GO:0006704
JSON
glucocorticoid biosynthetic process
Biological Process
Definition (GO:0006704 GONUTS page)
The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| glucocorticoid synthesis | exact |
| glucocorticoid anabolism | exact |
| glucocorticoid biosynthesis | exact |
| glucocorticoid formation | exact |
Ancestor Chart
Ancestor chart for GO:0006704
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0006704
| Child Term | Relationship to GO:0006704 |
|---|---|
|
positive regulation of glucocorticoid biosynthetic process
|
positively_regulates |
|
negative regulation of glucocorticoid biosynthetic process
|
negatively_regulates |
|
regulation of glucocorticoid biosynthetic process
|
regulates |
|
cortisol biosynthetic process
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | P95028 | 83331 | P95028_MYCTO | GO:0008610 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16952959 | |
| NOT-qualified manual | protein | Q0UV92 | 321614 | Q0UV92_PHANO | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | Q4WKE9 | 330879 | Q4WKE9_ASPFU | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | Q5BGM7 | 227321 | Q5BGM7_EMENI | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | Q6C017 | 284591 | Q6C017_YARLI | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
| NOT-qualified manual | protein | Q7SGR1 | 367110 | Q7SGR1_NEUCR | GO:0008202 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
| Database | ID | Description |
|---|---|---|
| Reactome | R-HSA-194002 |
Cross-Ontology Relations
| Relation | Other Ontology | ID | Term |
|---|---|---|---|
| has_primary_output | CHEBI | CHEBI:24261 | glucocorticoid |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0006704 based on ALL annotations
The top 100 of 295 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
glucocorticoid biosynthetic process
|
28,015.67 | 100.00 | 7,073 | 7,073 |
|
cortisol metabolic process
|
27,454.57 | 95.63 | 6,899 | 7,040 |
|
cellular response to peptide hormone stimulus
|
26,137.59 | 91.03 | 6,889 | 7,384 |
|
C21-steroid hormone biosynthetic process
|
27,962.85 | 89.65 | 6,352 | 6,364 |
|
C21-steroid hormone metabolic process
|
22,570.80 | 16.27 | 1,198 | 1,487 |
|
cholesterol monooxygenase (side-chain-cleaving) activity
|
26,320.69 | 15.22 | 1,087 | 1,157 |
|
cholesterol metabolic process
|
2,918.58 | 10.39 | 6,899 | 66,224 |
|
corticosterone 18-monooxygenase activity
|
27,966.87 | 8.10 | 573 | 574 |
|
steroid 11-beta-monooxygenase activity
|
26,801.66 | 8.09 | 574 | 600 |
|
aldosterone biosynthetic process
|
24,486.82 | 7.95 | 569 | 651 |
| Totals | 89942 | 18998135 | ||
No co-occurrence statistics for GO:0006704 based on MANUAL annotations
The top 100 of 176 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
glucocorticoid biosynthetic process
|
15,016.31 | 100.00 | 94 | 94 |
|
cortisol metabolic process
|
13,764.95 | 66.00 | 66 | 72 |
|
C21-steroid hormone biosynthetic process
|
12,062.28 | 46.23 | 49 | 61 |
|
cellular response to peptide hormone stimulus
|
8,314.82 | 45.27 | 67 | 121 |
|
corticosterone 18-monooxygenase activity
|
15,016.31 | 26.60 | 25 | 25 |
|
steroid 11-beta-monooxygenase activity
|
13,764.95 | 22.92 | 22 | 24 |
|
aldosterone biosynthetic process
|
12,706.11 | 22.45 | 22 | 26 |
|
steroid 21-monooxygenase activity
|
15,016.31 | 19.15 | 18 | 18 |
|
cholesterol monooxygenase (side-chain-cleaving) activity
|
9,454.71 | 16.35 | 17 | 27 |
|
cholesterol metabolic process
|
1,849.02 | 11.70 | 66 | 536 |
| Totals | 704 | 17907 | ||
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-12-05 | Added | XREF | Reactome:R-HSA-194002 |
| 2022-09-16 | Deleted | RELATION | is a GO:0006694 (steroid biosynthetic process) |
| 2022-09-16 | Added | RELATION | is a GO:0120178 (steroid hormone biosynthetic process) |
| 2020-06-02 | Deleted | RELATION | is a GO:0120178 (steroid hormone biosynthetic process) |
