This term is obsolete.
A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.

GO:0007269 JSON

neurotransmitter secretion

Biological Process

Definition (GO:0007269 GONUTS page)

The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.

Comments

A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.

Secondary IDs

GO:0010554

100,185 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
neurotransmitter secretory pathway exact
neurotransmitter release exact

Ancestor Chart

Ancestor chart for GO:0007269
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007269

Child Term Relationship to
GO:0007269
serotonin secretion, neurotransmission
is_a
catecholamine secretion, neurotransmission
is_a
positive regulation of neurotransmitter secretion
positively_regulates
negative regulation of neurotransmitter secretion
negatively_regulates
neurotransmitter secretion involved in regulation of skeletal muscle contraction
is_a
evoked neurotransmitter secretion
is_a
synaptic vesicle exocytosis
part_of
histamine secretion, neurotransmission
is_a
synchronous neurotransmitter secretion
is_a
substance P secretion, neurotransmission
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0007269 neurotransmitter secretion Only in Taxon 33208 Metazoa

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P05067-PRO_0000000092 9606 A4_HUMAN GO:0007268 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18216187
NOT-qualified manual protein P91645 7227 CAC1A_DROME GO:0007269 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:25811491
NOT-qualified manual protein P96210 83332 ESPG1_MYCTU GO:0046903 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21196469
NOT-qualified manual protein P9WJD1 83332 ESPF_MYCTU GO:0046903 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21196469
NOT-qualified manual protein Q9NFU0 7227 FMR1_DROME GO:0007268 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:12086643

Cross-references

Database ID Description
InterPro IPR001359 Synapsin

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0007269 based on ALL annotations
The top 100 of 1,311 co-occurring terms
Co-occurring Term PR S% #Together #Compared
neurotransmitter secretion
26,131.21 100.00 7,460 7,460
MPP7-DLG1-LIN7 complex
23,483.55 21.35 1,632 1,816
synaptic vesicle
1,749.31 6.40 4,402 65,757
synaptic vesicle membrane
1,510.51 5.59 4,666 80,720
synaptic vesicle cycle
18,440.94 3.11 235 333
L27 domain binding
18,299.84 3.03 229 327
Schaffer collateral - CA1 synapse
1,528.27 2.98 426 7,284
associative learning
3,118.81 2.94 280 2,346
presynapse
772.57 2.83 2,915 98,596
synaptic vesicle clustering
3,448.10 2.32 204 1,546
Totals 44407 1413905
No co-occurrence statistics for GO:0007269 based on MANUAL annotations
The top 100 of 1,118 co-occurring terms
Co-occurring Term PR S% #Together #Compared
neurotransmitter secretion
5,568.10 100.00 232 232
MPP7-DLG1-LIN7 complex
5,022.21 19.41 46 51
regulation of synaptic assembly at neuromuscular junction
1,656.85 16.22 61 205
synaptic vesicle transport
1,239.41 14.38 67 301
synaptic vesicle docking
711.90 6.62 28 219
synaptic vesicle priming
448.01 5.07 28 348
cytoskeletal matrix organization at active zone
1,749.97 4.30 11 35
synaptic vesicle exocytosis
425.05 4.22 20 262
presynaptic active zone cytoplasmic component
410.93 4.14 20 271
presynaptic active zone
327.54 4.07 27 459
Totals 1658 32652

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_synapse 357

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:33208 (Metazoa)
2023-08-08 Deleted RELATION is a GO:0001505 (obsolete regulation of neurotransmitter levels)
2020-03-15 Added RELATION is a GO:0051649 (establishment of localization in cell)
2019-08-30 Deleted RELATION is a GO:0051649 (establishment of localization in cell)
2018-04-13 Deleted RELATION is a GO:0099531 (presynaptic process involved in chemical synaptic transmission)
2018-04-13 Added RELATION occurs in GO:0098793 (presynapse)
2017-12-03 Added DEFINITION The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
2017-12-03 Deleted DEFINITION The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission.
2017-11-08 Deleted RELATION occurs in GO:0098793 (presynapse)
2017-05-22 Added RELATION occurs in GO:0098793 (presynapse)
Timestamp Action Category Detail
2002-08-15 Updated TERM neurotransmitter secretion
2002-02-06 Updated TERM neurotransmitter release
2001-04-03 Updated TERM neurotransmitter release
2001-03-30 Added TERM neurotransmitter release
Timestamp Action Category Detail
2017-12-03 Added DEFINITION The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
2017-12-03 Deleted DEFINITION The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission.
2016-03-27 Added DEFINITION The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission.
2016-03-27 Deleted DEFINITION The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
2016-03-27 Added SYNONYM neurotransmitter secretory pathway
2008-07-27 Added DEFINITION The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
2008-07-27 Deleted DEFINITION The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, y aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
2008-05-13 Added DEFINITION The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, y aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
2008-05-12 Deleted DEFINITION The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, y aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
2007-11-27 Updated DEFINITION The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, y aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
2007-08-09 Deleted SYNONYM neurotransmitter release
2007-08-09 Added SYNONYM neurotransmitter release
2004-04-19 Added SYNONYM neurotransmitter release
2004-04-16 Deleted SYNONYM neurotransmitter release
2002-11-27 Updated DEFINITION The regulated release of neurotransmitter into the synaptic cleft.
2002-08-15 Added SYNONYM neurotransmitter release
2001-08-06 Added DEFINITION The release of neurotransmitter into the synaptic cleft.
Timestamp Action Category Detail
2023-08-08 Deleted RELATION is a GO:0001505 (obsolete regulation of neurotransmitter levels)
2020-03-15 Added RELATION is a GO:0051649 (establishment of localization in cell)
2019-08-30 Deleted RELATION is a GO:0051649 (establishment of localization in cell)
2018-04-13 Deleted RELATION is a GO:0099531 (presynaptic process involved in chemical synaptic transmission)
2018-04-13 Added RELATION occurs in GO:0098793 (presynapse)
2017-11-08 Deleted RELATION occurs in GO:0098793 (presynapse)
2017-05-22 Added RELATION occurs in GO:0098793 (presynapse)
2017-04-06 Deleted RELATION occurs in GO:0098793 (presynapse)
2016-03-27 Added RELATION is a GO:0051649 (establishment of localization in cell)
2016-03-27 Deleted RELATION is a GO:0023061 (signal release)
2016-03-27 Added RELATION is a GO:0099643 (signal release from synapse)
2016-03-02 Added RELATION is a GO:0099531 (presynaptic process involved in chemical synaptic transmission)
2016-03-02 Added RELATION occurs in GO:0098793 (presynapse)
2015-05-29 Added RELATION part of GO:0007268 (chemical synaptic transmission)
2013-07-03 Deleted RELATION is a GO:0032940 (secretion by cell)
2010-04-30 Deleted RELATION is a GO:0003001 (obsolete generation of a signal involved in cell-cell signaling)
2010-04-30 Added RELATION is a GO:0023061 (signal release)
2008-05-13 Added RELATION is a GO:0006836 (neurotransmitter transport)
2008-04-01 Updated RELATION is a GO:0001505 (obsolete regulation of neurotransmitter levels)
2008-04-01 Updated RELATION is a GO:0032940 (secretion by cell)
2008-04-01 Updated RELATION is a GO:0003001 (obsolete generation of a signal involved in cell-cell signaling)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:33208 (Metazoa)
2016-03-27 Added SECONDARY GO:0010554 (neurotransmitter secretory pathway)
2015-05-29 Added SUBSET goslim_synapse
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