This term is obsolete.

GO:0006086 JSON

pyruvate decarboxylation to acetyl-CoA

Biological Process

Definition (GO:0006086 GONUTS page)

The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.

103,271 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
acetyl-CoA biosynthetic process from pyruvate exact
pyruvate decarboxylation narrow
oxidative decarboxylation of pyruvate exact
pyruvate dehydrogenase pathway exact
acetyl-CoA synthesis from pyruvate exact
acetyl-CoA formation from pyruvate exact
acetyl-CoA anabolism from pyruvate exact

Ancestor Chart

Ancestor chart for GO:0006086
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006086

Child Term Relationship to
GO:0006086
negative regulation of acetyl-CoA biosynthetic process from pyruvate
negatively_regulates
regulation of acetyl-CoA biosynthetic process from pyruvate
regulates
pyruvate synthase activity
part_of
pyruvate dehydrogenase (NAD+) activity
part_of

Cross-references

Database ID Description
InterPro IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
InterPro IPR027110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial-type
InterPro IPR045257 Dihydrolipoamide acetyltransferase/Pyruvate dehydrogenase protein X component
MetaCyc PYRUVDEHYD-PWY
Reactome R-HSA-9861559

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:15361 pyruvate
has_primary_output CHEBI CHEBI:57288 acetyl-CoA(4-)

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0061732 obsolete mitochondrial acetyl-CoA biosynthetic process from pyruvate replaced_by GO:0006086

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0006086 based on ALL annotations
The top 100 of 540 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pyruvate decarboxylation to acetyl-CoA
2,099.63 100.00 94,376 94,376
pyruvate dehydrogenase complex
2,077.27 38.62 36,601 36,995
pyruvate dehydrogenase (acetyl-transferring) activity
1,278.34 36.56 45,101 74,077
dihydrolipoyllysine-residue acetyltransferase activity
1,984.87 27.29 26,167 27,680
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
365.05 10.01 18,006 103,565
lipoic acid binding
432.72 8.88 12,747 61,851
pyruvate synthase activity
2,099.63 8.32 7,850 7,850
acetyltransferase activity
228.19 6.43 12,833 118,082
2-oxobutyrate synthase activity
2,099.63 3.34 3,150 3,150
pyruvate metabolic process
85.80 3.09 10,648 260,574
Totals 446375 102464195
No co-occurrence statistics for GO:0006086 based on MANUAL annotations
The top 100 of 121 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pyruvate decarboxylation to acetyl-CoA
2,109.91 100.00 669 669
pyruvate dehydrogenase (acetyl-transferring) activity
2,079.67 81.24 550 558
pyruvate dehydrogenase complex
1,541.86 34.68 266 364
dihydrolipoyllysine-residue acetyltransferase activity
768.95 10.10 82 225
pyruvate dehydrogenase (NAD+) activity
2,025.52 3.58 24 25
lipoic acid binding
152.26 1.65 14 194
acetyltransferase activity
59.96 1.32 16 563
pyruvate dehydrogenase activity
1,875.48 1.19 8 9
dihydrolipoyl dehydrogenase (NADH) activity
67.19 1.03 10 314
acetyltransferase complex
2,109.91 0.90 6 6
Totals 1881 106584

Change Log

Timestamp Action Category Detail
2025-01-21 Updated TERM pyruvate decarboxylation to acetyl-CoA
2025-01-21 Added SYNONYM oxidative decarboxylation of pyruvate
2025-01-21 Added SYNONYM pyruvate decarboxylation
2025-01-21 Added SYNONYM acetyl-CoA biosynthetic process from pyruvate
2024-12-05 Added XREF Reactome:R-HSA-9861559
2024-05-30 Deleted XREF Reactome:R-HSA-372342.1
2024-05-30 Deleted XREF Reactome:R-HSA-71397.1
2022-11-08 Added XREF Reactome:R-HSA-372342.1
2022-11-08 Added XREF Reactome:R-HSA-71397.1
2019-03-05 Added RELATION is a GO:0006090 (pyruvate metabolic process)
Timestamp Action Category Detail
2025-01-21 Updated TERM pyruvate decarboxylation to acetyl-CoA
2007-01-15 Updated TERM acetyl-CoA biosynthetic process from pyruvate
2002-10-12 Updated TERM acetyl-CoA biosynthesis from pyruvate
2002-02-06 Updated TERM acetyl-CoA biosynthesis, from pyruvate
2001-10-15 Updated TERM acetyl-CoA biosynthesis, from pyruvate
2001-04-03 Updated TERM pyruvate dehydrogenase pathway
2001-03-30 Added TERM pyruvate dehydrogenase pathway
Timestamp Action Category Detail
2025-01-21 Added SYNONYM oxidative decarboxylation of pyruvate
2025-01-21 Added SYNONYM pyruvate decarboxylation
2025-01-21 Added SYNONYM acetyl-CoA biosynthetic process from pyruvate
2008-05-13 Added DEFINITION The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
2008-01-27 Updated DEFINITION The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
2007-08-09 Added SYNONYM pyruvate dehydrogenase pathway
2007-08-09 Added SYNONYM acetyl-CoA anabolism from pyruvate
2007-08-09 Added SYNONYM acetyl-CoA formation from pyruvate
2007-08-09 Deleted SYNONYM acetyl-CoA anabolism from pyruvate
2007-08-09 Deleted SYNONYM acetyl-CoA formation from pyruvate
2007-08-09 Deleted SYNONYM pyruvate dehydrogenase pathway
2007-08-09 Deleted SYNONYM acetyl-CoA synthesis from pyruvate
2007-08-09 Added SYNONYM acetyl-CoA synthesis from pyruvate
2006-05-04 Updated DEFINITION The chemical reactions and pathways resulting in the formation of acetyl-CoA from other compounds, including pyruvate.
2005-08-10 Added SYNONYM acetyl-CoA anabolism from pyruvate
2005-08-10 Added SYNONYM acetyl-CoA formation from pyruvate
2005-08-10 Added SYNONYM acetyl-CoA synthesis from pyruvate
2004-04-19 Added SYNONYM pyruvate dehydrogenase pathway
2004-04-16 Deleted SYNONYM pyruvate dehydrogenase pathway
2003-10-27 Added SYNONYM pyruvate dehydrogenase pathway
2003-03-19 Deleted SYNONYM pyruvate dehydrogenase pathway
2002-11-27 Added DEFINITION The formation of acetyl-CoA from simpler components, including pyruvate.
2001-10-15 Added SYNONYM pyruvate dehydrogenase pathway
Timestamp Action Category Detail
2019-03-05 Added RELATION is a GO:0006090 (pyruvate metabolic process)
2019-02-28 Deleted RELATION is a GO:0006090 (pyruvate metabolic process)
2017-08-13 Deleted RELATION is a GO:0044711 (obsolete single-organism biosynthetic process)
2013-11-28 Added RELATION is a GO:0044711 (obsolete single-organism biosynthetic process)
2008-04-01 Updated RELATION is a GO:0006085 (acetyl-CoA biosynthetic process)
2008-04-01 Updated RELATION is a GO:0006090 (pyruvate metabolic process)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-9861559
2024-05-30 Deleted XREF Reactome:R-HSA-372342.1
2024-05-30 Deleted XREF Reactome:R-HSA-71397.1
2022-11-08 Added XREF Reactome:R-HSA-372342.1
2022-11-08 Added XREF Reactome:R-HSA-71397.1
2003-10-27 Added XREF MetaCyc:PYRUVDEHYD-PWY
Timestamp Action Category Detail
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