This term is obsolete.

GO:0006270 JSON

DNA replication initiation

Biological Process

Definition (GO:0006270 GONUTS page)

The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding. PMID:28209641

Secondary IDs

GO:0042024

236,018 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
DNA-dependent DNA replication initiation exact
DNA endoreduplication initiation narrow
DNA re-replication initiation narrow

Ancestor Chart

Ancestor chart for GO:0006270
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006270

Child Term Relationship to
GO:0006270
regulation of DNA-templated DNA replication initiation
regulates
negative regulation of DNA-templated DNA replication initiation
negatively_regulates
cell cycle DNA replication initiation
is_a
positive regulation of DNA-templated DNA replication initiation
positively_regulates

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein D3ZVK1 10116 MCM8_RAT GO:0006260 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F1M5F3 10116 MCM9_RAT GO:0006260 3 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein F1N2W9 9913 MCM9_BOVIN GO:0006260 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein O61847 6239 CDK2_CAEEL GO:0006260 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:10207147
NOT-qualified manual protein Q2KHI9 10090 MCM9_MOUSE GO:0006260 2 NOT-qualified manual annotations exist with evidence code ECO:0000315 from these references: PMID:21987787, PMID:23401855
NOT-qualified manual protein Q9NXL9 9606 MCM9_HUMAN GO:0006260 1 NOT-qualified manual annotation exists with evidence code ECO:0000316 from this reference: PMID:23401855
NOT-qualified manual protein Q9UJA3 9606 MCM8_HUMAN GO:0006260 1 NOT-qualified manual annotation exists with evidence code ECO:0000316 from this reference: PMID:23401855

Cross-references

Database ID Description
InterPro IPR000525 Initiator Rep protein, WH1 domain
InterPro IPR001957 Chromosomal replication control, initiator DnaA
InterPro IPR003874 CDC45 family
InterPro IPR008045 DNA replication licensing factor Mcm2
InterPro IPR008046 DNA replication licensing factor Mcm3
InterPro IPR008047 Mini-chromosome maintenance complex protein 4
InterPro IPR008048 DNA replication licensing factor Mcm5
InterPro IPR008049 DNA replication licensing factor Mcm6
InterPro IPR008050 DNA replication licensing factor Mcm7
InterPro IPR009731 Replication P-like

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0006270 based on ALL annotations
The top 100 of 1,279 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA replication initiation
924.46 100.00 210,868 210,868
DNA replication origin binding
799.82 39.65 89,104 102,990
DNA unwinding involved in DNA replication
357.72 22.25 72,449 187,230
regulation of DNA replication
647.85 20.49 47,337 67,548
double-strand break repair via break-induced replication
651.05 16.25 36,786 52,234
MCM complex
690.28 14.54 32,260 43,204
DNA replication, synthesis of primer
227.92 12.70 43,786 177,597
primosome complex
252.96 12.35 38,733 141,554
DNA replication preinitiation complex
894.97 11.57 24,493 25,300
3'-5' DNA helicase activity
153.73 11.57 58,057 349,121
Totals 2292753 166609566
No co-occurrence statistics for GO:0006270 based on MANUAL annotations
The top 100 of 493 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA replication initiation
790.09 100.00 1,635 1,635
DNA replication origin binding
553.85 30.12 565 806
nuclear origin of replication recognition complex
607.29 22.36 392 510
mitotic DNA replication checkpoint signaling
336.84 15.76 327 767
DNA replication preinitiation complex
744.94 14.01 231 245
double-strand break repair via break-induced replication
223.61 13.75 345 1,219
alpha DNA polymerase:primase complex
435.39 12.72 232 421
MCM complex
208.07 9.84 222 843
single-stranded DNA helicase activity
186.81 9.32 218 922
single-stranded DNA binding
82.87 8.20 447 4,262
Totals 7550 374699

Change Log

Timestamp Action Category Detail
2023-01-16 Added DEFINITION The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
2023-01-16 Deleted DEFINITION The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
2018-02-15 Added DEFINITION The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
2018-02-15 Deleted DEFINITION The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
2013-07-27 Deleted RELATION has part GO:0033260 (nuclear DNA replication)
2012-09-08 Updated TERM DNA replication initiation
2012-09-08 Added DEFINITION The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
2012-09-08 Deleted DEFINITION The process in which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
2012-09-08 Added SYNONYM DNA-dependent DNA replication initiation
2012-09-08 Deleted SYNONYM DNA replication initiation
Timestamp Action Category Detail
2012-09-08 Updated TERM DNA replication initiation
2010-05-27 Updated TERM DNA-dependent DNA replication initiation
2002-02-06 Updated TERM DNA replication initiation
2001-04-03 Updated TERM DNA replication initiation
2001-03-30 Added TERM DNA replication initiation
Timestamp Action Category Detail
2023-01-16 Added DEFINITION The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
2023-01-16 Deleted DEFINITION The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
2018-02-15 Added DEFINITION The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
2018-02-15 Deleted DEFINITION The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
2012-09-08 Added DEFINITION The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
2012-09-08 Deleted DEFINITION The process in which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
2012-09-08 Added SYNONYM DNA-dependent DNA replication initiation
2012-09-08 Deleted SYNONYM DNA replication initiation
2012-09-02 Added SYNONYM DNA replication initiation
2010-11-24 Deleted DEFINITION The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
2010-11-24 Added DEFINITION The process in which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
2010-10-15 Added SYNONYM DNA re-replication initiation
2010-10-15 Added SYNONYM DNA endoreduplication initiation
2008-05-13 Added DEFINITION The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
2008-05-12 Deleted DEFINITION The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
2004-04-24 Added DEFINITION The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
Timestamp Action Category Detail
2013-07-27 Deleted RELATION has part GO:0033260 (nuclear DNA replication)
2010-10-31 Added RELATION has part GO:0033260 (nuclear DNA replication)
2010-10-15 Added RELATION has part GO:0042023 (DNA endoreduplication)
2008-04-01 Updated RELATION part of GO:0006261 (DNA-templated DNA replication)
2008-04-01 Updated RELATION is a GO:0006259 (DNA metabolic process)
Timestamp Action Category Detail
Timestamp Action Category Detail
2010-10-15 Added SECONDARY GO:0042024 (DNA endoreduplication initiation)
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