This term is obsolete.
This term should only be used in cases when the regulator directly interacts with the enzyme.

GO:0008047 JSON

enzyme activator activity

Molecular Function

Definition (GO:0008047 GONUTS page)

Binds to and increases the activity of an enzyme.

Comments

This term should only be used in cases when the regulator directly interacts with the enzyme.

Secondary IDs

GO:0010577

845,259 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
metalloenzyme activator activity narrow

Ancestor Chart

Ancestor chart for GO:0008047
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008047

Child Term Relationship to
GO:0008047
acetyltransferase activator activity
is_a
GTPase activator activity
is_a
phosphatase activator activity
is_a
tryptophan hydroxylase activator activity
is_a
urease activator activity
is_a
enzyme activator complex
capable_of
recombinase activator activity
is_a
tyrosine 3-monooxygenase activator activity
is_a
phosphatidylcholine-sterol O-acyltransferase activator activity
is_a
DNA polymerase processivity factor activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Cross-references

Database ID Description
InterPro IPR000671 Peptidase A31 family
InterPro IPR001446 5-lipoxygenase-activating protein
InterPro IPR001981 Colipase
InterPro IPR008019 Apolipoprotein C-II
InterPro IPR010334 mRNA-decapping enzyme subunit 1
InterPro IPR017913 Colipase, N-terminal
InterPro IPR017914 Colipase, C-terminal
InterPro IPR017915 Colipase, conserved site
InterPro IPR018295 FLAP/GST2/LTC4S, conserved site
InterPro IPR028996 Ganglioside GM2 activator

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0090216 obsolete positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity consider GO:0008047
GO:1900490 obsolete positive regulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity consider GO:0008047
GO:1905643 obsolete positive regulation of DNA methylation consider GO:0008047

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008047 based on ALL annotations
The top 100 of 1,949 co-occurring terms
Co-occurring Term PR S% #Together #Compared
enzyme activator activity
2,405.46 100.00 81,040 81,040
DNA synthesis involved in DNA repair
1,027.81 32.01 45,446 106,361
single-stranded DNA helicase activity
974.94 30.76 45,447 112,131
DNA-templated DNA replication
245.17 9.44 45,447 445,900
deadenylation-independent decapping of nuclear-transcribed mRNA
873.92 6.07 5,507 15,158
protein processing
181.27 5.96 18,023 239,165
deadenylation-dependent decapping of nuclear-transcribed mRNA
552.31 5.91 5,979 26,040
DNA duplex unwinding
133.51 5.32 45,482 819,479
endopeptidase activity
151.48 5.16 18,023 286,200
P-body
107.22 2.80 5,674 127,299
Totals 608887 64523650
No co-occurrence statistics for GO:0008047 based on MANUAL annotations
The top 100 of 1,443 co-occurring terms
Co-occurring Term PR S% #Together #Compared
enzyme activator activity
3,197.52 100.00 404 404
DNA synthesis involved in DNA repair
1,076.09 17.18 105 312
execution phase of apoptosis
834.91 8.75 47 180
single-stranded DNA helicase activity
360.68 8.51 104 922
death-inducing signaling complex
2,344.85 7.93 33 45
DNA-templated DNA replication
196.94 5.25 106 1,721
phospholipase D activator activity
2,780.45 4.91 20 23
keratinocyte differentiation
318.79 4.70 33 331
positive regulation of neuron apoptotic process
215.87 4.50 48 711
toxin metabolic process
999.23 4.46 20 64
Totals 1572 20741

Change Log

Timestamp Action Category Detail
2023-04-24 Added RELATION is a GO:0140677 (molecular function activator activity)
2023-04-02 Deleted RELATION is a GO:0140677 (molecular function activator activity)
2022-09-16 Added RELATION is a GO:0140677 (molecular function activator activity)
2021-10-04 Deleted RELATION is a GO:0140677 (molecular function activator activity)
2021-07-10 Added RELATION is a GO:0140677 (molecular function activator activity)
2021-05-15 Deleted RELATION is a GO:0003674 (molecular_function)
2021-05-15 Added RELATION is a GO:0030234 (enzyme regulator activity)
2021-02-17 Deleted RELATION is a GO:0030234 (enzyme regulator activity)
2021-02-17 Added RELATION is a GO:0003674 (molecular_function)
2020-11-10 Deleted RELATION part of GO:0043085 (positive regulation of catalytic activity)
Timestamp Action Category Detail
2003-03-19 Updated TERM enzyme activator activity
2002-02-06 Updated TERM enzyme activator
2001-04-03 Updated TERM enzyme activator
2001-03-30 Added TERM enzyme activator
Timestamp Action Category Detail
2016-04-14 Added SYNONYM metalloenzyme activator activity
2015-07-11 Deleted DEFINITION Increases the activity of an enzyme.
2015-07-11 Added DEFINITION Binds to and increases the activity of an enzyme.
2008-05-13 Added DEFINITION Increases the activity of an enzyme.
2008-05-12 Deleted DEFINITION Increases the activity of an enzyme.
2003-07-29 Updated DEFINITION Increases the activity of an enzyme.
2003-06-17 Added DEFINITION Increases the activity of an ezyme.
Timestamp Action Category Detail
2023-04-24 Added RELATION is a GO:0140677 (molecular function activator activity)
2023-04-02 Deleted RELATION is a GO:0140677 (molecular function activator activity)
2022-09-16 Added RELATION is a GO:0140677 (molecular function activator activity)
2021-10-04 Deleted RELATION is a GO:0140677 (molecular function activator activity)
2021-07-10 Added RELATION is a GO:0140677 (molecular function activator activity)
2021-05-15 Deleted RELATION is a GO:0003674 (molecular_function)
2021-05-15 Added RELATION is a GO:0030234 (enzyme regulator activity)
2021-02-17 Deleted RELATION is a GO:0030234 (enzyme regulator activity)
2021-02-17 Added RELATION is a GO:0003674 (molecular_function)
2020-11-10 Deleted RELATION part of GO:0043085 (positive regulation of catalytic activity)
2017-05-05 Deleted RELATION regulates GO:0003824 (catalytic activity)
2017-05-01 Added RELATION regulates GO:0003824 (catalytic activity)
2017-05-01 Added RELATION positively regulates GO:0003824 (catalytic activity)
2011-04-24 Added RELATION part of GO:0043085 (positive regulation of catalytic activity)
2008-04-01 Updated RELATION is a GO:0030234 (enzyme regulator activity)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:18.02.01.01
2019-05-04 Added XREF MIPS_funcat:18.02.01.01
Timestamp Action Category Detail
2016-04-14 Added SECONDARY GO:0010577 (metalloenzyme activator activity)
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