This term is obsolete.

GO:0006357 JSON

regulation of transcription by RNA polymerase II

Biological Process

Definition (GO:0006357 GONUTS page)

Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

Secondary IDs

GO:0006358, GO:0010551

6,159,667 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
regulation of transcription from RNA polymerase II promoter exact
regulation of global transcription from Pol II promoter related
regulation of transcription from RNA polymerase II promoter, global related
global transcription regulation from Pol II promoter related
regulation of transcription from Pol II promoter exact
regulation of gene-specific transcription from RNA polymerase II promoter related

Ancestor Chart

Ancestor chart for GO:0006357
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006357

Child Term Relationship to
GO:0006357
negative regulation of transcription by RNA polymerase II
is_a
DNA-binding transcription factor activity, RNA polymerase II-specific
part_of
mBAF complex
capable_of_part_of
bBAF complex
capable_of_part_of
esBAF complex
capable_of_part_of
nitrogen catabolite regulation of transcription from RNA polymerase II promoter
is_a
positive regulation of transcription by RNA polymerase II
is_a
RNA polymerase II CTD heptapeptide repeat modifying activity
part_of
RSC-type complex
capable_of_part_of
regulation of snRNA transcription by RNA polymerase II
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to transcription processes Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P26801 10116 CEBPG_RAT GO:0006355 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P42224-2 9606 STAT1_HUMAN GO:0006357 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10820245
NOT-qualified manual protein P53568 10090 CEBPG_MOUSE GO:0006355 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:1371974
NOT-qualified manual protein P9WNV7 83332 DNAJ2_MYCTU GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15207487
NOT-qualified manual protein Q6QGW5 10116 SRA1_RAT GO:0006357 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein Q8NF99-1 9606 ZN397_HUMAN GO:0006355 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12801647
NOT-qualified manual protein Q90998 9031 Q90998_CHICK GO:0010468 3 NOT-qualified manual annotations exist with evidence code ECO:0000315 from this reference: PMID:11500982
NOT-qualified manual protein Q90999 9031 TGFR2_CHICK GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11500982
NOT-qualified manual protein Q96AE4 9606 FUBP1_HUMAN GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:8125259
NOT-qualified manual protein Q9HD15 9606 SRA1_HUMAN GO:0006357 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:24486609

Cross-references

Database ID Description
InterPro IPR000580 TSC22/Bun
InterPro IPR000837 AP-1 transcription factor
InterPro IPR007018 Mediator complex, subunit Med6
InterPro IPR008626 Mediator complex, subunit Med15, fungi
InterPro IPR009244 Mediator complex, subunit Med7
InterPro IPR009332 Mediator of RNA polymerase II transcription subunit 22
InterPro IPR009401 Mediator complex subunit Med13, C-terminal
InterPro IPR011363 Dorsal-related immunity factor Dif
InterPro IPR011425 Mediator of RNA polymerase II transcription subunit 9
InterPro IPR013921 Mediator complex, subunit Med20

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0000083 obsolete regulation of transcription involved in G1/S transition of mitotic cell cycle consider GO:0006357
GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle consider GO:0006357
GO:0000115 obsolete regulation of transcription involved in S phase of mitotic cell cycle consider GO:0006357
GO:0000116 obsolete regulation of transcription involved in G2-phase of mitotic cell cycle consider GO:0006357
GO:0000117 obsolete regulation of transcription involved in G2/M transition of mitotic cell cycle consider GO:0006357
GO:0007468 obsolete regulation of rhodopsin gene expression consider GO:0006357
GO:0010672 obsolete regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle consider GO:0006357
GO:0010767 obsolete regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage consider GO:0006357
GO:0021882 obsolete regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment consider GO:0006357
GO:0021909 obsolete regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning consider GO:0006357

