GO:0008389
JSON
coumarin 7-hydroxylase activity
Molecular Function
Definition (GO:0008389 GONUTS page)
Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. PMID:10490589 PMID:2733794
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
cytochrome P450 CYP2A5 | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2U8U1P3 | 7227 | A0A2U8U1P3_DROME | GO:0004497 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683 | |
NOT-qualified manual | protein | A0A2U8U1P3 | 7227 | A0A2U8U1P3_DROME | GO:0016705 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 |
Cross-references
Database | ID | Description |
---|---|---|
Reactome | R-HSA-211881 | |
Reactome | R-HSA-76453 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008389 based on ALL annotations
The top 26 of 26 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
coumarin 7-hydroxylase activity
|
39,630,972.00 | 100.00 | 5 | 5 |
coumarin catabolic process
|
13,210,324.00 | 22.22 | 2 | 6 |
aflatoxin metabolic process
|
412,822.62 | 1.00 | 1 | 96 |
coumarin metabolic process
|
247,178.64 | 0.62 | 3 | 481 |
xenobiotic catabolic process
|
54,588.12 | 0.14 | 2 | 1,452 |
testosterone 6-beta-hydroxylase activity
|
46,352.02 | 0.12 | 2 | 1,710 |
epoxygenase P450 pathway
|
22,824.52 | 0.06 | 3 | 5,209 |
arachidonate epoxygenase activity
|
22,745.92 | 0.06 | 3 | 5,227 |
aromatase activity
|
9,375.67 | 0.02 | 2 | 8,454 |
xenobiotic metabolic process
|
2,721.91 | 0.01 | 3 | 43,680 |
Totals | 75 | 112844397 |
No co-occurrence statistics for GO:0008389 based on MANUAL annotations
The top 20 of 20 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
coumarin 7-hydroxylase activity
|
352,883.25 | 100.00 | 4 | 4 |
coumarin catabolic process
|
70,576.65 | 12.50 | 1 | 5 |
coumarin metabolic process
|
20,757.84 | 5.56 | 2 | 34 |
aromatase activity
|
16,413.18 | 4.44 | 2 | 43 |
aflatoxin metabolic process
|
14,703.47 | 3.70 | 1 | 24 |
testosterone 6-beta-hydroxylase activity
|
9,940.37 | 2.74 | 2 | 71 |
xenobiotic catabolic process
|
5,513.80 | 1.49 | 1 | 64 |
arachidonate epoxygenase activity
|
3,313.46 | 0.93 | 2 | 213 |
epoxygenase P450 pathway
|
3,313.46 | 0.93 | 2 | 213 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
683.22 | 0.19 | 2 | 1,033 |
Totals | 38 | 285784 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-76453 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-211881 |
2019-04-01 | Added | XREF | Reactome:R-HSA-76453 |
2019-04-01 | Added | XREF | Reactome:R-HSA-211881 |
2018-12-11 | Added | XREF | reactome:R-HSA-76453 |
2018-12-11 | Added | XREF | reactome:R-HSA-211881 |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. |
2008-04-01 | Updated | RELATION | is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen) |
2008-04-01 | Updated | RELATION | is a GO:0004497 (monooxygenase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | coumarin 7-hydroxylase activity |
2002-02-06 | Updated | TERM | coumarin 7-hydroxylase |
2001-04-03 | Updated | TERM | coumarin 7-hydroxylase |
2001-03-30 | Added | TERM | coumarin 7-hydroxylase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. |
2007-08-09 | Deleted | SYNONYM | cytochrome P450 CYP2A5 |
2007-08-09 | Added | SYNONYM | cytochrome P450 CYP2A5 |
2005-03-22 | Added | DEFINITION | Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. |
2004-04-19 | Added | SYNONYM | cytochrome P450 CYP2A5 |
2004-04-16 | Deleted | SYNONYM | cytochrome P450 CYP2A5 |
2001-03-30 | Added | SYNONYM | cytochrome P450 CYP2A5 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen) |
2008-04-01 | Updated | RELATION | is a GO:0004497 (monooxygenase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Deleted | XREF | reactome:R-HSA-76453 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-211881 |
2019-04-01 | Added | XREF | Reactome:R-HSA-76453 |
2019-04-01 | Added | XREF | Reactome:R-HSA-211881 |
2018-12-11 | Added | XREF | reactome:R-HSA-76453 |
2018-12-11 | Added | XREF | reactome:R-HSA-211881 |
Timestamp | Action | Category | Detail |
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