This term is obsolete.

GO:0008173 JSON

RNA methyltransferase activity

Molecular Function

Definition (GO:0008173 GONUTS page)

Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.

1,469,122 annotations

Ancestor Chart

Ancestor chart for GO:0008173
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008173

Child Term Relationship to
GO:0008173
mRNA methyltransferase activity
is_a
tRNA methyltransferase activity
is_a
rRNA methyltransferase activity
is_a
RNA cap trimethylguanosine synthase activity
is_a
RNA 2'-O-methyltransferase activity
is_a
RNA 5'-gamma-phosphate methyltransferase activity
is_a
snRNA methyltransferase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A8I6AGH5 10116 A0A8I6AGH5_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3Z930 10116 D3Z930_RAT GO:0008168 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
InterPro IPR001537 tRNA/rRNA methyltransferase, SpoU type
InterPro IPR001566 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD
InterPro IPR004383 Ribosomal RNA large subunit methyltransferase RlmN/Cfr
InterPro IPR004384 RNA methyltransferase TrmJ/LasT
InterPro IPR004441 RNA methyltransferase TrmH
InterPro IPR010280 (Uracil-5)-methyltransferase family
InterPro IPR023267 RNA (C5-cytosine) methyltransferase
InterPro IPR026610 3'-RNA ribose 2'-O-methyltransferase, Hen1
Reactome R-HSA-191784

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008173 based on ALL annotations
The top 100 of 1,228 co-occurring terms
Co-occurring Term PR S% #Together #Compared
RNA methyltransferase activity
584.42 100.00 333,562 333,562
RNA methylation
374.89 23.06 88,292 137,640
rRNA base methylation
245.80 20.84 97,532 231,889
RNA processing
121.28 18.70 218,327 1,052,040
tRNA methylation
142.02 13.53 77,981 320,887
rRNA (uridine-C5-)-methyltransferase activity
580.76 13.50 45,083 45,367
rRNA (adenine(2503)-C2-)-methyltransferase activity
580.03 10.66 35,575 35,844
tRNA (adenine(37)-C2)-methyltransferase activity
580.03 10.65 35,546 35,815
methylation
53.90 9.22 332,368 3,603,867
methyltransferase activity
51.98 8.89 332,603 3,739,251
Totals 2844898 124537636
No co-occurrence statistics for GO:0008173 based on MANUAL annotations
The top 100 of 146 co-occurring terms
Co-occurring Term PR S% #Together #Compared
RNA methyltransferase activity
3,902.72 100.00 331 331
snRNA modification
3,862.48 28.92 96 97
snRNA binding
1,227.68 17.66 95 302
wobble position ribose methylation
2,939.71 16.57 58 77
O-methyltransferase activity
491.27 11.60 197 1,565
negative regulation of pre-miRNA processing
2,956.60 7.37 25 33
siRNA processing
294.25 6.02 76 1,008
site-specific DNA-methyltransferase (adenine-specific) activity
961.54 4.44 17 69
piRNA processing
274.96 4.19 31 440
RNA methylation
264.29 4.03 30 443
Totals 1283 35763

Change Log

Timestamp Action Category Detail
2023-09-23 Deleted RELATION part of GO:0001510 (RNA methylation)
2019-04-01 Deleted XREF reactome:R-HSA-191784
2019-04-01 Added XREF Reactome:R-HSA-191784
2018-12-11 Added XREF reactome:R-HSA-191784
2018-02-16 Deleted XREF EC:2.1.1
2017-09-19 Added RELATION is a GO:0140098 (catalytic activity, acting on RNA)
2016-10-03 Deleted XREF EC:2.1.1.-
2016-10-03 Added XREF EC:2.1.1
2010-07-16 Added RELATION part of GO:0001510 (RNA methylation)
2008-05-13 Added DEFINITION Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.
Timestamp Action Category Detail
2003-03-19 Updated TERM RNA methyltransferase activity
2002-02-06 Updated TERM RNA methyltransferase
2001-04-03 Updated TERM RNA methyltransferase
2001-03-30 Added TERM RNA methyltransferase
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.
2008-05-12 Deleted DEFINITION Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.
2003-06-18 Added DEFINITION Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.
Timestamp Action Category Detail
2023-09-23 Deleted RELATION part of GO:0001510 (RNA methylation)
2017-09-19 Added RELATION is a GO:0140098 (catalytic activity, acting on RNA)
2010-07-16 Added RELATION part of GO:0001510 (RNA methylation)
2008-04-01 Updated RELATION is a GO:0008168 (methyltransferase activity)
Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-191784
2019-04-01 Added XREF Reactome:R-HSA-191784
2018-12-11 Added XREF reactome:R-HSA-191784
2018-02-16 Deleted XREF EC:2.1.1
2016-10-03 Deleted XREF EC:2.1.1.-
2016-10-03 Added XREF EC:2.1.1
2001-03-30 Added XREF EC:2.1.1.-
Timestamp Action Category Detail
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