This term is obsolete.
This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition.

GO:0007193 JSON

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

Biological Process

Definition (GO:0007193 GONUTS page)

A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).

Comments

This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition.

30,308 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
G-protein signaling, adenylate cyclase inhibiting pathway exact
G protein signaling, adenylate cyclase inhibiting pathway exact
G protein signalling, adenylate cyclase inhibiting pathway exact
inhibition of adenylate cyclase activity by G-protein signaling pathway related
adenylate cyclase-inhibiting GPCR signaling pathway exact
G-protein signalling, adenylyl cyclase inhibiting pathway exact
GPCR signaling pathway via inhibition of adenylate cyclase activity exact
G protein signalling, adenylyl cyclase inhibiting pathway exact
G-protein signaling, adenylyl cyclase inhibiting pathway exact
G-protein signalling, adenylate cyclase inhibiting pathway exact

Ancestor Chart

Ancestor chart for GO:0007193
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007193

Child Term Relationship to
GO:0007193
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
is_a
adenylate cyclase-inhibiting serotonin receptor signaling pathway
is_a
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
is_a
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
is_a
adenylate cyclase-inhibiting dopamine receptor signaling pathway
is_a
adenylate cyclase-inhibiting opioid receptor signaling pathway
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein G3QNC0 9595 G3QNC0_GORGO GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:8910290
NOT-qualified manual protein O15529 9606 GPR42_HUMAN GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12496283
NOT-qualified manual protein O43813 9606 LANC1_HUMAN GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10944443
NOT-qualified manual protein O89112 10090 LANC1_MOUSE GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q7JQF1 7227 OAMB_DROME GO:0007188 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15816867
NOT-qualified manual protein Q90ZL2 7955 LANC1_DANRE GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q99463 9606 NPY6R_HUMAN GO:0007186 2 NOT-qualified manual annotations exist with evidence code ECO:0000320 from these references: PMID:8910290, PMID:9013614
NOT-qualified manual protein Q9QX69 10116 LANC1_RAT GO:0007186 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0007193 based on ALL annotations
The top 100 of 1,245 co-occurring terms
Co-occurring Term PR S% #Together #Compared
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
14,331.63 100.00 13,602 13,602
prosaposin receptor activity
14,331.63 9.87 1,343 1,343
regulation of lipid metabolic process
2,061.57 7.37 1,784 12,402
G protein-coupled adenosine receptor signaling pathway
2,553.04 6.47 1,255 7,045
cAMP biosynthetic process
704.00 4.45 4,384 89,247
G protein-coupled peptide receptor activity
722.24 4.07 2,375 47,128
gamma-aminobutyric acid signaling pathway
925.24 4.07 1,346 20,849
adenylate cyclase-activating G protein-coupled receptor signaling pathway
626.19 4.04 4,755 108,827
positive regulation of MAPK cascade
666.02 3.94 2,788 59,993
adenylate cyclase-inhibiting serotonin receptor signaling pathway
5,959.01 3.07 437 1,051
Totals 72899 2161888
No co-occurrence statistics for GO:0007193 based on MANUAL annotations
The top 100 of 1,111 co-occurring terms
Co-occurring Term PR S% #Together #Compared
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
3,548.90 100.00 364 364
cAMP biosynthetic process
1,326.36 20.18 111 297
adenylate cyclase activity
760.97 14.34 110 513
prosaposin receptor activity
3,387.58 5.75 21 22
epithelial cell differentiation involved in prostate gland development
2,661.67 5.66 21 28
prostate gland growth
1,910.95 5.50 21 39
G protein-coupled adenosine receptor signaling pathway
877.26 5.10 22 89
G protein-coupled receptor binding
198.02 4.42 64 1,147
adenylate cyclase-activating G protein-coupled receptor signaling pathway
154.77 4.04 130 2,981
gamma-aminobutyric acid signaling pathway
201.64 3.48 30 528
Totals 1722 34023

