This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition.
GO:0007193
JSON
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process
Definition (GO:0007193 GONUTS page)
A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).
Comments
This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
G-protein signaling, adenylate cyclase inhibiting pathway | exact |
G protein signaling, adenylate cyclase inhibiting pathway | exact |
G protein signalling, adenylate cyclase inhibiting pathway | exact |
inhibition of adenylate cyclase activity by G-protein signaling pathway | related |
adenylate cyclase-inhibiting GPCR signaling pathway | exact |
G-protein signalling, adenylyl cyclase inhibiting pathway | exact |
GPCR signaling pathway via inhibition of adenylate cyclase activity | exact |
G protein signalling, adenylyl cyclase inhibiting pathway | exact |
G-protein signaling, adenylyl cyclase inhibiting pathway | exact |
G-protein signalling, adenylate cyclase inhibiting pathway | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0007193
Child Term | Relationship to GO:0007193 |
---|---|
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
|
is_a |
adenylate cyclase-inhibiting serotonin receptor signaling pathway
|
is_a |
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
|
is_a |
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
|
is_a |
adenylate cyclase-inhibiting dopamine receptor signaling pathway
|
is_a |
adenylate cyclase-inhibiting opioid receptor signaling pathway
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
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signalling | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | G3QNC0 | 9595 | G3QNC0_GORGO | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:8910290 | |
NOT-qualified manual | protein | O15529 | 9606 | GPR42_HUMAN | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12496283 | |
NOT-qualified manual | protein | O43813 | 9606 | LANC1_HUMAN | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10944443 | |
NOT-qualified manual | protein | O89112 | 10090 | LANC1_MOUSE | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q7JQF1 | 7227 | OAMB_DROME | GO:0007188 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15816867 | |
NOT-qualified manual | protein | Q90ZL2 | 7955 | LANC1_DANRE | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q99463 | 9606 | NPY6R_HUMAN | GO:0007186 | 2 NOT-qualified manual annotations exist with evidence code ECO:0000320 from these references: PMID:8910290, PMID:9013614 | |
NOT-qualified manual | protein | Q9QX69 | 10116 | LANC1_RAT | GO:0007186 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0007193 based on ALL annotations
The top 100 of 1,245 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
|
14,331.63 | 100.00 | 13,602 | 13,602 |
prosaposin receptor activity
|
14,331.63 | 9.87 | 1,343 | 1,343 |
regulation of lipid metabolic process
|
2,061.57 | 7.37 | 1,784 | 12,402 |
G protein-coupled adenosine receptor signaling pathway
|
2,553.04 | 6.47 | 1,255 | 7,045 |
cAMP biosynthetic process
|
704.00 | 4.45 | 4,384 | 89,247 |
G protein-coupled peptide receptor activity
|
722.24 | 4.07 | 2,375 | 47,128 |
gamma-aminobutyric acid signaling pathway
|
925.24 | 4.07 | 1,346 | 20,849 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway
|
626.19 | 4.04 | 4,755 | 108,827 |
positive regulation of MAPK cascade
|
666.02 | 3.94 | 2,788 | 59,993 |
adenylate cyclase-inhibiting serotonin receptor signaling pathway
|
5,959.01 | 3.07 | 437 | 1,051 |
Totals | 72899 | 2161888 |
No co-occurrence statistics for GO:0007193 based on MANUAL annotations
The top 100 of 1,111 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
|
3,548.90 | 100.00 | 364 | 364 |
cAMP biosynthetic process
|
1,326.36 | 20.18 | 111 | 297 |
adenylate cyclase activity
|
760.97 | 14.34 | 110 | 513 |
prosaposin receptor activity
|
3,387.58 | 5.75 | 21 | 22 |
epithelial cell differentiation involved in prostate gland development
|
2,661.67 | 5.66 | 21 | 28 |
prostate gland growth
|
1,910.95 | 5.50 | 21 | 39 |
G protein-coupled adenosine receptor signaling pathway
|
877.26 | 5.10 | 22 | 89 |
G protein-coupled receptor binding
|
198.02 | 4.42 | 64 | 1,147 |
adenylate cyclase-activating G protein-coupled receptor signaling pathway
|
154.77 | 4.04 | 130 | 2,981 |
gamma-aminobutyric acid signaling pathway
|
201.64 | 3.48 | 30 | 528 |
Totals | 1722 | 34023 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-14 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). |
2022-03-14 | Added | DEFINITION | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). |
2018-09-08 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). |
2018-09-08 | Updated | TERM | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
2018-09-08 | Added | DEFINITION | The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). |
2012-05-27 | Added | SYNONYM | adenylate cyclase-inhibiting GPCR signaling pathway |
2012-05-27 | Added | DEFINITION | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). |
