This term is obsolete.

GO:0008686 JSON

3,4-dihydroxy-2-butanone-4-phosphate synthase activity

Molecular Function

Definition (GO:0008686 GONUTS page)

Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+.

50,727 annotations

Ancestor Chart

Ancestor chart for GO:0008686
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q946J8 3702 LHP1_ARATH GO:0008686 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:23203051

Cross-references

Database ID Description
EC 4.1.99.12
InterPro IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB
KEGG_REACTION R07281
MetaCyc DIOHBUTANONEPSYN-RXN
RHEA 18457

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58121 D-ribulose 5-phosphate(2-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:15740 formate
has_participant CHEBI CHEBI:58830 (2S)-2-hydroxy-3-oxobutyl phosphate(2-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0008686 based on ALL annotations
The top 100 of 245 co-occurring terms
Co-occurring Term PR S% #Together #Compared
3,4-dihydroxy-2-butanone-4-phosphate synthase activity
3,920.21 100.00 50,547 50,547
GTP cyclohydrolase II activity
2,768.64 59.79 40,225 56,956
riboflavin biosynthetic process
584.73 14.91 50,511 338,644
manganese ion binding
274.43 6.76 33,656 480,768
mitochondrial intermembrane space
71.39 1.19 1,684 92,473
catalytic activity
42.21 1.08 50,124 4,655,290
magnesium ion binding
41.13 1.04 33,660 3,208,148
lyase activity
35.83 0.91 41,336 4,523,172
GTP binding
35.68 0.90 22,970 2,523,530
cytosol
13.65 0.35 48,705 13,989,509
Totals 471613 106035479
No co-occurrence statistics for GO:0008686 based on MANUAL annotations
The top 30 of 30 co-occurring terms
Co-occurring Term PR S% #Together #Compared
3,4-dihydroxy-2-butanone-4-phosphate synthase activity
7,629.91 100.00 185 185
riboflavin biosynthetic process
2,654.51 34.66 183 526
GTP cyclohydrolase II activity
457.79 1.29 3 50
chloroplast
73.12 0.95 108 11,269
mitochondrial intermembrane space
80.74 0.95 16 1,512
shoot system morphogenesis
762.99 0.52 1 10
vernalization response
448.82 0.50 1 17
photoperiodism
158.96 0.43 1 48
photoperiodism, flowering
152.60 0.43 1 50
multidimensional cell growth
61.04 0.32 1 125
Totals 597 420208

Change Log

Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+).
2019-06-20 Deleted XREF KEGG:R07281
2019-06-20 Added XREF KEGG_REACTION:R07281
2018-07-13 Deleted XREF RHEA:18460
2018-07-13 Added XREF RHEA:18457
2010-10-11 Deleted DEFINITION Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate.
2010-10-11 Added DEFINITION Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+).
2010-10-11 Added XREF KEGG:R07281
2010-10-11 Added XREF RHEA:18460
Timestamp Action Category Detail
2004-10-29 Updated TERM 3,4-dihydroxy-2-butanone-4-phosphate synthase activity
2003-03-19 Updated TERM 3,4 dihydroxy-2-butanone-4-phosphate synthase activity
2002-02-06 Updated TERM 3,4 dihydroxy-2-butanone-4-phosphate synthase
2001-04-03 Updated TERM 3,4 dihydroxy-2-butanone-4-phosphate synthase
2001-03-30 Added TERM 3,4 dihydroxy-2-butanone-4-phosphate synthase
Timestamp Action Category Detail
2022-09-01 Added DEFINITION Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+.
2022-09-01 Deleted DEFINITION Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+).
2010-10-11 Deleted DEFINITION Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate.
2010-10-11 Added DEFINITION Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+).
2008-05-13 Added DEFINITION Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate.
2003-10-30 Updated DEFINITION Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate.
2003-03-26 Added DEFINITION Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-P + formate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016830 (carbon-carbon lyase activity)
Timestamp Action Category Detail
2019-06-20 Deleted XREF KEGG:R07281
2019-06-20 Added XREF KEGG_REACTION:R07281
2018-07-13 Deleted XREF RHEA:18460
2018-07-13 Added XREF RHEA:18457
2010-10-11 Added XREF KEGG:R07281
2010-10-11 Added XREF RHEA:18460
2007-12-02 Added XREF EC:4.1.99.12
2003-10-27 Added XREF MetaCyc:DIOHBUTANONEPSYN-RXN
Timestamp Action Category Detail
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