A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
GO:0007269
JSON
neurotransmitter secretion
Biological Process
Definition (GO:0007269 GONUTS page)
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
Comments
A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.
Secondary IDs
GO:0010554
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
neurotransmitter secretory pathway | exact |
neurotransmitter release | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0007269
Child Term | Relationship to GO:0007269 |
---|---|
serotonin secretion, neurotransmission
|
is_a |
catecholamine secretion, neurotransmission
|
is_a |
positive regulation of neurotransmitter secretion
|
positively_regulates |
negative regulation of neurotransmitter secretion
|
negatively_regulates |
neurotransmitter secretion involved in regulation of skeletal muscle contraction
|
is_a |
evoked neurotransmitter secretion
|
is_a |
synaptic vesicle exocytosis
|
part_of |
histamine secretion, neurotransmission
|
is_a |
synchronous neurotransmitter secretion
|
is_a |
substance P secretion, neurotransmission
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0007269 | neurotransmitter secretion | Only in Taxon | 33208 | Metazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | P05067-PRO_0000000092 | 9606 | A4_HUMAN | GO:0007268 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18216187 | |
NOT-qualified manual | protein | P91645 | 7227 | CAC1A_DROME | GO:0007269 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:25811491 | |
NOT-qualified manual | protein | P96210 | 83332 | ESPG1_MYCTU | GO:0046903 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21196469 | |
NOT-qualified manual | protein | P9WJD1 | 83332 | ESPF_MYCTU | GO:0046903 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21196469 | |
NOT-qualified manual | protein | Q9NFU0 | 7227 | FMR1_DROME | GO:0007268 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:12086643 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR001359 | Synapsin |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0007269 based on ALL annotations
The top 100 of 1,311 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
neurotransmitter secretion
|
26,131.21 | 100.00 | 7,460 | 7,460 |
MPP7-DLG1-LIN7 complex
|
23,483.55 | 21.35 | 1,632 | 1,816 |
synaptic vesicle
|
1,749.31 | 6.40 | 4,402 | 65,757 |
synaptic vesicle membrane
|
1,510.51 | 5.59 | 4,666 | 80,720 |
synaptic vesicle cycle
|
18,440.94 | 3.11 | 235 | 333 |
L27 domain binding
|
18,299.84 | 3.03 | 229 | 327 |
Schaffer collateral - CA1 synapse
|
1,528.27 | 2.98 | 426 | 7,284 |
associative learning
|
3,118.81 | 2.94 | 280 | 2,346 |
presynapse
|
772.57 | 2.83 | 2,915 | 98,596 |
synaptic vesicle clustering
|
3,448.10 | 2.32 | 204 | 1,546 |
Totals | 44407 | 1413905 |
No co-occurrence statistics for GO:0007269 based on MANUAL annotations
The top 100 of 1,118 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
neurotransmitter secretion
|
5,568.10 | 100.00 | 232 | 232 |
MPP7-DLG1-LIN7 complex
|
5,022.21 | 19.41 | 46 | 51 |
regulation of synaptic assembly at neuromuscular junction
|
1,656.85 | 16.22 | 61 | 205 |
synaptic vesicle transport
|
1,239.41 | 14.38 | 67 | 301 |
synaptic vesicle docking
|
711.90 | 6.62 | 28 | 219 |
synaptic vesicle priming
|
448.01 | 5.07 | 28 | 348 |
cytoskeletal matrix organization at active zone
|
1,749.97 | 4.30 | 11 | 35 |
synaptic vesicle exocytosis
|
425.05 | 4.22 | 20 | 262 |
presynaptic active zone cytoplasmic component
|
410.93 | 4.14 | 20 | 271 |
presynaptic active zone
|
327.54 | 4.07 | 27 | 459 |
Totals | 1658 | 32652 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_synapse | 357 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
2023-08-08 | Deleted | RELATION | is a GO:0001505 (obsolete regulation of neurotransmitter levels) |
2020-03-15 | Added | RELATION | is a GO:0051649 (establishment of localization in cell) |
2019-08-30 | Deleted | RELATION | is a GO:0051649 (establishment of localization in cell) |
2018-04-13 | Deleted | RELATION | is a GO:0099531 (presynaptic process involved in chemical synaptic transmission) |
2018-04-13 | Added | RELATION | occurs in GO:0098793 (presynapse) |
2017-12-03 | Added | DEFINITION | The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. |
