Added | SYNONYM | acetyl-CoA formation from pyruvate |
2007-08-09 | Deleted | SYNONYM | acetyl-CoA anabolism from pyruvate |
2007-08-09 | Deleted | SYNONYM | acetyl-CoA formation from pyruvate |
2007-08-09 | Deleted | SYNONYM | pyruvate dehydrogenase pathway |
2007-08-09 | Deleted | SYNONYM | acetyl-CoA synthesis from pyruvate |
2007-08-09 | Added | SYNONYM | acetyl-CoA synthesis from pyruvate |
2006-05-04 | Updated | DEFINITION | The chemical reactions and pathways resulting in the formation of acetyl-CoA from other compounds, including pyruvate. |
2005-08-10 | Added | SYNONYM | acetyl-CoA anabolism from pyruvate |
2005-08-10 | Added | SYNONYM | acetyl-CoA formation from pyruvate |
2005-08-10 | Added | SYNONYM | acetyl-CoA synthesis from pyruvate |
2004-04-19 | Added | SYNONYM | pyruvate dehydrogenase pathway |
2004-04-16 | Deleted | SYNONYM | pyruvate dehydrogenase pathway |
2003-10-27 | Added | SYNONYM | pyruvate dehydrogenase pathway |
2003-03-19 | Deleted | SYNONYM | pyruvate dehydrogenase pathway |
2002-11-27 | Added | DEFINITION | The formation of acetyl-CoA from simpler components, including pyruvate. |
2001-10-15 | Added | SYNONYM | pyruvate dehydrogenase pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-03-05 | Added | RELATION | is a GO:0006090 (pyruvate metabolic process) |
2019-02-28 | Deleted | RELATION | is a GO:0006090 (pyruvate metabolic process) |
2017-08-13 | Deleted | RELATION | is a GO:0044711 (obsolete single-organism biosynthetic process) |
2013-11-28 | Added | RELATION | is a GO:0044711 (obsolete single-organism biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0006085 (acetyl-CoA biosynthetic process) |
2008-04-01 | Updated | RELATION | is a GO:0006090 (pyruvate metabolic process) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | XREF | Reactome:R-HSA-9861559 |
2024-05-30 | Deleted | XREF | Reactome:R-HSA-372342.1 |
2024-05-30 | Deleted | XREF | Reactome:R-HSA-71397.1 |
2022-11-08 | Added | XREF | Reactome:R-HSA-372342.1 |
2022-11-08 | Added | XREF | Reactome:R-HSA-71397.1 |
2003-10-27 | Added | XREF | MetaCyc:PYRUVDEHYD-PWY |
Timestamp | Action | Category | Detail |
---|
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