Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis.
GO:0006590
JSON
thyroid hormone generation
Biological Process
Definition (GO:0006590 GONUTS page)
The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
Comments
Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis.
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0006590
Child Term | Relationship to GO:0006590 |
---|---|
regulation of thyroid hormone generation
|
regulates |
positive regulation of thyroid hormone generation
|
positively_regulates |
negative regulation of thyroid hormone generation
|
negatively_regulates |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0006590 | thyroid hormone generation | Never in Taxon | 4895 | Schizosaccharomyces |
More information on taxon constraints in GO is available here
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR029589 | Thyroid peroxidase |
InterPro | IPR035689 | Sodium/iodide cotransporter |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0006590 based on ALL annotations
The top 100 of 391 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
thyroid hormone generation
|
35,933.41 | 100.00 | 5,425 | 5,425 |
positive regulation of steroid biosynthetic process
|
32,099.65 | 17.82 | 988 | 1,106 |
follicle-stimulating hormone complex
|
31,840.55 | 17.80 | 988 | 1,115 |
follicle-stimulating hormone activity
|
21,477.45 | 16.22 | 988 | 1,653 |
iodide peroxidase activity
|
34,997.65 | 13.74 | 748 | 768 |
hormone biosynthetic process
|
5,246.19 | 11.91 | 2,132 | 14,603 |
superoxide-generating NAD(P)H oxidase activity
|
3,485.70 | 7.17 | 1,169 | 12,051 |
NADPH oxidase complex
|
2,861.26 | 6.17 | 1,169 | 14,681 |
NAD(P)H oxidase H2O2-forming activity
|
2,590.85 | 5.13 | 819 | 11,359 |
iodide transport
|
12,583.18 | 4.88 | 291 | 831 |
Totals | 29656 | 825560 |
No co-occurrence statistics for GO:0006590 based on MANUAL annotations
The top 100 of 334 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
thyroid hormone generation
|
12,664.70 | 100.00 | 102 | 102 |
positive regulation of steroid biosynthetic process
|
3,819.51 | 13.01 | 19 | 63 |
follicle-stimulating hormone complex
|
2,830.93 | 11.31 | 19 | 85 |
follicle-stimulating hormone activity
|
2,336.21 | 10.22 | 19 | 103 |
iodide transport
|
3,837.79 | 8.00 | 10 | 33 |
metallodipeptidase activity
|
1,569.08 | 6.97 | 14 | 113 |
enucleate erythrocyte development
|
9,850.32 | 6.73 | 7 | 9 |
mammary gland branching involved in pregnancy
|
6,332.35 | 6.42 | 7 | 14 |
G0 to G1 transition
|
5,540.80 | 6.31 | 7 | 16 |
mammary gland branching involved in thelarche
|
5,214.88 | 6.25 | 7 | 17 |
Totals | 706 | 9382 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4895 (Schizosaccharomyces) |
2008-05-13 | Added | DEFINITION | The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. |
2008-05-12 | Deleted | DEFINITION | The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. |
2008-04-01 | Updated | RELATION | is a GO:0042403 (thyroid hormone metabolic process) |
2002-11-27 | Added | DEFINITION | The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. |
2002-08-01 | Updated | TERM | thyroid hormone generation |
2002-02-06 | Updated | TERM | thyroid hormone biosynthesis |
2001-04-03 | Updated | TERM | thyroid hormone biosynthesis |
2001-03-30 | Added | TERM | thyroid hormone biosynthesis |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-08-01 | Updated | TERM | thyroid hormone generation |
2002-02-06 | Updated | TERM | thyroid hormone biosynthesis |
2001-04-03 | Updated | TERM | thyroid hormone biosynthesis |
2001-03-30 | Added | TERM | thyroid hormone biosynthesis |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. |
2008-05-12 | Deleted | DEFINITION | The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. |
2002-11-27 | Added | DEFINITION | The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0042403 (thyroid hormone metabolic process) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4895 (Schizosaccharomyces) |
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