This term is obsolete.

GO:0008238 JSON

exopeptidase activity

Molecular Function

Definition (GO:0008238 GONUTS page)

Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.

2,555,836 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
exoprotease activity narrow

Ancestor Chart

Ancestor chart for GO:0008238
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008238

Child Term Relationship to
GO:0008238
dipeptidyl-peptidase activity
is_a
tripeptidase activity
is_a
aminopeptidase activity
is_a
cysteine-type exopeptidase activity
is_a
dipeptidase activity
is_a
serine-type exopeptidase activity
is_a
carboxypeptidase activity
is_a
metalloexopeptidase activity
is_a
eoxin E4 synthase activity
is_a
peptidyl-dipeptidase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4JCV5 7227 A0A0B4JCV5_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4JD89 7227 A0A0B4JD89_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4K6V8 7227 A0A0B4K6V8_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4K7A7 7227 A0A0B4K7A7_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4K7P3 7227 A0A0B4K7P3_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4KFB1 7227 A0A0B4KFB1_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4KFH4 7227 A0A0B4KFH4_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4KGE6 7227 A0A0B4KGE6_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047
NOT-qualified manual protein A0A0B4LEH6 7227 A0A0B4LEH6_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10913309
NOT-qualified manual protein A0A0B4LG43 7227 A0A0B4LG43_DROME GO:0008233 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: GO_REF:0000047

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008238 based on ALL annotations
The top 100 of 160 co-occurring terms
Co-occurring Term PR S% #Together #Compared
exopeptidase activity
564,543.75 100.00 351 351
substance P catabolic process
355,378.28 38.55 175 278
neuropeptide processing
474,933.66 28.57 106 126
bradykinin catabolic process
173,935.14 23.52 175 568
creatinine metabolic process
270,776.66 22.75 106 221
leukotriene D4 catabolic process
227,688.92 15.90 73 181
bradykinin receptor binding
244,990.69 15.65 69 159
cell proliferation in bone marrow
252,559.05 15.63 68 152
negative regulation of gap junction assembly
250,908.33 15.60 68 153
regulation of angiotensin metabolic process
241,947.33 15.58 69 161
Totals 7316 3461453
No co-occurrence statistics for GO:0008238 based on MANUAL annotations
The top 100 of 148 co-occurring terms
Co-occurring Term PR S% #Together #Compared
exopeptidase activity
128,321.19 100.00 11 11
substance P catabolic process
30,193.22 16.67 4 17
bradykinin receptor binding
64,160.59 15.38 2 4
negative regulation of gap junction assembly
51,328.47 14.29 2 5
neuropeptide processing
42,773.73 13.33 2 6
cell proliferation in bone marrow
32,080.30 11.76 2 8
leukotriene D4 catabolic process
25,664.24 10.53 2 10
regulation of angiotensin metabolic process
25,664.24 10.53 2 10
bradykinin catabolic process
12,832.12 8.51 4 40
hormone catabolic process
12,221.07 8.16 4 42
Totals 182 21623

Change Log

Timestamp Action Category Detail
2020-07-19 Deleted RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2020-07-19 Added RELATION is a GO:0008233 (peptidase activity)
2016-02-14 Added SYNONYM exoprotease activity
2016-02-14 Deleted SYNONYM exoprotease activity
2008-08-18 Added RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2008-08-18 Deleted DEFINITION Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases.
2008-08-18 Deleted RELATION is a GO:0008233 (peptidase activity)
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.
2008-05-13 Added DEFINITION Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases.
2008-05-12 Deleted DEFINITION Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases.
Timestamp Action Category Detail
2003-03-19 Updated TERM exopeptidase activity
2002-02-06 Updated TERM exopeptidase
2001-04-03 Updated TERM exopeptidase
2001-03-30 Added TERM exopeptidase
Timestamp Action Category Detail
2016-02-14 Added SYNONYM exoprotease activity
2016-02-14 Deleted SYNONYM exoprotease activity
2008-08-18 Deleted DEFINITION Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases.
2008-08-18 Added DEFINITION Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.
2008-05-13 Added DEFINITION Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases.
2008-05-12 Deleted DEFINITION Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases.
2007-11-08 Added SYNONYM exoprotease activity
2007-11-08 Deleted SYNONYM exoprotease
2007-08-09 Deleted SYNONYM exoprotease
2007-08-09 Added SYNONYM exoprotease
2004-04-19 Added SYNONYM exoprotease
2004-04-16 Deleted SYNONYM exoprotease
2003-07-30 Added DEFINITION Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases.
2001-03-30 Added SYNONYM exoprotease
Timestamp Action Category Detail
2020-07-19 Deleted RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2020-07-19 Added RELATION is a GO:0008233 (peptidase activity)
2008-08-18 Added RELATION is a GO:0070011 (peptidase activity, acting on L-amino acid peptides)
2008-08-18 Deleted RELATION is a GO:0008233 (peptidase activity)
2008-04-01 Updated RELATION is a GO:0008233 (peptidase activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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