GO:0007166
JSON
cell surface receptor signaling pathway
Biological Process
Definition (GO:0007166 GONUTS page)
The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
cell surface receptor linked signalling pathway | exact |
cell surface receptor linked signal transduction | exact |
cell surface receptor linked signaling pathway | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0007166
Child Term | Relationship to GO:0007166 |
---|---|
positive regulation of integrin activation by cell surface receptor linked signal transduction
|
is_a |
smoothened signaling pathway
|
is_a |
cell surface receptor signaling pathway involved in heart development
|
is_a |
CD40 signaling pathway
|
is_a |
Roundabout signaling pathway
|
is_a |
Wnt signaling pathway
|
is_a |
purinergic nucleotide receptor signaling pathway
|
is_a |
integrin-mediated signaling pathway
|
is_a |
neurotrophin signaling pathway
|
is_a |
cytokine-mediated signaling pathway
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000539 | Frizzled/Smoothened, 7TM |
InterPro | IPR003110 | Phosphorylated immunoreceptor signalling ITAM |
InterPro | IPR003153 | Adaptor protein Cbl, N-terminal helical |
InterPro | IPR017981 | GPCR, family 2-like, 7TM |
InterPro | IPR036537 | Adaptor protein Cbl, N-terminal domain superfamily |
InterPro | IPR042340 | High affinity immunoglobulin epsilon receptor subunit gamma |
InterPro | IPR045274 | Receptor-like kinase WAK-like |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:1905114 | obsolete cell surface receptor signaling pathway involved in cell-cell signaling | consider GO:0007166 |
GO:0198738 | obsolete cell-cell signaling by wnt | replaced_by GO:0007166 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0007166 based on ALL annotations
The top 100 of 4,612 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cell surface receptor signaling pathway
|
1,090.24 | 100.00 | 178,804 | 178,804 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway
|
388.52 | 15.58 | 38,782 | 108,827 |
G protein-coupled receptor activity
|
119.32 | 9.70 | 82,191 | 750,974 |
G protein-coupled peptide receptor activity
|
446.25 | 9.33 | 19,290 | 47,128 |
peptide hormone binding
|
754.63 | 9.02 | 16,797 | 24,267 |
G protein-coupled receptor signaling pathway
|
103.22 | 8.52 | 82,062 | 866,741 |
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
|
407.85 | 7.86 | 16,186 | 43,267 |
external side of plasma membrane
|
141.15 | 7.58 | 27,650 | 213,567 |
transmembrane signaling receptor activity
|
113.32 | 6.95 | 31,052 | 298,744 |
non-canonical Wnt signaling pathway
|
635.72 | 6.02 | 11,241 | 19,278 |
Totals | 975052 | 36481053 |
No co-occurrence statistics for GO:0007166 based on MANUAL annotations
The top 100 of 2,861 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
cell surface receptor signaling pathway
|
329.29 | 100.00 | 3,923 | 3,923 |
external side of plasma membrane
|
29.04 | 5.58 | 517 | 5,862 |
signaling adaptor activity
|
79.81 | 5.53 | 262 | 1,081 |
transmembrane signaling receptor activity
|
70.87 | 5.44 | 266 | 1,236 |
positive regulation of T cell proliferation
|
107.76 | 3.78 | 161 | 492 |
positive regulation of extrinsic apoptotic signaling pathway
|
141.93 | 3.64 | 150 | 348 |
T cell costimulation
|
156.09 | 3.57 | 146 | 308 |
negative regulation of T cell proliferation
|
132.09 | 3.43 | 142 | 354 |
immune response
|
16.15 | 3.19 | 328 | 6,687 |
positive regulation of canonical NF-kappaB signal transduction
|
35.00 | 3.19 | 171 | 1,609 |
Totals | 13338 | 337128 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_drosophila | 173 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-04-24 | Deleted | XREF | https://github.com/geneontology/go-ontology/issues/26960 |
2024-02-24 | Deleted | DEFINITION | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
2024-02-24 | Added | DEFINITION | The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
2024-02-24 | Added | XREF | https://github.com/geneontology/go-ontology/issues/26960 |
2022-03-14 | Deleted | DEFINITION | A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
2020-02-28 | Deleted | XREF | MIPS_funcat:30.05 |
2019-11-09 | Added | SUBSET | goslim_drosophila |
2019-05-04 | Added | XREF | MIPS_funcat:30.05 |
2012-01-14 | Updated | TERM | cell surface receptor signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-01-14 | Updated | TERM | cell surface receptor signaling pathway |
2010-02-20 | Updated | TERM | cell surface receptor linked signaling pathway |
2002-02-06 | Updated | TERM | cell surface receptor linked signal transduction |
2001-04-03 | Updated | TERM | cell surface receptor linked signal transduction |
2001-03-30 | Added | TERM | cell surface receptor linked signal transduction |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-02-24 | Deleted | DEFINITION | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
2024-02-24 | Added | DEFINITION | The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Deleted | DEFINITION | A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
2012-01-14 | Added | SYNONYM | cell surface receptor linked signaling pathway |
2011-11-26 | Deleted | DEFINITION | Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. |
2011-11-26 | Added | DEFINITION | A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
2010-11-17 | Added | SYNONYM | cell surface receptor linked signalling pathway |
2010-02-20 | Added | SYNONYM | cell surface receptor linked signal transduction |
2008-05-13 | Added | DEFINITION | Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. |
2008-05-12 | Deleted | DEFINITION | Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. |
2004-07-25 | Updated | DEFINITION | Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. |
2004-02-12 | Updated | DEFINITION | Any pathway of signal transduction initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. |
2004-02-12 | Updated | DEFINITION | Any pathway of signal transduction initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. |
2002-11-27 | Added | DEFINITION | Any pathway of signal transduction initiated by binding of a ligand to an extracellular ligand to a receptor on the surface of the target cell. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-01-16 | Added | RELATION | is a GO:0007165 (signal transduction) |
2011-01-16 | Deleted | RELATION | is a GO:0023033 (signaling pathway) |
2010-02-20 | Added | RELATION | is a GO:0023033 (signaling pathway) |
2010-02-20 | Deleted | RELATION | is a GO:0007165 (signal transduction) |
2008-04-01 | Updated | RELATION | is a GO:0007165 (signal transduction) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-04-24 | Deleted | XREF | https://github.com/geneontology/go-ontology/issues/26960 |
2024-02-24 | Added | XREF | https://github.com/geneontology/go-ontology/issues/26960 |
2020-02-28 | Deleted | XREF | MIPS_funcat:30.05 |
2019-05-04 | Added | XREF | MIPS_funcat:30.05 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-11-09 | Added | SUBSET | goslim_drosophila |
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