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0006357 based on ALL annotations
The top 100 of 10,792 co-occurring terms
Co-occurring Term PR S% #Together #Compared
regulation of transcription by RNA polymerase II
85.60 100.00 2,314,777 2,314,777
DNA-binding transcription factor activity, RNA polymerase II-specific
77.50 55.57 1,365,723 1,508,451
RNA polymerase II cis-regulatory region sequence-specific DNA binding
73.99 38.36 944,874 1,093,198
nucleus
14.81 16.41 1,764,421 10,201,488
RNA polymerase II CTD heptapeptide repeat P3 isomerase activity
85.55 9.70 224,455 224,589
RNA polymerase II CTD heptapeptide repeat P6 isomerase activity
85.55 9.70 224,455 224,589
zinc ion binding
9.56 9.37 850,551 7,614,055
RNA polymerase II transcription regulatory region sequence-specific DNA binding
68.30 9.15 216,926 271,879
peptidyl-prolyl cis-trans isomerase activity
40.85 8.73 223,444 468,194
regulation of DNA-templated transcription
7.63 7.75 858,839 9,631,576
Totals 15137778 129823180
No co-occurrence statistics for GO:0006357 based on MANUAL annotations
The top 100 of 6,988 co-occurring terms
Co-occurring Term PR S% #Together #Compared
regulation of transcription by RNA polymerase II
29.54 100.00 47,787 47,787
DNA-binding transcription factor activity, RNA polymerase II-specific
24.31 53.88 29,128 35,397
RNA polymerase II cis-regulatory region sequence-specific DNA binding
22.53 44.66 24,785 32,501
nucleus
3.76 11.55 26,498 208,176
RNA polymerase II transcription regulatory region sequence-specific DNA binding
23.13 10.95 5,398 6,894
chromatin
9.69 7.21 4,039 12,307
DNA-binding transcription factor activity
6.12 6.74 4,337 20,929
cell differentiation
13.59 6.26 3,230 7,022
transcription coregulator activity
16.31 5.27 2,629 4,761
DNA-binding transcription activator activity, RNA polymerase II-specific
18.70 4.82 2,368 3,740
Totals 207010 941761

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-8864260
2018-01-20 Added DEFINITION Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2018-01-20 Updated TERM regulation of transcription by RNA polymerase II
2018-01-20 Added SYNONYM regulation of transcription from RNA polymerase II promoter
2018-01-20 Deleted DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2011-06-05 Added SYNONYM regulation of global transcription from Pol II promoter
2011-06-05 Added SYNONYM regulation of transcription from RNA polymerase II promoter, global
2011-06-05 Added SECONDARY GO:0006358 (regulation of transcription from RNA polymerase II promoter, global)
2011-06-05 Added SYNONYM global transcription regulation from Pol II promoter
2011-05-15 Added SECONDARY GO:0010551 (regulation of gene-specific transcription from RNA polymerase II promoter)
Timestamp Action Category Detail
2018-01-20 Updated TERM regulation of transcription by RNA polymerase II
2005-03-27 Updated TERM regulation of transcription from RNA polymerase II promoter
2002-07-17 Updated TERM regulation of transcription from Pol II promoter
2002-07-16 Updated TERM transcription regulation from Pol II promoter
2002-02-06 Updated TERM transcription regulation, from Pol II promoter
2001-10-04 Updated TERM transcription regulation, from Pol II promoter
2001-04-03 Updated TERM transcription regulation from Pol II promoter
2001-03-30 Added TERM transcription regulation from Pol II promoter
Timestamp Action Category Detail
2018-01-20 Added DEFINITION Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2018-01-20 Added SYNONYM regulation of transcription from RNA polymerase II promoter
2018-01-20 Deleted DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2011-06-05 Added SYNONYM regulation of global transcription from Pol II promoter
2011-06-05 Added SYNONYM regulation of transcription from RNA polymerase II promoter, global
2011-06-05 Added SYNONYM global transcription regulation from Pol II promoter
2011-05-15 Added SYNONYM regulation of gene-specific transcription from RNA polymerase II promoter
2008-05-13 Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2008-05-12 Deleted DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2007-08-09 Added SYNONYM regulation of transcription from Pol II promoter
2007-08-09 Deleted SYNONYM regulation of transcription from Pol II promoter
2005-03-27 Added SYNONYM regulation of transcription from Pol II promoter
2005-03-25 Updated DEFINITION Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2002-11-27 Added DEFINITION Any process that modulates the frequency, rate or extent of transcription from Pol II promoter.
Timestamp Action Category Detail
2008-04-01 Updated RELATION part of GO:0006366 (transcription by RNA polymerase II)
2008-04-01 Updated RELATION is a GO:0006355 (regulation of DNA-templated transcription)
2008-04-01 Deleted RELATION part of GO:0006366 (transcription by RNA polymerase II)
2008-04-01 Added RELATION regulates GO:0006366 (transcription by RNA polymerase II)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-8864260
Timestamp Action Category Detail
2011-06-05 Added SECONDARY GO:0006358 (regulation of transcription from RNA polymerase II promoter, global)
2011-05-15 Added SECONDARY GO:0010551 (regulation of gene-specific transcription from RNA polymerase II promoter)
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