This term is obsolete.

GO:0008191 JSON

metalloendopeptidase inhibitor activity

Molecular Function

Definition (GO:0008191 GONUTS page)

Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.

10,186 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
metalloproteinase inhibitor narrow
metalloprotease inhibitor narrow

Ancestor Chart

Ancestor chart for GO:0008191
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A1Z6V5 7227 A1Z6V5_DROME GO:0030414 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829
NOT-qualified manual protein C0PVD9 7227 C0PVD9_DROME GO:0030414 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829
NOT-qualified manual protein M9NEE3 7227 M9NEE3_DROME GO:0030414 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829
NOT-qualified manual protein P01012 9031 OVAL_CHICK GO:0030414 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9126838
NOT-qualified manual protein P84995 5315 GANOD_GANLU GO:0030414 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16039755
NOT-qualified manual protein Q3HKQ3 7227 Q3HKQ3_DROME GO:0030414 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829
NOT-qualified manual protein Q4V3G2 7227 Q4V3G2_DROME GO:0030414 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829
NOT-qualified manual protein Q4V3R8 7227 Q4V3R8_DROME GO:0030414 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829
NOT-qualified manual protein Q7K1P6 7227 Q7K1P6_DROME GO:0030414 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829
NOT-qualified manual protein Q7K508 7227 Q7K508_DROME GO:0030414 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829

Cross-references

Database ID Description
InterPro IPR001820 Protease inhibitor I35 (TIMP)
InterPro IPR019509 Carboxypeptidase inhibitor I68
InterPro IPR022815 Protease inhibitor
InterPro IPR032767 Ascaris metallocarboxypeptidase inhibitor
InterPro IPR039016 Reversion-inducing cysteine-rich protein with Kazal motifs

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008191 based on ALL annotations
The top 100 of 359 co-occurring terms
Co-occurring Term PR S% #Together #Compared
metalloendopeptidase inhibitor activity
19,503.63 100.00 9,995 9,995
negative regulation of membrane protein ectodomain proteolysis
18,213.31 42.73 4,404 4,716
response to cytokine
6,399.36 18.41 2,953 9,000
peptidase inhibitor activity
3,013.52 13.77 5,578 36,101
protease binding
3,069.37 13.02 4,299 27,317
blood vessel maturation
13,315.69 11.92 1,261 1,847
response to hormone
2,134.60 8.68 2,951 26,963
sprouting angiogenesis
1,467.61 4.94 1,258 16,718
binding of sperm to zona pellucida
826.19 2.64 656 15,486
endopeptidase inhibitor activity
547.64 2.48 1,738 61,897
Totals 60620 9271706
No co-occurrence statistics for GO:0008191 based on MANUAL annotations
The top 100 of 214 co-occurring terms
Co-occurring Term PR S% #Together #Compared
metalloendopeptidase inhibitor activity
5,272.65 100.00 245 245
negative regulation of membrane protein ectodomain proteolysis
3,907.07 36.65 103 139
response to cytokine
762.18 10.78 73 505
negative regulation of endopeptidase activity
2,216.04 10.18 29 69
response to hormone
651.27 9.57 73 591
negative regulation of cell-substrate adhesion
946.37 4.53 14 78
regulation of integrin-mediated signaling pathway
1,757.55 4.46 12 36
node of Ranvier
777.02 4.29 14 95
negative regulation of catalytic activity
1,291.26 4.26 12 49
cellular response to UV-A
855.02 3.91 12 74
Totals 1306 69807

Change Log

Timestamp Action Category Detail
2021-02-17 Added DEFINITION Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2021-02-17 Deleted DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2016-04-14 Deleted RELATION is a GO:0048551 (metalloenzyme inhibitor activity)
2016-02-14 Added SYNONYM metalloprotease inhibitor
2016-02-14 Added SYNONYM metalloproteinase inhibitor
2016-02-14 Deleted SYNONYM metalloprotease inhibitor
2016-02-14 Deleted SYNONYM metalloproteinase inhibitor
2010-06-15 Added RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2010-06-08 Added RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
Timestamp Action Category Detail
2003-03-19 Updated TERM metalloendopeptidase inhibitor activity
2002-07-09 Updated TERM metalloendopeptidase inhibitor
2002-02-06 Updated TERM metalloprotease inhibitor
2001-04-03 Updated TERM metalloprotease inhibitor
2001-03-30 Added TERM metalloprotease inhibitor
Timestamp Action Category Detail
2021-02-17 Added DEFINITION Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2021-02-17 Deleted DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2016-02-14 Added SYNONYM metalloprotease inhibitor
2016-02-14 Added SYNONYM metalloproteinase inhibitor
2016-02-14 Deleted SYNONYM metalloprotease inhibitor
2016-02-14 Deleted SYNONYM metalloproteinase inhibitor
2008-08-18 Deleted DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-08-18 Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2007-08-09 Deleted SYNONYM metalloprotease inhibitor
2007-08-09 Added SYNONYM metalloprotease inhibitor
2007-08-09 Added SYNONYM metalloproteinase inhibitor
2007-08-09 Deleted SYNONYM metalloproteinase inhibitor
2004-04-19 Added SYNONYM metalloproteinase inhibitor
2004-04-19 Added SYNONYM metalloprotease inhibitor
2004-04-16 Deleted SYNONYM metalloproteinase inhibitor
2004-04-16 Deleted SYNONYM metalloprotease inhibitor
2004-01-08 Added DEFINITION Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
2003-03-19 Deleted SYNONYM metalloendopeptidase inhibitor
2002-07-09 Added SYNONYM metalloprotease inhibitor
2002-07-09 Added SYNONYM metalloproteinase inhibitor
2001-08-22 Added SYNONYM metalloendopeptidase inhibitor
Timestamp Action Category Detail
2016-04-14 Deleted RELATION is a GO:0048551 (metalloenzyme inhibitor activity)
2010-06-15 Added RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2010-06-08 Added RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2009-03-16 Added RELATION is a GO:0048551 (metalloenzyme inhibitor activity)
2009-02-25 Deleted RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2009-02-22 Added RELATION negatively regulates GO:0004222 (metalloendopeptidase activity)
2008-04-01 Updated RELATION is a GO:0004866 (endopeptidase inhibitor activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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