This term is obsolete.

GO:0006415 JSON

translational termination

Biological Process

Definition (GO:0006415 GONUTS page)

The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).

Secondary IDs

GO:0006443, GO:0006456

426,412 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
translation termination exact
translational complex disassembly exact
protein synthesis termination broad

Ancestor Chart

Ancestor chart for GO:0006415
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006415

Child Term Relationship to
GO:0006415
positive regulation of translational termination
positively_regulates
negative regulation of translational termination
negatively_regulates
translation termination factor activity
part_of
mitochondrial translational termination
is_a
cytoplasmic translational termination
is_a
regulation of translational termination
regulates

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0006415 translational termination Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Cross-references

Database ID Description
InterPro IPR000352 Peptide chain release factor class I
InterPro IPR003285 Eukaryotic peptide chain release factor GTP-binding subunit
InterPro IPR004373 Peptide chain release factor 1
InterPro IPR004374 Peptide chain release factor 2
InterPro IPR004403 Peptide chain release factor eRF1/aRF1
InterPro IPR004548 Peptide chain release factor 3
InterPro IPR005139 Peptide chain release factor
InterPro IPR020918 Peptide chain release factor aRF1
Reactome R-HSA-72764

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0016148 obsolete protein-synthesizing GTPase activity, termination consider GO:0006415

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0006415 based on ALL annotations
The top 100 of 813 co-occurring terms
Co-occurring Term PR S% #Together #Compared
translational termination
940.10 100.00 210,780 210,780
translation release factor activity, codon specific
940.10 50.35 106,119 106,119
translation release factor activity
940.01 27.43 57,828 57,834
translation release factor activity, codon nonspecific
931.91 14.33 30,240 30,506
regulation of translational termination
783.22 11.16 24,054 28,872
ribosomal large subunit binding
190.27 10.63 38,542 190,428
aminoacyl-tRNA hydrolase activity
247.83 8.20 22,435 85,102
rescue of stalled ribosome
233.25 7.15 19,255 77,605
cytoplasmic translational termination
902.91 7.01 14,809 15,419
ribosome binding
36.00 2.78 19,384 506,182
Totals 1038815 85351759
No co-occurrence statistics for GO:0006415 based on MANUAL annotations
The top 100 of 151 co-occurring terms
Co-occurring Term PR S% #Together #Compared
translational termination
3,877.84 100.00 364 364
protein-glutamine N-methyltransferase activity
3,303.34 24.21 92 108
ribosomal small subunit binding
686.58 14.97 179 1,011
iron ion binding
642.72 14.15 179 1,080
translation release factor activity, codon nonspecific
1,387.86 8.00 34 95
translation release factor activity
736.57 6.68 34 179
translational initiation
228.18 5.55 180 3,059
translation release factor complex
223.11 2.97 21 365
ATP binding
101.91 2.56 180 6,849
regulation of translational termination
401.16 2.04 9 87
Totals 1606 184325

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-72764
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2022-01-12 Deleted RELATION is a GO:0043624 (cellular protein complex disassembly)
2022-01-12 Added RELATION is a GO:0032984 (protein-containing complex disassembly)
2020-02-28 Deleted XREF MIPS_funcat:12.04.03
2019-05-04 Added XREF MIPS_funcat:12.04.03
2017-05-01 Added RELATION has part GO:0006412 (translation)
2008-05-13 Added DEFINITION The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
2008-05-12 Deleted DEFINITION The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
2008-04-01 Updated RELATION part of GO:0006412 (translation)
Timestamp Action Category Detail
2002-08-05 Updated TERM translational termination
2002-02-06 Updated TERM protein synthesis termination
2001-04-03 Updated TERM protein synthesis termination
2001-03-30 Added TERM protein synthesis termination
Timestamp Action Category Detail
2008-05-13 Added DEFINITION The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
2008-05-12 Deleted DEFINITION The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
2007-08-09 Added SYNONYM translational complex disassembly
2007-08-09 Deleted SYNONYM translation termination
2007-08-09 Deleted SYNONYM protein synthesis termination
2007-08-09 Deleted SYNONYM translational complex disassembly
2007-08-09 Added SYNONYM translation termination
2007-08-09 Added SYNONYM protein synthesis termination
2007-07-11 Deleted SYNONYM protein-synthesizing GTPase activity, termination
2007-01-15 Added SYNONYM translational complex disassembly
2005-08-19 Added SYNONYM translation termination
2005-08-10 Added SYNONYM protein-synthesizing GTPase activity, termination
2004-08-29 Updated DEFINITION The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
2004-04-19 Added SYNONYM protein synthesis termination
2004-04-16 Deleted SYNONYM protein synthesis termination
2002-11-27 Added DEFINITION The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA).
2002-08-05 Added SYNONYM protein synthesis termination
Timestamp Action Category Detail
2022-01-12 Deleted RELATION is a GO:0043624 (cellular protein complex disassembly)
2022-01-12 Added RELATION is a GO:0032984 (protein-containing complex disassembly)
2017-05-01 Added RELATION has part GO:0006412 (translation)
2008-04-01 Updated RELATION part of GO:0006412 (translation)
2008-04-01 Updated RELATION is a GO:0043624 (cellular protein complex disassembly)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-72764
2020-02-28 Deleted XREF MIPS_funcat:12.04.03
2019-05-04 Added XREF MIPS_funcat:12.04.03
Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
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