This term is obsolete.

GO:0008657 JSON

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

Molecular Function

Definition (GO:0008657 GONUTS page)

Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.

14,973 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
DNA gyrase inhibitor activity exact

Ancestor Chart

Ancestor chart for GO:0008657
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Cross-references

Database ID Description
InterPro IPR002712 Toxin CcdB
InterPro IPR024911 DNA gyrase inhibitor GyrI

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008657 based on ALL annotations
The top 48 of 48 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
13,021.96 100.00 14,970 14,970
plasmid maintenance
5,718.58 19.15 3,796 8,644
zinc ion binding
28.69 0.22 10,224 4,641,088
regulation of DNA-templated transcription
14.04 0.11 10,212 9,472,174
metal ion binding
5.59 0.04 10,213 23,771,070
tRNA threonylcarbamoyladenosine modification
2.13 0.01 23 140,419
negative regulation of DNA-templated DNA replication
104.18 0.01 2 250
protein binding
1.25 0.01 4 41,817
plasmid partitioning
153.20 0.01 1 85
protein heterotetramerization
10.82 0.01 1 1,204
Totals 50568 228553489
No co-occurrence statistics for GO:0008657 based on MANUAL annotations
The top 12 of 12 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
258,359.80 100.00 5 5
plasmid partitioning
28,706.65 7.69 1 9
negative regulation of DNA-templated DNA replication
16,147.49 5.00 1 16
glutamate racemase activity
8,073.74 2.78 1 32
protein heterotetramerization
2,327.57 0.87 1 111
peptidoglycan biosynthetic process
997.53 0.38 1 259
response to antibiotic
711.74 0.27 1 363
protein homodimerization activity
97.15 0.04 2 5,319
DNA damage response
68.35 0.03 1 3,780
zinc ion binding
40.82 0.02 1 6,330
Totals 19 189969

Change Log

Timestamp Action Category Detail
2022-12-12 Added RELATION is a GO:0042030 (ATPase inhibitor activity)
2022-09-16 Deleted RELATION is a GO:0042030 (ATPase inhibitor activity)
2021-06-22 Deleted RELATION part of GO:2000372 (negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity)
2021-06-18 Added RELATION is a GO:0004857 (enzyme inhibitor activity)
2021-02-17 Added DEFINITION Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2021-02-17 Deleted DEFINITION Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2019-08-23 Updated TERM DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
2011-08-12 Added RELATION part of GO:2000372 (negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity)
2011-08-12 Added RELATION is a GO:0072586 (DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity)
2011-08-12 Added RELATION is a GO:0042030 (ATPase inhibitor activity)
Timestamp Action Category Detail
2019-08-23 Updated TERM DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
2009-01-29 Updated TERM DNA topoisomerase (ATP-hydrolyzing) inhibitor activity
2003-03-19 Updated TERM DNA gyrase inhibitor activity
2002-02-06 Updated TERM DNA gyrase inhibitor
2001-04-03 Updated TERM DNA gyrase inhibitor
2001-03-30 Added TERM DNA gyrase inhibitor
Timestamp Action Category Detail
2021-02-17 Added DEFINITION Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2021-02-17 Deleted DEFINITION Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2009-01-29 Added SYNONYM DNA gyrase inhibitor activity
2009-01-29 Deleted DEFINITION Stops, prevents or reduces the activity of DNA gyrase.
2009-01-29 Added DEFINITION Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of DNA gyrase.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of DNA gyrase.
2003-06-17 Added DEFINITION Stops, prevents or reduces the activity of DNA gyrase.
Timestamp Action Category Detail
2022-12-12 Added RELATION is a GO:0042030 (ATPase inhibitor activity)
2022-09-16 Deleted RELATION is a GO:0042030 (ATPase inhibitor activity)
2021-06-22 Deleted RELATION part of GO:2000372 (negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity)
2021-06-18 Added RELATION is a GO:0004857 (enzyme inhibitor activity)
2011-08-12 Added RELATION part of GO:2000372 (negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity)
2011-08-12 Added RELATION is a GO:0072586 (DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity)
2011-08-12 Added RELATION is a GO:0042030 (ATPase inhibitor activity)
2011-08-12 Added RELATION negatively regulates GO:0003918 (DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity)
2011-08-12 Deleted RELATION is a GO:0004857 (enzyme inhibitor activity)
2008-04-01 Updated RELATION is a GO:0004857 (enzyme inhibitor activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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