This term is obsolete.

GO:0006606 JSON

protein import into nucleus

Biological Process

Definition (GO:0006606 GONUTS page)

The directed movement of a protein from the cytoplasm to the nucleus.

180,194 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
protein transport from cytoplasm to nucleus exact
protein import into cell nucleus exact
establishment of protein localization to nucleus exact
protein nucleus import exact

Ancestor Chart

Ancestor chart for GO:0006606
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006606

Child Term Relationship to
GO:0006606
NLS-bearing protein import into nucleus
is_a
regulation of protein import into nucleus
regulates
positive regulation of protein import into nucleus
positively_regulates
ribosomal protein import into nucleus
is_a
negative regulation of protein import into nucleus
negatively_regulates

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0006606 protein import into nucleus Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein D3ZHD6 10116 D3ZHD6_RAT GO:0006913 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F1MA98 10116 TPR_RAT GO:0006606 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein F6ZDS4 10090 TPR_MOUSE GO:0006606 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein P02650 10116 APOE_RAT GO:0008104 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P04639 10116 APOA1_RAT GO:0008104 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P08226 10090 APOE_MOUSE GO:0008104 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9325076
NOT-qualified manual protein P12270 9606 TPR_HUMAN GO:0006606 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000314, ECO:0000315 from these references: PMID:11952838, PMID:9864356
NOT-qualified manual protein Q00623 10090 APOA1_MOUSE GO:0008104 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9325076
NOT-qualified manual protein Q5EE04 8355 TPR_XENLA GO:0006606 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q7K2X8 7227 SEH1_DROME GO:0006606 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:20547758

Cross-references

Database ID Description
InterPro IPR002652 Importin-alpha, importin-beta-binding domain
InterPro IPR012929 Nucleoprotein TPR/MLP1
InterPro IPR024931 Importin subunit alpha
InterPro IPR036975 Importin-alpha, importin-beta-binding domain superfamily
InterPro IPR040122 Importin beta family
InterPro IPR040150 RNA polymerase II nuclear localization protein Iwr1

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0000189 obsolete MAPK import into nucleus consider GO:0006606
GO:0000201 obsolete MAPK import into nucleus involved in cell wall organization or biogenesis consider GO:0006606
GO:0000208 obsolete MAPK import into nucleus involved in osmosensory signaling pathway consider GO:0006606
GO:0002146 obsolete steroid hormone receptor import into nucleus consider GO:0006606
GO:0003929 obsolete RAN small monomeric GTPase activity consider GO:0006606
GO:0006608 obsolete snRNP protein import into nucleus consider GO:0006606
GO:0006609 obsolete mRNA-binding (hnRNP) protein import into nucleus consider GO:0006606
GO:0035048 obsolete splicing factor protein import into nucleus consider GO:0006606
GO:0035105 obsolete sterol regulatory element binding protein import into nucleus consider GO:0006606
GO:0035424 obsolete MAPK import into nucleus involved in innate immune response consider GO:0006606

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0006606 based on ALL annotations
The top 100 of 3,674 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein import into nucleus
1,180.30 100.00 167,885 167,885
structural constituent of nuclear pore
799.78 28.32 54,957 81,105
nuclear pore
503.28 23.55 57,887 135,758
nuclear envelope
376.82 16.61 43,176 135,239
RNA export from nucleus
969.40 15.01 26,048 31,715
mRNA transport
302.70 13.94 39,286 153,185
nuclear import signal receptor activity
1,137.17 13.61 22,963 23,834
nuclear pore outer ring
832.40 11.10 19,541 27,708
small GTPase binding
171.13 10.24 43,347 298,974
nucleocytoplasmic transport
303.23 8.73 19,614 76,345
Totals 1080155 51541251
No co-occurrence statistics for GO:0006606 based on MANUAL annotations
The top 100 of 2,787 co-occurring terms
Co-occurring Term PR S% #Together #Compared
protein import into nucleus
365.78 100.00 3,859 3,859
nuclear localization sequence binding
222.24 24.15 1,104 1,817
structural constituent of nuclear pore
235.46 23.96 1,066 1,656
nuclear import signal receptor activity
221.84 22.39 1,011 1,667
RNA export from nucleus
252.03 14.89 616 894
nuclear pore outer ring
239.50 12.01 495 756
nuclear envelope
75.81 10.48 675 3,257
nuclear pore
87.91 8.49 448 1,864
post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
259.87 7.34 292 411
mRNA export from nucleus
63.66 5.99 323 1,856
Totals 19593 769750

