This term is obsolete.

GO:0008589 JSON

regulation of smoothened signaling pathway

Biological Process

Definition (GO:0008589 GONUTS page)

Any process that modulates the frequency, rate or extent of smoothened signaling.

Secondary IDs

GO:0007226, GO:0043109

14,618 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
regulation of smoothened by patched related
regulation of smoothened activity related
regulation of hedgehog signaling pathway exact
regulation of hh signaling pathway exact
regulation of smoothened signalling pathway exact
regulation of smoothened receptor activity by patched related

Ancestor Chart

Ancestor chart for GO:0008589
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008589

Child Term Relationship to
GO:0008589
positive regulation of smoothened signaling pathway
is_a
regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
is_a
negative regulation of smoothened signaling pathway
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008589 based on ALL annotations
The top 100 of 836 co-occurring terms
Co-occurring Term PR S% #Together #Compared
regulation of smoothened signaling pathway
113,932.66 100.00 1,711 1,711
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
63,420.65 11.95 226 406
spinal cord dorsal/ventral patterning
43,805.48 10.98 228 593
neural tube formation
25,732.32 10.88 297 1,315
embryonic camera-type eye development
24,659.64 10.44 287 1,326
embryonic digit morphogenesis
13,623.95 9.64 568 4,750
limb development
13,558.41 9.33 516 4,336
limb morphogenesis
16,321.81 9.28 357 2,492
dorsal/ventral neural tube patterning
24,275.72 9.19 238 1,117
branching morphogenesis of an epithelial tube
16,438.56 8.84 318 2,204
Totals 15620 77278
No co-occurrence statistics for GO:0008589 based on MANUAL annotations
The top 100 of 728 co-occurring terms
Co-occurring Term PR S% #Together #Compared
regulation of smoothened signaling pathway
8,554.96 100.00 151 151
mesenchymal cell differentiation involved in lung development
8,554.96 15.89 24 24
branch elongation involved in salivary gland morphogenesis
8,554.96 15.89 24 24
fibroblast growth factor receptor signaling pathway involved in mammary gland specification
8,554.96 15.23 23 23
mammary gland bud formation
8,554.96 15.23 23 23
bud elongation involved in lung branching
5,866.26 14.81 24 35
lateral sprouting from an epithelium
8,554.96 14.57 22 22
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
7,842.05 14.38 22 24
epithelial cell proliferation involved in salivary gland morphogenesis
4,888.55 14.20 24 42
prostate epithelial cord elongation
7,238.81 14.19 22 26
Totals 2221 12034

Change Log

Timestamp Action Category Detail
2011-01-16 Deleted RELATION is a GO:0035466 (regulation of signaling pathway)
2011-01-16 Added RELATION is a GO:0009966 (regulation of signal transduction)
2010-05-23 Added SYNONYM regulation of hh signaling pathway
2010-05-23 Added SYNONYM regulation of hedgehog signaling pathway
2010-04-21 Added RELATION is a GO:0035466 (regulation of signaling pathway)
2010-04-21 Deleted RELATION is a GO:0009966 (regulation of signal transduction)
2008-05-13 Added DEFINITION Any process that modulates the frequency, rate or extent of smoothened signaling.
2008-05-12 Deleted DEFINITION Any process that modulates the frequency, rate or extent of smoothened signaling.
2008-04-01 Added RELATION regulates GO:0007224 (smoothened signaling pathway)
2008-04-01 Deleted RELATION part of GO:0007224 (smoothened signaling pathway)
Timestamp Action Category Detail
2004-12-17 Updated TERM regulation of smoothened signaling pathway
2003-12-20 Updated TERM regulation of smoothened receptor signaling pathway
2003-08-12 Updated TERM regulation of smoothened signaling pathway
2002-02-06 Updated TERM regulation of smoothened receptor signaling pathway
2001-11-27 Updated TERM regulation of smoothened receptor signaling pathway
2001-04-03 Updated TERM regulation of smo receptor signaling pathway
2001-03-30 Added TERM regulation of smo receptor signaling pathway
Timestamp Action Category Detail
2010-05-23 Added SYNONYM regulation of hh signaling pathway
2010-05-23 Added SYNONYM regulation of hedgehog signaling pathway
2008-05-13 Added DEFINITION Any process that modulates the frequency, rate or extent of smoothened signaling.
2008-05-12 Deleted DEFINITION Any process that modulates the frequency, rate or extent of smoothened signaling.
2008-01-21 Added SYNONYM regulation of smoothened activity
2008-01-21 Added SYNONYM regulation of smoothened receptor activity by patched
2008-01-21 Added SYNONYM regulation of smoothened by patched
2007-08-09 Deleted SYNONYM regulation of smoothened signalling pathway
2007-08-09 Added SYNONYM regulation of smoothened signalling pathway
2004-12-17 Updated DEFINITION Any process that modulates the frequency, rate or extent of smoothened signaling.
2004-04-19 Added SYNONYM regulation of smoothened signalling pathway
2004-04-16 Deleted SYNONYM regulation of smoothened signalling pathway
2003-11-13 Added SYNONYM regulation of smoothened signalling pathway
2002-11-27 Added DEFINITION Any process that modulates the frequency, rate or extent of smoothened receptor signaling pathway activity.
Timestamp Action Category Detail
2011-01-16 Deleted RELATION is a GO:0035466 (regulation of signaling pathway)
2011-01-16 Added RELATION is a GO:0009966 (regulation of signal transduction)
2010-04-21 Added RELATION is a GO:0035466 (regulation of signaling pathway)
2010-04-21 Deleted RELATION is a GO:0009966 (regulation of signal transduction)
2008-04-01 Added RELATION regulates GO:0007224 (smoothened signaling pathway)
2008-04-01 Deleted RELATION part of GO:0007224 (smoothened signaling pathway)
2008-04-01 Updated RELATION is a GO:0009966 (regulation of signal transduction)
2008-04-01 Updated RELATION part of GO:0007224 (smoothened signaling pathway)
Timestamp Action Category Detail
Timestamp Action Category Detail
2008-01-21 Added SECONDARY GO:0043109 (regulation of smoothened activity)
2008-01-21 Added SECONDARY GO:0007226 (regulation of smoothened receptor activity by patched)
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