GO:0008663
JSON
2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
Molecular Function
Definition (GO:0008663 GONUTS page)
Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
2',3'-cyclic nucleotidase activity | related |
2':3'-cyclic phosphodiesterase activity | related |
2',3'-cyclic AMP 2'-phosphohydrolase activity | related |
cyclic phosphodiesterase:3'-nucleotidase activity | related |
nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity | related |
cyclic 2',3'-nucleotide 2'-phosphodiesterase activity | related |
2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity | related |
cyclic 2',3'-nucleotide phosphodiesterase | broad |
2',3'-cyclic nucleotide phosphohydrolase | broad |
2',3'-cyclic nucleoside monophosphate phosphodiesterase | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.1.4.16 | |
InterPro | IPR006294 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase |
MetaCyc | CYCPHOSDIESTER-RXN | |
RHEA | 19621 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:66954 | 2',3'-cyclic nucleotide(1-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:66949 | nucleoside 3'-phosphate(2-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0008663 based on ALL annotations
The top 100 of 262 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
|
20,860.22 | 100.00 | 9,345 | 9,345 |
CDP-glycerol diphosphatase activity
|
20,460.27 | 27.77 | 2,609 | 2,660 |
3'-nucleotidase activity
|
3,968.90 | 16.89 | 5,611 | 29,491 |
ADP-ribose diphosphatase activity
|
2,588.55 | 9.40 | 2,609 | 21,025 |
nucleotidase activity
|
1,975.17 | 9.04 | 6,213 | 65,617 |
nucleotide catabolic process
|
1,743.34 | 8.05 | 6,439 | 77,047 |
hydrolase activity, acting on ester bonds
|
218.17 | 1.03 | 3,969 | 379,489 |
cell envelope
|
177.12 | 0.84 | 5,885 | 693,121 |
outer membrane-bounded periplasmic space
|
150.25 | 0.72 | 6,357 | 882,563 |
manganese ion binding
|
115.61 | 0.55 | 2,610 | 470,951 |
Totals | 75911 | 54243392 |
No co-occurrence statistics for GO:0008663 based on MANUAL annotations
The top 22 of 22 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
|
14,514.60 | 100.00 | 89 | 89 |
CDP-glycerol diphosphatase activity
|
14,514.60 | 96.63 | 86 | 86 |
ADP-ribose diphosphatase activity
|
3,066.97 | 20.98 | 86 | 407 |
manganese ion binding
|
1,151.11 | 7.92 | 87 | 1,097 |
poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends
|
1,814.32 | 1.04 | 1 | 8 |
3'-nucleotidase activity
|
230.39 | 0.66 | 1 | 63 |
U6 snRNA 3'-end processing
|
156.07 | 0.55 | 1 | 93 |
phosphate ion binding
|
152.79 | 0.55 | 1 | 95 |
cell wall modification
|
75.99 | 0.36 | 1 | 191 |
ferric iron binding
|
19.46 | 0.12 | 1 | 746 |
Totals | 367 | 617753 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | ribonucleoside 2',3'-cyclic phosphate diesterase activity |
2020-10-08 | Added | SYNONYM | ribonucleoside 2',3'-cyclic phosphate diesterase activity |
2020-10-08 | Added | SYNONYM | 2',3'-cyclic nucleotidase activity |
2020-10-08 | Deleted | SYNONYM | cyclic phosphodiesterase:3'-nucleotidase activity |
2020-10-08 | Added | SYNONYM | nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity |
2020-10-08 | Added | SYNONYM | cyclic phosphodiesterase:3'-nucleotidase activity |
2020-10-08 | Added | SYNONYM | cyclic 2',3'-nucleotide 2'-phosphodiesterase activity |
2020-10-08 | Added | SYNONYM | 2',3 '-cyclic AMP phosphodiesterase activity |
2020-10-08 | Added | SYNONYM | 2':3'-cyclic phosphodiesterase activity |
2020-10-08 | Added | SYNONYM | 2',3'-cyclic AMP 2'-phosphohydrolase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity |
2002-02-06 | Updated | TERM | 2',3'-cyclic-nucleotide 2'-phosphodiesterase |
2001-04-03 | Updated | TERM | 2',3'-cyclic-nucleotide 2'-phosphodiesterase |
2001-03-30 | Added | TERM | 2',3'-cyclic-nucleotide 2'-phosphodiesterase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | ribonucleoside 2',3'-cyclic phosphate diesterase activity |
2020-10-08 | Added | SYNONYM | ribonucleoside 2',3'-cyclic phosphate diesterase activity |
2020-10-08 | Added | SYNONYM | 2',3'-cyclic nucleotidase activity |
2020-10-08 | Deleted | SYNONYM | cyclic phosphodiesterase:3'-nucleotidase activity |
2020-10-08 | Added | SYNONYM | nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity |
2020-10-08 | Added | SYNONYM | cyclic phosphodiesterase:3'-nucleotidase activity |
2020-10-08 | Added | SYNONYM | cyclic 2',3'-nucleotide 2'-phosphodiesterase activity |
2020-10-08 | Added | SYNONYM | 2',3 '-cyclic AMP phosphodiesterase activity |
2020-10-08 | Added | SYNONYM | 2':3'-cyclic phosphodiesterase activity |
2020-10-08 | Added | SYNONYM | 2',3'-cyclic AMP 2'-phosphohydrolase activity |
2020-10-08 | Deleted | SYNONYM | nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity |
2020-10-08 | Added | SYNONYM | 2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity |
2020-10-08 | Deleted | SYNONYM | 2',3 '-cyclic AMP phosphodiesterase activity |
2020-10-08 | Deleted | SYNONYM | 2',3'-cyclic AMP 2'-phosphohydrolase activity |
2020-10-08 | Deleted | SYNONYM | 2',3'-cyclic nucleotidase activity |
2020-10-08 | Deleted | SYNONYM | 2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity |
2020-10-08 | Deleted | SYNONYM | 2':3'-cyclic phosphodiesterase activity |
2020-10-08 | Deleted | SYNONYM | cyclic 2',3'-nucleotide 2'-phosphodiesterase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate. |
2007-11-08 | Added | SYNONYM | 2',3 '-cyclic AMP phosphodiesterase activity |
2007-11-08 | Added | SYNONYM | 2',3'-cyclic AMP 2'-phosphohydrolase activity |
2007-11-08 | Added | SYNONYM | 2',3'-cyclic nucleoside monophosphate phosphodiesterase |
2007-11-08 | Added | SYNONYM | 2',3'-cyclic nucleotidase activity |
2007-11-08 | Added | SYNONYM | 2',3'-cyclic nucleotide phosphohydrolase |
2007-11-08 | Added | SYNONYM | 2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity |
2007-11-08 | Added | SYNONYM | 2':3'-cyclic phosphodiesterase activity |
2007-11-08 | Added | SYNONYM | cyclic 2',3'-nucleotide 2'-phosphodiesterase activity |
2007-11-08 | Added | SYNONYM | cyclic 2',3'-nucleotide phosphodiesterase |
2007-11-08 | Added | SYNONYM | cyclic phosphodiesterase:3'-nucleotidase activity |
2007-11-08 | Added | SYNONYM | nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity |
2007-11-08 | Added | SYNONYM | ribonucleoside 2',3'-cyclic phosphate diesterase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0004112 (cyclic-nucleotide phosphodiesterase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:19621 |
2003-10-27 | Added | XREF | MetaCyc:CYCPHOSDIESTER-RXN |
2001-03-30 | Added | XREF | EC:3.1.4.16 |
Timestamp | Action | Category | Detail |
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