This term is obsolete.

GO:0007166 JSON

cell surface receptor signaling pathway

Biological Process

Definition (GO:0007166 GONUTS page)

The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

3,245,783 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cell surface receptor linked signalling pathway exact
cell surface receptor linked signal transduction exact
cell surface receptor linked signaling pathway exact

Ancestor Chart

Ancestor chart for GO:0007166
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007166

Child Term Relationship to
GO:0007166
positive regulation of integrin activation by cell surface receptor linked signal transduction
is_a
smoothened signaling pathway
is_a
cell surface receptor signaling pathway involved in heart development
is_a
CD40 signaling pathway
is_a
Roundabout signaling pathway
is_a
Wnt signaling pathway
is_a
purinergic nucleotide receptor signaling pathway
is_a
integrin-mediated signaling pathway
is_a
neurotrophin signaling pathway
is_a
cytokine-mediated signaling pathway
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Cross-references

Database ID Description
InterPro IPR000539 Frizzled/Smoothened, 7TM
InterPro IPR003110 Phosphorylated immunoreceptor signalling ITAM
InterPro IPR003153 Adaptor protein Cbl, N-terminal helical
InterPro IPR017981 GPCR, family 2-like, 7TM
InterPro IPR036537 Adaptor protein Cbl, N-terminal domain superfamily
InterPro IPR042340 High affinity immunoglobulin epsilon receptor subunit gamma
InterPro IPR045274 Receptor-like kinase WAK-like

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:1905114 obsolete cell surface receptor signaling pathway involved in cell-cell signaling consider GO:0007166
GO:0198738 obsolete cell-cell signaling by wnt replaced_by GO:0007166

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0007166 based on ALL annotations
The top 100 of 4,612 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cell surface receptor signaling pathway
1,090.24 100.00 178,804 178,804
adenylate cyclase-activating G protein-coupled receptor signaling pathway
388.52 15.58 38,782 108,827
G protein-coupled receptor activity
119.32 9.70 82,191 750,974
G protein-coupled peptide receptor activity
446.25 9.33 19,290 47,128
peptide hormone binding
754.63 9.02 16,797 24,267
G protein-coupled receptor signaling pathway
103.22 8.52 82,062 866,741
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
407.85 7.86 16,186 43,267
external side of plasma membrane
141.15 7.58 27,650 213,567
transmembrane signaling receptor activity
113.32 6.95 31,052 298,744
non-canonical Wnt signaling pathway
635.72 6.02 11,241 19,278
Totals 975052 36481053
No co-occurrence statistics for GO:0007166 based on MANUAL annotations
The top 100 of 2,861 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cell surface receptor signaling pathway
329.29 100.00 3,923 3,923
external side of plasma membrane
29.04 5.58 517 5,862
signaling adaptor activity
79.81 5.53 262 1,081
transmembrane signaling receptor activity
70.87 5.44 266 1,236
positive regulation of T cell proliferation
107.76 3.78 161 492
positive regulation of extrinsic apoptotic signaling pathway
141.93 3.64 150 348
T cell costimulation
156.09 3.57 146 308
negative regulation of T cell proliferation
132.09 3.43 142 354
immune response
16.15 3.19 328 6,687
positive regulation of canonical NF-kappaB signal transduction
35.00 3.19 171 1,609
Totals 13338 337128

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_drosophila 173

Change Log

Timestamp Action Category Detail
2024-04-24 Deleted XREF https://github.com/geneontology/go-ontology/issues/26960
2024-02-24 Deleted DEFINITION The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2024-02-24 Added DEFINITION The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2024-02-24 Added XREF https://github.com/geneontology/go-ontology/issues/26960
2022-03-14 Deleted DEFINITION A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Added DEFINITION The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2020-02-28 Deleted XREF MIPS_funcat:30.05
2019-11-09 Added SUBSET goslim_drosophila
2019-05-04 Added XREF MIPS_funcat:30.05
2012-01-14 Updated TERM cell surface receptor signaling pathway
Timestamp Action Category Detail
2012-01-14 Updated TERM cell surface receptor signaling pathway
2010-02-20 Updated TERM cell surface receptor linked signaling pathway
2002-02-06 Updated TERM cell surface receptor linked signal transduction
2001-04-03 Updated TERM cell surface receptor linked signal transduction
2001-03-30 Added TERM cell surface receptor linked signal transduction
Timestamp Action Category Detail
2024-02-24 Deleted DEFINITION The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2024-02-24 Added DEFINITION The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Deleted DEFINITION A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Added DEFINITION The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-14 Added SYNONYM cell surface receptor linked signaling pathway
2011-11-26 Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2011-11-26 Added DEFINITION A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2010-11-17 Added SYNONYM cell surface receptor linked signalling pathway
2010-02-20 Added SYNONYM cell surface receptor linked signal transduction
2008-05-13 Added DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2008-05-12 Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2004-07-25 Updated DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2004-02-12 Updated DEFINITION Any pathway of signal transduction initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2004-02-12 Updated DEFINITION Any pathway of signal transduction initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2002-11-27 Added DEFINITION Any pathway of signal transduction initiated by binding of a ligand to an extracellular ligand to a receptor on the surface of the target cell.
Timestamp Action Category Detail
2011-01-16 Added RELATION is a GO:0007165 (signal transduction)
2011-01-16 Deleted RELATION is a GO:0023033 (signaling pathway)
2010-02-20 Added RELATION is a GO:0023033 (signaling pathway)
2010-02-20 Deleted RELATION is a GO:0007165 (signal transduction)
2008-04-01 Updated RELATION is a GO:0007165 (signal transduction)
Timestamp Action Category Detail
2024-04-24 Deleted XREF https://github.com/geneontology/go-ontology/issues/26960
2024-02-24 Added XREF https://github.com/geneontology/go-ontology/issues/26960
2020-02-28 Deleted XREF MIPS_funcat:30.05
2019-05-04 Added XREF MIPS_funcat:30.05
Timestamp Action Category Detail
2019-11-09 Added SUBSET goslim_drosophila
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