GO:0008238
JSON
exopeptidase activity
Molecular Function
Definition (GO:0008238 GONUTS page)
Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
exoprotease activity | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0008238
Child Term | Relationship to GO:0008238 |
---|---|
dipeptidyl-peptidase activity
|
is_a |
tripeptidase activity
|
is_a |
aminopeptidase activity
|
is_a |
cysteine-type exopeptidase activity
|
is_a |
dipeptidase activity
|
is_a |
serine-type exopeptidase activity
|
is_a |
carboxypeptidase activity
|
is_a |
metalloexopeptidase activity
|
is_a |
eoxin E4 synthase activity
|
is_a |
peptidyl-dipeptidase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4JCV5 | 7227 | A0A0B4JCV5_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4JD89 | 7227 | A0A0B4JD89_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4K6V8 | 7227 | A0A0B4K6V8_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4K7A7 | 7227 | A0A0B4K7A7_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4K7P3 | 7227 | A0A0B4K7P3_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4KFB1 | 7227 | A0A0B4KFB1_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4KFH4 | 7227 | A0A0B4KFH4_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4KGE6 | 7227 | A0A0B4KGE6_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 | |
NOT-qualified manual | protein | A0A0B4LEH6 | 7227 | A0A0B4LEH6_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10913309 | |
NOT-qualified manual | protein | A0A0B4LG43 | 7227 | A0A0B4LG43_DROME | GO:0008233 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008238 based on ALL annotations
The top 100 of 160 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
exopeptidase activity
|
564,543.75 | 100.00 | 351 | 351 |
substance P catabolic process
|
355,378.28 | 38.55 | 175 | 278 |
neuropeptide processing
|
474,933.66 | 28.57 | 106 | 126 |
bradykinin catabolic process
|
173,935.14 | 23.52 | 175 | 568 |
creatinine metabolic process
|
270,776.66 | 22.75 | 106 | 221 |
leukotriene D4 catabolic process
|
227,688.92 | 15.90 | 73 | 181 |
bradykinin receptor binding
|
244,990.69 | 15.65 | 69 | 159 |
cell proliferation in bone marrow
|
252,559.05 | 15.63 | 68 | 152 |
negative regulation of gap junction assembly
|
250,908.33 | 15.60 | 68 | 153 |
regulation of angiotensin metabolic process
|
241,947.33 | 15.58 | 69 | 161 |
Totals | 7316 | 3461453 |
No co-occurrence statistics for GO:0008238 based on MANUAL annotations
The top 100 of 148 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
exopeptidase activity
|
128,321.19 | 100.00 | 11 | 11 |
substance P catabolic process
|
30,193.22 | 16.67 | 4 | 17 |
bradykinin receptor binding
|
64,160.59 | 15.38 | 2 | 4 |
negative regulation of gap junction assembly
|
51,328.47 | 14.29 | 2 | 5 |
neuropeptide processing
|
42,773.73 | 13.33 | 2 | 6 |
cell proliferation in bone marrow
|
32,080.30 | 11.76 | 2 | 8 |
leukotriene D4 catabolic process
|
25,664.24 | 10.53 | 2 | 10 |
regulation of angiotensin metabolic process
|
25,664.24 | 10.53 | 2 | 10 |
bradykinin catabolic process
|
12,832.12 | 8.51 | 4 | 40 |
hormone catabolic process
|
12,221.07 | 8.16 | 4 | 42 |
Totals | 182 | 21623 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-07-19 | Deleted | RELATION | is a GO:0070011 (peptidase activity, acting on L-amino acid peptides) |
2020-07-19 | Added | RELATION | is a GO:0008233 (peptidase activity) |
2016-02-14 | Added | SYNONYM | exoprotease activity |
2016-02-14 | Deleted | SYNONYM | exoprotease activity |
2008-08-18 | Added | RELATION | is a GO:0070011 (peptidase activity, acting on L-amino acid peptides) |
2008-08-18 | Deleted | DEFINITION | Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases. |
2008-08-18 | Deleted | RELATION | is a GO:0008233 (peptidase activity) |
2008-08-18 | Added | DEFINITION | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. |
2008-05-13 | Added | DEFINITION | Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | exopeptidase activity |
2002-02-06 | Updated | TERM | exopeptidase |
2001-04-03 | Updated | TERM | exopeptidase |
2001-03-30 | Added | TERM | exopeptidase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-02-14 | Added | SYNONYM | exoprotease activity |
2016-02-14 | Deleted | SYNONYM | exoprotease activity |
2008-08-18 | Deleted | DEFINITION | Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases. |
2008-08-18 | Added | DEFINITION | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. |
2008-05-13 | Added | DEFINITION | Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases. |
2007-11-08 | Added | SYNONYM | exoprotease activity |
2007-11-08 | Deleted | SYNONYM | exoprotease |
2007-08-09 | Deleted | SYNONYM | exoprotease |
2007-08-09 | Added | SYNONYM | exoprotease |
2004-04-19 | Added | SYNONYM | exoprotease |
2004-04-16 | Deleted | SYNONYM | exoprotease |
2003-07-30 | Added | DEFINITION | Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases. |
2001-03-30 | Added | SYNONYM | exoprotease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-07-19 | Deleted | RELATION | is a GO:0070011 (peptidase activity, acting on L-amino acid peptides) |
2020-07-19 | Added | RELATION | is a GO:0008233 (peptidase activity) |
2008-08-18 | Added | RELATION | is a GO:0070011 (peptidase activity, acting on L-amino acid peptides) |
2008-08-18 | Deleted | RELATION | is a GO:0008233 (peptidase activity) |
2008-04-01 | Updated | RELATION | is a GO:0008233 (peptidase activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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