Change Log

Timestamp Action Category Detail
2022-03-14 Deleted DEFINITION The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
2022-03-14 Added DEFINITION A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).
2018-09-08 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
2018-09-08 Updated TERM adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
2018-09-08 Added DEFINITION The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
2012-05-27 Added SYNONYM adenylate cyclase-inhibiting GPCR signaling pathway
2012-05-27 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
2012-05-27 Updated TERM adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
2012-05-27 Added SYNONYM inhibition of adenylate cyclase activity by G-protein signaling pathway
2012-05-27 Deleted RELATION is a GO:0007194 (negative regulation of adenylate cyclase activity)
Timestamp Action Category Detail
2018-09-08 Updated TERM adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
2012-05-27 Updated TERM adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
2010-06-09 Updated TERM inhibition of adenylate cyclase activity by G-protein signaling pathway
2010-06-08 Updated TERM inhibition of adenylate cyclase activity by G-protein signaling pathway
2009-11-11 Updated TERM inhibition of adenylate cyclase activity by G-protein signaling pathway
2009-02-25 Updated TERM inhibition of adenylate cyclase activity by G-protein signaling
2009-02-22 Updated TERM inhibition of adenylate cyclase activity by G-protein signaling
2009-01-31 Updated TERM inhibition of adenylate cyclase activity by G-protein signaling
2002-02-06 Updated TERM G-protein signaling, adenylate cyclase inhibiting pathway
2001-04-03 Updated TERM G-protein signaling, adenylate cyclase inhibiting pathway
2001-03-30 Added TERM G-protein signaling, adenylate cyclase inhibiting pathway
Timestamp Action Category Detail
2022-03-14 Deleted DEFINITION The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
2022-03-14 Added DEFINITION A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP).
2018-09-08 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
2018-09-08 Added DEFINITION The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
2012-05-27 Added SYNONYM adenylate cyclase-inhibiting GPCR signaling pathway
2012-05-27 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).
2012-05-27 Added SYNONYM inhibition of adenylate cyclase activity by G-protein signaling pathway
2012-05-27 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP.
2012-05-27 Added SYNONYM GPCR signaling pathway via inhibition of adenylate cyclase activity
2009-01-31 Added SYNONYM G-protein signaling, adenylate cyclase inhibiting pathway
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP.
2007-08-09 Added SYNONYM G protein signalling, adenylate cyclase inhibiting pathway
2007-08-09 Added SYNONYM G protein signalling, adenylyl cyclase inhibiting pathway
2007-08-09 Added SYNONYM G-protein signaling, adenylyl cyclase inhibiting pathway
2007-08-09 Added SYNONYM G-protein signalling, adenylate cyclase inhibiting pathway
2007-08-09 Deleted SYNONYM G protein signaling, adenylate cyclase inhibiting pathway
2007-08-09 Deleted SYNONYM G-protein signalling, adenylyl cyclase inhibiting pathway
2007-08-09 Deleted SYNONYM G-protein signalling, adenylate cyclase inhibiting pathway
2007-08-09 Deleted SYNONYM G-protein signaling, adenylyl cyclase inhibiting pathway
2007-08-09 Deleted SYNONYM G protein signalling, adenylyl cyclase inhibiting pathway
2007-08-09 Deleted SYNONYM G protein signalling, adenylate cyclase inhibiting pathway
2007-08-09 Deleted SYNONYM G protein signaling, adenylyl cyclase inhibiting pathway
2007-08-09 Added SYNONYM G-protein signalling, adenylyl cyclase inhibiting pathway
2007-08-09 Added SYNONYM G protein signaling, adenylyl cyclase inhibiting pathway
2007-08-09 Added SYNONYM G protein signaling, adenylate cyclase inhibiting pathway
2005-06-27 Added SYNONYM G-protein signalling, adenylyl cyclase inhibiting pathway
2005-06-27 Added SYNONYM G protein signalling, adenylyl cyclase inhibiting pathway
2005-06-27 Added SYNONYM G protein signalling, adenylate cyclase inhibiting pathway
2005-06-27 Added SYNONYM G protein signaling, adenylate cyclase inhibiting pathway
2005-06-27 Added SYNONYM G protein signaling, adenylyl cyclase inhibiting pathway
2004-09-03 Added SYNONYM G-protein signaling, adenylyl cyclase inhibiting pathway
2004-07-28 Added DEFINITION The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP.
2004-04-19 Added SYNONYM G-protein signalling, adenylate cyclase inhibiting pathway
2004-04-16 Deleted SYNONYM G-protein signalling, adenylate cyclase inhibiting pathway
2003-11-13 Added SYNONYM G-protein signalling, adenylate cyclase inhibiting pathway
Timestamp Action Category Detail
2012-05-27 Deleted RELATION is a GO:0007194 (negative regulation of adenylate cyclase activity)
2008-10-02 Added RELATION is a GO:0007194 (negative regulation of adenylate cyclase activity)
2008-04-01 Updated RELATION is a GO:0007188 (adenylate cyclase-modulating G protein-coupled receptor signaling pathway)
Timestamp Action Category Detail
Timestamp Action Category Detail
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