This term is obsolete.

GO:0008531 JSON

riboflavin kinase activity

Molecular Function

Definition (GO:0008531 GONUTS page)

Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+.

51,539 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
riboflavin kinase (phosphorylating) related
riboflavine kinase activity related
flavokinase activity related
FK related
ATP:riboflavin 5'-phosphotransferase activity related

Ancestor Chart

Ancestor chart for GO:0008531
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A1L8END5 8355 A0A1L8END5_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8EV37 8355 A0A1L8EV37_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3Q0M1 9615 A0A8I3Q0M1_CANLF GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I6AKN3 10116 A0A8I6AKN3_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ALM9 10116 A0A8I6ALM9_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GLX5 10116 A0A8I6GLX5_RAT GO:0016301 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8J0TR01 8355 A0A8J0TR01_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8J0TZJ2 8355 A0A8J0TZJ2_XENLA GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8M2B232 7955 A0A8M2B232_DANRE GO:0016773 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 2.7.1.26
InterPro IPR002606 Riboflavin kinase, bacterial
InterPro IPR015865 Riboflavin kinase domain, bacterial/eukaryotic
InterPro IPR023465 Riboflavin kinase domain superfamily
InterPro IPR023470 Riboflavin kinase, archaeal
KEGG_REACTION R00549
MetaCyc RIBOFLAVINKIN-RXN
RHEA 14357
Reactome R-HSA-196964

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57986 riboflavin(1-)
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:456216 ADP(3-)
has_participant CHEBI CHEBI:58210 FMN(3-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008531 based on ALL annotations
The top 100 of 361 co-occurring terms
Co-occurring Term PR S% #Together #Compared
riboflavin kinase activity
3,859.43 100.00 51,343 51,343
FMN biosynthetic process
3,859.43 97.47 50,046 50,046
riboflavin metabolic process
3,839.56 91.03 46,959 47,202
FMN adenylyltransferase activity
3,263.60 69.06 40,571 47,978
FAD biosynthetic process
3,279.55 67.83 39,572 46,569
riboflavin biosynthetic process
584.63 15.15 51,298 338,644
nucleotidyltransferase activity
81.50 2.10 40,821 1,933,012
kinase activity
33.16 0.86 45,960 5,349,025
phosphotransferase activity, alcohol group as acceptor
32.94 0.64 1,303 152,679
glycerol biosynthetic process
500.52 0.39 204 1,573
Totals 433964 116864455
No co-occurrence statistics for GO:0008531 based on MANUAL annotations
The top 18 of 18 co-occurring terms
Co-occurring Term PR S% #Together #Compared
riboflavin kinase activity
7,429.12 100.00 190 190
FMN biosynthetic process
7,429.12 97.37 185 185
riboflavin metabolic process
6,985.59 93.56 189 201
flavin adenine dinucleotide biosynthetic process
2,476.37 2.02 4 12
reactive oxygen species metabolic process
124.86 0.94 4 238
FMN adenylyltransferase activity
88.44 0.56 2 168
positive regulation of NAD(P)H oxidase activity
1,061.30 0.51 1 7
riboflavin biosynthetic process
42.37 0.42 3 526
apoptotic process
20.87 0.25 5 1,780
mitochondrion
8.50 0.11 56 48,955
Totals 656 618873

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+).
2022-09-01 Added DEFINITION Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+.
2020-10-08 Deleted SYNONYM riboflavin kinase (phosphorylating)
2020-10-08 Deleted SYNONYM ATP:riboflavin 5'-phosphotransferase activity
2020-10-08 Added SYNONYM riboflavin kinase (phosphorylating)
2020-10-08 Added SYNONYM flavokinase activity
2020-10-08 Added SYNONYM ATP:riboflavin 5'-phosphotransferase activity
2020-10-08 Deleted SYNONYM riboflavine kinase activity
2020-10-08 Deleted SYNONYM flavokinase activity
2020-10-08 Added SYNONYM riboflavine kinase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM riboflavin kinase activity
2002-02-06 Updated TERM riboflavin kinase
2001-04-03 Updated TERM riboflavin kinase
2001-03-30 Added TERM riboflavin kinase
Timestamp Action Category Detail
2022-09-01 Deleted DEFINITION Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+).
2022-09-01 Added DEFINITION Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H+.
2020-10-08 Deleted SYNONYM riboflavin kinase (phosphorylating)
2020-10-08 Deleted SYNONYM ATP:riboflavin 5'-phosphotransferase activity
2020-10-08 Added SYNONYM riboflavin kinase (phosphorylating)
2020-10-08 Added SYNONYM flavokinase activity
2020-10-08 Added SYNONYM ATP:riboflavin 5'-phosphotransferase activity
2020-10-08 Deleted SYNONYM riboflavine kinase activity
2020-10-08 Deleted SYNONYM flavokinase activity
2020-10-08 Added SYNONYM riboflavine kinase activity
2010-10-11 Added DEFINITION Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+).
2010-10-11 Deleted DEFINITION Catalysis of the reaction: ATP + riboflavin = ADP + FMN.
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + riboflavin = ADP + FMN.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + riboflavin = ADP + FMN.
2007-11-08 Added SYNONYM riboflavine kinase activity
2007-11-08 Added SYNONYM FK
2007-11-08 Added SYNONYM riboflavin kinase (phosphorylating)
2007-11-08 Added SYNONYM ATP:riboflavin 5'-phosphotransferase activity
2007-09-06 Added SYNONYM flavokinase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + riboflavin = ADP + FMN.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
2008-04-01 Updated RELATION is a GO:0016301 (kinase activity)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R00549
2019-06-20 Added XREF KEGG_REACTION:R00549
2019-04-01 Deleted XREF reactome:R-HSA-196964
2019-04-01 Added XREF Reactome:R-HSA-196964
2018-12-11 Added XREF reactome:R-HSA-196964
2018-07-13 Deleted XREF RHEA:14360
2018-07-13 Added XREF RHEA:14357
2010-10-11 Added XREF KEGG:R00549
2010-10-11 Added XREF RHEA:14360
2003-10-27 Added XREF MetaCyc:RIBOFLAVINKIN-RXN
2001-03-30 Added XREF EC:2.7.1.26
Timestamp Action Category Detail
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