This term is obsolete.

GO:0007166 JSON

cell surface receptor signaling pathway

Biological Process

Definition (GO:0007166 GONUTS page)

The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

3,278,920 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cell surface receptor linked signaling pathway exact
cell surface receptor linked signal transduction exact
cell surface receptor linked signalling pathway exact

Ancestor Chart

Ancestor chart for GO:0007166
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007166

Child Term Relationship to
GO:0007166
positive regulation of integrin activation by cell surface receptor linked signal transduction
is_a
Roundabout signaling pathway
is_a
cell surface receptor signaling pathway involved in heart development
is_a
neurotrophin signaling pathway
is_a
smoothened signaling pathway
is_a
integrin-mediated signaling pathway
is_a
urokinase plasminogen activator signaling pathway
is_a
Wnt signaling pathway
is_a
semaphorin-plexin signaling pathway
is_a
purinergic nucleotide receptor signaling pathway
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Cross-references

Database ID Description
InterPro IPR000539 Frizzled/Smoothened, 7TM
InterPro IPR003110 Phosphorylated immunoreceptor signalling ITAM
InterPro IPR003153 Adaptor protein Cbl, N-terminal helical
InterPro IPR017981 GPCR, family 2-like, 7TM
InterPro IPR036537 Adaptor protein Cbl, N-terminal domain superfamily
InterPro IPR042340 High affinity immunoglobulin epsilon receptor subunit gamma
InterPro IPR045274 Receptor-like kinase WAK-like
Reactome R-HSA-73887

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:1905114 obsolete cell surface receptor signaling pathway involved in cell-cell signaling consider GO:0007166
GO:0198738 obsolete cell-cell signaling by wnt replaced_by GO:0007166

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0007166 based on ALL annotations
The top 100 of 4,596 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cell surface receptor signaling pathway
1,070.67 100.00 185,076 185,076
adenylate cyclase-activating G protein-coupled receptor signaling pathway
382.43 15.59 40,094 112,250
G protein-coupled receptor activity
117.21 9.69 84,819 774,765
G protein-coupled peptide receptor activity
432.56 9.32 20,004 49,514
peptide hormone binding
738.27 8.91 17,189 24,928
G protein-coupled receptor signaling pathway
100.78 8.45 83,540 887,535
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
397.66 7.84 16,719 45,014
external side of plasma membrane
138.51 7.51 28,133 217,464
transmembrane signaling receptor activity
112.31 6.99 32,093 305,943
non-canonical Wnt signaling pathway
624.33 5.97 11,544 19,797
Totals 1009090 37334785
No co-occurrence statistics for GO:0007166 based on MANUAL annotations
The top 100 of 2,890 co-occurring terms
Co-occurring Term PR S% #Together #Compared
cell surface receptor signaling pathway
324.64 100.00 4,348 4,348
external side of plasma membrane
33.12 6.50 661 6,480
transmembrane signaling receptor activity
76.23 6.35 348 1,482
positive regulation of extrinsic apoptotic signaling pathway
146.61 3.98 182 403
positive regulation of T cell proliferation
111.58 3.78 177 515
immune response
18.64 3.70 411 7,158
T cell costimulation
157.93 3.58 162 333
positive regulation of canonical NF-kappaB signal transduction
39.18 3.53 207 1,715
negative regulation of T cell proliferation
129.04 3.46 159 400
cellular response to lipopolysaccharide
39.30 3.03 169 1,396
Totals 14955 376467

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_drosophila 173

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-73887
2024-04-24 Deleted XREF https://github.com/geneontology/go-ontology/issues/26960
2024-02-24 Deleted DEFINITION The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2024-02-24 Added DEFINITION The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2024-02-24 Added XREF https://github.com/geneontology/go-ontology/issues/26960
2022-03-14 Added DEFINITION The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Deleted DEFINITION A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2020-02-28 Deleted XREF MIPS_funcat:30.05
2019-11-09 Added SUBSET goslim_drosophila
2019-05-04 Added XREF MIPS_funcat:30.05
Timestamp Action Category Detail
2012-01-14 Updated TERM cell surface receptor signaling pathway
2010-02-20 Updated TERM cell surface receptor linked signaling pathway
2002-02-06 Updated TERM cell surface receptor linked signal transduction
2001-04-03 Updated TERM cell surface receptor linked signal transduction
2001-03-30 Added TERM cell surface receptor linked signal transduction
Timestamp Action Category Detail
2024-02-24 Deleted DEFINITION The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2024-02-24 Added DEFINITION The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Added DEFINITION The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Deleted DEFINITION A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2012-01-14 Added SYNONYM cell surface receptor linked signaling pathway
2011-11-26 Added DEFINITION A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2011-11-26 Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2010-11-17 Added SYNONYM cell surface receptor linked signalling pathway
2010-02-20 Added SYNONYM cell surface receptor linked signal transduction
2008-05-13 Added DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2008-05-12 Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2004-07-25 Updated DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2004-02-12 Updated DEFINITION Any pathway of signal transduction initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2004-02-12 Updated DEFINITION Any pathway of signal transduction initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
2002-11-27 Added DEFINITION Any pathway of signal transduction initiated by binding of a ligand to an extracellular ligand to a receptor on the surface of the target cell.
Timestamp Action Category Detail
2011-01-16 Added RELATION is a GO:0007165 (signal transduction)
2011-01-16 Deleted RELATION is a GO:0023033 (signaling pathway)
2010-02-20 Deleted RELATION is a GO:0007165 (signal transduction)
2010-02-20 Added RELATION is a GO:0023033 (signaling pathway)
2008-04-01 Updated RELATION is a GO:0007165 (signal transduction)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-73887
2024-04-24 Deleted XREF https://github.com/geneontology/go-ontology/issues/26960
2024-02-24 Added XREF https://github.com/geneontology/go-ontology/issues/26960
2020-02-28 Deleted XREF MIPS_funcat:30.05
2019-05-04 Added XREF MIPS_funcat:30.05
Timestamp Action Category Detail
2019-11-09 Added SUBSET goslim_drosophila
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