This term is obsolete.

GO:0008440 JSON

inositol-1,4,5-trisphosphate 3-kinase activity

Molecular Function

Definition (GO:0008440 GONUTS page)

Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+.

6,564 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
1D-myo-inositol-trisphosphate 3-kinase activity broad
inositol-trisphosphate 3-kinase activity broad
IP3 3-kinase activity narrow
IP3K activity narrow
Ins(1,4,5)P3 3-kinase activity related
inositol trisphosphate 3-kinase activity broad

Ancestor Chart

Ancestor chart for GO:0008440
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3Q0M1 9615 A0A8I3Q0M1_CANLF GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I6AKN3 10116 A0A8I6AKN3_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ALM9 10116 A0A8I6ALM9_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GLX5 10116 A0A8I6GLX5_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J0TR01 8355 A0A8J0TR01_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8J0TZJ2 8355 A0A8J0TZJ2_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8M2B232 7955 A0A8M2B232_DANRE GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 2.7.1.127
EC 2.7.1.151
KEGG_REACTION R03433
MetaCyc 2.7.1.127-RXN
RHEA 11020
Reactome R-HSA-1855153
Reactome R-HSA-1855233

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:203600 1D-myo-inositol 1,4,5-trisphosphate(6-)
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:57895 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
has_participant CHEBI CHEBI:456216 ADP(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008440 based on ALL annotations
The top 100 of 151 co-occurring terms
Co-occurring Term PR S% #Together #Compared
inositol-1,4,5-trisphosphate 3-kinase activity
30,707.40 100.00 6,453 6,453
inositol-1,4,5,6-tetrakisphosphate 3-kinase activity
30,707.40 59.18 3,819 3,819
inositol tetrakisphosphate kinase activity
30,707.40 42.82 2,763 2,763
inositol phosphate biosynthetic process
6,606.28 21.51 6,450 29,981
inositol-1,3,4,6-tetrakisphosphate 5-kinase activity
30,336.80 17.72 1,146 1,160
inositol-1,3,4,5-tetrakisphosphate 6-kinase activity
26,371.71 9.01 590 687
inositol-1,4,5-trisphosphate 6-kinase activity
30,707.40 7.93 512 512
inositol-1,2,3,4,6-pentakisphosphate 5-kinase activity
30,707.40 7.02 453 453
phosphatidylinositol phosphate biosynthetic process
698.40 2.23 3,634 159,781
inositol phosphate kinase activity
10,265.05 1.75 117 350
Totals 49119 67760248
No co-occurrence statistics for GO:0008440 based on MANUAL annotations
The top 74 of 74 co-occurring terms
Co-occurring Term PR S% #Together #Compared
inositol-1,4,5-trisphosphate 3-kinase activity
8,503.21 100.00 166 166
inositol tetrakisphosphate kinase activity
8,431.76 70.66 118 119
inositol phosphate biosynthetic process
2,200.51 25.71 162 626
inositol-1,4,5,6-tetrakisphosphate 3-kinase activity
8,030.81 20.24 34 36
inositol-1,4,5-trisphosphate 6-kinase activity
6,613.61 4.17 7 9
inositol-1,3,4,6-tetrakisphosphate 5-kinase activity
8,503.21 3.01 5 5
inositol trisphosphate metabolic process
3,270.47 2.87 5 13
inositol-1,3,4,5-tetrakisphosphate 6-kinase activity
2,500.94 2.81 5 17
inositol hexakisphosphate kinase activity
306.21 2.53 13 361
phosphatidylinositol phosphate biosynthetic process
212.58 2.34 45 1,800
Totals 1025 814439