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2022-04-05 Deleted RELATION is a GO:0017038 (protein import)
2018-06-04 Deleted RELATION part of GO:0034504 (protein localization to nucleus)
2018-02-16 Added RELATION is a GO:0006886 (intracellular protein transport)
2017-12-25 Added RELATION is a GO:0051170 (import into nucleus)
2017-12-08 Deleted RELATION is a GO:0051170 (import into nucleus)
2017-12-08 Deleted RELATION is a GO:0006886 (intracellular protein transport)
2017-08-13 Deleted RELATION is a GO:1902593 (single-organism nuclear import)
2017-08-13 Added RELATION is a GO:0051170 (import into nucleus)
2017-06-29 Added RELATION part of GO:0034504 (protein localization to nucleus)
Timestamp Action Category Detail
2005-09-29 Updated TERM protein import into nucleus
2002-02-06 Updated TERM protein-nucleus import
2001-04-03 Updated TERM protein-nucleus import
2001-03-30 Added TERM protein-nucleus import
Timestamp Action Category Detail
2012-12-09 Deleted SYNONYM protein targeting to nucleus
2011-02-15 Added SYNONYM establishment of protein localization to nucleus
2009-04-29 Added SYNONYM protein targeting to nucleus
2008-08-04 Added SYNONYM protein import into cell nucleus
2008-05-13 Added DEFINITION The directed movement of a protein from the cytoplasm to the nucleus.
2008-05-12 Deleted DEFINITION The directed movement of a protein from the cytoplasm to the nucleus.
2007-08-09 Deleted SYNONYM protein transport from cytoplasm to nucleus
2007-08-09 Deleted SYNONYM protein nucleus import
2007-08-09 Added SYNONYM protein transport from cytoplasm to nucleus
2007-08-09 Added SYNONYM protein nucleus import
2007-07-11 Deleted SYNONYM RAN small monomeric GTPase activity
2005-09-29 Added SYNONYM protein nucleus import
2005-09-29 Added SYNONYM protein transport from cytoplasm to nucleus
2005-08-10 Added SYNONYM RAN small monomeric GTPase activity
2003-04-08 Updated DEFINITION The directed movement of a protein from the cytoplasm to the nucleus.
2002-11-27 Added DEFINITION The movement of a protein from the cytoplasm to the nucleus.
Timestamp Action Category Detail
2022-04-05 Deleted RELATION is a GO:0017038 (protein import)
2018-06-04 Deleted RELATION part of GO:0034504 (protein localization to nucleus)
2018-02-16 Added RELATION is a GO:0006886 (intracellular protein transport)
2017-12-25 Added RELATION is a GO:0051170 (import into nucleus)
2017-12-08 Deleted RELATION is a GO:0051170 (import into nucleus)
2017-12-08 Deleted RELATION is a GO:0006886 (intracellular protein transport)
2017-08-13 Deleted RELATION is a GO:1902593 (single-organism nuclear import)
2017-08-13 Added RELATION is a GO:0051170 (import into nucleus)
2017-06-29 Added RELATION part of GO:0034504 (protein localization to nucleus)
2017-06-29 Deleted RELATION part of GO:0044744 (protein targeting to nucleus)
2017-06-22 Deleted RELATION is a GO:0051169 (nuclear transport)
2017-06-22 Added RELATION is a GO:1902593 (single-organism nuclear import)
2017-06-22 Deleted RELATION is a GO:1902582 (single-organism intracellular transport)
2017-06-06 Added RELATION is a GO:0051169 (nuclear transport)
2017-05-22 Deleted RELATION is a GO:1902593 (single-organism nuclear import)
2017-05-22 Added RELATION is a GO:1902582 (single-organism intracellular transport)
2016-06-26 Deleted RELATION is a GO:1902580 (single-organism cellular localization)
2014-09-18 Added RELATION is a GO:1902580 (single-organism cellular localization)
2014-09-18 Added RELATION is a GO:0034504 (protein localization to nucleus)
2014-09-13 Deleted RELATION part of GO:0034504 (protein localization to nucleus)
2013-12-21 Added RELATION is a GO:1902593 (single-organism nuclear import)
2013-12-21 Deleted RELATION is a GO:0051170 (import into nucleus)
2013-08-29 Added RELATION is a GO:0072594 (establishment of protein localization to organelle)
2012-12-15 Added RELATION is a GO:0017038 (protein import)
2012-12-15 Deleted RELATION is a GO:0044743 (protein transmembrane import into intracellular organelle)
2012-12-15 Added RELATION is a GO:0006886 (intracellular protein transport)
2012-11-09 Added RELATION part of GO:0044744 (protein targeting to nucleus)
2012-11-09 Added RELATION is a GO:0044743 (protein transmembrane import into intracellular organelle)
2012-11-09 Deleted RELATION is a GO:0017038 (protein import)
2012-11-09 Deleted RELATION is a GO:0006605 (protein targeting)
2009-03-21 Added RELATION part of GO:0034504 (protein localization to nucleus)
2008-04-01 Updated RELATION is a GO:0017038 (protein import)
2008-04-01 Updated RELATION is a GO:0051170 (import into nucleus)
2008-04-01 Updated RELATION is a GO:0006605 (protein targeting)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
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