GO:0006606
JSON
protein import into nucleus
Biological Process
Definition (GO:0006606 GONUTS page)
The directed movement of a protein from the cytoplasm to the nucleus.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
protein transport from cytoplasm to nucleus | exact |
protein import into cell nucleus | exact |
establishment of protein localization to nucleus | exact |
protein nucleus import | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0006606
Child Term | Relationship to GO:0006606 |
---|---|
NLS-bearing protein import into nucleus
|
is_a |
positive regulation of protein import into nucleus
|
positively_regulates |
regulation of protein import into nucleus
|
regulates |
ribosomal protein import into nucleus
|
is_a |
negative regulation of protein import into nucleus
|
negatively_regulates |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0006606 | protein import into nucleus | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | D3ZHD6 | 10116 | D3ZHD6_RAT | GO:0006913 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F1MA98 | 10116 | TPR_RAT | GO:0006606 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | F6ZDS4 | 10090 | TPR_MOUSE | GO:0006606 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | P02650 | 10116 | APOE_RAT | GO:0008104 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P04639 | 10116 | APOA1_RAT | GO:0008104 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P08226 | 10090 | APOE_MOUSE | GO:0008104 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9325076 | |
NOT-qualified manual | protein | P12270 | 9606 | TPR_HUMAN | GO:0006606 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000314, ECO:0000315 from these references: PMID:11952838, PMID:9864356 | |
NOT-qualified manual | protein | Q00623 | 10090 | APOA1_MOUSE | GO:0008104 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9325076 | |
NOT-qualified manual | protein | Q5EE04 | 8355 | TPR_XENLA | GO:0006606 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q7K2X8 | 7227 | SEH1_DROME | GO:0006606 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:20547758 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR002652 | Importin-alpha, importin-beta-binding domain |
InterPro | IPR012929 | Nucleoprotein TPR/MLP1 |
InterPro | IPR024931 | Importin subunit alpha |
InterPro | IPR036975 | Importin-alpha, importin-beta-binding domain superfamily |
InterPro | IPR040122 | Importin beta family |
InterPro | IPR040150 | RNA polymerase II nuclear localization protein Iwr1 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0000189 | obsolete MAPK import into nucleus | consider GO:0006606 |
GO:0000201 | obsolete MAPK import into nucleus involved in cell wall organization or biogenesis | consider GO:0006606 |
GO:0000208 | obsolete MAPK import into nucleus involved in osmosensory signaling pathway | consider GO:0006606 |
GO:0002146 | obsolete steroid hormone receptor import into nucleus | consider GO:0006606 |
GO:0003929 | obsolete RAN small monomeric GTPase activity | consider GO:0006606 |
GO:0006608 | obsolete snRNP protein import into nucleus | consider GO:0006606 |
GO:0006609 | obsolete mRNA-binding (hnRNP) protein import into nucleus | consider GO:0006606 |
GO:0035048 | obsolete splicing factor protein import into nucleus | consider GO:0006606 |
GO:0035105 | obsolete sterol regulatory element binding protein import into nucleus | consider GO:0006606 |
GO:0035424 | obsolete MAPK import into nucleus involved in innate immune response | consider GO:0006606 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0006606 based on ALL annotations
The top 100 of 3,657 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein import into nucleus
|
1,204.10 | 100.00 | 161,896 | 161,896 |
structural constituent of nuclear pore
|
812.29 | 28.30 | 53,067 | 78,664 |
nuclear pore
|
509.50 | 23.49 | 55,945 | 132,214 |
nuclear envelope
|
372.62 | 16.31 | 41,506 | 134,123 |
RNA export from nucleus
|
990.21 | 15.02 | 25,138 | 30,568 |
nuclear import signal receptor activity
|
1,161.89 | 13.55 | 22,051 | 22,852 |
mRNA transport
|
277.23 | 12.39 | 34,249 | 148,756 |
nuclear pore outer ring
|
849.24 | 11.09 | 18,827 | 26,694 |
small GTPase binding
|
172.95 | 10.16 | 41,696 | 290,296 |
nucleocytoplasmic transport
|
306.00 | 8.68 | 18,860 | 74,214 |
Totals | 1029918 | 50811065 |
No co-occurrence statistics for GO:0006606 based on MANUAL annotations
The top 100 of 2,773 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
protein import into nucleus
|
363.07 | 100.00 | 3,558 | 3,558 |
nuclear localization sequence binding
|
221.94 | 24.23 | 1,019 | 1,667 |
structural constituent of nuclear pore
|
231.80 | 23.68 | 973 | 1,524 |
nuclear import signal receptor activity
|
223.48 | 22.74 | 943 | 1,532 |
RNA export from nucleus
|
249.24 | 14.54 | 554 | 807 |
nuclear pore outer ring
|
235.99 | 11.96 | 455 | 700 |
nuclear envelope
|
75.28 | 10.53 | 627 | 3,024 |
nuclear pore
|
79.58 | 8.16 | 409 | 1,866 |
post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
|
259.06 | 7.34 | 269 | 377 |
mRNA export from nucleus
|
62.88 | 5.95 | 296 | 1,709 |
Totals | 18119 | 710048 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2022-04-05 | Deleted | RELATION | is a GO:0017038 (protein import) |
