GO:0008379
JSON
thioredoxin peroxidase activity
Molecular Function
Definition (GO:0008379 GONUTS page)
Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O.
Secondary IDs
GO:0009031
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
TPx activity | exact |
TrxPx activity | exact |
thiol peroxidase activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0008379
Child Term | Relationship to GO:0008379 |
---|---|
regulation of thioredoxin peroxidase activity
|
regulates |
negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
|
negatively_regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I5Y865 | 10116 | A0A8I5Y865_RAT | GO:0098869 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8J8YB21 | 10116 | A0A8J8YB21_RAT | GO:0098869 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR002065 | Thiol peroxidase Tpx |
InterPro | IPR037944 | Peroxiredoxin-5-like |
MetaCyc | RXN0-267 | |
RHEA | 63528 | |
Reactome | R-HSA-2161612 | |
Reactome | R-HSA-3322995 | |
Reactome | R-HSA-3341343 | |
Reactome | R-HSA-3697882 | |
Reactome | R-HSA-3697894 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:50058 | L-cystine residue |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:29950 | L-cysteine residue |
has_participant | CHEBI | CHEBI:16240 | hydrogen peroxide |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008379 based on ALL annotations
The top 100 of 538 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
thioredoxin peroxidase activity
|
1,421.48 | 100.00 | 137,138 | 137,138 |
cell redox homeostasis
|
507.29 | 34.18 | 122,040 | 341,966 |
cellular response to stress
|
824.21 | 27.37 | 46,820 | 80,748 |
peroxidase activity
|
368.64 | 25.69 | 132,241 | 509,922 |
hydrogen peroxide catabolic process
|
483.67 | 24.93 | 66,161 | 194,445 |
cellular response to oxidative stress
|
441.05 | 24.75 | 75,456 | 243,191 |
antioxidant activity
|
463.90 | 23.77 | 63,991 | 196,082 |
cellular oxidant detoxification
|
229.44 | 16.09 | 134,399 | 832,643 |
thioredoxin-dependent peroxiredoxin activity
|
1,268.28 | 15.24 | 21,293 | 23,865 |
peroxiredoxin activity
|
319.34 | 14.09 | 37,603 | 167,380 |
Totals | 1133631 | 71811421 |
No co-occurrence statistics for GO:0008379 based on MANUAL annotations
The top 100 of 195 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
thioredoxin peroxidase activity
|
1,701.97 | 100.00 | 759 | 759 |
cell redox homeostasis
|
539.14 | 31.50 | 746 | 2,355 |
hydrogen peroxide catabolic process
|
601.23 | 30.55 | 526 | 1,489 |
cellular response to oxidative stress
|
306.20 | 16.21 | 471 | 2,618 |
response to oxidative stress
|
270.90 | 12.66 | 290 | 1,822 |
leukocyte activation
|
1,543.65 | 5.11 | 39 | 43 |
removal of superoxide radicals
|
132.26 | 3.82 | 53 | 682 |
peroxiredoxin activity
|
823.54 | 1.94 | 15 | 31 |
chloroplast thylakoid membrane
|
31.24 | 1.44 | 48 | 2,615 |
peroxisome
|
23.30 | 1.17 | 58 | 4,236 |
Totals | 4072 | 378651 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-05 | Added | XREF | Reactome:R-HSA-2161612 |
2024-11-03 | Deleted | XREF | Reactome:R-HSA-2161612 |
2024-11-02 | Added | XREF | Reactome:R-HSA-2161612 |
2024-11-01 | Deleted | XREF | Reactome:R-HSA-2161612 |
2024-10-26 | Added | XREF | Reactome:R-HSA-2161612 |
2024-10-09 | Deleted | XREF | Reactome:R-HSA-2161612 |
2022-06-26 | Deleted | DEFINITION | Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O. |
2022-06-26 | Added | DEFINITION | Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O. |
2022-06-26 | Deleted | RELATION | is a GO:0004601 (peroxidase activity) |
2022-06-26 | Added | RELATION | is a GO:0140824 (thioredoxin-dependent peroxiredoxin activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | thioredoxin peroxidase activity |
2002-02-06 | Updated | TERM | thioredoxin peroxidase |