2017-12-03 | Deleted | DEFINITION | The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission. |
2017-11-08 | Deleted | RELATION | occurs in GO:0098793 (presynapse) |
2017-05-22 | Added | RELATION | occurs in GO:0098793 (presynapse) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-08-15 | Updated | TERM | neurotransmitter secretion |
2002-02-06 | Updated | TERM | neurotransmitter release |
2001-04-03 | Updated | TERM | neurotransmitter release |
2001-03-30 | Added | TERM | neurotransmitter release |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-12-03 | Added | DEFINITION | The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. |
2017-12-03 | Deleted | DEFINITION | The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission. |
2016-03-27 | Added | DEFINITION | The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission. |
2016-03-27 | Deleted | DEFINITION | The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. |
2016-03-27 | Added | SYNONYM | neurotransmitter secretory pathway |
2008-07-27 | Added | DEFINITION | The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. |
2008-07-27 | Deleted | DEFINITION | The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, y aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. |
2008-05-13 | Added | DEFINITION | The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, y aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. |
2008-05-12 | Deleted | DEFINITION | The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, y aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. |
2007-11-27 | Updated | DEFINITION | The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, y aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. |
2007-08-09 | Deleted | SYNONYM | neurotransmitter release |
2007-08-09 | Added | SYNONYM | neurotransmitter release |
2004-04-19 | Added | SYNONYM | neurotransmitter release |
2004-04-16 | Deleted | SYNONYM | neurotransmitter release |
2002-11-27 | Updated | DEFINITION | The regulated release of neurotransmitter into the synaptic cleft. |
2002-08-15 | Added | SYNONYM | neurotransmitter release |
2001-08-06 | Added | DEFINITION | The release of neurotransmitter into the synaptic cleft. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-08 | Deleted | RELATION | is a GO:0001505 (obsolete regulation of neurotransmitter levels) |
2020-03-15 | Added | RELATION | is a GO:0051649 (establishment of localization in cell) |
2019-08-30 | Deleted | RELATION | is a GO:0051649 (establishment of localization in cell) |
2018-04-13 | Deleted | RELATION | is a GO:0099531 (presynaptic process involved in chemical synaptic transmission) |
2018-04-13 | Added | RELATION | occurs in GO:0098793 (presynapse) |
2017-11-08 | Deleted | RELATION | occurs in GO:0098793 (presynapse) |
2017-05-22 | Added | RELATION | occurs in GO:0098793 (presynapse) |
2017-04-06 | Deleted | RELATION | occurs in GO:0098793 (presynapse) |
2016-03-27 | Added | RELATION | is a GO:0051649 (establishment of localization in cell) |
2016-03-27 | Deleted | RELATION | is a GO:0023061 (signal release) |
2016-03-27 | Added | RELATION | is a GO:0099643 (signal release from synapse) |
2016-03-02 | Added | RELATION | is a GO:0099531 (presynaptic process involved in chemical synaptic transmission) |
2016-03-02 | Added | RELATION | occurs in GO:0098793 (presynapse) |
2015-05-29 | Added | RELATION | part of GO:0007268 (chemical synaptic transmission) |
2013-07-03 | Deleted | RELATION | is a GO:0032940 (secretion by cell) |
2010-04-30 | Deleted | RELATION | is a GO:0003001 (obsolete generation of a signal involved in cell-cell signaling) |
2010-04-30 | Added | RELATION | is a GO:0023061 (signal release) |
2008-05-13 | Added | RELATION | is a GO:0006836 (neurotransmitter transport) |
2008-04-01 | Updated | RELATION | is a GO:0001505 (obsolete regulation of neurotransmitter levels) |
2008-04-01 | Updated | RELATION | is a GO:0032940 (secretion by cell) |
2008-04-01 | Updated | RELATION | is a GO:0003001 (obsolete generation of a signal involved in cell-cell signaling) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
2016-03-27 | Added | SECONDARY | GO:0010554 (neurotransmitter secretory pathway) |
2015-05-29 | Added | SUBSET | goslim_synapse |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link