GO:0008657
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DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
Molecular Function
Definition (GO:0008657 GONUTS page)
Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
DNA gyrase inhibitor activity | exact |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR002712 | Toxin CcdB |
InterPro | IPR024911 | DNA gyrase inhibitor GyrI |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008657 based on ALL annotations
The top 48 of 48 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
|
13,021.96 | 100.00 | 14,970 | 14,970 |
plasmid maintenance
|
5,718.58 | 19.15 | 3,796 | 8,644 |
zinc ion binding
|
28.69 | 0.22 | 10,224 | 4,641,088 |
regulation of DNA-templated transcription
|
14.04 | 0.11 | 10,212 | 9,472,174 |
metal ion binding
|
5.59 | 0.04 | 10,213 | 23,771,070 |
tRNA threonylcarbamoyladenosine modification
|
2.13 | 0.01 | 23 | 140,419 |
negative regulation of DNA-templated DNA replication
|
104.18 | 0.01 | 2 | 250 |
protein binding
|
1.25 | 0.01 | 4 | 41,817 |
plasmid partitioning
|
153.20 | 0.01 | 1 | 85 |
protein heterotetramerization
|
10.82 | 0.01 | 1 | 1,204 |
Totals | 50568 | 228553489 |
No co-occurrence statistics for GO:0008657 based on MANUAL annotations
The top 12 of 12 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
|
258,359.80 | 100.00 | 5 | 5 |
plasmid partitioning
|
28,706.65 | 7.69 | 1 | 9 |
negative regulation of DNA-templated DNA replication
|
16,147.49 | 5.00 | 1 | 16 |
glutamate racemase activity
|
8,073.74 | 2.78 | 1 | 32 |
protein heterotetramerization
|
2,327.57 | 0.87 | 1 | 111 |
peptidoglycan biosynthetic process
|
997.53 | 0.38 | 1 | 259 |
response to antibiotic
|
711.74 | 0.27 | 1 | 363 |
protein homodimerization activity
|
97.15 | 0.04 | 2 | 5,319 |
DNA damage response
|
68.35 | 0.03 | 1 | 3,780 |
zinc ion binding
|
40.82 | 0.02 | 1 | 6,330 |
Totals | 19 | 189969 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-12 | Added | RELATION | is a GO:0042030 (ATPase inhibitor activity) |
2022-09-16 | Deleted | RELATION | is a GO:0042030 (ATPase inhibitor activity) |
2021-06-22 | Deleted | RELATION | part of GO:2000372 (negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity) |
2021-06-18 | Added | RELATION | is a GO:0004857 (enzyme inhibitor activity) |
2021-02-17 | Added | DEFINITION | Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. |
2021-02-17 | Deleted | DEFINITION | Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. |
2019-08-23 | Updated | TERM | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity |
2011-08-12 | Added | RELATION | part of GO:2000372 (negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity) |
2011-08-12 | Added | RELATION | is a GO:0072586 (DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity) |
2011-08-12 | Added | RELATION | is a GO:0042030 (ATPase inhibitor activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-08-23 | Updated | TERM | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity |
2009-01-29 | Updated | TERM | DNA topoisomerase (ATP-hydrolyzing) inhibitor activity |
2003-03-19 | Updated | TERM | DNA gyrase inhibitor activity |
2002-02-06 | Updated | TERM | DNA gyrase inhibitor |
2001-04-03 | Updated | TERM | DNA gyrase inhibitor |
2001-03-30 | Added | TERM | DNA gyrase inhibitor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-02-17 | Added | DEFINITION | Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. |
2021-02-17 | Deleted | DEFINITION | Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. |
2009-01-29 | Added | SYNONYM | DNA gyrase inhibitor activity |
2009-01-29 | Deleted | DEFINITION | Stops, prevents or reduces the activity of DNA gyrase. |
2009-01-29 | Added | DEFINITION | Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. |
2008-05-13 | Added | DEFINITION | Stops, prevents or reduces the activity of DNA gyrase. |
2008-05-12 | Deleted | DEFINITION | Stops, prevents or reduces the activity of DNA gyrase. |
2003-06-17 | Added | DEFINITION | Stops, prevents or reduces the activity of DNA gyrase. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-12 | Added | RELATION | is a GO:0042030 (ATPase inhibitor activity) |
2022-09-16 | Deleted | RELATION | is a GO:0042030 (ATPase inhibitor activity) |
2021-06-22 | Deleted | RELATION | part of GO:2000372 (negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity) |
2021-06-18 | Added | RELATION | is a GO:0004857 (enzyme inhibitor activity) |
2011-08-12 | Added | RELATION | part of GO:2000372 (negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity) |
2011-08-12 | Added | RELATION | is a GO:0072586 (DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity) |
2011-08-12 | Added | RELATION | is a GO:0042030 (ATPase inhibitor activity) |
2011-08-12 | Added | RELATION | negatively regulates GO:0003918 (DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity) |
2011-08-12 | Deleted | RELATION | is a GO:0004857 (enzyme inhibitor activity) |
2008-04-01 | Updated | RELATION | is a GO:0004857 (enzyme inhibitor activity) |
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Timestamp | Action | Category | Detail |
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