This term is obsolete.

GO:0008081 JSON

phosphoric diester hydrolase activity

Molecular Function

Definition (GO:0008081 GONUTS page)

Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.

Secondary IDs

GO:0004434, GO:0016792

782,743 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
phosphodiesterase narrow

Ancestor Chart

Ancestor chart for GO:0008081
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008081

Child Term Relationship to
GO:0008081
phosphodiesterase I activity
is_a
glycerophosphocholine phosphodiesterase activity
is_a
serine-ethanolaminephosphate phosphodiesterase activity
is_a
cardiolipin hydrolase activity
is_a
glycerophosphodiester phosphodiesterase activity
is_a
cyclic-nucleotide phosphodiesterase activity
is_a
phospholipase D activity
is_a
cyclic-guanylate-specific phosphodiesterase activity
is_a
7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity
is_a
N-acylphosphatidylethanolamine-specific phospholipase D activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
EC 3.1.4.-
InterPro IPR010347 Tyrosyl-DNA phosphodiesterase I
InterPro IPR012387 tRNA ligase Trl1, fungi
InterPro IPR017693 Phosphonate metabolism protein PhnP
InterPro IPR017766 Sphingomyelinase C/phospholipase C
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
InterPro IPR023088 3'5'-cyclic nucleotide phosphodiesterase
InterPro IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
InterPro IPR024225 Cyclic-AMP phosphodiesterase class-II, conserved site
InterPro IPR030395 Glycerophosphodiester phosphodiesterase domain

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0008845 obsolete endonuclease VIII activity consider GO:0008081

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008081 based on ALL annotations
The top 100 of 2,012 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phosphoric diester hydrolase activity
696.48 100.00 284,508 284,508
DNA-(apurinic or apyrimidinic site) endonuclease activity
230.32 13.94 55,236 167,035
lipid metabolic process
86.56 11.02 140,099 1,127,241
glycerophosphodiester phosphodiesterase activity
665.52 10.85 31,014 32,457
double-stranded DNA 3'-5' DNA exonuclease activity
314.56 9.26 29,692 65,743
base-excision repair
100.86 9.05 55,240 381,448
RNA 2',3'-cyclic 3'-phosphodiesterase activity
615.14 7.61 21,862 24,753
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
356.10 7.16 21,874 42,783
[protein-PII] uridylyltransferase activity
353.15 6.06 18,311 36,113
deoxyribonuclease IV (phage-T4-induced) activity
646.77 5.93 16,941 18,243
Totals 1298765 191302958
No co-occurrence statistics for GO:0008081 based on MANUAL annotations
The top 100 of 349 co-occurring terms
Co-occurring Term PR S% #Together #Compared
phosphoric diester hydrolase activity
1,146.66 100.00 1,231 1,231
double-stranded DNA 3'-5' DNA exonuclease activity
1,126.06 39.68 492 501
DNA-(apurinic or apyrimidinic site) endonuclease activity
694.29 34.65 551 910
base-excision repair
499.06 28.31 551 1,266
glycerophospholipid catabolic process
136.28 3.49 58 488
lysophospholipase activity
139.77 3.33 54 443
N-acylethanolamine metabolic process
132.10 1.76 25 217
sphingomyelin phosphodiesterase activity
223.37 1.16 15 77
sphingomyelin catabolic process
98.99 0.88 12 139
glycerophosphocholine cholinephosphodiesterase activity
891.84 0.57 7 9
Totals 3976 305469

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2021-01-04 Deleted XREF EC:3.1.4
2021-01-04 Added XREF EC:3.1.4.-
2019-04-01 Added XREF Reactome:R-HSA-5693578
2019-04-01 Deleted XREF reactome:R-HSA-5693578
2018-12-11 Added XREF reactome:R-HSA-5693578
2017-09-19 Deleted SYNONYM inositol or phosphatidylinositol phosphodiesterase activity
2017-09-19 Deleted SYNONYM endonuclease VIII activity
2017-09-19 Deleted SYNONYM inositol/phosphatidylinositol phosphodiesterase activity
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
Timestamp Action Category Detail
2003-03-19 Updated TERM phosphoric diester hydrolase activity
2002-06-07 Updated TERM phosphoric diester hydrolase
2002-02-06 Updated TERM phosphodiesterase
2001-04-03 Updated TERM phosphodiesterase
2001-03-30 Added TERM phosphodiesterase
Timestamp Action Category Detail
2017-09-19 Deleted SYNONYM inositol or phosphatidylinositol phosphodiesterase activity
2017-09-19 Deleted SYNONYM endonuclease VIII activity
2017-09-19 Deleted SYNONYM inositol/phosphatidylinositol phosphodiesterase activity
2010-10-07 Added SYNONYM inositol or phosphatidylinositol phosphodiesterase activity
2010-10-07 Added SYNONYM inositol/phosphatidylinositol phosphodiesterase activity
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
2007-08-09 Added SYNONYM phosphodiesterase
2007-08-09 Deleted SYNONYM phosphodiesterase
2007-08-09 Deleted SYNONYM endonuclease VIII activity
2007-08-09 Added SYNONYM endonuclease VIII activity
2005-08-10 Added SYNONYM endonuclease VIII activity
2004-04-19 Added SYNONYM phosphodiesterase
2004-04-16 Deleted SYNONYM phosphodiesterase
2003-03-26 Added DEFINITION Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
2002-06-07 Added SYNONYM phosphodiesterase
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0042578 (phosphoric ester hydrolase activity)
Timestamp Action Category Detail
2021-01-04 Deleted XREF EC:3.1.4
2021-01-04 Added XREF EC:3.1.4.-
2019-04-01 Added XREF Reactome:R-HSA-5693578
2019-04-01 Deleted XREF reactome:R-HSA-5693578
2018-12-11 Added XREF reactome:R-HSA-5693578
2011-05-03 Deleted XREF EC:3.1.4.-
2010-10-07 Added XREF EC:3.1.4.-
2006-02-09 Added XREF EC:3.1.4
2006-02-09 Deleted XREF EC:3.1.4.-
2001-03-30 Added XREF EC:3.1.4.-
Timestamp Action Category Detail
2015-05-19 Added SUBSET goslim_chembl
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-11 Added SUBSET goslim_ChEMBL
2010-10-07 Added SECONDARY GO:0004434 (inositol or phosphatidylinositol phosphodiesterase activity)
2002-06-07 Added SECONDARY GO:0016792 (phosphoric diester hydrolase)
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