GO:0006270
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DNA replication initiation
Biological Process
Definition (GO:0006270 GONUTS page)
The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding. PMID:28209641
Secondary IDs
GO:0042024
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
DNA-dependent DNA replication initiation | exact |
DNA endoreduplication initiation | narrow |
DNA re-replication initiation | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0006270
Child Term | Relationship to GO:0006270 |
---|---|
regulation of DNA-templated DNA replication initiation
|
regulates |
negative regulation of DNA-templated DNA replication initiation
|
negatively_regulates |
cell cycle DNA replication initiation
|
is_a |
positive regulation of DNA-templated DNA replication initiation
|
positively_regulates |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | D3ZVK1 | 10116 | MCM8_RAT | GO:0006260 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F1M5F3 | 10116 | MCM9_RAT | GO:0006260 | 3 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | F1N2W9 | 9913 | MCM9_BOVIN | GO:0006260 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | O61847 | 6239 | CDK2_CAEEL | GO:0006260 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:10207147 | |
NOT-qualified manual | protein | Q2KHI9 | 10090 | MCM9_MOUSE | GO:0006260 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000315 from these references: PMID:21987787, PMID:23401855 | |
NOT-qualified manual | protein | Q9NXL9 | 9606 | MCM9_HUMAN | GO:0006260 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000316 from this reference: PMID:23401855 | |
NOT-qualified manual | protein | Q9UJA3 | 9606 | MCM8_HUMAN | GO:0006260 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000316 from this reference: PMID:23401855 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000525 | Initiator Rep protein, WH1 domain |
InterPro | IPR001957 | Chromosomal replication control, initiator DnaA |
InterPro | IPR003874 | CDC45 family |
InterPro | IPR008045 | DNA replication licensing factor Mcm2 |
InterPro | IPR008046 | DNA replication licensing factor Mcm3 |
InterPro | IPR008047 | Mini-chromosome maintenance complex protein 4 |
InterPro | IPR008048 | DNA replication licensing factor Mcm5 |
InterPro | IPR008049 | DNA replication licensing factor Mcm6 |
InterPro | IPR008050 | DNA replication licensing factor Mcm7 |
InterPro | IPR009731 | Replication P-like |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0006270 based on ALL annotations
The top 100 of 1,279 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA replication initiation
|
924.46 | 100.00 | 210,868 | 210,868 |
DNA replication origin binding
|
799.82 | 39.65 | 89,104 | 102,990 |
DNA unwinding involved in DNA replication
|
357.72 | 22.25 | 72,449 | 187,230 |
regulation of DNA replication
|
647.85 | 20.49 | 47,337 | 67,548 |
double-strand break repair via break-induced replication
|
651.05 | 16.25 | 36,786 | 52,234 |
MCM complex
|
690.28 | 14.54 | 32,260 | 43,204 |
DNA replication, synthesis of primer
|
227.92 | 12.70 | 43,786 | 177,597 |
primosome complex
|
252.96 | 12.35 | 38,733 | 141,554 |
DNA replication preinitiation complex
|
894.97 | 11.57 | 24,493 | 25,300 |
3'-5' DNA helicase activity
|
153.73 | 11.57 | 58,057 | 349,121 |
Totals | 2292753 | 166609566 |
No co-occurrence statistics for GO:0006270 based on MANUAL annotations
The top 100 of 493 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA replication initiation
|
790.09 | 100.00 | 1,635 | 1,635 |
DNA replication origin binding
|
553.85 | 30.12 | 565 | 806 |
nuclear origin of replication recognition complex
|
607.29 | 22.36 | 392 | 510 |
mitotic DNA replication checkpoint signaling
|
336.84 | 15.76 | 327 | 767 |
DNA replication preinitiation complex
|
744.94 | 14.01 | 231 | 245 |
double-strand break repair via break-induced replication
|
223.61 | 13.75 | 345 | 1,219 |
alpha DNA polymerase:primase complex
|
435.39 | 12.72 | 232 | 421 |
MCM complex
|
208.07 | 9.84 | 222 | 843 |
single-stranded DNA helicase activity
|
186.81 | 9.32 | 218 | 922 |
single-stranded DNA binding
|
82.87 | 8.20 | 447 | 4,262 |
Totals | 7550 | 374699 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-01-16 | Added | DEFINITION | The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding. |
2023-01-16 | Deleted | DEFINITION | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
2018-02-15 | Added | DEFINITION | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
2018-02-15 | Deleted | DEFINITION | The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. |
2013-07-27 | Deleted | RELATION | has part GO:0033260 (nuclear DNA replication) |
2012-09-08 | Updated | TERM | DNA replication initiation |
2012-09-08 | Added | DEFINITION | The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. |
2012-09-08 | Deleted | DEFINITION | The process in which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. |
2012-09-08 | Added | SYNONYM | DNA-dependent DNA replication initiation |
2012-09-08 | Deleted | SYNONYM | DNA replication initiation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-09-08 | Updated | TERM | DNA replication initiation |
2010-05-27 | Updated | TERM | DNA-dependent DNA replication initiation |
2002-02-06 | Updated | TERM | DNA replication initiation |
2001-04-03 | Updated | TERM | DNA replication initiation |
2001-03-30 | Added | TERM | DNA replication initiation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-01-16 | Added | DEFINITION | The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding. |
2023-01-16 | Deleted | DEFINITION | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
2018-02-15 | Added | DEFINITION | The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. |
2018-02-15 | Deleted | DEFINITION | The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. |
2012-09-08 | Added | DEFINITION | The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. |
2012-09-08 | Deleted | DEFINITION | The process in which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. |
2012-09-08 | Added | SYNONYM | DNA-dependent DNA replication initiation |
2012-09-08 | Deleted | SYNONYM | DNA replication initiation |
2012-09-02 | Added | SYNONYM | DNA replication initiation |
2010-11-24 | Deleted | DEFINITION | The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. |
2010-11-24 | Added | DEFINITION | The process in which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. |
2010-10-15 | Added | SYNONYM | DNA re-replication initiation |
2010-10-15 | Added | SYNONYM | DNA endoreduplication initiation |
2008-05-13 | Added | DEFINITION | The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. |
2008-05-12 | Deleted | DEFINITION | The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. |
2004-04-24 | Added | DEFINITION | The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2013-07-27 | Deleted | RELATION | has part GO:0033260 (nuclear DNA replication) |
2010-10-31 | Added | RELATION | has part GO:0033260 (nuclear DNA replication) |
2010-10-15 | Added | RELATION | has part GO:0042023 (DNA endoreduplication) |
2008-04-01 | Updated | RELATION | part of GO:0006261 (DNA-templated DNA replication) |
2008-04-01 | Updated | RELATION | is a GO:0006259 (DNA metabolic process) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-10-15 | Added | SECONDARY | GO:0042024 (DNA endoreduplication initiation) |
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