This term is obsolete.

GO:0006614 JSON

SRP-dependent cotranslational protein targeting to membrane

Biological Process

Definition (GO:0006614 GONUTS page)

The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.

280,019 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ER translocation broad
SRP-dependent cotranslational protein-membrane targeting exact
SRP-dependent cotranslational membrane targeting exact

Ancestor Chart

Ancestor chart for GO:0006614
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006614

Child Term Relationship to
GO:0006614
SRP-dependent cotranslational protein targeting to membrane, docking
part_of
SRP-dependent cotranslational protein targeting to membrane, signal sequence processing
part_of
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
part_of
SRP-dependent cotranslational protein targeting to membrane, translocation
part_of

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0006614 SRP-dependent cotranslational protein targeting to membrane Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P02650 10116 APOE_RAT GO:0008104 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P04639 10116 APOA1_RAT GO:0008104 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P08226 10090 APOE_MOUSE GO:0008104 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9325076
NOT-qualified manual protein Q00623 10090 APOA1_MOUSE GO:0008104 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9325076

Cross-references

Database ID Description
InterPro IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain
InterPro IPR002778 Signal recognition particle, SRP19 subunit
InterPro IPR003210 Signal recognition particle, SRP14 subunit
InterPro IPR004125 Signal recognition particle, SRP54 subunit, M-domain
InterPro IPR004390 Signal-recognition particle receptor FtsY
InterPro IPR004780 Signal recognition particle protein
InterPro IPR006325 Signal recognition particle, SRP54 subunit, eukaryotic
InterPro IPR008832 Signal recognition particle SRP9
InterPro IPR009018 Signal recognition particle, SRP9/SRP14 subunit
InterPro IPR009779 Translocon-associated protein subunit gamma

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0006614 based on ALL annotations
The top 100 of 992 co-occurring terms
Co-occurring Term PR S% #Together #Compared
SRP-dependent cotranslational protein targeting to membrane
1,357.02 100.00 143,652 143,652
7S RNA binding
1,355.65 49.41 71,021 71,093
signal recognition particle
1,357.02 44.96 64,587 64,587
signal recognition particle binding
1,340.07 44.65 64,511 65,327
protein targeting to membrane
835.78 39.81 76,079 123,526
signal recognition particle, endoplasmic reticulum targeting
635.38 15.87 27,805 59,385
protein targeting
245.88 14.02 54,937 303,203
endoplasmic reticulum signal peptide binding
1,357.02 9.87 14,176 14,176
GTPase activity
96.45 6.95 109,373 1,538,801
GTP binding
60.92 4.43 111,833 2,491,223
Totals 1334952 165325191
No co-occurrence statistics for GO:0006614 based on MANUAL annotations
The top 88 of 88 co-occurring terms
Co-occurring Term PR S% #Together #Compared
SRP-dependent cotranslational protein targeting to membrane
2,845.37 100.00 454 454
signal recognition particle, endoplasmic reticulum targeting
1,283.44 37.81 318 705
Sec62/Sec63 complex
2,424.58 25.47 121 142
post-translational protein targeting to endoplasmic reticulum membrane
1,139.97 19.50 125 312
7S RNA binding
838.56 15.94 117 397
signal recognition particle binding
494.47 11.45 114 656
protein transmembrane transporter activity
198.92 5.90 125 1,788
ribosome binding
127.52 3.96 115 2,566
signal recognition particle
1,497.56 2.16 10 19
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
161.44 1.36 8 141
Totals 1787 1193787

Change Log

Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2008-05-13 Added DEFINITION The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
2008-05-12 Deleted DEFINITION The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
2008-04-01 Updated RELATION is a GO:0006613 (cotranslational protein targeting to membrane)
2008-04-01 Updated RELATION is a GO:0045047 (protein targeting to ER)
2007-08-09 Added SYNONYM ER translocation
2007-08-09 Deleted SYNONYM SRP-dependent cotranslational membrane targeting
2007-08-09 Deleted SYNONYM SRP-dependent cotranslational protein-membrane targeting
2007-08-09 Deleted SYNONYM ER translocation
2007-08-09 Added SYNONYM SRP-dependent cotranslational protein-membrane targeting
Timestamp Action Category Detail
2005-09-29 Updated TERM SRP-dependent cotranslational protein targeting to membrane
2004-09-19 Updated TERM SRP-dependent cotranslational protein-membrane targeting
2003-04-29 Updated TERM SRP-dependent cotranslational membrane targeting
2002-02-06 Updated TERM SRP-dependent, co-translational membrane targeting
2001-04-03 Updated TERM SRP-dependent, co-translational membrane targeting
2001-03-30 Added TERM SRP-dependent, co-translational membrane targeting
Timestamp Action Category Detail
2008-05-13 Added DEFINITION The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
2008-05-12 Deleted DEFINITION The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
2007-08-09 Added SYNONYM ER translocation
2007-08-09 Deleted SYNONYM SRP-dependent cotranslational membrane targeting
2007-08-09 Deleted SYNONYM SRP-dependent cotranslational protein-membrane targeting
2007-08-09 Deleted SYNONYM ER translocation
2007-08-09 Added SYNONYM SRP-dependent cotranslational protein-membrane targeting
2007-08-09 Added SYNONYM SRP-dependent cotranslational membrane targeting
2005-09-29 Added SYNONYM SRP-dependent cotranslational protein-membrane targeting
2004-09-19 Added SYNONYM SRP-dependent cotranslational membrane targeting
2004-04-19 Added SYNONYM ER translocation
2004-04-16 Deleted SYNONYM ER translocation
2004-03-24 Updated DEFINITION The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
2002-11-27 Added DEFINITION The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the ER signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
2002-01-25 Added SYNONYM ER translocation
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0006613 (cotranslational protein targeting to membrane)
2008-04-01 Updated RELATION is a GO:0045047 (protein targeting to ER)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.