GO:0008180
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COP9 signalosome
Cellular Component
Definition (GO:0008180 GONUTS page)
A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. PMID:11019806 PMID:12186635 PMID:14570571
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
COP9 complex | exact |
CSN | exact |
signalosome | broad |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0008180 | COP9 signalosome | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A096MJ18 | 10116 | A0A096MJ18_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A096MK97 | 10116 | A0A096MK97_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2JW23 | 10116 | A0A0G2JW23_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K8T1 | 10116 | A0A0G2K8T1_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A1B0GR71 | 10090 | A0A1B0GR71_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1B0GRK6 | 10090 | A0A1B0GRK6_MOUSE | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16904636 | |
NOT-qualified manual | protein | A0A1D8PHF8 | 237561 | A0A1D8PHF8_CANAL | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:8760936 | |
NOT-qualified manual | protein | A0A1W2Q633 | 10116 | A0A1W2Q633_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y8H4 | 10116 | A0A8I5Y8H4_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A0E5 | 10116 | A0A8I6A0E5_RAT | GO:0005634 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR016806 | COP9 signalosome complex, subunit 9, fungi |
InterPro | IPR033205 | COP9 signalosome, subunit CSN8 |
InterPro | IPR033859 | COP9 signalosome subunit 6 |
InterPro | IPR041481 | COP9 signalosome complex subunit 7, helix I |
UniProtKB-KW | KW-0736 | Signalosome |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008180 based on ALL annotations
The top 100 of 1,049 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
COP9 signalosome
|
5,240.43 | 100.00 | 37,199 | 37,199 |
protein deneddylation
|
3,082.30 | 16.72 | 7,044 | 11,976 |
COP9 signalosome assembly
|
5,148.31 | 13.04 | 4,862 | 4,949 |
protein-containing complex
|
88.26 | 1.32 | 2,148 | 127,538 |
ubiquitin-dependent protein catabolic process
|
64.20 | 1.12 | 4,202 | 342,991 |
synaptic vesicle
|
84.32 | 1.04 | 1,058 | 65,757 |
deNEDDylase activity
|
217.33 | 0.61 | 266 | 6,414 |
intracellular membrane-bounded organelle
|
33.41 | 0.61 | 5,185 | 813,169 |
metallopeptidase activity
|
29.64 | 0.55 | 7,517 | 1,329,122 |
neurotrophin TRKA receptor binding
|
2,035.12 | 0.53 | 200 | 515 |
Totals | 106540 | 13442199 |
No co-occurrence statistics for GO:0008180 based on MANUAL annotations
The top 100 of 698 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
COP9 signalosome
|
1,359.79 | 100.00 | 950 | 950 |
protein deneddylation
|
857.61 | 23.82 | 263 | 417 |
deNEDDylase activity
|
557.46 | 9.69 | 107 | 261 |
metallopeptidase activity
|
204.93 | 6.89 | 107 | 710 |
epidermal growth factor receptor binding
|
230.47 | 4.18 | 50 | 295 |
phosphotyrosine residue binding
|
216.53 | 4.12 | 50 | 314 |
regulation of MAPK cascade
|
108.53 | 3.32 | 51 | 639 |
regulation of protein neddylation
|
345.71 | 1.51 | 15 | 59 |
ubiquitin-dependent protein catabolic process
|
13.38 | 0.91 | 101 | 10,261 |
positive regulation of protein localization to cell cortex
|
214.70 | 0.90 | 9 | 57 |
Totals | 2352 | 62673 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2020-11-03 | Added | RELATION | is a GO:0140513 (nuclear protein-containing complex) |
2020-11-03 | Deleted | RELATION | is a GO:0032991 (protein-containing complex) |
2020-11-03 | Deleted | RELATION | part of GO:0005634 (nucleus) |
2019-09-12 | Added | RELATION | part of GO:0005634 (nucleus) |
2019-09-12 | Deleted | RELATION | is a GO:0044428 (obsolete nuclear part) |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2016-08-31 | Added | RELATION | capable of GO:0000338 (protein deneddylation) |
2013-07-22 | Added | SYNONYM | signalosome |
Timestamp | Action | Category | Detail |
---|---|---|---|
2013-07-22 | Updated | TERM | COP9 signalosome |
2007-06-14 | Updated | TERM | signalosome |
2002-05-24 | Updated | TERM | signalosome complex |
2002-02-06 | Updated | TERM | signalosome |
2001-04-03 | Updated | TERM | signalosome |
2001-03-30 | Added | TERM | signalosome |
Timestamp | Action | Category | Detail |
---|---|---|---|
2013-07-22 | Added | SYNONYM | signalosome |
2013-07-22 | Added | SYNONYM | COP9 complex |
2013-07-22 | Deleted | SYNONYM | COP9 complex |
2008-05-13 | Added | DEFINITION | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
2008-05-12 | Deleted | DEFINITION | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
2007-08-09 | Deleted | SYNONYM | CSN |
2007-08-09 | Deleted | SYNONYM | COP9 complex |
2007-08-09 | Added | SYNONYM | CSN |
2007-08-09 | Added | SYNONYM | COP9 complex |
2007-06-27 | Updated | DEFINITION | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
2005-08-04 | Added | SYNONYM | CSN |
2005-08-03 | Updated | DEFINITION | A complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
2005-08-02 | Updated | DEFINITION | A complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. |
2004-04-19 | Added | SYNONYM | COP9 complex |
2004-04-16 | Deleted | SYNONYM | COP9 complex |
2002-11-27 | Updated | DEFINITION | A complex involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome; a distinguishing feature is its activity in deneddylation. |
2001-08-06 | Added | DEFINITION | A complex involved in regulation of development in many species; also regulates photomorphogenesis in plants; its subuits are related to those of the proteasome |
2001-03-30 | Added | SYNONYM | COP9 complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-03 | Added | RELATION | is a GO:0140513 (nuclear protein-containing complex) |
2020-11-03 | Deleted | RELATION | is a GO:0032991 (protein-containing complex) |
2020-11-03 | Deleted | RELATION | part of GO:0005634 (nucleus) |
2019-09-12 | Added | RELATION | part of GO:0005634 (nucleus) |
2019-09-12 | Deleted | RELATION | is a GO:0044428 (obsolete nuclear part) |
2018-02-18 | Added | RELATION | is a GO:0032991 (protein-containing complex) |
2018-02-18 | Deleted | RELATION | is a GO:0043234 (protein complex) |
2016-08-31 | Added | RELATION | capable of GO:0000338 (protein deneddylation) |
2008-04-01 | Updated | RELATION | is a GO:0044428 (obsolete nuclear part) |
2008-04-01 | Updated | RELATION | is a GO:0043234 (protein complex) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
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