2012-05-27 | Updated | TERM | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
2012-05-27 | Added | SYNONYM | inhibition of adenylate cyclase activity by G-protein signaling pathway |
2012-05-27 | Deleted | RELATION | is a GO:0007194 (negative regulation of adenylate cyclase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-09-08 | Updated | TERM | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
2012-05-27 | Updated | TERM | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway |
2010-06-09 | Updated | TERM | inhibition of adenylate cyclase activity by G-protein signaling pathway |
2010-06-08 | Updated | TERM | inhibition of adenylate cyclase activity by G-protein signaling pathway |
2009-11-11 | Updated | TERM | inhibition of adenylate cyclase activity by G-protein signaling pathway |
2009-02-25 | Updated | TERM | inhibition of adenylate cyclase activity by G-protein signaling |
2009-02-22 | Updated | TERM | inhibition of adenylate cyclase activity by G-protein signaling |
2009-01-31 | Updated | TERM | inhibition of adenylate cyclase activity by G-protein signaling |
2002-02-06 | Updated | TERM | G-protein signaling, adenylate cyclase inhibiting pathway |
2001-04-03 | Updated | TERM | G-protein signaling, adenylate cyclase inhibiting pathway |
2001-03-30 | Added | TERM | G-protein signaling, adenylate cyclase inhibiting pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-14 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). |
2022-03-14 | Added | DEFINITION | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). |
2018-09-08 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). |
2018-09-08 | Added | DEFINITION | The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). |
2012-05-27 | Added | SYNONYM | adenylate cyclase-inhibiting GPCR signaling pathway |
2012-05-27 | Added | DEFINITION | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). |
2012-05-27 | Added | SYNONYM | inhibition of adenylate cyclase activity by G-protein signaling pathway |
2012-05-27 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. |
2012-05-27 | Added | SYNONYM | GPCR signaling pathway via inhibition of adenylate cyclase activity |
2009-01-31 | Added | SYNONYM | G-protein signaling, adenylate cyclase inhibiting pathway |
2008-05-13 | Added | DEFINITION | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. |
2008-05-12 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. |
2007-08-09 | Added | SYNONYM | G protein signalling, adenylate cyclase inhibiting pathway |
2007-08-09 | Added | SYNONYM | G protein signalling, adenylyl cyclase inhibiting pathway |
2007-08-09 | Added | SYNONYM | G-protein signaling, adenylyl cyclase inhibiting pathway |
2007-08-09 | Added | SYNONYM | G-protein signalling, adenylate cyclase inhibiting pathway |
2007-08-09 | Deleted | SYNONYM | G protein signaling, adenylate cyclase inhibiting pathway |
2007-08-09 | Deleted | SYNONYM | G-protein signalling, adenylyl cyclase inhibiting pathway |
2007-08-09 | Deleted | SYNONYM | G-protein signalling, adenylate cyclase inhibiting pathway |
2007-08-09 | Deleted | SYNONYM | G-protein signaling, adenylyl cyclase inhibiting pathway |
2007-08-09 | Deleted | SYNONYM | G protein signalling, adenylyl cyclase inhibiting pathway |
2007-08-09 | Deleted | SYNONYM | G protein signalling, adenylate cyclase inhibiting pathway |
2007-08-09 | Deleted | SYNONYM | G protein signaling, adenylyl cyclase inhibiting pathway |
2007-08-09 | Added | SYNONYM | G-protein signalling, adenylyl cyclase inhibiting pathway |
2007-08-09 | Added | SYNONYM | G protein signaling, adenylyl cyclase inhibiting pathway |
2007-08-09 | Added | SYNONYM | G protein signaling, adenylate cyclase inhibiting pathway |
2005-06-27 | Added | SYNONYM | G-protein signalling, adenylyl cyclase inhibiting pathway |
2005-06-27 | Added | SYNONYM | G protein signalling, adenylyl cyclase inhibiting pathway |
2005-06-27 | Added | SYNONYM | G protein signalling, adenylate cyclase inhibiting pathway |
2005-06-27 | Added | SYNONYM | G protein signaling, adenylate cyclase inhibiting pathway |
2005-06-27 | Added | SYNONYM | G protein signaling, adenylyl cyclase inhibiting pathway |
2004-09-03 | Added | SYNONYM | G-protein signaling, adenylyl cyclase inhibiting pathway |
2004-07-28 | Added | DEFINITION | The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. |
2004-04-19 | Added | SYNONYM | G-protein signalling, adenylate cyclase inhibiting pathway |
2004-04-16 | Deleted | SYNONYM | G-protein signalling, adenylate cyclase inhibiting pathway |
2003-11-13 | Added | SYNONYM | G-protein signalling, adenylate cyclase inhibiting pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-05-27 | Deleted | RELATION | is a GO:0007194 (negative regulation of adenylate cyclase activity) |
2008-10-02 | Added | RELATION | is a GO:0007194 (negative regulation of adenylate cyclase activity) |
2008-04-01 | Updated | RELATION | is a GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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