2001-04-03 | Updated | TERM | thioredoxin peroxidase |
2001-03-30 | Added | TERM | thioredoxin peroxidase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-06-26 | Deleted | DEFINITION | Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O. |
2022-06-26 | Added | DEFINITION | Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O. |
2010-09-03 | Deleted | DEFINITION | Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O. |
2010-09-03 | Added | DEFINITION | Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O. |
2007-08-09 | Deleted | SYNONYM | TPx activity |
2007-08-09 | Added | SYNONYM | TPx activity |
2007-08-09 | Added | SYNONYM | TrxPx activity |
2007-08-09 | Added | SYNONYM | thiol peroxidase activity |
2007-08-09 | Deleted | SYNONYM | TrxPx activity |
2007-08-09 | Deleted | SYNONYM | thiol peroxidase activity |
2007-05-12 | Added | SYNONYM | TPx activity |
2007-05-12 | Added | SYNONYM | TrxPx activity |
2006-03-11 | Deleted | SYNONYM | peroxiredoxin activity |
2006-03-11 | Added | SYNONYM | thiol peroxidase activity |
2006-02-04 | Updated | DEFINITION | Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O. |
2004-04-19 | Added | SYNONYM | peroxiredoxin activity |
2004-04-16 | Deleted | SYNONYM | peroxiredoxin activity |
2003-10-27 | Added | SYNONYM | peroxiredoxin activity |
2003-10-23 | Updated | DEFINITION | Catalysis of the reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O. |
2003-08-21 | Added | DEFINITION | Catalysis of the reaction: reduced thioredoxin + hydrogen peroxide = oxidized thioredoxin + H2O. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-06-26 | Deleted | RELATION | is a GO:0004601 (peroxidase activity) |
2022-06-26 | Added | RELATION | is a GO:0140824 (thioredoxin-dependent peroxiredoxin activity) |
2022-05-26 | Deleted | RELATION | is a GO:0051920 (peroxiredoxin activity) |
2010-02-04 | Added | RELATION | is a GO:0004601 (peroxidase activity) |
2008-04-01 | Updated | RELATION | is a GO:0051920 (peroxiredoxin activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-05 | Added | XREF | Reactome:R-HSA-2161612 |
2024-11-03 | Deleted | XREF | Reactome:R-HSA-2161612 |
2024-11-02 | Added | XREF | Reactome:R-HSA-2161612 |
2024-11-01 | Deleted | XREF | Reactome:R-HSA-2161612 |
2024-10-26 | Added | XREF | Reactome:R-HSA-2161612 |
2024-10-09 | Deleted | XREF | Reactome:R-HSA-2161612 |
2022-05-26 | Deleted | XREF | EC:1.11.1.24 |
2022-05-07 | Added | XREF | EC:1.11.1.24 |
2020-11-14 | Added | XREF | RHEA:63528 |
2020-04-06 | Deleted | XREF | EC:1.11.1 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-3341343 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-3697894 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-3697882 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-2161612 |
2019-04-01 | Added | XREF | Reactome:R-HSA-3697882 |
2019-04-01 | Added | XREF | Reactome:R-HSA-3697894 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-3322995 |
2019-04-01 | Added | XREF | Reactome:R-HSA-3322995 |
2019-04-01 | Added | XREF | Reactome:R-HSA-3341343 |
2019-04-01 | Added | XREF | Reactome:R-HSA-2161612 |
2018-12-11 | Added | XREF | reactome:R-HSA-3322995 |
2018-12-11 | Added | XREF | reactome:R-HSA-3697894 |
2018-12-11 | Added | XREF | reactome:R-HSA-3697882 |
2018-12-11 | Added | XREF | reactome:R-HSA-2161612 |
2018-12-11 | Added | XREF | reactome:R-HSA-3341343 |
2016-10-03 | Deleted | XREF | EC:1.11.1.- |
2016-10-03 | Added | XREF | EC:1.11.1 |
2003-10-27 | Added | XREF | MetaCyc:RXN0-267 |
2001-03-30 | Added | XREF | EC:1.11.1.- |
Timestamp | Action | Category | Detail |
---|---|---|---|
2006-03-11 | Added | SECONDARY | GO:0009031 (thiol peroxidase activity) |
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