This term is obsolete.

GO:0008389 JSON

coumarin 7-hydroxylase activity

Molecular Function

Definition (GO:0008389 GONUTS page)

Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. PMID:10490589 PMID:2733794

8 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
cytochrome P450 CYP2A5 narrow

Ancestor Chart

Ancestor chart for GO:0008389
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0004497 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0016705 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163

Cross-references

Database ID Description
Reactome R-HSA-211881
Reactome R-HSA-76453

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008389 based on ALL annotations
The top 26 of 26 co-occurring terms
Co-occurring Term PR S% #Together #Compared
coumarin 7-hydroxylase activity
39,630,972.00 100.00 5 5
coumarin catabolic process
13,210,324.00 22.22 2 6
aflatoxin metabolic process
412,822.62 1.00 1 96
coumarin metabolic process
247,178.64 0.62 3 481
xenobiotic catabolic process
54,588.12 0.14 2 1,452
testosterone 6-beta-hydroxylase activity
46,352.02 0.12 2 1,710
epoxygenase P450 pathway
22,824.52 0.06 3 5,209
arachidonate epoxygenase activity
22,745.92 0.06 3 5,227
aromatase activity
9,375.67 0.02 2 8,454
xenobiotic metabolic process
2,721.91 0.01 3 43,680
Totals 75 112844397
No co-occurrence statistics for GO:0008389 based on MANUAL annotations
The top 20 of 20 co-occurring terms
Co-occurring Term PR S% #Together #Compared
coumarin 7-hydroxylase activity
352,883.25 100.00 4 4
coumarin catabolic process
70,576.65 12.50 1 5
coumarin metabolic process
20,757.84 5.56 2 34
aromatase activity
16,413.18 4.44 2 43
aflatoxin metabolic process
14,703.47 3.70 1 24
testosterone 6-beta-hydroxylase activity
9,940.37 2.74 2 71
xenobiotic catabolic process
5,513.80 1.49 1 64
arachidonate epoxygenase activity
3,313.46 0.93 2 213
epoxygenase P450 pathway
3,313.46 0.93 2 213
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
683.22 0.19 2 1,033
Totals 38 285784

Change Log

Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-76453
2019-04-01 Deleted XREF reactome:R-HSA-211881
2019-04-01 Added XREF Reactome:R-HSA-76453
2019-04-01 Added XREF Reactome:R-HSA-211881
2018-12-11 Added XREF reactome:R-HSA-76453
2018-12-11 Added XREF reactome:R-HSA-211881
2008-05-13 Added DEFINITION Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+.
2008-04-01 Updated RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2008-04-01 Updated RELATION is a GO:0004497 (monooxygenase activity)
Timestamp Action Category Detail
2003-03-19 Updated TERM coumarin 7-hydroxylase activity
2002-02-06 Updated TERM coumarin 7-hydroxylase
2001-04-03 Updated TERM coumarin 7-hydroxylase
2001-03-30 Added TERM coumarin 7-hydroxylase
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+.
2007-08-09 Deleted SYNONYM cytochrome P450 CYP2A5
2007-08-09 Added SYNONYM cytochrome P450 CYP2A5
2005-03-22 Added DEFINITION Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+.
2004-04-19 Added SYNONYM cytochrome P450 CYP2A5
2004-04-16 Deleted SYNONYM cytochrome P450 CYP2A5
2001-03-30 Added SYNONYM cytochrome P450 CYP2A5
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
2008-04-01 Updated RELATION is a GO:0004497 (monooxygenase activity)
Timestamp Action Category Detail
2019-04-01 Deleted XREF reactome:R-HSA-76453
2019-04-01 Deleted XREF reactome:R-HSA-211881
2019-04-01 Added XREF Reactome:R-HSA-76453
2019-04-01 Added XREF Reactome:R-HSA-211881
2018-12-11 Added XREF reactome:R-HSA-76453
2018-12-11 Added XREF reactome:R-HSA-211881
Timestamp Action Category Detail
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