GO:0008173
JSON
RNA methyltransferase activity
Molecular Function
Definition (GO:0008173 GONUTS page)
Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.
Ancestor Chart
Ancestor chart for GO:0008173
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0008173
Child Term | Relationship to GO:0008173 |
---|---|
mRNA methyltransferase activity
|
is_a |
tRNA methyltransferase activity
|
is_a |
rRNA methyltransferase activity
|
is_a |
RNA cap trimethylguanosine synthase activity
|
is_a |
RNA 2'-O-methyltransferase activity
|
is_a |
RNA 5'-gamma-phosphate methyltransferase activity
|
is_a |
snRNA methyltransferase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A8I6AGH5 | 10116 | A0A8I6AGH5_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3Z930 | 10116 | D3Z930_RAT | GO:0008168 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR001537 | tRNA/rRNA methyltransferase, SpoU type |
InterPro | IPR001566 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD |
InterPro | IPR004383 | Ribosomal RNA large subunit methyltransferase RlmN/Cfr |
InterPro | IPR004384 | RNA methyltransferase TrmJ/LasT |
InterPro | IPR004441 | RNA methyltransferase TrmH |
InterPro | IPR010280 | (Uracil-5)-methyltransferase family |
InterPro | IPR023267 | RNA (C5-cytosine) methyltransferase |
InterPro | IPR026610 | 3'-RNA ribose 2'-O-methyltransferase, Hen1 |
Reactome | R-HSA-191784 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008173 based on ALL annotations
The top 100 of 1,228 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
RNA methyltransferase activity
|
584.42 | 100.00 | 333,562 | 333,562 |
RNA methylation
|
374.89 | 23.06 | 88,292 | 137,640 |
rRNA base methylation
|
245.80 | 20.84 | 97,532 | 231,889 |
RNA processing
|
121.28 | 18.70 | 218,327 | 1,052,040 |
tRNA methylation
|
142.02 | 13.53 | 77,981 | 320,887 |
rRNA (uridine-C5-)-methyltransferase activity
|
580.76 | 13.50 | 45,083 | 45,367 |
rRNA (adenine(2503)-C2-)-methyltransferase activity
|
580.03 | 10.66 | 35,575 | 35,844 |
tRNA (adenine(37)-C2)-methyltransferase activity
|
580.03 | 10.65 | 35,546 | 35,815 |
methylation
|
53.90 | 9.22 | 332,368 | 3,603,867 |
methyltransferase activity
|
51.98 | 8.89 | 332,603 | 3,739,251 |
Totals | 2844898 | 124537636 |
No co-occurrence statistics for GO:0008173 based on MANUAL annotations
The top 100 of 146 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
RNA methyltransferase activity
|
3,902.72 | 100.00 | 331 | 331 |
snRNA modification
|
3,862.48 | 28.92 | 96 | 97 |
snRNA binding
|
1,227.68 | 17.66 | 95 | 302 |
wobble position ribose methylation
|
2,939.71 | 16.57 | 58 | 77 |
O-methyltransferase activity
|
491.27 | 11.60 | 197 | 1,565 |
negative regulation of pre-miRNA processing
|
2,956.60 | 7.37 | 25 | 33 |
siRNA processing
|
294.25 | 6.02 | 76 | 1,008 |
site-specific DNA-methyltransferase (adenine-specific) activity
|
961.54 | 4.44 | 17 | 69 |
piRNA processing
|
274.96 | 4.19 | 31 | 440 |
RNA methylation
|
264.29 | 4.03 | 30 | 443 |
Totals | 1283 | 35763 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
- Cross-references
- Other
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-23 | Deleted | RELATION | part of GO:0001510 (RNA methylation) |
2019-04-01 | Deleted | XREF | reactome:R-HSA-191784 |
2019-04-01 | Added | XREF | Reactome:R-HSA-191784 |
2018-12-11 | Added | XREF | reactome:R-HSA-191784 |
2018-02-16 | Deleted | XREF | EC:2.1.1 |
2017-09-19 | Added | RELATION | is a GO:0140098 (catalytic activity, acting on RNA) |
2016-10-03 | Deleted | XREF | EC:2.1.1.- |
2016-10-03 | Added | XREF | EC:2.1.1 |
2010-07-16 | Added | RELATION | part of GO:0001510 (RNA methylation) |
2008-05-13 | Added | DEFINITION | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | RNA methyltransferase activity |
2002-02-06 | Updated | TERM | RNA methyltransferase |
2001-04-03 | Updated | TERM | RNA methyltransferase |
2001-03-30 | Added | TERM | RNA methyltransferase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
2003-06-18 | Added | DEFINITION | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-23 | Deleted | RELATION | part of GO:0001510 (RNA methylation) |
2017-09-19 | Added | RELATION | is a GO:0140098 (catalytic activity, acting on RNA) |
2010-07-16 | Added | RELATION | part of GO:0001510 (RNA methylation) |
2008-04-01 | Updated | RELATION | is a GO:0008168 (methyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-191784 |
2019-04-01 | Added | XREF | Reactome:R-HSA-191784 |
2018-12-11 | Added | XREF | reactome:R-HSA-191784 |
2018-02-16 | Deleted | XREF | EC:2.1.1 |
2016-10-03 | Deleted | XREF | EC:2.1.1.- |
2016-10-03 | Added | XREF | EC:2.1.1 |
2001-03-30 | Added | XREF | EC:2.1.1.- |
Timestamp | Action | Category | Detail |
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