This term is obsolete.

GO:0008180 JSON

COP9 signalosome

Cellular Component

Definition (GO:0008180 GONUTS page)

A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. PMID:11019806 PMID:12186635 PMID:14570571

38,116 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
COP9 complex exact
CSN exact
signalosome broad

Ancestor Chart

Ancestor chart for GO:0008180
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0008180 COP9 signalosome Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A096MJ18 10116 A0A096MJ18_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A096MK97 10116 A0A096MK97_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2JW23 10116 A0A0G2JW23_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K8T1 10116 A0A0G2K8T1_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A1B0GR71 10090 A0A1B0GR71_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1B0GRK6 10090 A0A1B0GRK6_MOUSE GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636
NOT-qualified manual protein A0A1D8PHF8 237561 A0A1D8PHF8_CANAL GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936
NOT-qualified manual protein A0A1W2Q633 10116 A0A1W2Q633_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y8H4 10116 A0A8I5Y8H4_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A0E5 10116 A0A8I6A0E5_RAT GO:0005634 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR016806 COP9 signalosome complex, subunit 9, fungi
InterPro IPR033205 COP9 signalosome, subunit CSN8
InterPro IPR033859 COP9 signalosome subunit 6
InterPro IPR041481 COP9 signalosome complex subunit 7, helix I
UniProtKB-KW KW-0736 Signalosome

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008180 based on ALL annotations
The top 100 of 1,049 co-occurring terms
Co-occurring Term PR S% #Together #Compared
COP9 signalosome
5,240.43 100.00 37,199 37,199
protein deneddylation
3,082.30 16.72 7,044 11,976
COP9 signalosome assembly
5,148.31 13.04 4,862 4,949
protein-containing complex
88.26 1.32 2,148 127,538
ubiquitin-dependent protein catabolic process
64.20 1.12 4,202 342,991
synaptic vesicle
84.32 1.04 1,058 65,757
deNEDDylase activity
217.33 0.61 266 6,414
intracellular membrane-bounded organelle
33.41 0.61 5,185 813,169
metallopeptidase activity
29.64 0.55 7,517 1,329,122
neurotrophin TRKA receptor binding
2,035.12 0.53 200 515
Totals 106540 13442199
No co-occurrence statistics for GO:0008180 based on MANUAL annotations
The top 100 of 698 co-occurring terms
Co-occurring Term PR S% #Together #Compared
COP9 signalosome
1,359.79 100.00 950 950
protein deneddylation
857.61 23.82 263 417
deNEDDylase activity
557.46 9.69 107 261
metallopeptidase activity
204.93 6.89 107 710
epidermal growth factor receptor binding
230.47 4.18 50 295
phosphotyrosine residue binding
216.53 4.12 50 314
regulation of MAPK cascade
108.53 3.32 51 639
regulation of protein neddylation
345.71 1.51 15 59
ubiquitin-dependent protein catabolic process
13.38 0.91 101 10,261
positive regulation of protein localization to cell cortex
214.70 0.90 9 57
Totals 2352 62673

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2020-11-03 Added RELATION is a GO:0140513 (nuclear protein-containing complex)
2020-11-03 Deleted RELATION is a GO:0032991 (protein-containing complex)
2020-11-03 Deleted RELATION part of GO:0005634 (nucleus)
2019-09-12 Added RELATION part of GO:0005634 (nucleus)
2019-09-12 Deleted RELATION is a GO:0044428 (obsolete nuclear part)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2016-08-31 Added RELATION capable of GO:0000338 (protein deneddylation)
2013-07-22 Added SYNONYM signalosome
Timestamp Action Category Detail
2013-07-22 Updated TERM COP9 signalosome
2007-06-14 Updated TERM signalosome
2002-05-24 Updated TERM signalosome complex
2002-02-06 Updated TERM signalosome
2001-04-03 Updated TERM signalosome
2001-03-30 Added TERM signalosome
Timestamp Action Category Detail
2013-07-22 Added SYNONYM signalosome
2013-07-22 Added SYNONYM COP9 complex
2013-07-22 Deleted SYNONYM COP9 complex
2008-05-13 Added DEFINITION A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2008-05-12 Deleted DEFINITION A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2007-08-09 Deleted SYNONYM CSN
2007-08-09 Deleted SYNONYM COP9 complex
2007-08-09 Added SYNONYM CSN
2007-08-09 Added SYNONYM COP9 complex
2007-06-27 Updated DEFINITION A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2005-08-04 Added SYNONYM CSN
2005-08-03 Updated DEFINITION A complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2005-08-02 Updated DEFINITION A complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
2004-04-19 Added SYNONYM COP9 complex
2004-04-16 Deleted SYNONYM COP9 complex
2002-11-27 Updated DEFINITION A complex involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome; a distinguishing feature is its activity in deneddylation.
2001-08-06 Added DEFINITION A complex involved in regulation of development in many species; also regulates photomorphogenesis in plants; its subuits are related to those of the proteasome
2001-03-30 Added SYNONYM COP9 complex
Timestamp Action Category Detail
2020-11-03 Added RELATION is a GO:0140513 (nuclear protein-containing complex)
2020-11-03 Deleted RELATION is a GO:0032991 (protein-containing complex)
2020-11-03 Deleted RELATION part of GO:0005634 (nucleus)
2019-09-12 Added RELATION part of GO:0005634 (nucleus)
2019-09-12 Deleted RELATION is a GO:0044428 (obsolete nuclear part)
2018-02-18 Added RELATION is a GO:0032991 (protein-containing complex)
2018-02-18 Deleted RELATION is a GO:0043234 (protein complex)
2016-08-31 Added RELATION capable of GO:0000338 (protein deneddylation)
2008-04-01 Updated RELATION is a GO:0044428 (obsolete nuclear part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
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