GO:0008191
JSON
metalloendopeptidase inhibitor activity
Molecular Function
Definition (GO:0008191 GONUTS page)
Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
metalloproteinase inhibitor | narrow |
metalloprotease inhibitor | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A1Z6V5 | 7227 | A1Z6V5_DROME | GO:0030414 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829 | |
NOT-qualified manual | protein | C0PVD9 | 7227 | C0PVD9_DROME | GO:0030414 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829 | |
NOT-qualified manual | protein | M9NEE3 | 7227 | M9NEE3_DROME | GO:0030414 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829 | |
NOT-qualified manual | protein | P01012 | 9031 | OVAL_CHICK | GO:0030414 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9126838 | |
NOT-qualified manual | protein | P84995 | 5315 | GANOD_GANLU | GO:0030414 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16039755 | |
NOT-qualified manual | protein | Q3HKQ3 | 7227 | Q3HKQ3_DROME | GO:0030414 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829 | |
NOT-qualified manual | protein | Q4V3G2 | 7227 | Q4V3G2_DROME | GO:0030414 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829 | |
NOT-qualified manual | protein | Q4V3R8 | 7227 | Q4V3R8_DROME | GO:0030414 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829 | |
NOT-qualified manual | protein | Q7K1P6 | 7227 | Q7K1P6_DROME | GO:0030414 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829 | |
NOT-qualified manual | protein | Q7K508 | 7227 | Q7K508_DROME | GO:0030414 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR001820 | Protease inhibitor I35 (TIMP) |
InterPro | IPR019509 | Carboxypeptidase inhibitor I68 |
InterPro | IPR022815 | Protease inhibitor |
InterPro | IPR032767 | Ascaris metallocarboxypeptidase inhibitor |
InterPro | IPR039016 | Reversion-inducing cysteine-rich protein with Kazal motifs |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008191 based on ALL annotations
The top 100 of 359 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
metalloendopeptidase inhibitor activity
|
19,503.63 | 100.00 | 9,995 | 9,995 |
negative regulation of membrane protein ectodomain proteolysis
|
18,213.31 | 42.73 | 4,404 | 4,716 |
response to cytokine
|
6,399.36 | 18.41 | 2,953 | 9,000 |
peptidase inhibitor activity
|
3,013.52 | 13.77 | 5,578 | 36,101 |
protease binding
|
3,069.37 | 13.02 | 4,299 | 27,317 |
blood vessel maturation
|
13,315.69 | 11.92 | 1,261 | 1,847 |
response to hormone
|
2,134.60 | 8.68 | 2,951 | 26,963 |
sprouting angiogenesis
|
1,467.61 | 4.94 | 1,258 | 16,718 |
binding of sperm to zona pellucida
|
826.19 | 2.64 | 656 | 15,486 |
endopeptidase inhibitor activity
|
547.64 | 2.48 | 1,738 | 61,897 |
Totals | 60620 | 9271706 |
No co-occurrence statistics for GO:0008191 based on MANUAL annotations
The top 100 of 214 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
metalloendopeptidase inhibitor activity
|
5,272.65 | 100.00 | 245 | 245 |
negative regulation of membrane protein ectodomain proteolysis
|
3,907.07 | 36.65 | 103 | 139 |
response to cytokine
|
762.18 | 10.78 | 73 | 505 |
negative regulation of endopeptidase activity
|
2,216.04 | 10.18 | 29 | 69 |
response to hormone
|
651.27 | 9.57 | 73 | 591 |
negative regulation of cell-substrate adhesion
|
946.37 | 4.53 | 14 | 78 |
regulation of integrin-mediated signaling pathway
|
1,757.55 | 4.46 | 12 | 36 |
node of Ranvier
|
777.02 | 4.29 | 14 | 95 |
negative regulation of catalytic activity
|
1,291.26 | 4.26 | 12 | 49 |
cellular response to UV-A
|
855.02 | 3.91 | 12 | 74 |
Totals | 1306 | 69807 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-17 | Added | DEFINITION | Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
