This term is obsolete.

GO:0008663 JSON

2',3'-cyclic-nucleotide 2'-phosphodiesterase activity

Molecular Function

Definition (GO:0008663 GONUTS page)

Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.

9,348 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
2',3'-cyclic nucleotidase activity related
2':3'-cyclic phosphodiesterase activity related
2',3'-cyclic AMP 2'-phosphohydrolase activity related
cyclic phosphodiesterase:3'-nucleotidase activity related
nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity related
cyclic 2',3'-nucleotide 2'-phosphodiesterase activity related
2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity related
cyclic 2',3'-nucleotide phosphodiesterase broad
2',3'-cyclic nucleotide phosphohydrolase broad
2',3'-cyclic nucleoside monophosphate phosphodiesterase broad

Ancestor Chart

Ancestor chart for GO:0008663
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
EC 3.1.4.16
InterPro IPR006294 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
MetaCyc CYCPHOSDIESTER-RXN
RHEA 19621

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:66954 2',3'-cyclic nucleotide(1-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:66949 nucleoside 3'-phosphate(2-)
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008663 based on ALL annotations
The top 100 of 262 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
20,860.22 100.00 9,345 9,345
CDP-glycerol diphosphatase activity
20,460.27 27.77 2,609 2,660
3'-nucleotidase activity
3,968.90 16.89 5,611 29,491
ADP-ribose diphosphatase activity
2,588.55 9.40 2,609 21,025
nucleotidase activity
1,975.17 9.04 6,213 65,617
nucleotide catabolic process
1,743.34 8.05 6,439 77,047
hydrolase activity, acting on ester bonds
218.17 1.03 3,969 379,489
cell envelope
177.12 0.84 5,885 693,121
outer membrane-bounded periplasmic space
150.25 0.72 6,357 882,563
manganese ion binding
115.61 0.55 2,610 470,951
Totals 75911 54243392
No co-occurrence statistics for GO:0008663 based on MANUAL annotations
The top 22 of 22 co-occurring terms
Co-occurring Term PR S% #Together #Compared
2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
14,514.60 100.00 89 89
CDP-glycerol diphosphatase activity
14,514.60 96.63 86 86
ADP-ribose diphosphatase activity
3,066.97 20.98 86 407
manganese ion binding
1,151.11 7.92 87 1,097
poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends
1,814.32 1.04 1 8
3'-nucleotidase activity
230.39 0.66 1 63
U6 snRNA 3'-end processing
156.07 0.55 1 93
phosphate ion binding
152.79 0.55 1 95
cell wall modification
75.99 0.36 1 191
ferric iron binding
19.46 0.12 1 746
Totals 367 617753

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM ribonucleoside 2',3'-cyclic phosphate diesterase activity
2020-10-08 Added SYNONYM ribonucleoside 2',3'-cyclic phosphate diesterase activity
2020-10-08 Added SYNONYM 2',3'-cyclic nucleotidase activity
2020-10-08 Deleted SYNONYM cyclic phosphodiesterase:3'-nucleotidase activity
2020-10-08 Added SYNONYM nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity
2020-10-08 Added SYNONYM cyclic phosphodiesterase:3'-nucleotidase activity
2020-10-08 Added SYNONYM cyclic 2',3'-nucleotide 2'-phosphodiesterase activity
2020-10-08 Added SYNONYM 2',3 '-cyclic AMP phosphodiesterase activity
2020-10-08 Added SYNONYM 2':3'-cyclic phosphodiesterase activity
2020-10-08 Added SYNONYM 2',3'-cyclic AMP 2'-phosphohydrolase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity
2002-02-06 Updated TERM 2',3'-cyclic-nucleotide 2'-phosphodiesterase
2001-04-03 Updated TERM 2',3'-cyclic-nucleotide 2'-phosphodiesterase
2001-03-30 Added TERM 2',3'-cyclic-nucleotide 2'-phosphodiesterase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM ribonucleoside 2',3'-cyclic phosphate diesterase activity
2020-10-08 Added SYNONYM ribonucleoside 2',3'-cyclic phosphate diesterase activity
2020-10-08 Added SYNONYM 2',3'-cyclic nucleotidase activity
2020-10-08 Deleted SYNONYM cyclic phosphodiesterase:3'-nucleotidase activity
2020-10-08 Added SYNONYM nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity
2020-10-08 Added SYNONYM cyclic phosphodiesterase:3'-nucleotidase activity
2020-10-08 Added SYNONYM cyclic 2',3'-nucleotide 2'-phosphodiesterase activity
2020-10-08 Added SYNONYM 2',3 '-cyclic AMP phosphodiesterase activity
2020-10-08 Added SYNONYM 2':3'-cyclic phosphodiesterase activity
2020-10-08 Added SYNONYM 2',3'-cyclic AMP 2'-phosphohydrolase activity
2020-10-08 Deleted SYNONYM nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity
2020-10-08 Added SYNONYM 2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity
2020-10-08 Deleted SYNONYM 2',3 '-cyclic AMP phosphodiesterase activity
2020-10-08 Deleted SYNONYM 2',3'-cyclic AMP 2'-phosphohydrolase activity
2020-10-08 Deleted SYNONYM 2',3'-cyclic nucleotidase activity
2020-10-08 Deleted SYNONYM 2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity
2020-10-08 Deleted SYNONYM 2':3'-cyclic phosphodiesterase activity
2020-10-08 Deleted SYNONYM cyclic 2',3'-nucleotide 2'-phosphodiesterase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.
2007-11-08 Added SYNONYM 2',3 '-cyclic AMP phosphodiesterase activity
2007-11-08 Added SYNONYM 2',3'-cyclic AMP 2'-phosphohydrolase activity
2007-11-08 Added SYNONYM 2',3'-cyclic nucleoside monophosphate phosphodiesterase
2007-11-08 Added SYNONYM 2',3'-cyclic nucleotidase activity
2007-11-08 Added SYNONYM 2',3'-cyclic nucleotide phosphohydrolase
2007-11-08 Added SYNONYM 2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity
2007-11-08 Added SYNONYM 2':3'-cyclic phosphodiesterase activity
2007-11-08 Added SYNONYM cyclic 2',3'-nucleotide 2'-phosphodiesterase activity
2007-11-08 Added SYNONYM cyclic 2',3'-nucleotide phosphodiesterase
2007-11-08 Added SYNONYM cyclic phosphodiesterase:3'-nucleotidase activity
2007-11-08 Added SYNONYM nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity
2007-11-08 Added SYNONYM ribonucleoside 2',3'-cyclic phosphate diesterase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0004112 (cyclic-nucleotide phosphodiesterase activity)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:19621
2003-10-27 Added XREF MetaCyc:CYCPHOSDIESTER-RXN
2001-03-30 Added XREF EC:3.1.4.16
Timestamp Action Category Detail
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