| 2020-06-02 | Added | RELATION | is a GO:0006694 (steroid biosynthetic process) |
| 2019-05-22 | Added | RELATION | is a GO:0120178 (steroid hormone biosynthetic process) |
| 2019-05-22 | Deleted | RELATION | is a GO:0042446 (hormone biosynthetic process) |
| 2019-05-22 | Deleted | RELATION | is a GO:0006694 (steroid biosynthetic process) |
| 2017-11-29 | Added | RELATION | is a GO:0042446 (hormone biosynthetic process) |
| 2012-10-29 | Added | RELATION | is a GO:0006694 (steroid biosynthetic process) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2007-01-15 | Updated | TERM | glucocorticoid biosynthetic process |
| 2002-02-06 | Updated | TERM | glucocorticoid biosynthesis |
| 2001-04-03 | Updated | TERM | glucocorticoid biosynthesis |
| 2001-03-30 | Added | TERM | glucocorticoid biosynthesis |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-05-13 | Added | DEFINITION | The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. |
| 2008-05-12 | Deleted | DEFINITION | The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. |
| 2007-08-09 | Deleted | SYNONYM | glucocorticoid formation |
| 2007-08-09 | Deleted | SYNONYM | glucocorticoid synthesis |
| 2007-08-09 | Added | SYNONYM | glucocorticoid formation |
| 2007-08-09 | Added | SYNONYM | glucocorticoid synthesis |
| 2007-08-09 | Deleted | SYNONYM | glucocorticoid biosynthesis |
| 2007-08-09 | Deleted | SYNONYM | glucocorticoid anabolism |
| 2007-08-09 | Added | SYNONYM | glucocorticoid biosynthesis |
| 2007-08-09 | Added | SYNONYM | glucocorticoid anabolism |
| 2007-01-15 | Added | SYNONYM | glucocorticoid biosynthesis |
| 2006-05-04 | Updated | DEFINITION | The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. |
| 2005-08-10 | Added | SYNONYM | glucocorticoid anabolism |
| 2005-08-10 | Added | SYNONYM | glucocorticoid formation |
| 2005-08-10 | Added | SYNONYM | glucocorticoid synthesis |
| 2002-11-27 | Added | DEFINITION | The formation from simpler components of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2022-09-16 | Deleted | RELATION | is a GO:0006694 (steroid biosynthetic process) |
| 2022-09-16 | Added | RELATION | is a GO:0120178 (steroid hormone biosynthetic process) |
| 2020-06-02 | Deleted | RELATION | is a GO:0120178 (steroid hormone biosynthetic process) |
| 2020-06-02 | Added | RELATION | is a GO:0006694 (steroid biosynthetic process) |
| 2019-05-22 | Added | RELATION | is a GO:0120178 (steroid hormone biosynthetic process) |
| 2019-05-22 | Deleted | RELATION | is a GO:0042446 (hormone biosynthetic process) |
| 2019-05-22 | Deleted | RELATION | is a GO:0006694 (steroid biosynthetic process) |
| 2017-11-29 | Added | RELATION | is a GO:0042446 (hormone biosynthetic process) |
| 2012-10-29 | Added | RELATION | is a GO:0006694 (steroid biosynthetic process) |
| 2012-10-29 | Deleted | RELATION | is a GO:0006700 (C21-steroid hormone biosynthetic process) |
| 2010-09-03 | Deleted | RELATION | is a GO:0044249 (obsolete cellular biosynthetic process) |
| 2010-09-03 | Deleted | RELATION | is a GO:0042446 (hormone biosynthetic process) |
| 2010-08-04 | Deleted | RELATION | is a GO:0006694 (steroid biosynthetic process) |
| 2010-08-04 | Added | RELATION | is a GO:0006700 (C21-steroid hormone biosynthetic process) |
| 2010-02-13 | Added | RELATION | is a GO:0044249 (obsolete cellular biosynthetic process) |
| 2008-04-01 | Updated | RELATION | is a GO:0042446 (hormone biosynthetic process) |
| 2008-04-01 | Updated | RELATION | is a GO:0008211 (glucocorticoid metabolic process) |
| 2008-04-01 | Updated | RELATION | is a GO:0006694 (steroid biosynthetic process) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-12-05 | Added | XREF | Reactome:R-HSA-194002 |
| Timestamp | Action | Category | Detail |
|---|
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