Change Log

Timestamp Action Category Detail
2024-07-06 Added XREF EC:2.7.1.151
2023-11-08 Added SYNONYM inositol-trisphosphate 3-kinase activity
2023-11-08 Added SYNONYM 1D-myo-inositol-trisphosphate 3-kinase activity
2023-11-08 Deleted SYNONYM ins(1,4,5)P(3) 3-kinase activity
2023-11-08 Deleted SYNONYM inositol-trisphosphate 3-kinase activity
2023-11-08 Deleted SYNONYM 1D-myo-inositol-trisphosphate 3-kinase activity
2023-11-08 Deleted DEFINITION Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+.
2023-11-08 Added DEFINITION Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+.
2023-11-08 Deleted SYNONYM inositol trisphosphate 3-kinase activity
2023-11-08 Added SYNONYM inositol trisphosphate 3-kinase activity
Timestamp Action Category Detail
2011-11-30 Updated TERM inositol-1,4,5-trisphosphate 3-kinase activity
2005-07-25 Updated TERM inositol trisphosphate 3-kinase activity
2003-09-09 Updated TERM inositol-trisphosphate 3-kinase activity
2003-03-19 Updated TERM 1D-myo-inositol-trisphosphate 3-kinase activity
2002-02-06 Updated TERM 1D-myo-inositol-trisphosphate 3-kinase
2001-04-03 Updated TERM 1D-myo-inositol-trisphosphate 3-kinase
2001-03-30 Added TERM 1D-myo-inositol-trisphosphate 3-kinase
Timestamp Action Category Detail
2023-11-08 Added SYNONYM inositol-trisphosphate 3-kinase activity
2023-11-08 Added SYNONYM 1D-myo-inositol-trisphosphate 3-kinase activity
2023-11-08 Deleted SYNONYM ins(1,4,5)P(3) 3-kinase activity
2023-11-08 Deleted SYNONYM inositol-trisphosphate 3-kinase activity
2023-11-08 Deleted SYNONYM 1D-myo-inositol-trisphosphate 3-kinase activity
2023-11-08 Deleted DEFINITION Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+.
2023-11-08 Added DEFINITION Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+.
2023-11-08 Deleted SYNONYM inositol trisphosphate 3-kinase activity
2023-11-08 Added SYNONYM inositol trisphosphate 3-kinase activity
2023-11-08 Deleted SYNONYM ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity
2022-09-01 Deleted DEFINITION Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).
2022-09-01 Added DEFINITION Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H+.
2020-10-08 Added SYNONYM ins(1,4,5)P(3) 3-kinase activity
2020-10-08 Added SYNONYM ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity
2020-10-08 Deleted SYNONYM Ins(1,4,5)P3 3-kinase activity
2020-10-08 Deleted SYNONYM ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity
2020-10-08 Deleted SYNONYM ins(1,4,5)P(3) 3-kinase activity
2020-10-08 Added SYNONYM Ins(1,4,5)P3 3-kinase activity
2011-11-30 Deleted SYNONYM inositol 1,4,5-trisphosphate 3-kinase activity
2011-11-30 Added SYNONYM inositol trisphosphate 3-kinase activity
2010-10-11 Deleted DEFINITION Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
2010-10-11 Added DEFINITION Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
2007-11-08 Added SYNONYM ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity
2007-11-08 Added SYNONYM Ins(1,4,5)P3 3-kinase activity
2007-09-06 Added SYNONYM IP3K activity
2007-09-06 Added SYNONYM ins(1,4,5)P(3) 3-kinase activity
2007-09-06 Added SYNONYM IP3 3-kinase activity
2007-08-09 Added SYNONYM 1D-myo-inositol-trisphosphate 3-kinase activity
2007-08-09 Added SYNONYM inositol-trisphosphate 3-kinase activity
2007-08-09 Deleted SYNONYM 1D-myo-inositol-trisphosphate 3-kinase activity
2007-08-09 Deleted SYNONYM inositol 1,4,5-trisphosphate 3-kinase activity
2007-08-09 Deleted SYNONYM inositol-trisphosphate 3-kinase activity
2007-08-09 Added SYNONYM inositol 1,4,5-trisphosphate 3-kinase activity
2005-12-25 Added SYNONYM inositol 1,4,5-trisphosphate 3-kinase activity
2005-07-25 Added SYNONYM inositol-trisphosphate 3-kinase activity
2004-04-19 Added SYNONYM 1D-myo-inositol-trisphosphate 3-kinase activity
2004-04-16 Deleted SYNONYM 1D-myo-inositol-trisphosphate 3-kinase activity
2003-10-27 Added SYNONYM 1D-myo-inositol-trisphosphate 3-kinase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0051766 (inositol trisphosphate kinase activity)
Timestamp Action Category Detail
2024-07-06 Added XREF EC:2.7.1.151
2019-06-20 Deleted XREF KEGG:R03433
2019-06-20 Added XREF KEGG_REACTION:R03433
2019-04-01 Added XREF Reactome:R-HSA-1855153
2019-04-01 Added XREF Reactome:R-HSA-1855233
2019-04-01 Deleted XREF reactome:R-HSA-1855233
2019-04-01 Deleted XREF reactome:R-HSA-1855153
2018-12-11 Added XREF reactome:R-HSA-1855233
2018-12-11 Added XREF reactome:R-HSA-1855153
2018-07-13 Added XREF RHEA:11020
2018-07-13 Deleted XREF RHEA:11023
2010-10-11 Added XREF RHEA:11023
2010-10-11 Added XREF KEGG:R03433
2003-10-27 Added XREF MetaCyc:2.7.1.127-RXN
2001-03-30 Added XREF EC:2.7.1.127
Timestamp Action Category Detail
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