This term is obsolete.

GO:0008379 JSON

thioredoxin peroxidase activity

Molecular Function

Definition (GO:0008379 GONUTS page)

Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O.

Secondary IDs

GO:0009031

137,448 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
TPx activity exact
TrxPx activity exact
thiol peroxidase activity exact

Ancestor Chart

Ancestor chart for GO:0008379
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008379

Child Term Relationship to
GO:0008379
regulation of thioredoxin peroxidase activity
regulates
negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation
negatively_regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I5Y865 10116 A0A8I5Y865_RAT GO:0098869 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J8YB21 10116 A0A8J8YB21_RAT GO:0098869 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163

Cross-references

Database ID Description
InterPro IPR002065 Thiol peroxidase Tpx
InterPro IPR037944 Peroxiredoxin-5-like
MetaCyc RXN0-267
RHEA 63528
Reactome R-HSA-2161612
Reactome R-HSA-3322995
Reactome R-HSA-3341343
Reactome R-HSA-3697882
Reactome R-HSA-3697894

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:50058 L-cystine residue
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:29950 L-cysteine residue
has_participant CHEBI CHEBI:16240 hydrogen peroxide

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008379 based on ALL annotations
The top 100 of 538 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thioredoxin peroxidase activity
1,421.48 100.00 137,138 137,138
cell redox homeostasis
507.29 34.18 122,040 341,966
cellular response to stress
824.21 27.37 46,820 80,748
peroxidase activity
368.64 25.69 132,241 509,922
hydrogen peroxide catabolic process
483.67 24.93 66,161 194,445
cellular response to oxidative stress
441.05 24.75 75,456 243,191
antioxidant activity
463.90 23.77 63,991 196,082
cellular oxidant detoxification
229.44 16.09 134,399 832,643
thioredoxin-dependent peroxiredoxin activity
1,268.28 15.24 21,293 23,865
peroxiredoxin activity
319.34 14.09 37,603 167,380
Totals 1133631 71811421
No co-occurrence statistics for GO:0008379 based on MANUAL annotations
The top 100 of 195 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thioredoxin peroxidase activity
1,701.97 100.00 759 759
cell redox homeostasis
539.14 31.50 746 2,355
hydrogen peroxide catabolic process
601.23 30.55 526 1,489
cellular response to oxidative stress
306.20 16.21 471 2,618
response to oxidative stress
270.90 12.66 290 1,822
leukocyte activation
1,543.65 5.11 39 43
removal of superoxide radicals
132.26 3.82 53 682
peroxiredoxin activity
823.54 1.94 15 31
chloroplast thylakoid membrane
31.24 1.44 48 2,615
peroxisome
23.30 1.17 58 4,236
Totals 4072 378651

