GO:0008081
JSON
phosphoric diester hydrolase activity
Molecular Function
Definition (GO:0008081 GONUTS page)
Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
Secondary IDs
GO:0004434, GO:0016792
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
phosphodiesterase | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0008081
Child Term | Relationship to GO:0008081 |
---|---|
sphingomyelin phosphodiesterase activity
|
is_a |
phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase activity
|
is_a |
[acyl-carrier-protein] phosphodiesterase activity
|
is_a |
protein adenylylhydrolase activity
|
is_a |
GPI-mannose ethanolamine phosphate phosphodiesterase activity
|
is_a |
tyrosyl-RNA phosphodiesterase activity
|
is_a |
glycerophosphoinositol inositolphosphodiesterase activity
|
is_a |
glycerophosphoinositol glycerophosphodiesterase activity
|
is_a |
CMP-N-acylneuraminate phosphodiesterase activity
|
is_a |
glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.1.4.- | |
InterPro | IPR010347 | Tyrosyl-DNA phosphodiesterase I |
InterPro | IPR012387 | tRNA ligase Trl1, fungi |
InterPro | IPR017693 | Phosphonate metabolism protein PhnP |
InterPro | IPR017766 | Sphingomyelinase C/phospholipase C |
InterPro | IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily |
InterPro | IPR023088 | 3'5'-cyclic nucleotide phosphodiesterase |
InterPro | IPR023174 | 3'5'-cyclic nucleotide phosphodiesterase, conserved site |
InterPro | IPR024225 | Cyclic-AMP phosphodiesterase class-II, conserved site |
InterPro | IPR030395 | Glycerophosphodiester phosphodiesterase domain |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0008845 | obsolete endonuclease VIII activity | consider GO:0008081 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008081 based on ALL annotations
The top 100 of 1,986 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phosphoric diester hydrolase activity
|
709.36 | 100.00 | 274,809 | 274,809 |
DNA-(apurinic or apyrimidinic site) endonuclease activity
|
234.17 | 14.06 | 54,084 | 163,834 |
lipid metabolic process
|
103.79 | 12.73 | 136,091 | 930,097 |
glycerophosphodiester phosphodiesterase activity
|
677.39 | 10.92 | 30,176 | 31,600 |
double-stranded DNA 3'-5' DNA exonuclease activity
|
319.62 | 9.36 | 29,028 | 64,424 |
base-excision repair
|
102.62 | 9.10 | 54,088 | 373,869 |
RNA 2',3'-cyclic 3'-phosphodiesterase activity
|
627.55 | 7.74 | 21,500 | 24,303 |
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
|
362.75 | 7.28 | 21,512 | 42,067 |
[protein-PII] uridylyltransferase activity
|
366.35 | 6.28 | 18,340 | 35,512 |
deoxyribonuclease IV (phage-T4-induced) activity
|
662.45 | 6.02 | 16,607 | 17,783 |
Totals | 1279283 | 186019313 |
No co-occurrence statistics for GO:0008081 based on MANUAL annotations
The top 100 of 358 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phosphoric diester hydrolase activity
|
1,190.60 | 100.00 | 1,085 | 1,085 |
double-stranded DNA 3'-5' DNA exonuclease activity
|
1,163.05 | 34.73 | 380 | 389 |
DNA-(apurinic or apyrimidinic site) endonuclease activity
|
673.75 | 30.82 | 438 | 774 |
base-excision repair
|
478.86 | 25.23 | 438 | 1,089 |
glycerophospholipid catabolic process
|
141.35 | 3.54 | 52 | 438 |
lysophospholipase activity
|
140.07 | 3.32 | 48 | 408 |
N-acylethanolamine metabolic process
|
139.71 | 1.83 | 23 | 196 |
sphingomyelin phosphodiesterase activity
|
224.11 | 1.39 | 16 | 85 |
polyphosphate catabolic process
|
314.50 | 1.25 | 14 | 53 |
endopolyphosphatase activity
|
137.76 | 1.17 | 14 | 121 |
Totals | 3420 | 279392 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_chembl | 296 |
Change Log
- All changes
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- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
- Cross-references
- Other
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-01-04 | Added | XREF | EC:3.1.4.- |
2021-01-04 | Deleted | XREF | EC:3.1.4 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5693578 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5693578 |
2018-12-11 | Added | XREF | reactome:R-HSA-5693578 |
2017-09-19 | Deleted | SYNONYM | inositol or phosphatidylinositol phosphodiesterase activity |
2017-09-19 | Deleted | SYNONYM | inositol/phosphatidylinositol phosphodiesterase activity |
2017-09-19 | Deleted | SYNONYM | endonuclease VIII activity |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | phosphoric diester hydrolase activity |
2002-06-07 | Updated | TERM | phosphoric diester hydrolase |
2002-02-06 | Updated | TERM | phosphodiesterase |
2001-04-03 | Updated | TERM | phosphodiesterase |
2001-03-30 | Added | TERM | phosphodiesterase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-09-19 | Deleted | SYNONYM | inositol or phosphatidylinositol phosphodiesterase activity |
2017-09-19 | Deleted | SYNONYM | inositol/phosphatidylinositol phosphodiesterase activity |
2017-09-19 | Deleted | SYNONYM | endonuclease VIII activity |
2010-10-07 | Added | SYNONYM | inositol or phosphatidylinositol phosphodiesterase activity |
2010-10-07 | Added | SYNONYM | inositol/phosphatidylinositol phosphodiesterase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. |
2007-08-09 | Deleted | SYNONYM | phosphodiesterase |
2007-08-09 | Deleted | SYNONYM | endonuclease VIII activity |
2007-08-09 | Added | SYNONYM | endonuclease VIII activity |
2007-08-09 | Added | SYNONYM | phosphodiesterase |
2005-08-10 | Added | SYNONYM | endonuclease VIII activity |
2004-04-19 | Added | SYNONYM | phosphodiesterase |
2004-04-16 | Deleted | SYNONYM | phosphodiesterase |
2003-03-26 | Added | DEFINITION | Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. |
2002-06-07 | Added | SYNONYM | phosphodiesterase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0042578 (phosphoric ester hydrolase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-01-04 | Added | XREF | EC:3.1.4.- |
2021-01-04 | Deleted | XREF | EC:3.1.4 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5693578 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5693578 |
2018-12-11 | Added | XREF | reactome:R-HSA-5693578 |
2011-05-03 | Deleted | XREF | EC:3.1.4.- |
2010-10-07 | Added | XREF | EC:3.1.4.- |
2006-02-09 | Deleted | XREF | EC:3.1.4.- |
2006-02-09 | Added | XREF | EC:3.1.4 |
2001-03-30 | Added | XREF | EC:3.1.4.- |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2010-10-07 | Added | SECONDARY | GO:0004434 (inositol or phosphatidylinositol phosphodiesterase activity) |
2002-06-07 | Added | SECONDARY | GO:0016792 (phosphoric diester hydrolase) |
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