GO:0006614
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SRP-dependent cotranslational protein targeting to membrane
Biological Process
Definition (GO:0006614 GONUTS page)
The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ER translocation | broad |
SRP-dependent cotranslational protein-membrane targeting | exact |
SRP-dependent cotranslational membrane targeting | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0006614
Child Term | Relationship to GO:0006614 |
---|---|
SRP-dependent cotranslational protein targeting to membrane, docking
|
part_of |
SRP-dependent cotranslational protein targeting to membrane, signal sequence processing
|
part_of |
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
|
part_of |
SRP-dependent cotranslational protein targeting to membrane, translocation
|
part_of |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P02650 | 10116 | APOE_RAT | GO:0008104 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P04639 | 10116 | APOA1_RAT | GO:0008104 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P08226 | 10090 | APOE_MOUSE | GO:0008104 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9325076 | |
NOT-qualified manual | protein | Q00623 | 10090 | APOA1_MOUSE | GO:0008104 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9325076 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000897 | Signal recognition particle, SRP54 subunit, GTPase domain |
InterPro | IPR002778 | Signal recognition particle, SRP19 subunit |
InterPro | IPR003210 | Signal recognition particle, SRP14 subunit |
InterPro | IPR004125 | Signal recognition particle, SRP54 subunit, M-domain |
InterPro | IPR004390 | Signal-recognition particle receptor FtsY |
InterPro | IPR004780 | Signal recognition particle protein |
InterPro | IPR006325 | Signal recognition particle, SRP54 subunit, eukaryotic |
InterPro | IPR008832 | Signal recognition particle SRP9 |
InterPro | IPR009018 | Signal recognition particle, SRP9/SRP14 subunit |
InterPro | IPR009779 | Translocon-associated protein subunit gamma |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0006614 based on ALL annotations
The top 100 of 992 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
SRP-dependent cotranslational protein targeting to membrane
|
1,357.02 | 100.00 | 143,652 | 143,652 |
7S RNA binding
|
1,355.65 | 49.41 | 71,021 | 71,093 |
signal recognition particle
|
1,357.02 | 44.96 | 64,587 | 64,587 |
signal recognition particle binding
|
1,340.07 | 44.65 | 64,511 | 65,327 |
protein targeting to membrane
|
835.78 | 39.81 | 76,079 | 123,526 |
signal recognition particle, endoplasmic reticulum targeting
|
635.38 | 15.87 | 27,805 | 59,385 |
protein targeting
|
245.88 | 14.02 | 54,937 | 303,203 |
endoplasmic reticulum signal peptide binding
|
1,357.02 | 9.87 | 14,176 | 14,176 |
GTPase activity
|
96.45 | 6.95 | 109,373 | 1,538,801 |
GTP binding
|
60.92 | 4.43 | 111,833 | 2,491,223 |
Totals | 1334952 | 165325191 |
No co-occurrence statistics for GO:0006614 based on MANUAL annotations
The top 88 of 88 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
SRP-dependent cotranslational protein targeting to membrane
|
2,845.37 | 100.00 | 454 | 454 |
signal recognition particle, endoplasmic reticulum targeting
|
1,283.44 | 37.81 | 318 | 705 |
Sec62/Sec63 complex
|
2,424.58 | 25.47 | 121 | 142 |
post-translational protein targeting to endoplasmic reticulum membrane
|
1,139.97 | 19.50 | 125 | 312 |
7S RNA binding
|
838.56 | 15.94 | 117 | 397 |
signal recognition particle binding
|
494.47 | 11.45 | 114 | 656 |
protein transmembrane transporter activity
|
198.92 | 5.90 | 125 | 1,788 |
ribosome binding
|
127.52 | 3.96 | 115 | 2,566 |
signal recognition particle
|
1,497.56 | 2.16 | 10 | 19 |
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
|
161.44 | 1.36 | 8 | 141 |
Totals | 1787 | 1193787 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2008-05-13 | Added | DEFINITION | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
2008-05-12 | Deleted | DEFINITION | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
2008-04-01 | Updated | RELATION | is a GO:0006613 (cotranslational protein targeting to membrane) |
2008-04-01 | Updated | RELATION | is a GO:0045047 (protein targeting to ER) |
2007-08-09 | Added | SYNONYM | ER translocation |
2007-08-09 | Deleted | SYNONYM | SRP-dependent cotranslational membrane targeting |
2007-08-09 | Deleted | SYNONYM | SRP-dependent cotranslational protein-membrane targeting |
2007-08-09 | Deleted | SYNONYM | ER translocation |
2007-08-09 | Added | SYNONYM | SRP-dependent cotranslational protein-membrane targeting |
Timestamp | Action | Category | Detail |
---|---|---|---|
2005-09-29 | Updated | TERM | SRP-dependent cotranslational protein targeting to membrane |
2004-09-19 | Updated | TERM | SRP-dependent cotranslational protein-membrane targeting |
2003-04-29 | Updated | TERM | SRP-dependent cotranslational membrane targeting |
2002-02-06 | Updated | TERM | SRP-dependent, co-translational membrane targeting |
2001-04-03 | Updated | TERM | SRP-dependent, co-translational membrane targeting |
2001-03-30 | Added | TERM | SRP-dependent, co-translational membrane targeting |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
2008-05-12 | Deleted | DEFINITION | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
2007-08-09 | Added | SYNONYM | ER translocation |
2007-08-09 | Deleted | SYNONYM | SRP-dependent cotranslational membrane targeting |
2007-08-09 | Deleted | SYNONYM | SRP-dependent cotranslational protein-membrane targeting |
2007-08-09 | Deleted | SYNONYM | ER translocation |
2007-08-09 | Added | SYNONYM | SRP-dependent cotranslational protein-membrane targeting |
2007-08-09 | Added | SYNONYM | SRP-dependent cotranslational membrane targeting |
2005-09-29 | Added | SYNONYM | SRP-dependent cotranslational protein-membrane targeting |
2004-09-19 | Added | SYNONYM | SRP-dependent cotranslational membrane targeting |
2004-04-19 | Added | SYNONYM | ER translocation |
2004-04-16 | Deleted | SYNONYM | ER translocation |
2004-03-24 | Updated | DEFINITION | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
2002-11-27 | Added | DEFINITION | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the ER signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
2002-01-25 | Added | SYNONYM | ER translocation |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0006613 (cotranslational protein targeting to membrane) |
2008-04-01 | Updated | RELATION | is a GO:0045047 (protein targeting to ER) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
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