2018-06-04 | Deleted | RELATION | part of GO:0034504 (protein localization to nucleus) |
2018-02-16 | Added | RELATION | is a GO:0006886 (intracellular protein transport) |
2017-12-25 | Added | RELATION | is a GO:0051170 (import into nucleus) |
2017-12-08 | Deleted | RELATION | is a GO:0051170 (import into nucleus) |
2017-12-08 | Deleted | RELATION | is a GO:0006886 (intracellular protein transport) |
2017-08-13 | Deleted | RELATION | is a GO:1902593 (single-organism nuclear import) |
2017-08-13 | Added | RELATION | is a GO:0051170 (import into nucleus) |
2017-06-29 | Added | RELATION | part of GO:0034504 (protein localization to nucleus) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2005-09-29 | Updated | TERM | protein import into nucleus |
2002-02-06 | Updated | TERM | protein-nucleus import |
2001-04-03 | Updated | TERM | protein-nucleus import |
2001-03-30 | Added | TERM | protein-nucleus import |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-12-09 | Deleted | SYNONYM | protein targeting to nucleus |
2011-02-15 | Added | SYNONYM | establishment of protein localization to nucleus |
2009-04-29 | Added | SYNONYM | protein targeting to nucleus |
2008-08-04 | Added | SYNONYM | protein import into cell nucleus |
2008-05-13 | Added | DEFINITION | The directed movement of a protein from the cytoplasm to the nucleus. |
2008-05-12 | Deleted | DEFINITION | The directed movement of a protein from the cytoplasm to the nucleus. |
2007-08-09 | Added | SYNONYM | protein transport from cytoplasm to nucleus |
2007-08-09 | Deleted | SYNONYM | protein nucleus import |
2007-08-09 | Deleted | SYNONYM | protein transport from cytoplasm to nucleus |
2007-08-09 | Added | SYNONYM | protein nucleus import |
2007-07-11 | Deleted | SYNONYM | RAN small monomeric GTPase activity |
2005-09-29 | Added | SYNONYM | protein transport from cytoplasm to nucleus |
2005-09-29 | Added | SYNONYM | protein nucleus import |
2005-08-10 | Added | SYNONYM | RAN small monomeric GTPase activity |
2003-04-08 | Updated | DEFINITION | The directed movement of a protein from the cytoplasm to the nucleus. |
2002-11-27 | Added | DEFINITION | The movement of a protein from the cytoplasm to the nucleus. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-04-05 | Deleted | RELATION | is a GO:0017038 (protein import) |
2018-06-04 | Deleted | RELATION | part of GO:0034504 (protein localization to nucleus) |
2018-02-16 | Added | RELATION | is a GO:0006886 (intracellular protein transport) |
2017-12-25 | Added | RELATION | is a GO:0051170 (import into nucleus) |
2017-12-08 | Deleted | RELATION | is a GO:0051170 (import into nucleus) |
2017-12-08 | Deleted | RELATION | is a GO:0006886 (intracellular protein transport) |
2017-08-13 | Deleted | RELATION | is a GO:1902593 (single-organism nuclear import) |
2017-08-13 | Added | RELATION | is a GO:0051170 (import into nucleus) |
2017-06-29 | Added | RELATION | part of GO:0034504 (protein localization to nucleus) |
2017-06-29 | Deleted | RELATION | part of GO:0044744 (protein targeting to nucleus) |
2017-06-22 | Deleted | RELATION | is a GO:1902582 (single-organism intracellular transport) |
2017-06-22 | Deleted | RELATION | is a GO:0051169 (nuclear transport) |
2017-06-22 | Added | RELATION | is a GO:1902593 (single-organism nuclear import) |
2017-06-06 | Added | RELATION | is a GO:0051169 (nuclear transport) |
2017-05-22 | Deleted | RELATION | is a GO:1902593 (single-organism nuclear import) |
2017-05-22 | Added | RELATION | is a GO:1902582 (single-organism intracellular transport) |
2016-06-26 | Deleted | RELATION | is a GO:1902580 (single-organism cellular localization) |
2014-09-18 | Added | RELATION | is a GO:1902580 (single-organism cellular localization) |
2014-09-18 | Added | RELATION | is a GO:0034504 (protein localization to nucleus) |
2014-09-13 | Deleted | RELATION | part of GO:0034504 (protein localization to nucleus) |
2013-12-21 | Deleted | RELATION | is a GO:0051170 (import into nucleus) |
2013-12-21 | Added | RELATION | is a GO:1902593 (single-organism nuclear import) |
2013-08-29 | Added | RELATION | is a GO:0072594 (establishment of protein localization to organelle) |
2012-12-15 | Added | RELATION | is a GO:0017038 (protein import) |
2012-12-15 | Deleted | RELATION | is a GO:0044743 (protein transmembrane import into intracellular organelle) |
2012-12-15 | Added | RELATION | is a GO:0006886 (intracellular protein transport) |
2012-11-09 | Deleted | RELATION | is a GO:0006605 (protein targeting) |
2012-11-09 | Added | RELATION | is a GO:0044743 (protein transmembrane import into intracellular organelle) |
2012-11-09 | Deleted | RELATION | is a GO:0017038 (protein import) |
2012-11-09 | Added | RELATION | part of GO:0044744 (protein targeting to nucleus) |
2009-03-21 | Added | RELATION | part of GO:0034504 (protein localization to nucleus) |
2008-04-01 | Updated | RELATION | is a GO:0051170 (import into nucleus) |
2008-04-01 | Updated | RELATION | is a GO:0017038 (protein import) |
2008-04-01 | Updated | RELATION | is a GO:0006605 (protein targeting) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
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