2021-02-17 | Deleted | DEFINITION | Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
2016-04-14 | Deleted | RELATION | is a GO:0048551 (metalloenzyme inhibitor activity) |
2016-02-14 | Added | SYNONYM | metalloprotease inhibitor |
2016-02-14 | Added | SYNONYM | metalloproteinase inhibitor |
2016-02-14 | Deleted | SYNONYM | metalloprotease inhibitor |
2016-02-14 | Deleted | SYNONYM | metalloproteinase inhibitor |
2010-06-15 | Added | RELATION | negatively regulates GO:0004222 (metalloendopeptidase activity) |
2010-06-14 | Deleted | RELATION | negatively regulates GO:0004222 (metalloendopeptidase activity) |
2010-06-08 | Added | RELATION | negatively regulates GO:0004222 (metalloendopeptidase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | metalloendopeptidase inhibitor activity |
2002-07-09 | Updated | TERM | metalloendopeptidase inhibitor |
2002-02-06 | Updated | TERM | metalloprotease inhibitor |
2001-04-03 | Updated | TERM | metalloprotease inhibitor |
2001-03-30 | Added | TERM | metalloprotease inhibitor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-17 | Added | DEFINITION | Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
2021-02-17 | Deleted | DEFINITION | Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
2016-02-14 | Added | SYNONYM | metalloprotease inhibitor |
2016-02-14 | Added | SYNONYM | metalloproteinase inhibitor |
2016-02-14 | Deleted | SYNONYM | metalloprotease inhibitor |
2016-02-14 | Deleted | SYNONYM | metalloproteinase inhibitor |
2008-08-18 | Deleted | DEFINITION | Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
2008-08-18 | Added | DEFINITION | Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
2008-05-13 | Added | DEFINITION | Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
2008-05-12 | Deleted | DEFINITION | Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
2007-08-09 | Deleted | SYNONYM | metalloprotease inhibitor |
2007-08-09 | Added | SYNONYM | metalloprotease inhibitor |
2007-08-09 | Added | SYNONYM | metalloproteinase inhibitor |
2007-08-09 | Deleted | SYNONYM | metalloproteinase inhibitor |
2004-04-19 | Added | SYNONYM | metalloproteinase inhibitor |
2004-04-19 | Added | SYNONYM | metalloprotease inhibitor |
2004-04-16 | Deleted | SYNONYM | metalloproteinase inhibitor |
2004-04-16 | Deleted | SYNONYM | metalloprotease inhibitor |
2004-01-08 | Added | DEFINITION | Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity. |
2003-03-19 | Deleted | SYNONYM | metalloendopeptidase inhibitor |
2002-07-09 | Added | SYNONYM | metalloprotease inhibitor |
2002-07-09 | Added | SYNONYM | metalloproteinase inhibitor |
2001-08-22 | Added | SYNONYM | metalloendopeptidase inhibitor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-04-14 | Deleted | RELATION | is a GO:0048551 (metalloenzyme inhibitor activity) |
2010-06-15 | Added | RELATION | negatively regulates GO:0004222 (metalloendopeptidase activity) |
2010-06-14 | Deleted | RELATION | negatively regulates GO:0004222 (metalloendopeptidase activity) |
2010-06-08 | Added | RELATION | negatively regulates GO:0004222 (metalloendopeptidase activity) |
2009-03-16 | Added | RELATION | is a GO:0048551 (metalloenzyme inhibitor activity) |
2009-02-25 | Deleted | RELATION | negatively regulates GO:0004222 (metalloendopeptidase activity) |
2009-02-22 | Added | RELATION | negatively regulates GO:0004222 (metalloendopeptidase activity) |
2008-04-01 | Updated | RELATION | is a GO:0004866 (endopeptidase inhibitor activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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