Change Log

Timestamp Action Category Detail
2024-11-05 Added XREF Reactome:R-HSA-2161612
2024-11-03 Deleted XREF Reactome:R-HSA-2161612
2024-11-02 Added XREF Reactome:R-HSA-2161612
2024-11-01 Deleted XREF Reactome:R-HSA-2161612
2024-10-26 Added XREF Reactome:R-HSA-2161612
2024-10-09 Deleted XREF Reactome:R-HSA-2161612
2022-06-26 Deleted DEFINITION Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.
2022-06-26 Added DEFINITION Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O.
2022-06-26 Deleted RELATION is a GO:0004601 (peroxidase activity)
2022-06-26 Added RELATION is a GO:0140824 (thioredoxin-dependent peroxiredoxin activity)
Timestamp Action Category Detail
2003-03-19 Updated TERM thioredoxin peroxidase activity
2002-02-06 Updated TERM thioredoxin peroxidase
2001-04-03 Updated TERM thioredoxin peroxidase
2001-03-30 Added TERM thioredoxin peroxidase
Timestamp Action Category Detail
2022-06-26 Deleted DEFINITION Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.
2022-06-26 Added DEFINITION Catalysis of the reaction: [thioredoxin]-dithiol + hydrogen peroxide = [thioredoxin]-disulfide + H2O.
2010-09-03 Deleted DEFINITION Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O.
2010-09-03 Added DEFINITION Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.
2008-05-13 Added DEFINITION Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O.
2007-08-09 Deleted SYNONYM TPx activity
2007-08-09 Added SYNONYM TPx activity
2007-08-09 Added SYNONYM TrxPx activity
2007-08-09 Added SYNONYM thiol peroxidase activity
2007-08-09 Deleted SYNONYM TrxPx activity
2007-08-09 Deleted SYNONYM thiol peroxidase activity
2007-05-12 Added SYNONYM TPx activity
2007-05-12 Added SYNONYM TrxPx activity
2006-03-11 Deleted SYNONYM peroxiredoxin activity
2006-03-11 Added SYNONYM thiol peroxidase activity
2006-02-04 Updated DEFINITION Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O.
2004-04-19 Added SYNONYM peroxiredoxin activity
2004-04-16 Deleted SYNONYM peroxiredoxin activity
2003-10-27 Added SYNONYM peroxiredoxin activity
2003-10-23 Updated DEFINITION Catalysis of the reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O.
2003-08-21 Added DEFINITION Catalysis of the reaction: reduced thioredoxin + hydrogen peroxide = oxidized thioredoxin + H2O.
Timestamp Action Category Detail
2022-06-26 Deleted RELATION is a GO:0004601 (peroxidase activity)
2022-06-26 Added RELATION is a GO:0140824 (thioredoxin-dependent peroxiredoxin activity)
2022-05-26 Deleted RELATION is a GO:0051920 (peroxiredoxin activity)
2010-02-04 Added RELATION is a GO:0004601 (peroxidase activity)
2008-04-01 Updated RELATION is a GO:0051920 (peroxiredoxin activity)
Timestamp Action Category Detail
2024-11-05 Added XREF Reactome:R-HSA-2161612
2024-11-03 Deleted XREF Reactome:R-HSA-2161612
2024-11-02 Added XREF Reactome:R-HSA-2161612
2024-11-01 Deleted XREF Reactome:R-HSA-2161612
2024-10-26 Added XREF Reactome:R-HSA-2161612
2024-10-09 Deleted XREF Reactome:R-HSA-2161612
2022-05-26 Deleted XREF EC:1.11.1.24
2022-05-07 Added XREF EC:1.11.1.24
2020-11-14 Added XREF RHEA:63528
2020-04-06 Deleted XREF EC:1.11.1
2019-04-01 Deleted XREF reactome:R-HSA-3341343
2019-04-01 Deleted XREF reactome:R-HSA-3697894
2019-04-01 Deleted XREF reactome:R-HSA-3697882
2019-04-01 Deleted XREF reactome:R-HSA-2161612
2019-04-01 Added XREF Reactome:R-HSA-3697882
2019-04-01 Added XREF Reactome:R-HSA-3697894
2019-04-01 Deleted XREF reactome:R-HSA-3322995
2019-04-01 Added XREF Reactome:R-HSA-3322995
2019-04-01 Added XREF Reactome:R-HSA-3341343
2019-04-01 Added XREF Reactome:R-HSA-2161612
2018-12-11 Added XREF reactome:R-HSA-3322995
2018-12-11 Added XREF reactome:R-HSA-3697894
2018-12-11 Added XREF reactome:R-HSA-3697882
2018-12-11 Added XREF reactome:R-HSA-2161612
2018-12-11 Added XREF reactome:R-HSA-3341343
2016-10-03 Deleted XREF EC:1.11.1.-
2016-10-03 Added XREF EC:1.11.1
2003-10-27 Added XREF MetaCyc:RXN0-267
2001-03-30 Added XREF EC:1.11.1.-
Timestamp Action Category Detail
2006-03-11 Added SECONDARY GO:0009031 (thiol peroxidase activity)
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