This term is obsolete.
Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis.

GO:0006590 JSON

thyroid hormone generation

Biological Process

Definition (GO:0006590 GONUTS page)

The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.

Comments

Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis.

5,532 annotations

Ancestor Chart

Ancestor chart for GO:0006590
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006590

Child Term Relationship to
GO:0006590
negative regulation of thyroid hormone generation
negatively_regulates
positive regulation of thyroid hormone generation
positively_regulates
regulation of thyroid hormone generation
regulates

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0006590 thyroid hormone generation Never in Taxon 4895 Schizosaccharomyces

More information on taxon constraints in GO is available here

Cross-references

Database ID Description
InterPro IPR029589 Thyroid peroxidase
InterPro IPR035689 Sodium/iodide cotransporter
Reactome R-HSA-209968

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0006590 based on ALL annotations
The top 100 of 388 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thyroid hormone generation
36,258.90 100.00 5,465 5,465
positive regulation of steroid biosynthetic process
32,464.36 17.93 1,001 1,118
follicle-stimulating hormone complex
32,205.10 17.90 1,001 1,127
follicle-stimulating hormone activity
21,668.75 16.31 1,001 1,675
iodide peroxidase activity
35,324.39 13.78 756 776
hormone biosynthetic process
5,846.89 12.89 2,140 13,271
superoxide-generating NAD(P)H oxidase activity
3,421.71 7.00 1,163 12,324
NADPH oxidase complex
2,778.30 5.97 1,163 15,178
NAD(P)H oxidase H2O2-forming activity
2,508.11 4.97 819 11,840
iodide transport
12,640.31 4.81 289 829
Totals 28167 648234
No co-occurrence statistics for GO:0006590 based on MANUAL annotations
The top 100 of 333 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thyroid hormone generation
12,832.12 100.00 110 110
positive regulation of steroid biosynthetic process
4,528.98 15.58 24 68
follicle-stimulating hormone complex
3,421.90 13.64 24 90
follicle-stimulating hormone activity
2,799.73 12.24 24 110
metallodipeptidase activity
1,769.95 7.62 16 116
iodide transport
3,888.52 7.52 10 33
enucleate erythrocyte development
9,980.54 6.25 7 9
mammary gland branching involved in pregnancy
6,416.06 5.98 7 14
G0 to G1 transition
5,614.05 5.88 7 16
mammary gland branching involved in thelarche
5,283.81 5.83 7 17
Totals 724 9500

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-209968
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)
2008-05-13 Added DEFINITION The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
2008-05-12 Deleted DEFINITION The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
2008-04-01 Updated RELATION is a GO:0042403 (thyroid hormone metabolic process)
2002-11-27 Added DEFINITION The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
2002-08-01 Updated TERM thyroid hormone generation
2002-02-06 Updated TERM thyroid hormone biosynthesis
2001-04-03 Updated TERM thyroid hormone biosynthesis
2001-03-30 Added TERM thyroid hormone biosynthesis
Timestamp Action Category Detail
2002-08-01 Updated TERM thyroid hormone generation
2002-02-06 Updated TERM thyroid hormone biosynthesis
2001-04-03 Updated TERM thyroid hormone biosynthesis
2001-03-30 Added TERM thyroid hormone biosynthesis
Timestamp Action Category Detail
2008-05-13 Added DEFINITION The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
2008-05-12 Deleted DEFINITION The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
2002-11-27 Added DEFINITION The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0042403 (thyroid hormone metabolic process)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-209968
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)
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